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DK0540580T3 - Polymert lægemiddelafgivelsessystem - Google Patents

Polymert lægemiddelafgivelsessystem

Info

Publication number
DK0540580T3
DK0540580T3 DK91913230.8T DK91913230T DK0540580T3 DK 0540580 T3 DK0540580 T3 DK 0540580T3 DK 91913230 T DK91913230 T DK 91913230T DK 0540580 T3 DK0540580 T3 DK 0540580T3
Authority
DK
Denmark
Prior art keywords
drug delivery
delivery system
polymeric drug
polyamines
polymeric
Prior art date
Application number
DK91913230.8T
Other languages
English (en)
Inventor
Samuel J Tremont
Paul Waddell Collins
Williams Eldredge Perkins
Peter Hadley Jones
Original Assignee
Monsanto Co
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co, Searle & Co filed Critical Monsanto Co
Application granted granted Critical
Publication of DK0540580T3 publication Critical patent/DK0540580T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C08G73/0226—Quaternisation of polyalkylene(poly)amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/923—Aminoplast having terminal ethylenic unsaturation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
DK91913230.8T 1990-07-26 1991-07-22 Polymert lægemiddelafgivelsessystem DK0540580T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55804190A 1990-07-26 1990-07-26

Publications (1)

Publication Number Publication Date
DK0540580T3 true DK0540580T3 (da) 1994-05-16

Family

ID=24227945

Family Applications (2)

Application Number Title Priority Date Filing Date
DK91915184.5T DK0540670T3 (da) 1990-07-26 1991-07-22 Fremgangsmåde til fremstilling af tværbundne polyaminer
DK91913230.8T DK0540580T3 (da) 1990-07-26 1991-07-22 Polymert lægemiddelafgivelsessystem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK91915184.5T DK0540670T3 (da) 1990-07-26 1991-07-22 Fremgangsmåde til fremstilling af tværbundne polyaminer

Country Status (15)

Country Link
US (5) US5474767A (da)
EP (2) EP0540670B1 (da)
JP (2) JPH06502391A (da)
AT (2) ATE104154T1 (da)
AU (2) AU8418891A (da)
CA (2) CA2085366C (da)
DE (2) DE69118188T2 (da)
DK (2) DK0540670T3 (da)
ES (2) ES2084825T3 (da)
GR (1) GR3019804T3 (da)
IE (1) IE912630A1 (da)
NZ (1) NZ239133A (da)
PT (1) PT98442B (da)
WO (2) WO1992001730A1 (da)
ZA (1) ZA915892B (da)

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CA2111277C (en) * 1992-12-14 1998-06-23 Martin P. Mcgrath Controlled functional density poly(secondary amines) and method for preparation thereof
US5559193A (en) * 1993-12-20 1996-09-24 Monsanto Company Controlled functional density polyamines and method for preparation thereof
US5674950A (en) * 1994-03-07 1997-10-07 Exxon Chemical Patents Inc. Polymers having terminal hydroxyl aldehyde, or alkylamino substitutents and derivatives thereof
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US6890524B1 (en) 1997-04-04 2005-05-10 Monsanto Company Hydrolyzable delivery system using cross-linked polymeric resins as vehicles
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WO2007124131A2 (en) * 2006-04-20 2007-11-01 The University Of North Carolina At Chapel Hill Hybrid nanomaterials as multimodal imaging contrast agents
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US20110135571A1 (en) * 2008-02-22 2011-06-09 Wenbin Lin Hybrid nanoparticles as anti-cancer therapeutic agents and dual therapeutic/imaging contrast agents
US8945527B2 (en) * 2008-04-25 2015-02-03 The University Of North Carolina At Chapel Hill Degradable compounds and methods of use thereof, particularly with particle replication in non-wetting templates
WO2012037358A1 (en) 2010-09-16 2012-03-22 The University Of North Carolina At Chapel Hill Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents
EP3494974B1 (en) 2011-07-08 2023-10-18 The University of North Carolina at Chapel Hill Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders
WO2015069926A1 (en) 2013-11-06 2015-05-14 The University Of Chicago Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers
EP3206987B2 (en) 2014-10-14 2024-07-24 The University of Chicago Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof
US10806694B2 (en) 2014-10-14 2020-10-20 The University Of Chicago Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof
WO2017201528A1 (en) 2016-05-20 2017-11-23 The University Of Chicago Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof
WO2018118903A1 (en) 2016-12-19 2018-06-28 The Regents Of The University Of California Noncrushable pill formulatiions
EP3555280A4 (en) 2016-12-19 2020-09-09 The Regents of The University of California PEPTIDES SENSITIVE TO TWO ENZYMES
BR112019019658A2 (pt) 2017-03-22 2020-04-22 Ascendis Pharma As conjugados, composições farmacêuticas, método para tratar uma indicação ocular e método para produzir um conjugado de fármaco de hidrogel
WO2019028250A1 (en) 2017-08-02 2019-02-07 The University Of Chicago NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF
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Also Published As

Publication number Publication date
PT98442B (pt) 1999-01-29
JP2611073B2 (ja) 1997-05-21
CA2085366A1 (en) 1992-01-27
DE69118188T2 (de) 1996-10-31
EP0540670B1 (en) 1996-03-20
JPH06502391A (ja) 1994-03-17
CA2085366C (en) 2001-06-12
DE69118188D1 (de) 1996-04-25
ATE104154T1 (de) 1994-04-15
NZ239133A (en) 1993-10-26
IE912630A1 (en) 1992-01-29
EP0540580B1 (en) 1994-04-13
CA2086527A1 (en) 1992-01-27
AU8285991A (en) 1992-02-18
DE69101710D1 (de) 1994-05-19
ES2053333T3 (es) 1994-07-16
EP0540580A1 (en) 1993-05-12
ES2084825T3 (es) 1996-05-16
US5676939A (en) 1997-10-14
JPH05508680A (ja) 1993-12-02
EP0540670A1 (en) 1993-05-12
US5474767A (en) 1995-12-12
DE69101710T2 (de) 1994-08-18
AU8418891A (en) 1992-02-18
DK0540670T3 (da) 1996-04-29
US5795567A (en) 1998-08-18
PT98442A (pt) 1992-06-30
ZA915892B (en) 1992-09-30
US5693319A (en) 1997-12-02
US5827925A (en) 1998-10-27
WO1992001477A1 (en) 1992-02-06
WO1992001730A1 (en) 1992-02-06
GR3019804T3 (en) 1996-07-31
ATE135721T1 (de) 1996-04-15

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