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DE870508T1 - Influenza Vaccine - Google Patents

Influenza Vaccine

Info

Publication number
DE870508T1
DE870508T1 DE0870508T DE98201056T DE870508T1 DE 870508 T1 DE870508 T1 DE 870508T1 DE 0870508 T DE0870508 T DE 0870508T DE 98201056 T DE98201056 T DE 98201056T DE 870508 T1 DE870508 T1 DE 870508T1
Authority
DE
Germany
Prior art keywords
influenza
propagated
surface antigen
dna
influenza viruses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0870508T
Other languages
English (en)
Other versions
DE29801056U1 (de
Inventor
Rudi Brands
Gustaaf J. M. Van Scharrenburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8228174&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE870508(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Publication of DE870508T1 publication Critical patent/DE870508T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Claims (9)

98.201056.3 Duphar International Research B.V. Patentansprüche:
1. Influenza-Oberflächenantigen-Impfstoff, erhältlich durch Herstellung aus Influenzaviren, die in Tierzellkulturen vermehrt wurden, mit einem Gehalt an Wirtszell-DNA gleich oder weniger als 25 pg pro Dosis.
2. Influenza-Oberflächenantigen-Impfstoff gemäß Anspruch 1 mit einem Gehalt an Wirtszell-DNA von weniger als 10 pg pro Dosis.
3. Verfahren zur Herstellung von Oberflächenantigen-Proteinen aus Influenzaviren, die in Tierzellkulturen vermehrt wurden, das folgende Schritte umfaßt:
a. Behandlung der Flüssigkeit, die das ganze Virus enthält und aus der Zellkultur erhalten wurde, mit einem DNA-verdauenden Enzym, und
b. Zugabe eines kationischen Detergens,
gefolgt von der Isolierung der Oberflächenantigen-Proteine.
4. Verfahren nach Anspruch 3, worin die Behandlung mit dem DNA-verdauenden Enzym während der Vermehrung des Influenzavirus in der Zellkultur stattfindet.
5. Verfahren nach Anspruch 3, worin das kationische Detergens überwiegend besteht aus einer Verbindung der allgemeinen Formel
K S R3
^ +
N X
DE/EP O 870508T1
Rl, R2 und R3 gleich oder verschieden sind und jedes Alkyl oder Aryl bedeutet, R1 und R2, zusammen mit dem Stickstoffatom, an das diese gebunden sind, einen 5- oder 6-gliedrigen gesättigten heterocyclischen Ring bilden, und R3 Alkyl oder Aryl bedeutet, oder R^, R2 und R3 zusammen mit dem Stickstoffatom an das diese gebunden sind, einen 5- oder 6-gliedrigen heterocyclischen Ring bedeuten, der am Stickstoffatom ungesättigt ist,
R4 Alkyl oder Aryl bedeutet und
X ein Anion bedeutet.
6. Verfahren nach Anspruch 3, worin das kationische Detergens überwiegend Cetyltrimethylammoniumbromid enthält.
7. Verfahren nach Anspruch 3, worin das kationische Detergens durch ein nichtionisches Detergens ergänzt wird.
8. Verfahren nach Anspruch 3, worin die Influenzaviren in einer Tierzellinie vermehrt werden.
9. Verfahren nach Anspruch 3, worin die Influenzaviren in MDCK-Zellen vermehrt werden.
DE0870508T 1997-04-09 1998-04-02 Influenza Vaccine Pending DE870508T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201007 1997-04-09

Publications (1)

Publication Number Publication Date
DE870508T1 true DE870508T1 (de) 1999-08-19

Family

ID=8228174

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0870508T Pending DE870508T1 (de) 1997-04-09 1998-04-02 Influenza Vaccine
DE69800383T Expired - Lifetime DE69800383T2 (de) 1997-04-09 1998-04-02 Influenza Vaccine

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69800383T Expired - Lifetime DE69800383T2 (de) 1997-04-09 1998-04-02 Influenza Vaccine

Country Status (32)

Country Link
US (1) US5948410A (de)
EP (1) EP0870508B1 (de)
JP (1) JP5258127B2 (de)
KR (1) KR100593235B1 (de)
CN (1) CN1138564C (de)
AR (1) AR011216A1 (de)
AT (1) ATE197406T1 (de)
AU (1) AU728939B2 (de)
BR (1) BR9801015A (de)
CA (1) CA2234208C (de)
CZ (1) CZ297492B6 (de)
DE (2) DE870508T1 (de)
DK (1) DK0870508T3 (de)
DZ (1) DZ2462A1 (de)
ES (1) ES2129386T3 (de)
GR (2) GR990300017T1 (de)
HK (1) HK1010833A1 (de)
HR (1) HRP980187B1 (de)
HU (1) HUP9800802A3 (de)
ID (1) ID20399A (de)
IL (1) IL123961A (de)
NO (1) NO323349B1 (de)
NZ (1) NZ330131A (de)
PL (1) PL187982B1 (de)
PT (1) PT870508E (de)
RU (1) RU2197264C2 (de)
SI (1) SI0870508T1 (de)
SK (1) SK282614B6 (de)
TR (1) TR199800613A1 (de)
TW (1) TW570803B (de)
UA (1) UA42089C2 (de)
ZA (1) ZA982915B (de)

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NO323349B1 (no) 2007-04-02
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US5948410A (en) 1999-09-07
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JPH1121253A (ja) 1999-01-26
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CA2234208A1 (en) 1998-10-09
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