DK0511964T3 - Fremgangsmåde til fremstilling af et cytokin protein med mindst en intramolekylær disulfidbro ved reduktion af det tilsvarende reducerede rekombinante protein ved en pH-værdi lavere end 5,0 - Google Patents
Fremgangsmåde til fremstilling af et cytokin protein med mindst en intramolekylær disulfidbro ved reduktion af det tilsvarende reducerede rekombinante protein ved en pH-værdi lavere end 5,0Info
- Publication number
- DK0511964T3 DK0511964T3 DK91900265.9T DK91900265T DK0511964T3 DK 0511964 T3 DK0511964 T3 DK 0511964T3 DK 91900265 T DK91900265 T DK 91900265T DK 0511964 T3 DK0511964 T3 DK 0511964T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- preparing
- reducing
- pct
- corresponding reduced
- Prior art date
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 2
- 102000004127 Cytokines Human genes 0.000 title 1
- 108090000695 Cytokines Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 235000018102 proteins Nutrition 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 150000001945 cysteines Chemical class 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/FR1990/000843 WO1992009623A1 (fr) | 1990-11-23 | 1990-11-23 | PROCEDE DE PREPARATION D'UNE PROTEINE COMPORTANT AU MOINS UN PONT DISULFURE INTRAMOLECULAIRE PAR OXYDATION, A UN pH INFERIEUR A 5,0, DE LA PROTEINE RECOMBINANTE REDUITE CORRESPONDANTE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0511964T3 true DK0511964T3 (da) | 1998-06-02 |
Family
ID=9393086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91900265.9T DK0511964T3 (da) | 1990-11-23 | 1990-11-23 | Fremgangsmåde til fremstilling af et cytokin protein med mindst en intramolekylær disulfidbro ved reduktion af det tilsvarende reducerede rekombinante protein ved en pH-værdi lavere end 5,0 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5252708A (da) |
| EP (1) | EP0511964B1 (da) |
| JP (1) | JP3021040B2 (da) |
| AT (1) | ATE159260T1 (da) |
| CA (1) | CA2073564A1 (da) |
| DE (1) | DE69031596T2 (da) |
| DK (1) | DK0511964T3 (da) |
| ES (1) | ES2107449T3 (da) |
| GR (1) | GR3025246T3 (da) |
| WO (1) | WO1992009623A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2358609A1 (en) * | 1999-01-07 | 2000-07-13 | Takeda Chemical Industries, Ltd. | Process for producing activated protein |
| JP3734634B2 (ja) | 1999-03-03 | 2006-01-11 | ヒゲタ醤油株式会社 | タンパク質の活性化方法及び該装置 |
| CA2537119A1 (en) * | 2003-09-02 | 2005-03-10 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| KR20190140090A (ko) | 2007-07-09 | 2019-12-18 | 제넨테크, 인크. | 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450103A (en) * | 1982-03-01 | 1984-05-22 | Cetus Corporation | Process for recovering human IFN-β from a transformed microorganism |
| US4569790A (en) * | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
| US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
| DE3583880D1 (de) * | 1984-04-09 | 1991-10-02 | Takeda Chemical Industries Ltd | Stabile interleukin-2-zusammensetzung. |
| US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
| US4752585A (en) * | 1985-12-17 | 1988-06-21 | Cetus Corporation | Oxidation-resistant muteins |
| FR2635527B1 (fr) * | 1988-07-28 | 1992-06-12 | Roussel Uclaf | Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament |
| CA1340586C (en) * | 1988-09-23 | 1999-06-08 | Cetus Corporation | Process for recovering microbially produced interferon-beta |
-
1990
- 1990-11-23 ES ES91900265T patent/ES2107449T3/es not_active Expired - Lifetime
- 1990-11-23 JP JP03500968A patent/JP3021040B2/ja not_active Expired - Lifetime
- 1990-11-23 DE DE69031596T patent/DE69031596T2/de not_active Expired - Lifetime
- 1990-11-23 CA CA002073564A patent/CA2073564A1/fr not_active Abandoned
- 1990-11-23 DK DK91900265.9T patent/DK0511964T3/da active
- 1990-11-23 AT AT91900265T patent/ATE159260T1/de not_active IP Right Cessation
- 1990-11-23 WO PCT/FR1990/000843 patent/WO1992009623A1/fr active IP Right Grant
- 1990-11-23 US US07/856,042 patent/US5252708A/en not_active Expired - Fee Related
- 1990-11-23 EP EP91900265A patent/EP0511964B1/fr not_active Expired - Lifetime
-
1997
- 1997-11-05 GR GR970402882T patent/GR3025246T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5252708A (en) | 1993-10-12 |
| DE69031596D1 (de) | 1997-11-20 |
| CA2073564A1 (fr) | 1992-05-24 |
| JP3021040B2 (ja) | 2000-03-15 |
| GR3025246T3 (en) | 1998-02-27 |
| ES2107449T3 (es) | 1997-12-01 |
| WO1992009623A1 (fr) | 1992-06-11 |
| EP0511964B1 (fr) | 1997-10-15 |
| DE69031596T2 (de) | 1998-02-26 |
| ATE159260T1 (de) | 1997-11-15 |
| EP0511964A1 (fr) | 1992-11-11 |
| JPH05503004A (ja) | 1993-05-27 |
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