DE703976C - Process for the production of odorless and tasteless dry preparations - Google Patents
Process for the production of odorless and tasteless dry preparationsInfo
- Publication number
- DE703976C DE703976C DE1939K0153449 DEK0153449D DE703976C DE 703976 C DE703976 C DE 703976C DE 1939K0153449 DE1939K0153449 DE 1939K0153449 DE K0153449 D DEK0153449 D DE K0153449D DE 703976 C DE703976 C DE 703976C
- Authority
- DE
- Germany
- Prior art keywords
- odorless
- production
- dry preparations
- tasteless
- silica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung geruch- und geschmackfreier Trockenpräparate Es ist bekannt, daß gepulverte Kohle, insbesondere Asdsorptionskohle, flüssige oder gasförmige riechende Stoffe absorbiert, und daß auf diese Weise auch therapeutische Wirkstoffe, wie ätherische Öle, Pflaiizensäfte, Pflanzenauszüge u. dgl., durch Bindung an das Kohlepulver geruch- und geschmackfrei gemacht werden können. Die an die Kohle gebundenen riechenden Stoffe können aber meist nur bei erhöhten' Temperaturen und in -besonderen Lösungsmitteln wieder isoliert werden, da ihre Bindung an Kohle sehr fest ist.Process for the production of odorless and tasteless dry preparations It is known that powdered coal, especially Asdsorptionskohle, liquid or absorbs gaseous odorous substances, and that in this way also therapeutic Active ingredients, such as essential oils, vegetable juices, plant extracts and the like, by binding on which coal powder can be made odorless and tasteless. The one to the coal Bound odorous substances can usually only be used at elevated temperatures and in -special solvents can be isolated again, since their binding to carbon is very high is firm.
Aus diesem Grunde können auch die in den Pflanzenauszügen enthaltenen Öle gar nicht oder nur sehr unvollkommen vom Magen oder Darm resorbiert werden.-Nimmt man jedoch an Stelle von Kohlepulver zur Absorption flüssiger oder gasgelöster riechender Stoffe gepulverte Kieselerde und trocknet, so erhält man zwar, abgesehen von der für das Einnehmen ansprechenderen Farbe, ein Trockenpräparat. aus dem die wirksamen Bestandteile leicht z. B. durch Extraktion isoliert werden können. Diese Produkte haben jedoch den Nachteil, daß sie weder geschmack- noch geruchfrei sind.For this reason, those contained in the plant extracts can also be used Oils are not absorbed at all or only very imperfectly from the stomach or intestines.-Takes however, instead of carbon powder for the absorption of liquid or gas-dissolved odorous ones Substances powdered silica and dries, so you get, apart from that for ingestion more appealing color, a dry preparation. from which the effective Components easily z. B. can be isolated by extraction. These products however, have the disadvantage that they are neither tasteless nor odorless.
Es wurde nun gefunden, daß, wenn man zu den mit Kieselerde hergestellten Trockenpräparaten eine geringe Menge Adsorptionskohle zusetzt, das erhaltene Präparat geruch-und geschmackfrei ist und zur Isolierung der absorbierten riechenden Stoffe keiner erhöhten Temperatur oder besonderer Lösungsmittel bedarf. It has now been found that when one goes to those made with silica Add a small amount of adsorption charcoal to dry preparations, the preparation obtained Is odorless and tasteless and to isolate the absorbed odorous substances does not require any elevated temperature or special solvents.
Die Menge des zuzusetzenden Kohlepulvers ist durchgängig sehr gering und beträgt etwa O,I bis 0,5 Wo. Eine mit Knoblauchsaft gesättigte Kieselerde läßt sich durch einenkleineren Zusatz von gepulverter Adsorptionskohle geruchfrei machen als Kieselerde, die mit Pfefferminz-, Kümmel-, Fenchel- oder anderen ätherischen Ölen getränkt ist. The amount of carbon powder to be added is consistently very low and is about 0.1 to 0.5 wk. Leave a silica saturated with garlic juice Make yourself odor-free by adding a small amount of powdered adsorption carbon as silica, those with peppermint, caraway, fennel or other essential oils Soaked in oils.
Ausführungsbeispiel 50 g Kieselerde wurden mit 50 g handelsüblichem Knoblauchsaft in einem Mörser so lange innig vermengt, bis das Gemenge eine gleichmäßige, etwas bröcklige Masse bildete. Exemplary embodiment 50 g of silica were mixed with 50 g of commercially available Thoroughly mix the garlic juice in a mortar until the mixture has a uniform, some crumbly mass formed.
L)ie Verreibungszeit betrug etwa 3 Minuten.The rub-in time was about 3 minutes.
Die vorher rötlichweiß aussehende Kieselerde bekam nach der Aufnahme des Knoblauchsaftes eine hellgelbe Farbe. Der Geruch des Gemenges war noch deutlich nach Knoblauch, wenn auch wesentlich schwächer als der des zugesetzten Knoblauchsaftes selbst. Die imprägnierte Kieselerde wurde danach bei 80° etwa 30 Minuten getrocknet, wodurch ein Gewichtsverlust von nur etwa 1% eintrat. Nach dem Trocknen war der Geruch der impr.ignierten Kieselerde nach Knoblauch noch schwächer geworden. Danach wurde dem Gemisch o, I g Kohlepulver (Carbo medicinalis Merck in Pulverform) zugesetzt, und schon nach wenigen Sekunden war das Produkt vollkommen geruchfrei geworden. Durch sden Zusatz von Kohle hatte es eine hellgraue Farbe angenommen.The previously reddish-white looking silica got after the exposure of the garlic juice a light yellow color. The smell of the mixture was still clear like garlic, albeit much weaker than that of the added garlic juice itself. The impregnated silica was then dried at 80 ° for about 30 minutes, whereby there was a weight loss of only about 1%. After drying was the smell the impregnated silica became even weaker after garlic. After that it was 0.1 g of coal powder (Carbo medicinalis Merck in powder form) added to the mixture, and after a few seconds the product was completely odorless. With the addition of charcoal it had turned a light gray color.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1939K0153449 DE703976C (en) | 1939-02-14 | 1939-02-14 | Process for the production of odorless and tasteless dry preparations |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1939K0153449 DE703976C (en) | 1939-02-14 | 1939-02-14 | Process for the production of odorless and tasteless dry preparations |
Publications (1)
Publication Number | Publication Date |
---|---|
DE703976C true DE703976C (en) | 1941-03-20 |
Family
ID=7252819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1939K0153449 Expired DE703976C (en) | 1939-02-14 | 1939-02-14 | Process for the production of odorless and tasteless dry preparations |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE703976C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE934189C (en) * | 1942-10-18 | 1955-10-13 | Wilhelm Lindenberg | Method for rendering garlic preparations odorless |
-
1939
- 1939-02-14 DE DE1939K0153449 patent/DE703976C/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE934189C (en) * | 1942-10-18 | 1955-10-13 | Wilhelm Lindenberg | Method for rendering garlic preparations odorless |
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