DK0614887T3 - Indolsulfonamider som antitumormidler - Google Patents
Indolsulfonamider som antitumormidlerInfo
- Publication number
- DK0614887T3 DK0614887T3 DK94301671.7T DK94301671T DK0614887T3 DK 0614887 T3 DK0614887 T3 DK 0614887T3 DK 94301671 T DK94301671 T DK 94301671T DK 0614887 T3 DK0614887 T3 DK 0614887T3
- Authority
- DK
- Denmark
- Prior art keywords
- antitumor agents
- indolinesulfonamide
- indolesulfonamide
- chem
- derivatives
- Prior art date
Links
- RYMYQAMZUWJAEO-UHFFFAOYSA-N 1h-indole-2-sulfonamide Chemical class C1=CC=C2NC(S(=O)(=O)N)=CC2=C1 RYMYQAMZUWJAEO-UHFFFAOYSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- IWPJHISUYDXHGJ-UHFFFAOYSA-N 2,3-dihydroindole-1-sulfonamide Chemical class C1=CC=C2N(S(=O)(=O)N)CCC2=C1 IWPJHISUYDXHGJ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- -1 substituted-indolesulfonamide Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2909593A | 1993-03-10 | 1993-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0614887T3 true DK0614887T3 (da) | 1997-10-20 |
Family
ID=21847185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94301671.7T DK0614887T3 (da) | 1993-03-10 | 1994-03-09 | Indolsulfonamider som antitumormidler |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0614887B1 (xx) |
| JP (1) | JPH08507532A (xx) |
| KR (1) | KR960700710A (xx) |
| AT (1) | ATE154345T1 (xx) |
| AU (1) | AU687042B2 (xx) |
| BR (1) | BR9405997A (xx) |
| CA (1) | CA2157801A1 (xx) |
| CZ (1) | CZ232695A3 (xx) |
| DE (1) | DE69403695T2 (xx) |
| DK (1) | DK0614887T3 (xx) |
| ES (1) | ES2102774T3 (xx) |
| FI (1) | FI954213L (xx) |
| GR (1) | GR3023827T3 (xx) |
| HU (1) | HU218660B (xx) |
| NO (1) | NO953557L (xx) |
| NZ (1) | NZ263080A (xx) |
| PL (1) | PL310558A1 (xx) |
| RU (1) | RU2127259C1 (xx) |
| WO (1) | WO1994020101A1 (xx) |
| ZA (1) | ZA941500B (xx) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1079096C (zh) * | 1996-08-22 | 2002-02-13 | 同和药品工业株式会社 | 用作抗肿瘤剂的芳磺酰基咪唑啉酮衍生物 |
| DE19919793A1 (de) | 1999-04-30 | 2000-11-02 | Bayer Ag | Neue Sulfonamide |
| US7282595B2 (en) | 2002-11-22 | 2007-10-16 | Eli Lilly And Company | Antitumor benzoylsulfonamides |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1240866B (de) * | 1961-06-29 | 1967-05-24 | Heyden Chem Fab | Verfahren zur Herstellung von Indolin-6-sulfonylharnstoffen |
| US5116874A (en) * | 1985-09-23 | 1992-05-26 | Eli Lilly And Company | Anti-tumor method and compounds |
| IL80032A (en) * | 1985-09-23 | 1992-07-15 | Lilly Co Eli | Anti-tumor phenyl-aminocarbonylsulfonamides,their preparation and pharmaceutical compositions containing them |
| CA1331464C (en) * | 1987-05-12 | 1994-08-16 | Eli Lilly And Company | Anti-tumor method and compounds |
| NZ238911A (en) * | 1990-07-17 | 1993-10-26 | Lilly Co Eli | Furyl, pyrrolyl and thienyl sulphonyl urea derivatives, pharmaceutical compositions and intermediates therefor |
| US5169860A (en) * | 1992-03-13 | 1992-12-08 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
-
1994
- 1994-03-03 ZA ZA941500A patent/ZA941500B/xx unknown
- 1994-03-09 DE DE69403695T patent/DE69403695T2/de not_active Expired - Fee Related
- 1994-03-09 DK DK94301671.7T patent/DK0614887T3/da active
- 1994-03-09 ES ES94301671T patent/ES2102774T3/es not_active Expired - Lifetime
- 1994-03-09 EP EP94301671A patent/EP0614887B1/en not_active Expired - Lifetime
- 1994-03-09 AT AT94301671T patent/ATE154345T1/de not_active IP Right Cessation
- 1994-03-10 BR BR9405997A patent/BR9405997A/pt not_active Application Discontinuation
- 1994-03-10 CZ CZ952326A patent/CZ232695A3/cs unknown
- 1994-03-10 AU AU63638/94A patent/AU687042B2/en not_active Ceased
- 1994-03-10 RU RU95122639A patent/RU2127259C1/ru active
- 1994-03-10 CA CA002157801A patent/CA2157801A1/en not_active Abandoned
- 1994-03-10 KR KR1019950703798A patent/KR960700710A/ko not_active Ceased
- 1994-03-10 NZ NZ263080A patent/NZ263080A/en unknown
- 1994-03-10 HU HU9502627A patent/HU218660B/hu not_active IP Right Cessation
- 1994-03-10 JP JP6520310A patent/JPH08507532A/ja active Pending
- 1994-03-10 WO PCT/US1994/002606 patent/WO1994020101A1/en not_active Application Discontinuation
- 1994-03-10 PL PL94310558A patent/PL310558A1/xx unknown
-
1995
- 1995-09-08 NO NO953557A patent/NO953557L/no unknown
- 1995-09-08 FI FI954213A patent/FI954213L/fi unknown
-
1997
- 1997-06-19 GR GR970401465T patent/GR3023827T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO953557D0 (no) | 1995-09-08 |
| EP0614887A1 (en) | 1994-09-14 |
| AU6363894A (en) | 1994-09-26 |
| NZ263080A (en) | 1996-12-20 |
| JPH08507532A (ja) | 1996-08-13 |
| CA2157801A1 (en) | 1994-09-15 |
| ZA941500B (en) | 1995-09-04 |
| WO1994020101A1 (en) | 1994-09-15 |
| GR3023827T3 (en) | 1997-09-30 |
| EP0614887B1 (en) | 1997-06-11 |
| PL310558A1 (en) | 1995-12-27 |
| NO953557L (no) | 1995-11-02 |
| CZ232695A3 (en) | 1996-01-17 |
| HU218660B (hu) | 2000-10-28 |
| ATE154345T1 (de) | 1997-06-15 |
| AU687042B2 (en) | 1998-02-19 |
| FI954213A0 (fi) | 1995-09-08 |
| FI954213L (fi) | 1995-10-11 |
| RU2127259C1 (ru) | 1999-03-10 |
| DE69403695T2 (de) | 1997-10-30 |
| DE69403695D1 (de) | 1997-07-17 |
| BR9405997A (pt) | 1995-12-19 |
| HUT72897A (en) | 1996-06-28 |
| ES2102774T3 (es) | 1997-08-01 |
| HU9502627D0 (en) | 1995-11-28 |
| KR960700710A (ko) | 1996-02-24 |
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