[go: up one dir, main page]

DK0447324T3 - 2,4-pyrimidinedione derivatives and drugs containing them - Google Patents

2,4-pyrimidinedione derivatives and drugs containing them

Info

Publication number
DK0447324T3
DK0447324T3 DK91400699.4T DK91400699T DK0447324T3 DK 0447324 T3 DK0447324 T3 DK 0447324T3 DK 91400699 T DK91400699 T DK 91400699T DK 0447324 T3 DK0447324 T3 DK 0447324T3
Authority
DK
Denmark
Prior art keywords
drugs containing
denotes
pyrimidinedione derivatives
alkyl group
derivatives
Prior art date
Application number
DK91400699.4T
Other languages
Danish (da)
Inventor
Fur Gerard Le
Laurent Fraisse
Jean-Baptiste Verlhac
Original Assignee
Elf Aquitaine
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elf Aquitaine, Sanofi Sa filed Critical Elf Aquitaine
Application granted granted Critical
Publication of DK0447324T3 publication Critical patent/DK0447324T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

These derivatives correspond to the formula <IMAGE> in which one of the symbols R1, R2, R3 or R4 denotes a C7-C20 alkyl group and each of the others denotes H or a C1-C3 alkyl group and each of Z1 and Z2 denotes H or together they denote the carbonyl or thiocarbonyl group, and their addition salts with pharmaceutically acceptable acids. Medications.
DK91400699.4T 1990-03-15 1991-03-14 2,4-pyrimidinedione derivatives and drugs containing them DK0447324T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR909003342A FR2659656B1 (en) 1990-03-15 1990-03-15 PYRIMIDINEDIONE-2,4 DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM.

Publications (1)

Publication Number Publication Date
DK0447324T3 true DK0447324T3 (en) 1996-04-29

Family

ID=9394780

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91400699.4T DK0447324T3 (en) 1990-03-15 1991-03-14 2,4-pyrimidinedione derivatives and drugs containing them

Country Status (11)

Country Link
EP (1) EP0447324B1 (en)
JP (1) JP2983669B2 (en)
AT (1) ATE131817T1 (en)
CA (1) CA2038198A1 (en)
DE (1) DE69115526T2 (en)
DK (1) DK0447324T3 (en)
ES (1) ES2081446T3 (en)
FR (1) FR2659656B1 (en)
GR (1) GR3019123T3 (en)
IE (1) IE71192B1 (en)
PT (1) PT97035B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU214331B (en) * 1992-06-17 1998-03-02 Gyógyszerkutató Intézet Kft. Methods for producing piperazine and homopiperazine derivatives and pharmaceutical compositions containing them
WO1995023138A1 (en) * 1994-02-28 1995-08-31 Sunkyong Industries Co., Ltd. Pyrimidine acyclonucleoside derivatives
JP3497554B2 (en) * 1994-03-25 2004-02-16 日本臓器製薬株式会社 Novel purine derivatives and pharmaceutically acceptable salts thereof
DE19702785A1 (en) * 1997-01-27 1998-07-30 Bayer Ag New cyclic urea derivatives
US6417180B1 (en) * 1998-10-07 2002-07-09 University Of Massachusetts Zinc finger-reactive antimicrobial compounds
SE9903544D0 (en) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) * 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
SE0003828D0 (en) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
SE0101322D0 (en) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
AU2007286630A1 (en) * 2006-08-23 2008-02-28 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Derivatives of uric and thiouric acid for oxidative stress-related diseases
SMT202000071T1 (en) 2013-06-21 2020-03-13 Myokardia Inc Pyrimidinedione compounds against cardiac conditions
WO2014205234A1 (en) * 2013-06-21 2014-12-24 MyoKardia, Inc. Cycloalkyl-substituted pyrimidinedione compounds
CN108912121A (en) * 2018-08-08 2018-11-30 南京纽邦生物科技有限公司 Preparation method, the preparation method of intermediate and intermediate of three kinds of methyl-uric acid class compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2781344A (en) * 1953-05-04 1957-02-12 Monsanto Chemicals Formylation of amino-pyrimidines
DE2329399A1 (en) * 1973-06-08 1975-01-02 Wuelfing J A Fa 4-ALKYL-AMINOURACILE, THE METHOD FOR MANUFACTURING IT AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4452788A (en) * 1982-04-21 1984-06-05 Warner-Lambert Company Substituted 8-phenylxanthines
FR2531085A1 (en) * 1982-07-28 1984-02-03 Adir NOVEL XANTHINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

Also Published As

Publication number Publication date
IE71192B1 (en) 1997-02-12
DE69115526D1 (en) 1996-02-01
GR3019123T3 (en) 1996-05-31
IE910853A1 (en) 1991-09-25
PT97035B (en) 1998-07-31
JP2983669B2 (en) 1999-11-29
ES2081446T3 (en) 1996-03-16
DE69115526T2 (en) 1996-06-05
FR2659656A1 (en) 1991-09-20
PT97035A (en) 1991-10-31
EP0447324A1 (en) 1991-09-18
JPH04217672A (en) 1992-08-07
EP0447324B1 (en) 1995-12-20
CA2038198A1 (en) 1991-09-16
FR2659656B1 (en) 1994-09-09
ATE131817T1 (en) 1996-01-15

Similar Documents

Publication Publication Date Title
DK0447324T3 (en) 2,4-pyrimidinedione derivatives and drugs containing them
FI96204C (en) Process for the preparation of therapeutically useful heterocyclic compounds
NO2004004I1 (en) Bortezomib or a pharmaceutically acceptable ester thereof, optionally in the form of a pharmaceutically acceptable salt thereof
LU90856I2 (en) Uprima - apomorphine hydrochloride and its pharmaceutically acceptable derivatives
NO180166C (en) Pyrrolidine and thiazolidine derivatives as well as medicaments containing the compounds
NO2006018I2 (en) entecavir
ATE124405T1 (en) 1,4,7,10-TETRAAZACYCLODODECAN BUTYLTRIOLS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING SAME.
ATE81009T1 (en) N-ACETYL-3-FLUORONEURAMINIC ACID AS AN ANTIVIRAL MEDICINE.
IT1224416B (en) MACROCYCLIC CHELANTS AND THEIR CHELATES
DE69321875D1 (en) Benzimidezole derivatives with anti-diabetic and anti-platelet clumping effect
ES2091310T3 (en) NEW DERIVATIVES OF N-BENZOIL-PROLINA, ITS PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
ATE166875T1 (en) ELLIPTICINE DERIVATIVES WITH ANTI-TUMOR EFFECT
ES2111871T3 (en) NEW AMINO ACID DERIVATIVES, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DK0571243T3 (en) Thiochromane derivatives, processes for their preparation, and pharmaceutical agents containing ice
MX9205385A (en) PERHYDRO-1-H-PIRIDO (1,2-A) PIRACINAS 2-SUBSTITUTED NEUROLEPTICAS.
DK0623620T3 (en) 5-HT 3 pyrrolopyrazinderivater
DE59108565D1 (en) Haloalkyl azolyl derivatives
ES2095714T3 (en) NEW AMINO-ALKYL-CHROME, ITS PREPARATION PROCEDURES AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
ES2098517T3 (en) DERIVATIVES OF 1,2,4-TIADIAZINO (3,4-B) BENZOTIAZOLE, ITS PREPARATION AND THE MEDICINES CONTAINING THEM.
ES2093051T3 (en) PURINIL- AND PIRIMIDIL-TETRAHIDROFURANOS.
ATE117682T1 (en) SUBSTITUTED BENZOTHIAZOLINONES, THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DK0481288T3 (en) N-phenylpiperidyl-4-amines and drugs containing these compounds
TW279783B (en)
IT1242043B (en) DERIVATIVES OF 1,2,3,4, -TETRAIDRONAFTILAMINA WITH NOOTROPIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DE69412794D1 (en) 2&#39;-DESOXY-5-FLUORURIDINE, PHARMACEUTICAL APPLICABLE SALTS THEREOF, METHOD FOR THE PRODUCTION THEREOF AND ANTITUARY MEDICINE