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DK0453969T3 - - Google Patents

Info

Publication number
DK0453969T3
DK0453969T3 DK91106268.5T DK91106268T DK0453969T3 DK 0453969 T3 DK0453969 T3 DK 0453969T3 DK 91106268 T DK91106268 T DK 91106268T DK 0453969 T3 DK0453969 T3 DK 0453969T3
Authority
DK
Denmark
Prior art keywords
tendamistat
secreted
expressed
code
approximately
Prior art date
Application number
DK91106268.5T
Other languages
Danish (da)
Inventor
Klaus-Peter Dr Koller
Guenther Dr Riess
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0453969T3 publication Critical patent/DK0453969T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Gene structures which code for the signal sequence and approximately the first ten amino acids of tendamistat as well as a required protein are expressed in high yield in streptomyces host cells, and the fusion proteins are secreted into the medium.
DK91106268.5T 1990-04-21 1991-04-18 DK0453969T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4012818A DE4012818A1 (en) 1990-04-21 1990-04-21 METHOD FOR THE PRODUCTION OF FOREIGN PROTEINS IN STREPTOMYCETES

Publications (1)

Publication Number Publication Date
DK0453969T3 true DK0453969T3 (en) 1997-02-10

Family

ID=6404857

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91106268.5T DK0453969T3 (en) 1990-04-21 1991-04-18

Country Status (29)

Country Link
EP (1) EP0453969B1 (en)
JP (1) JP3319605B2 (en)
KR (1) KR0168669B1 (en)
CN (1) CN1049248C (en)
AT (1) ATE142263T1 (en)
AU (1) AU630287B2 (en)
BR (1) BR9101587A (en)
CA (1) CA2040810C (en)
CZ (1) CZ285440B6 (en)
DE (2) DE4012818A1 (en)
DK (1) DK0453969T3 (en)
ES (1) ES2093043T3 (en)
FI (1) FI911882L (en)
GR (1) GR3021040T3 (en)
HR (1) HRP940770A2 (en)
HU (1) HU210358B (en)
IE (1) IE911322A1 (en)
IL (1) IL97903A0 (en)
LT (1) LT3686B (en)
LV (1) LV10494B (en)
NO (1) NO911557L (en)
NZ (1) NZ237882A (en)
PL (2) PL169596B1 (en)
PT (1) PT97427B (en)
RU (1) RU2055892C1 (en)
SK (1) SK110191A3 (en)
TW (1) TW213487B (en)
YU (1) YU48435B (en)
ZA (1) ZA912937B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK279686B6 (en) * 1990-09-05 1999-02-11 Hoechst Aktiengesellschaft Process for hydrolysis of amino-acid chain of preproinsulins
EP0600372B1 (en) 1992-12-02 1997-02-05 Hoechst Aktiengesellschaft Process for the preparation of proinsulin with correctly linked cystin bridges
ES2161726T3 (en) * 1993-04-27 2001-12-16 Hoechst Ag MONOSPHERIC AMORPHES OF INSULIN DERIVATIVES.
DE4405179A1 (en) * 1994-02-18 1995-08-24 Hoechst Ag Method of obtaining insulin with correctly connected cystine bridges
CN1061375C (en) * 1996-07-19 2001-01-31 中国科学院上海生物工程研究中心 Using allogeneic promoter to express transparent Tremellineae haemoglobin in streptomycete
DE59711533D1 (en) 1996-07-26 2004-05-27 Aventis Pharma Gmbh Insulin derivatives with increased zinc binding
DE19825447A1 (en) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh New insulin analogues with increased zinc formation
CN1298742C (en) * 2003-06-03 2007-02-07 上海新药研究开发中心 A fusion protein suitable to highly effective expression and production method thereof
RU2395296C1 (en) * 2009-02-19 2010-07-27 Общество С Ограниченной Ответственностью "Концерн О3" Method for making oral proinsulin preparation
CN104818291A (en) * 2015-05-08 2015-08-05 江南大学 Construction and application of streptomycete recombinant expression vector

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366246A (en) 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
DE3418274A1 (en) 1984-05-17 1985-11-21 Hoechst Ag, 6230 Frankfurt SIGNAL PEPTIDE FOR THE EXCRETION OF PEPTIDES IN STREPTOMYCETS
DE3707150A1 (en) * 1987-03-06 1988-09-15 Hoechst Ag TENDAMISTAT DERIVATIVES
DE3714866A1 (en) * 1987-05-05 1988-11-24 Hoechst Ag METHOD FOR THE PRODUCTION OF FOREIGN PROTEINS IN STREPTOMYCETES
DE3715033A1 (en) 1987-05-06 1988-11-17 Hoechst Ag METHOD FOR ISOLATING FUSION PROTEINS
DE3716722A1 (en) 1987-05-19 1988-12-01 Hoechst Ag GENE TECHNOLOGICAL METHOD FOR PRODUCING ANGIOGENINES
DE3843713A1 (en) * 1988-04-25 1989-11-02 Henkel Kgaa USE OF CALCINATED HYDROTALCITES AS CATALYSTS FOR ETHOXYLATION OR PROPOXYLATION
ES2081826T3 (en) * 1988-11-03 1996-03-16 Hoechst Ag PROCEDURE FOR THE PREPARATION OF A PREVIOUS PRODUCT OF INSULIN IN STREPTOMICETS.

Also Published As

Publication number Publication date
YU48435B (en) 1998-07-10
HUT57268A (en) 1991-11-28
TW213487B (en) 1993-09-21
CA2040810A1 (en) 1991-10-22
NZ237882A (en) 1993-12-23
CN1055952A (en) 1991-11-06
AU7515491A (en) 1991-10-24
DE4012818A1 (en) 1991-10-24
LV10494B (en) 1996-02-20
ES2093043T3 (en) 1996-12-16
PL169178B1 (en) 1996-06-28
HRP940770A2 (en) 1997-06-30
YU69691A (en) 1995-12-04
FI911882L (en) 1991-10-22
DE59108128D1 (en) 1996-10-10
SK110191A3 (en) 1995-07-11
CZ110191A3 (en) 1993-08-11
ATE142263T1 (en) 1996-09-15
HU911302D0 (en) 1991-10-28
IE911322A1 (en) 1991-10-23
KR0168669B1 (en) 1999-01-15
LT3686B (en) 1996-01-25
CZ285440B6 (en) 1999-08-11
LTIP1523A (en) 1995-06-26
NO911557D0 (en) 1991-04-19
KR910018551A (en) 1991-11-30
NO911557L (en) 1991-10-22
EP0453969A1 (en) 1991-10-30
LV10494A (en) 1995-02-20
IL97903A0 (en) 1992-06-21
PL169596B1 (en) 1996-08-30
ZA912937B (en) 1991-12-24
CN1049248C (en) 2000-02-09
AU630287B2 (en) 1992-10-22
PL289953A1 (en) 1991-11-04
EP0453969B1 (en) 1996-09-04
RU2055892C1 (en) 1996-03-10
BR9101587A (en) 1991-12-10
GR3021040T3 (en) 1996-12-31
PT97427B (en) 1998-08-31
JPH04228086A (en) 1992-08-18
HU210358B (en) 1995-04-28
FI911882A0 (en) 1991-04-18
JP3319605B2 (en) 2002-09-03
CA2040810C (en) 2001-07-24
PT97427A (en) 1992-01-31

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