DE850535C - Rat and mouse poison - Google Patents
Rat and mouse poisonInfo
- Publication number
- DE850535C DE850535C DEP10230D DEP0010230D DE850535C DE 850535 C DE850535 C DE 850535C DE P10230 D DEP10230 D DE P10230D DE P0010230 D DEP0010230 D DE P0010230D DE 850535 C DE850535 C DE 850535C
- Authority
- DE
- Germany
- Prior art keywords
- rat
- poison
- mouse
- mouse poison
- acetylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002574 poison Substances 0.000 title claims description 5
- 231100000614 poison Toxicity 0.000 title claims description 5
- 230000021736 acetylation Effects 0.000 claims description 3
- 238000006640 acetylation reaction Methods 0.000 claims description 3
- FULZLIGZKMKICU-UHFFFAOYSA-N N-phenylthiourea Chemical class NC(=S)NC1=CC=CC=C1 FULZLIGZKMKICU-UHFFFAOYSA-N 0.000 claims description 2
- 241000700159 Rattus Species 0.000 description 5
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- 239000003128 rodenticide Substances 0.000 description 3
- 230000009967 tasteless effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- PIVQQUNOTICCSA-UHFFFAOYSA-N ANTU Chemical compound C1=CC=C2C(NC(=S)N)=CC=CC2=C1 PIVQQUNOTICCSA-UHFFFAOYSA-N 0.000 description 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical group NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- MVOLAEJPECOVSS-UHFFFAOYSA-N [Pb].CC(Cl)=O Chemical compound [Pb].CC(Cl)=O MVOLAEJPECOVSS-UHFFFAOYSA-N 0.000 description 1
- 230000000397 acetylating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- BOCMQCDHTYVVQY-UHFFFAOYSA-N n-acetyl-n-carbamothioylacetamide Chemical compound CC(=O)N(C(C)=O)C(N)=S BOCMQCDHTYVVQY-UHFFFAOYSA-N 0.000 description 1
- UZKMJXCRMUORAR-UHFFFAOYSA-N n-carbamothioyl-n-phenylacetamide Chemical compound CC(=O)N(C(N)=S)C1=CC=CC=C1 UZKMJXCRMUORAR-UHFFFAOYSA-N 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Ratten- und Mäusegift Es ist bekannt, daß Alpha-Naphthylthioharnstoff als wirksames Rattengift verwendet wird. Ähnliche Verbindungen, die zwar eine starke Giftigkeit besitzen, wie z. B. der Phenylthioharnstoff, zu diesem Zweck zu benutzen, scheitert daran, daß sie wegen ihres hervordringenden Geschmackes nicht von den Ratten angenommen werden.Rat and mouse poison It is known that alpha-naphthylthiourea used as an effective rat poison. Similar connections, though strong Possess toxicity, such as B. the phenylthiourea, to be used for this purpose, fails because it is not from the Rats are accepted.
Es wurde nun gefunden, daß durch Acetylieren dieses Harnstoffes Derivate entstehen, die hochgiftig, aber fast geschmacklos sind und von den Ratten leicht angenommen werden.It has now been found that by acetylating this urea derivatives which are highly toxic, but almost tasteless, and easy on the rats be accepted.
Die Acetylierung erfolgt in der Phenylamidgruppe und führt zunächst zum unsymmetrischen Acetylphenylthiollarnstoff. Dieser ist als Rattengift wirksam. Der durch Erhitzen über den Schmelzpunkt unter Umlagerung entstehende symmetrische AcetylphenyIthioharnstoff hat die gleichen pharmakologischen Eigenschaften und ist bei gleicher Toxität ebenfalls als Rattengift verwendbar. Durch Acetylierung mit 2 Molen Acetanhydrid oder Acetylchlorid gelangt man zum Diacetylthioharnstoff, der ebenfalls verwendbar ist. Die letale Dosis dieses erfindungsgemäßen Giftes beträgt 5 mg pro Kilogramm Rattengewicht. Der Tod erfolgt 15 bis 20 Stunden nach dem Fressen ohne quälende Krampferscheinungen und Unruhe. Da diese Substanz geschmack- und geruchlos ist, eine spezifische Wirkung gegenüber Nagetieren aufweist, dagegen Haustiere auch in größeren Dosen nicht beeinflußt, ist sie den meisten bisher in den Handel gebrachten Rattengiften überlegen. Ein weiterer Vorteil ist der, daß der Wirkstoff beständig ist und während der Lagerung keine Abschwächung der Wirksamkeit erfährt.The acetylation takes place in the phenylamide group and leads first to the asymmetrical acetylphenylthiol urea. This is effective as a rat poison. The symmetrical one created by heating above the melting point with rearrangement Acetylphenylthiourea has the same pharmacological properties and is Can also be used as a rat poison with the same toxicity. Acetylation with 2 moles of acetic anhydride or acetyl chloride lead to diacetylthiourea, the can also be used. The lethal dose of this poison according to the invention is 5 mg per kilogram of rat weight. Death occurs 15 to 20 hours after eating without agonizing symptoms of cramps and restlessness. Because this substance is tasteless and odorless has a specific effect on rodents, but so does domestic animals Unaffected in larger doses, it is most of them put on the market up to now Superior to rat poisons. Another advantage is that the active ingredient is permanent and does not experience any reduction in effectiveness during storage.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP10230D DE850535C (en) | 1948-10-02 | 1948-10-02 | Rat and mouse poison |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP10230D DE850535C (en) | 1948-10-02 | 1948-10-02 | Rat and mouse poison |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE850535C true DE850535C (en) | 1952-09-25 |
Family
ID=7362763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEP10230D Expired DE850535C (en) | 1948-10-02 | 1948-10-02 | Rat and mouse poison |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE850535C (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE534676C (en) * | 1928-11-24 | 1931-09-30 | I G Farbenindustrie Akt Ges | Process for the protection of wool, fur, hair and the like Like. Against textile pests |
-
1948
- 1948-10-02 DE DEP10230D patent/DE850535C/en not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE534676C (en) * | 1928-11-24 | 1931-09-30 | I G Farbenindustrie Akt Ges | Process for the protection of wool, fur, hair and the like Like. Against textile pests |
| DE546097C (en) * | 1928-11-24 | 1932-03-10 | I G Farbenindustrie Akt Ges | Process for the protection of wool, fur, hair and the like Like. Against textile pests |
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