DE911326C - Process for stabilizing solutions of 2-AEthoxy-6,9-diaminoacridine lactates against the addition of electrolytes - Google Patents
Process for stabilizing solutions of 2-AEthoxy-6,9-diaminoacridine lactates against the addition of electrolytesInfo
- Publication number
- DE911326C DE911326C DEP8087A DEP0008087A DE911326C DE 911326 C DE911326 C DE 911326C DE P8087 A DEP8087 A DE P8087A DE P0008087 A DEP0008087 A DE P0008087A DE 911326 C DE911326 C DE 911326C
- Authority
- DE
- Germany
- Prior art keywords
- addition
- diaminoacridine
- lactates
- electrolytes
- solutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Description
Verfahren zur Stabilisierung von Lösungen des 2-Äthoxy-6, 9-diaminoacridin-lactates gegen den Zusatz von Elektrolyten Es ist bekannt, daB Lösungen des 2-Äthoxy-6, 9-diaminoacridin-lactates bei Berührung mit Elektrolyten, insbesondere von Natriumchlorid, Fällungen zeigen. Diese Reaktion zwischen Farbstoff und Elektrolyt macht es unmöglich, Lösungen des Farbstoffs unter Verwendung von Natriumchlorid herzustellen.Process for stabilizing solutions of 2-ethoxy-6, 9-diaminoacridine lactates Against the addition of electrolytes It is known that solutions of 2-ethoxy-6,9-diaminoacridine lactates show precipitations on contact with electrolytes, especially sodium chloride. This reaction between the dye and the electrolyte makes it impossible to produce solutions of the Dye using sodium chloride.
Das folgende Verfahren, welches dadurch gekennzeichnet ist, daB man die Lösungen des 2-Äthoxy-6, 9-diaminoacridin-lactates unter gleichzeitiger Verwendung von 3, 6-Diamino-io-methylacridiniumchlorid herstellt, gestattet innerhalb der in den folgenden Vergleichsversuchen gekennzeichneten Grenzen die Herstellung auch natriumchloridhaltiger Lösungen des angeführten Farbstoffs bzw. deren Verwendung in Gegenwart von Elektrolyten, insbesondere Natriumchlorid. i. Die aus einer Mischung von 70 Gewichtsteilen 2-Äthoxy-6, 9-diaminoacridin-lactat (I) und 3o Gewichtsteilen 3, 6-Diamino-io-methylacridiniumchlorid (II) hergestellten o,i°/oigen, o,5°/oigen und 2°/oigen Lösungen, die mit 0,45 % Natriumchlorid versetzt waren, zeigten, mit Ausnahme der o,5°/jgen Lösung, nach 9tägiger Beobachtungszeit keine Veränderung. In der o,5°/oigen Lösung ist nach Ablauf der 8tägigen Beobachtungszeit eine einzelne Kristalldruse festzustellen. Nach weiteren 3 Tagen zeigen die o,i- und 2%ige Lösung keine Veränderung; die Kristallisation in der o,5°/@gen Lösung hat sich geringfügig vermehrt.The following process, which is characterized in that the solutions of 2-ethoxy-6, 9-diaminoacridine-lactates are prepared with simultaneous use of 3, 6-diamino-io-methylacridinium chloride, allows within the limits indicated in the following comparative experiments Production of sodium chloride-containing solutions of the specified dye or their use in the presence of electrolytes, in particular sodium chloride. i. From a mixture of 70 parts by weight of 2-ethoxy-6, 9-diaminoacridine lactate (I) and 3o parts by weight of 3,6-diamino-io-methylacridinium chloride (II) prepared o, i ° / oigen, o, 5% and 2% solutions to which 0.45 % sodium chloride was added showed, with the exception of the 0.5% solution, no change after an observation period of 9 days. A single crystal gland can be seen in the 0.5% solution after the eight-day observation period. After a further 3 days, the o, i and 2% solutions show no change; the crystallization in the 0.5% solution has increased slightly.
2. Die obigen Lösungen mit einem Zusatz von o,9 °/o Natriumchlorid weisen, mit Ausnahme der 2°/oigen Lösung, nach 9tägiger Beobachtungszeit keine Veränderung auf. In der 2°/oigen Lösung sind nach dem sechsten Beobachtungstage einige kleine Kriställchen feststellbar. Nach weiteren 3 Tagen gilt Analoges, was unter 1 festgestellt wurde.2. The above solutions with an addition of 0.9% sodium chloride show, with the exception of the 2% solution, no change after 9 days of observation on. In the 2% solution are after sixth observation days some small crystals detectable. After a further 3 days, the same thing applies under 1 was found.
3. Die aus gleichen Teilen I und II hergestellten o,1-,o,5-und -o/oigenLösungen zeigen bei einemZusatz von o,9 bzw. 1,5 % Natriumchlorid nach insgesamt 12 Tagen keinerlei Veränderung, während bei einem Zusatz von 2,9 0/0 @;atriumchlorid die o,5- und 2o/oigen Lösungen nach Ablauf von 5 Tagen einige Kriställchen aufweisen. Nach insgesamt 12tägiger Beobachtungszeit zeigt die o,1o/oige Lösung keine Veränderung, die Kristallisation in der o,5- und 2o/oigen Farbstoffgemischlösung ist gering vermehrt, bei der 2o/oigen Lösung etwas stärker als bei der o,5o/oigen Lösung.3. The o, 1-, o, 5-and -o / o solutions prepared from equal parts I and II show with an addition of 0.9 or 1.5% sodium chloride after a total of 12 days no change whatsoever, while with an addition of 2.9% atrium chloride the o, 5- and 20% solutions show a few crystals after 5 days. After a total of 12 days of observation, the o, 10 / o solution shows no change, the crystallization in the o, 5- and 20% dye mixture solution is slightly increased, somewhat stronger with the 20% solution than with the 0.5% solution.
4. Lösungen von I mit einem Gehalt von o,o85, 0,07 und o,o5 % I zeigen bei einem Zusatz von 0,45 % Natriumehlorid bereits nach 5 bis 6 Stunden beginnende Kristallisation. Nach 2 Tagen ist die Lösung farblos, d. h. die Kristallisation beendet.4. Show solutions of I with a content of 0.085, 0.07 and 0.05% I. with an addition of 0.45% sodium chloride, it already starts after 5 to 6 hours Crystallization. After 2 days the solution is colorless, i. H. the crystallization completed.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP8087A DE911326C (en) | 1952-07-29 | 1952-07-29 | Process for stabilizing solutions of 2-AEthoxy-6,9-diaminoacridine lactates against the addition of electrolytes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP8087A DE911326C (en) | 1952-07-29 | 1952-07-29 | Process for stabilizing solutions of 2-AEthoxy-6,9-diaminoacridine lactates against the addition of electrolytes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE911326C true DE911326C (en) | 1954-05-13 |
Family
ID=7361518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEP8087A Expired DE911326C (en) | 1952-07-29 | 1952-07-29 | Process for stabilizing solutions of 2-AEthoxy-6,9-diaminoacridine lactates against the addition of electrolytes |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE911326C (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE548835C (en) * | 1929-10-01 | 1932-04-20 | I G Farbenindustrie Akt Ges | Process for the preparation of durable solutions which contain salts of 3,6-diaminoacridine or 3,6-diamino-10-alkylacridinium or double compounds of such salts |
| DE556748C (en) * | 1931-01-16 | 1932-08-13 | I G Farbenindustrie Akt Ges | Process for the production of durable acridine salt solutions |
-
1952
- 1952-07-29 DE DEP8087A patent/DE911326C/en not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE548835C (en) * | 1929-10-01 | 1932-04-20 | I G Farbenindustrie Akt Ges | Process for the preparation of durable solutions which contain salts of 3,6-diaminoacridine or 3,6-diamino-10-alkylacridinium or double compounds of such salts |
| DE556748C (en) * | 1931-01-16 | 1932-08-13 | I G Farbenindustrie Akt Ges | Process for the production of durable acridine salt solutions |
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