[go: up one dir, main page]

DK0478729T3 - Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil - Google Patents

Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil

Info

Publication number
DK0478729T3
DK0478729T3 DK91906948.4T DK91906948T DK0478729T3 DK 0478729 T3 DK0478729 T3 DK 0478729T3 DK 91906948 T DK91906948 T DK 91906948T DK 0478729 T3 DK0478729 T3 DK 0478729T3
Authority
DK
Denmark
Prior art keywords
derivatives
dkp
novel intermediates
diketopiperazine
aspartame
Prior art date
Application number
DK91906948.4T
Other languages
English (en)
Inventor
John B Hill
Tse-Lok Ho
Mark R Johnson
Russell Klix
Gayle Webber
Robert A Erickson
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Application granted granted Critical
Publication of DK0478729T3 publication Critical patent/DK0478729T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK91906948.4T 1990-03-15 1991-03-12 Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil DK0478729T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49824390A 1990-03-15 1990-03-15
US60665690A 1990-10-31 1990-10-31
US65878491A 1991-02-26 1991-02-26
US66480691A 1991-03-08 1991-03-08

Publications (1)

Publication Number Publication Date
DK0478729T3 true DK0478729T3 (da) 1996-09-16

Family

ID=27504394

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91906948.4T DK0478729T3 (da) 1990-03-15 1991-03-12 Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil

Country Status (16)

Country Link
EP (1) EP0478729B1 (da)
CN (1) CN1057835A (da)
AT (1) ATE141613T1 (da)
AU (1) AU628257B2 (da)
CA (1) CA2060515A1 (da)
CS (1) CS70091A2 (da)
DE (1) DE69121502T2 (da)
DK (1) DK0478729T3 (da)
ES (1) ES2091324T3 (da)
GR (1) GR3020839T3 (da)
HU (1) HUT60712A (da)
IE (1) IE910896A1 (da)
NO (1) NO920193L (da)
NZ (1) NZ237469A (da)
PT (1) PT97049B (da)
WO (1) WO1991014378A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04234375A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物及びその製造法
JPH04234374A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc ジケトピペラジン誘導体の製造方法
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
US6465677B1 (en) * 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
DE10019879A1 (de) * 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
GB2382346B (en) * 2000-08-04 2004-08-11 Dmi Biosciences Inc Method of synthesizing diketopiperazines
AU2001279313B2 (en) 2000-08-04 2007-03-01 Ampio Pharmaceuticals, Inc. Method of using diketopiperazines and composition containing them
WO2004030522A2 (en) 2002-10-02 2004-04-15 Dmi Biosciences, Inc. Diagnosis and monitoring of diseases
CN102210852B (zh) 2003-05-15 2016-10-19 安皮奥制药股份有限公司 T-细胞介导的疾病的治疗
EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc METHODS AND THERAPEUTIC COMPOUNDS
WO2012033792A2 (en) 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
ES2795803T3 (es) 2011-10-10 2020-11-24 Ampio Pharmaceuticals Inc Tratamiento de artropatía degenerativa
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
JP6231484B2 (ja) 2011-10-28 2017-11-15 アンピオ ファーマシューティカルズ，インコーポレイテッド 鼻炎の処置
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
KR20170045274A (ko) 2014-08-18 2017-04-26 앰피오 파마슈티컬스 인코퍼레이티드 관절 징후의 치료
WO2016209969A1 (en) 2015-06-22 2016-12-29 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
JP7113761B2 (ja) * 2016-12-21 2022-08-05 サントリーホールディングス株式会社 シクロアスパルチルグリシン、グルコース、及びマルトースを含有する飲食品

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2038106A1 (de) * 1970-07-31 1972-02-10 Henkel & Cie Gmbh Aktivatoren fuer Perverbindungen
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
IT1197461B (it) * 1983-05-13 1988-11-30 Debi Derivati Biologici Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0647600B2 (ja) * 1985-06-04 1994-06-22 味の素株式会社 β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法
US4677220A (en) * 1985-10-31 1987-06-30 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids

Also Published As

Publication number Publication date
DE69121502T2 (de) 1997-01-16
AU7564891A (en) 1991-10-21
DE69121502D1 (de) 1996-09-26
NO920193D0 (no) 1992-01-15
AU628257B2 (en) 1992-09-10
EP0478729B1 (en) 1996-08-21
CN1057835A (zh) 1992-01-15
NO920193L (no) 1992-01-15
PT97049B (pt) 1998-07-31
CS70091A2 (en) 1991-10-15
EP0478729A4 (en) 1993-06-16
GR3020839T3 (en) 1996-11-30
NZ237469A (en) 1993-08-26
WO1991014378A1 (en) 1991-10-03
IE910896A1 (en) 1991-09-25
ES2091324T3 (es) 1996-11-01
PT97049A (pt) 1991-12-31
HUT60712A (en) 1992-10-28
ATE141613T1 (de) 1996-09-15
EP0478729A1 (en) 1992-04-08
CA2060515A1 (en) 1991-09-16

Similar Documents

Publication Publication Date Title
DK0478729T3 (da) Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil
DK0629608T3 (da) Fremgangsmåde til fremstilling af N-acyl-N,N',N'-ethylendiamintrieddikesyrederivater
DK0965591T3 (da) Fremgangsmåde til fremstilling af (S)-3-methyl-1-(2-piperidino-phenyl)-1-butylamin
FI914905L (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten merkaptoasetyyliamidopyrrolo- ja -pyridobentsatsepiinijohdannaisten valmistamiseksi
DK158723C (da) Analogifremgangsmaade til fremstilling af triphenylimidazol-2-yloxyalkansyrer og derivater deraf
DE69004353D1 (de) Verfahren zur Reinigung von Tryptophan.
DK342489D0 (da) Fremgangsmaade og mellemprodukter til syntese af l-(-)-2-amino-3-(3,4-dihydroxyphenyl)-propionsyre
DK0526529T3 (da) "Forbedret fremgangsmåde til fremstilling af substituerede indolonderivater"
DK0397350T3 (da) Fremgangsmåde og mellemprodukter til fremstillingen af oxophthalazinyleddikesyrer og analoge dertil
DK0560019T3 (da) Fremgangsmåde til fremstilling af dialkyl-2,3-pyridindicarboxylater og derivater deraf ud fra en alfa,beta-umættet oxim og et aminobutendioat
DK0751117T3 (da) Fremstilling af bicyclohexanderivat
DK247888D0 (da) Aminosyrederivater af 4-benzyl-1-(2h)-phthalazinon
DK0495953T3 (da) 10-(1-Hydroxyethyl)-11-oxo-1-azatricyclo-(7.2.0.0.3.8)undec-2-en-carboxylsyreestere og fremgangsmåde til fremstilling deraf
DK0536197T3 (da) Ren, krystallinsk form af rifapentine
DK361282A (da) Fremgangsmaade til fremstilling af o-alkyl-o-carbamoylglycerophosphocholiner
FI890678A (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisten 1,3-dioksaanialkeenihappojohdannaisten valmistamiseksi
ES2017900A4 (es) Derivados de acido tiazolidina-4-carboxilico, su preparacion y composiciones farmaceuticas conteniendolo
FI962592L (fi) Uudet välituotteet keinotekoisina makeutusaineina käyttökelpoisten L-aspartyyli-D-alfa-aminoalkanoyyli-(S)-N-alfa-alkyylibentsyyliamidien syntetisoimiseksi
DK309479A (da) Fremgangsmaade til fremstilling af alfadifluormethylaminosyrer og estere deraf
FR2510565B1 (fr) Procede de preparation de l'a-(3,4,5-trimethoxybenzoylthio)-propionyl glycine
NO912509D0 (no) Fremgangsmaate for fremstilling av substituerte acykliske nukleosider og mellomprodukter derav.
DK604783D0 (da) Fremgangsmade til fremstilling af et funktionelt hydrolysat ud fra mikrobielle proteinisolater
IS3907A (is) Hliðstæð aðferð við framleiðslu nýrra afleiða af 3-hýdroxýantralsýru og milliefni til þeirra nota
FR2612183B1 (fr) Nouveaux composes chimiques trifluoromethyles et leur procede de preparation
MA22038A1 (fr) Procede d'obtention de nouveaux derives alcoyles en 17/21 de la 19 - nor progestrone .