DE728188C - Process for the preparation of concentrated solutions of diiodotyrosine - Google Patents
Process for the preparation of concentrated solutions of diiodotyrosineInfo
- Publication number
- DE728188C DE728188C DEK154644D DEK0154644D DE728188C DE 728188 C DE728188 C DE 728188C DE K154644 D DEK154644 D DE K154644D DE K0154644 D DEK0154644 D DE K0154644D DE 728188 C DE728188 C DE 728188C
- Authority
- DE
- Germany
- Prior art keywords
- diiodotyrosine
- preparation
- concentrated solutions
- gelatin
- solutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NYPYHUZRZVSYKL-ZETCQYMHSA-N 3,5-diiodo-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC(I)=C(O)C(I)=C1 NYPYHUZRZVSYKL-ZETCQYMHSA-N 0.000 title claims description 10
- NYPYHUZRZVSYKL-UHFFFAOYSA-N -3,5-Diiodotyrosine Natural products OC(=O)C(N)CC1=CC(I)=C(O)C(I)=C1 NYPYHUZRZVSYKL-UHFFFAOYSA-N 0.000 title claims description 9
- 229960000415 diiodotyrosine Drugs 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title description 3
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
Verfahren zur Herstellung von konzentrierten Lösungen von Dijodtyrosin Im Hauptpatent 721 746 ist ein Verfahren zur Herstellung von konzentrierten Lösungen von Dijodtyrosin beschrieben, nach welchem man auf Dijodtyrosin mehr als ein Äquivalent eines basischen Stoffes in Gegenwart von Wasser einwirken läßt.Process for the preparation of concentrated solutions of diiodotyrosine The main patent 721 746 describes a process for the preparation of concentrated solutions of diiodotyrosine, according to which more than one equivalent of a basic substance is allowed to act on diiodotyrosine in the presence of water.
In weiterer Ausbildung des Verfahrens wurde nun gefunden, daß sich .die Konzentration dieser Lösungen wie auch ihre Stabilität durch Zusatz von Gelatine noch weiter steigern läßt. So zeigte sich insbesondere, daß die Löslichkeit des für therapeutische Zwecke besonders geeigneten, mit Calciumhydrotyd behandelten Dijodtyrosins in Wasser von Zimmertemperatur nur ungefähr o,3 beträgt, wogegen sich durch einen Zusatz von etwa 4% Gelatine der Dijodtyrosingehalt dieser Lösungen bis auf 1,20'o steigern läBt. Beispiel reg Dijodtyrosin und 2,044g reines Calciumhydroxyd werden mit 986 ccm 4o/oiger Gelatinelösung übergossen. Durch gelindes Erwärmen erhält man eine klare, schwach gelb gefärbte Lösung, die durch Filtrieren von Spuren Ungelöstem befreit wird. Die Sterilisation erfolgt bei roo'. Aus der Lösung scheidet sich bei Zimmertemperatur auch nach Impfung kein Calciumsalz ab; ihr Gehalt an Dijodtyrosin beträgt r,2%.In a further development of the process it has now been found that .The concentration of these solutions as well as their stability due to the addition of gelatin can be increased even further. It was found in particular that the solubility of the Treated with calcium hydrotide, particularly suitable for therapeutic purposes Diiodotyrosine in room temperature water is only about 0.3, whereas it is by adding about 4% gelatin, the diiodotyrosine content of these solutions can be increased can be increased to 1.20'o. Example reg Diiodotyrosine and 2.044g of pure calcium hydroxide 986 ccm 40 / o gelatin solution are poured over them. Preserved by gentle heating a clear, pale yellow solution, which can be obtained by filtering off traces of undissolved material is released. Sterilization takes place at roo '. The solution separates Room temperature, even after vaccination, no calcium salt drops; their content of diiodotyrosine is r.2%.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEK154644D DE728188C (en) | 1939-06-04 | 1939-06-04 | Process for the preparation of concentrated solutions of diiodotyrosine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEK154644D DE728188C (en) | 1939-06-04 | 1939-06-04 | Process for the preparation of concentrated solutions of diiodotyrosine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE728188C true DE728188C (en) | 1942-11-21 |
Family
ID=7253095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEK154644D Expired DE728188C (en) | 1939-06-04 | 1939-06-04 | Process for the preparation of concentrated solutions of diiodotyrosine |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE728188C (en) |
-
1939
- 1939-06-04 DE DEK154644D patent/DE728188C/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE728188C (en) | Process for the preparation of concentrated solutions of diiodotyrosine | |
| DE598780C (en) | Method of odorless hypochlorite bleached soaps | |
| DE485273C (en) | Process for the preparation of stable salts of p-aminophenylstibic acid | |
| AT112135B (en) | Process for the preparation of basic oxime ethers and their salts. | |
| DE510437C (en) | Process for the preparation of Benzimidazolonstibinsäuren | |
| AT132707B (en) | Process for the preparation of organic bromine derivatives. | |
| DE568339C (en) | Process for the production of a silver-containing preparation from ethylene diamine | |
| DE330673C (en) | Process for the production of aqueous fluids with a high camphor content | |
| DE721746C (en) | Process for the preparation of concentrated sterilizable solutions of diiodotyrosine | |
| DE657129C (en) | Process for the production of solutions or extracts from bacteria, pollen or other plant cells | |
| AT119480B (en) | Process for the preparation of addition compounds of sulfur dioxide with aromatic p-diamines. | |
| DE413380C (en) | Process for the preparation of pure 1-nitro-2-methylanthraquinone | |
| AT115379B (en) | Process for the production of an agent for combating epidemics, especially for disinfecting stable rooms and the like. like | |
| AT136393B (en) | Method of making a weed killer. | |
| DE432420C (en) | Process for the preparation of N-methylsulphurous acid salts of secondary amines | |
| DE650684C (en) | Process for the production of durable, acidic solutions of free humic acids | |
| DE936205C (en) | Process for obtaining the coferment of carbonic anhydrase | |
| DE574720C (en) | Production of phosphoric acid from monocalcium phosphate | |
| DE555938C (en) | Process for the preparation of oxybenzanthrones | |
| DE816696C (en) | Process for the preparation of the dibasic calcium salt of acetylglutamic acid | |
| CH189751A (en) | Process for the preparation of an aqueous digitalislanata glycoside solution. | |
| CH150744A (en) | Process for the preparation of a molecular compound of 2-phenylquinoline-4-carboxylic acid calcium with 1-phenyl-2,3-dimethyl-4-dimethylamino-5-pyrazolone. | |
| CH119982A (en) | Procedure for displaying 5. 7-diiodisatin. | |
| CH120257A (en) | Process for the preparation of a new oxynaphthalene carboxylic acid. | |
| CH131250A (en) | Process for the preparation of m-Oxy-N-methyldiethylaminoethylaniline. |