DK0454739T3 - Fremgangsmåde til isolering af oprenset EPI protein fra en opløsning, især en fermenteringsopløsning - Google Patents
Fremgangsmåde til isolering af oprenset EPI protein fra en opløsning, især en fermenteringsopløsningInfo
- Publication number
- DK0454739T3 DK0454739T3 DK90902177.6T DK90902177T DK0454739T3 DK 0454739 T3 DK0454739 T3 DK 0454739T3 DK 90902177 T DK90902177 T DK 90902177T DK 0454739 T3 DK0454739 T3 DK 0454739T3
- Authority
- DK
- Denmark
- Prior art keywords
- solution
- pct
- epi protein
- fermentation
- isolating purified
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 238000000855 fermentation Methods 0.000 title abstract 2
- 230000004151 fermentation Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 229920002684 Sepharose Polymers 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96461—Protein C (3.4.21.69)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK412389A DK412389D0 (da) | 1989-01-19 | 1989-01-19 | Fremgangsmaade til udvinding af oprenset epi protein fra en fermenteringsoploesning |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0454739T3 true DK0454739T3 (da) | 1994-04-25 |
Family
ID=8130438
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK412389A DK412389D0 (da) | 1989-01-19 | 1989-01-19 | Fremgangsmaade til udvinding af oprenset epi protein fra en fermenteringsoploesning |
| DK90902177.6T DK0454739T3 (da) | 1989-01-19 | 1990-01-18 | Fremgangsmåde til isolering af oprenset EPI protein fra en opløsning, især en fermenteringsopløsning |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK412389A DK412389D0 (da) | 1989-01-19 | 1989-01-19 | Fremgangsmaade til udvinding af oprenset epi protein fra en fermenteringsoploesning |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5219993A (da) |
| EP (1) | EP0454739B1 (da) |
| JP (1) | JP2896605B2 (da) |
| AT (1) | ATE99323T1 (da) |
| AU (1) | AU5024490A (da) |
| DE (1) | DE69005618T2 (da) |
| DK (2) | DK412389D0 (da) |
| ES (1) | ES2049021T3 (da) |
| WO (1) | WO1990008158A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378614A (en) * | 1989-08-18 | 1995-01-03 | Novo Nordisk A/S | Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast |
| US6063764A (en) * | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
| US20030171292A1 (en) | 1992-06-01 | 2003-09-11 | Creasey Abla A. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
| JP3428687B2 (ja) | 1993-06-30 | 2003-07-22 | 財団法人化学及血清療法研究所 | 組織因子凝固系インヒビターの調製法 |
| WO2003055442A2 (en) | 2001-10-15 | 2003-07-10 | Chiron Corporation | Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4721572A (en) * | 1985-07-12 | 1988-01-26 | Miles Laboratories, Inc. | Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices |
-
1989
- 1989-01-19 DK DK412389A patent/DK412389D0/da unknown
-
1990
- 1990-01-18 EP EP90902177A patent/EP0454739B1/en not_active Expired - Lifetime
- 1990-01-18 AT AT90902177T patent/ATE99323T1/de not_active IP Right Cessation
- 1990-01-18 DE DE90902177T patent/DE69005618T2/de not_active Expired - Fee Related
- 1990-01-18 US US07/730,860 patent/US5219993A/en not_active Expired - Fee Related
- 1990-01-18 ES ES90902177T patent/ES2049021T3/es not_active Expired - Lifetime
- 1990-01-18 DK DK90902177.6T patent/DK0454739T3/da not_active Application Discontinuation
- 1990-01-18 WO PCT/DK1990/000016 patent/WO1990008158A1/en active IP Right Grant
- 1990-01-18 AU AU50244/90A patent/AU5024490A/en not_active Abandoned
- 1990-12-31 JP JP3502550A patent/JP2896605B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK412389D0 (da) | 1989-01-19 |
| ES2049021T3 (es) | 1994-04-01 |
| DE69005618D1 (de) | 1994-02-10 |
| JPH05505385A (ja) | 1993-08-12 |
| AU5024490A (en) | 1990-08-13 |
| US5219993A (en) | 1993-06-15 |
| EP0454739A1 (en) | 1991-11-06 |
| EP0454739B1 (en) | 1993-12-29 |
| WO1990008158A1 (en) | 1990-07-26 |
| DE69005618T2 (de) | 1994-04-28 |
| JP2896605B2 (ja) | 1999-05-31 |
| ATE99323T1 (de) | 1994-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |