DK0581904T3 - Fremgangsmåde til inhibering af fibrose - Google Patents
Fremgangsmåde til inhibering af fibroseInfo
- Publication number
- DK0581904T3 DK0581904T3 DK92917284.9T DK92917284T DK0581904T3 DK 0581904 T3 DK0581904 T3 DK 0581904T3 DK 92917284 T DK92917284 T DK 92917284T DK 0581904 T3 DK0581904 T3 DK 0581904T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- fibrosis
- alkyl
- hydrogen
- compound
- Prior art date
Links
- 206010016654 Fibrosis Diseases 0.000 title abstract 3
- 230000004761 fibrosis Effects 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- WARCRYXKINZHGQ-UHFFFAOYSA-N benzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1 WARCRYXKINZHGQ-UHFFFAOYSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67847291A | 1991-04-01 | 1991-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0581904T3 true DK0581904T3 (da) | 1997-12-29 |
Family
ID=24722926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92917284.9T DK0581904T3 (da) | 1991-04-01 | 1992-03-31 | Fremgangsmåde til inhibering af fibrose |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5374660A (da) |
| EP (1) | EP0581904B1 (da) |
| JP (1) | JPH06506471A (da) |
| AT (1) | ATE153500T1 (da) |
| AU (1) | AU652644B2 (da) |
| CA (1) | CA2107371A1 (da) |
| DE (1) | DE69220050T2 (da) |
| DK (1) | DK0581904T3 (da) |
| ES (1) | ES2104938T3 (da) |
| GR (1) | GR3024548T3 (da) |
| WO (1) | WO1992017065A2 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0581904T3 (da) * | 1991-04-01 | 1997-12-29 | Univ Duke | Fremgangsmåde til inhibering af fibrose |
| US5645839A (en) * | 1995-06-07 | 1997-07-08 | Trustees Of Boston University | Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis |
| US6117445A (en) * | 1998-01-28 | 2000-09-12 | Link Technology Inc. | Methods for the prevention and treatment of fibrosis and sclerosis |
| EP2712617B2 (en) | 2004-03-12 | 2020-11-18 | Intercept Pharmaceuticals, Inc. | Treatment of fibrosis using Fxr ligands |
| AT509045B1 (de) | 2010-01-29 | 2011-06-15 | Planta Naturstoffe Vertriebsges M B H | Verbindungen zur behandlung von asthma bronchiale |
| ME02938B (me) | 2013-02-07 | 2018-04-20 | Scifluor Life Sciences Inc | Fluorirani antagonisti integrina |
| US9790222B2 (en) | 2015-02-19 | 2017-10-17 | Scifluor Life Sciences, Inc. | Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof |
| MX2017013880A (es) | 2015-04-30 | 2018-08-01 | Scifluor Life Sciences Inc | Derivados del acido tetrahidronaftiridinil propionico y usos de los mismos. |
| US10118929B2 (en) | 2016-04-27 | 2018-11-06 | Scifluor Life Sciences, Inc. | Nonanoic and decanoic acid derivatives and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB828344A (en) * | 1957-01-30 | 1960-02-17 | Ici Ltd | Veterinary compositions containing acid hydrazides |
| JPS5119135A (en) * | 1974-08-05 | 1976-02-16 | Itsuo Takeshita | Kohakusenzaino seiho |
| US4321273A (en) * | 1978-03-01 | 1982-03-23 | Ryuichi Sato | Germanium-containing organic polymer and its use in the treatment of pulmonary fibrosis |
| US4382941A (en) * | 1980-11-26 | 1983-05-10 | Sicardi Susana M | Bishydrazide quaternary salts and pharmaceutical compositions thereof |
| HU207051B (en) * | 1987-12-30 | 1993-03-01 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 4-chloro-3-sulfamoylbenzoic acid hydrazides and pharmaceutical compositions comprising such compounds |
| DK0581904T3 (da) * | 1991-04-01 | 1997-12-29 | Univ Duke | Fremgangsmåde til inhibering af fibrose |
-
1992
- 1992-03-31 DK DK92917284.9T patent/DK0581904T3/da active
- 1992-03-31 AT AT92917284T patent/ATE153500T1/de not_active IP Right Cessation
- 1992-03-31 AU AU18763/92A patent/AU652644B2/en not_active Ceased
- 1992-03-31 EP EP92917284A patent/EP0581904B1/en not_active Expired - Lifetime
- 1992-03-31 DE DE69220050T patent/DE69220050T2/de not_active Expired - Fee Related
- 1992-03-31 ES ES92917284T patent/ES2104938T3/es not_active Expired - Lifetime
- 1992-03-31 CA CA002107371A patent/CA2107371A1/en not_active Abandoned
- 1992-03-31 WO PCT/US1992/002618 patent/WO1992017065A2/en not_active Ceased
- 1992-03-31 JP JP4510233A patent/JPH06506471A/ja active Pending
-
1993
- 1993-02-16 US US08/017,795 patent/US5374660A/en not_active Expired - Lifetime
-
1994
- 1994-12-07 US US08/351,484 patent/US5571846A/en not_active Expired - Fee Related
-
1997
- 1997-08-27 GR GR970402158T patent/GR3024548T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992017065A3 (en) | 1992-11-26 |
| WO1992017065A2 (en) | 1992-10-15 |
| ES2104938T3 (es) | 1997-10-16 |
| EP0581904A4 (en) | 1994-05-25 |
| JPH06506471A (ja) | 1994-07-21 |
| EP0581904B1 (en) | 1997-05-28 |
| CA2107371A1 (en) | 1992-10-02 |
| AU652644B2 (en) | 1994-09-01 |
| AU1876392A (en) | 1992-11-02 |
| GR3024548T3 (en) | 1997-12-31 |
| US5571846A (en) | 1996-11-05 |
| EP0581904A1 (en) | 1994-02-09 |
| ATE153500T1 (de) | 1997-06-15 |
| US5374660A (en) | 1994-12-20 |
| DE69220050T2 (de) | 1998-01-22 |
| DE69220050D1 (de) | 1997-07-03 |
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