DE881652C - Process for the preparation of p- (AEthylureido) -benzalthiosemicarbazone - Google Patents
Process for the preparation of p- (AEthylureido) -benzalthiosemicarbazoneInfo
- Publication number
- DE881652C DE881652C DEW1298A DEW0001298A DE881652C DE 881652 C DE881652 C DE 881652C DE W1298 A DEW1298 A DE W1298A DE W0001298 A DEW0001298 A DE W0001298A DE 881652 C DE881652 C DE 881652C
- Authority
- DE
- Germany
- Prior art keywords
- benzalthiosemicarbazone
- preparation
- aethylureido
- ethylureido
- mixed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung von p-(Äthylureido)-benzalthiosemicarbazon Es wurde gefunden, .daß p-(Äthylureido)-benzalthiosemicarbazon der Formel eine das Wachstum von Tuberkelbazillen hemmend Wirkung .entfaltet.Process for the preparation of p- (Ethylureido) -benzalthiosemicarbazone It was found that p- (Ethylureido) -benzalthiosemicarbazone of the formula has an inhibiting effect on the growth of tubercle bacilli.
Gegenstand der Erfindung ist ein Verfahren zur Herstellung dieser Verbindung, welches dadurch gekennzeichnet ist, daß man p-Aminobenzalthiotemicarbazon mit Äthylisocyanat behandelt.The invention relates to a method for producing these Compound which is characterized in that p-aminobenzalthiotemicarbazone treated with ethyl isocyanate.
Vorzugsweise wird das Verfahren in einem geeigneten Lösungsmittel, wie Pyridin. Aceton, Dioxan, durchgeführt.The process is preferably carried out in a suitable solvent, like pyridine. Acetone, dioxane.
Beispiel 32 Gewichtsteile p-Aminob-enzalthiosemicarbazon @v@erden in i 5o Gewichtsteilen Pyridin gelöst und mit i9 Gewichtsteilen Athylisocyanat versetzt. Die Lösung erwärmt sich langsam bis auf etwa 35°. Sie wird nach einstündigem Stehen noch i Stunde lang auf dem Dampfbad erwärmt und sodann in. verdünnte Salzsäure gerührt. Dabei scheidet sich ein gelbliches, bald erstarrendes Harz ab. Dieses wird abgesaugt und mit Wasser nachgewaschen. Zur Reinigung wird es nun in. etwa i 1 5°/oiger Natronlauge bei 3o bis 4o,°' aufgenomm-en. Die trübe Lösung wird mit Tierkohle versetzt und, abgesaugt. Aus -dem Filtrat wird das Produkt durch Ansäuern als gelbliches Pulver ausgefällt und nun, in der gerade nötigen -Menge kochenden Alkohols gelöst und heiß mit dem doppelten Volumen heißen Wassers vermischt und erkalten gelassen. in feinen gelblichen Kristallen aus. F.: 22o°' (Zers).Example 32 parts by weight of p-aminobenzalthiosemicarbazon @ v @ earth dissolved in 15 parts by weight of pyridine and mixed with 19 parts by weight of ethyl isocyanate. The solution slowly warms up to about 35 °. After standing for one hour, it is warmed for another hour on the steam bath and then stirred in dilute hydrochloric acid. A yellowish, soon solidifying resin separates out. This is suctioned off and washed with water. To clean it, it is then taken up in about 15% sodium hydroxide solution at 3o to 4o ° '. The cloudy solution is mixed with animal charcoal and sucked off. The product is precipitated from the filtrate as a yellowish powder by acidification and then dissolved in the just necessary amount of boiling alcohol and mixed with twice the volume of hot water and allowed to cool. in fine yellowish crystals. F .: 22o ° '(dec).
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH881652X | 1949-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE881652C true DE881652C (en) | 1953-07-02 |
Family
ID=4544891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEW1298A Expired DE881652C (en) | 1949-05-24 | 1950-03-02 | Process for the preparation of p- (AEthylureido) -benzalthiosemicarbazone |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE881652C (en) |
-
1950
- 1950-03-02 DE DEW1298A patent/DE881652C/en not_active Expired
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