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DE69936168D1 - Mehrfachprobeninlassmassenspektrometer - Google Patents

Mehrfachprobeninlassmassenspektrometer

Info

Publication number
DE69936168D1
DE69936168D1 DE69936168T DE69936168T DE69936168D1 DE 69936168 D1 DE69936168 D1 DE 69936168D1 DE 69936168 T DE69936168 T DE 69936168T DE 69936168 T DE69936168 T DE 69936168T DE 69936168 D1 DE69936168 D1 DE 69936168D1
Authority
DE
Germany
Prior art keywords
mehrfachprobeninlassmassenspektrometer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69936168T
Other languages
English (en)
Other versions
DE69936168T2 (de
Inventor
Robert Harold Bateman
John Anthony David Hickson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9813225.1A external-priority patent/GB9813225D0/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Application granted granted Critical
Publication of DE69936168D1 publication Critical patent/DE69936168D1/de
Publication of DE69936168T2 publication Critical patent/DE69936168T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/107—Arrangements for using several ion sources
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/628—Multiplexing, i.e. several columns sharing a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Sampling And Sample Adjustment (AREA)
DE69936168T 1998-06-18 1999-06-17 Mehrfachprobeninlassmassenspektrometer Expired - Lifetime DE69936168T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9813225 1998-06-18
GBGB9813225.1A GB9813225D0 (en) 1998-06-18 1998-06-18 Multi-inlet mass spectrometer
GBGB9816342.1A GB9816342D0 (en) 1998-06-18 1998-07-27 Multi-inlet mass spectrometer
GB9816342 1998-07-27

Publications (2)

Publication Number Publication Date
DE69936168D1 true DE69936168D1 (de) 2007-07-12
DE69936168T2 DE69936168T2 (de) 2007-09-27

Family

ID=26313900

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69936168T Expired - Lifetime DE69936168T2 (de) 1998-06-18 1999-06-17 Mehrfachprobeninlassmassenspektrometer

Country Status (5)

Country Link
US (1) US6410915B1 (de)
EP (1) EP0966022B1 (de)
JP (1) JP4560656B2 (de)
CA (1) CA2275140C (de)
DE (1) DE69936168T2 (de)

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US7399961B2 (en) * 2001-04-20 2008-07-15 The University Of British Columbia High throughput ion source with multiple ion sprayers and ion lenses
US6803565B2 (en) * 2001-05-18 2004-10-12 Battelle Memorial Institute Ionization source utilizing a multi-capillary inlet and method of operation
US6690006B2 (en) 2001-05-24 2004-02-10 New Objective, Inc. Method and apparatus for multiple electrospray sample introduction
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US6649909B2 (en) 2002-02-20 2003-11-18 Agilent Technologies, Inc. Internal introduction of lock masses in mass spectrometer systems
US7405397B2 (en) * 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
US7214320B1 (en) 2002-08-08 2007-05-08 Nanostream, Inc. Systems and methods for high throughput sample analysis
AU2003259722A1 (en) * 2002-08-08 2004-02-25 Nanostream, Inc. Systems and methods for high-throughput microfluidic sample analysis
AU2003287449A1 (en) * 2002-10-31 2004-05-25 Nanostream, Inc. Parallel detection chromatography systems
US6936167B2 (en) * 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
US6987263B2 (en) * 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
US20060076482A1 (en) * 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
US6995362B1 (en) 2003-02-04 2006-02-07 Mayo Foundation For Medical Education And Research Dual electrospray ionization source for mass spectrometer
WO2005042127A2 (en) * 2003-05-29 2005-05-12 Upchurch Scientific, Inc. Improved apparatus and methods for electrospray applications
US7015466B2 (en) * 2003-07-24 2006-03-21 Purdue Research Foundation Electrosonic spray ionization method and device for the atmospheric ionization of molecules
US7204431B2 (en) 2003-10-31 2007-04-17 Agilent Technologies, Inc. Electrospray ion source for mass spectroscopy
US7005635B2 (en) * 2004-02-05 2006-02-28 Metara, Inc. Nebulizer with plasma source
US6974957B2 (en) * 2004-02-18 2005-12-13 Nanomat, Inc. Ionization device for aerosol mass spectrometer and method of ionization
US7424980B2 (en) * 2004-04-08 2008-09-16 Bristol-Myers Squibb Company Nano-electrospray nebulizer
US20060054805A1 (en) * 2004-09-13 2006-03-16 Flanagan Michael J Multi-inlet sampling device for mass spectrometer ion source
US7034291B1 (en) * 2004-10-22 2006-04-25 Agilent Technologies, Inc. Multimode ionization mode separator
DE102004051785B4 (de) * 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
WO2006060130A2 (en) * 2004-11-09 2006-06-08 E.I. Dupont De Nemours And Company Ion source for a mass spectrometer
US7145136B2 (en) * 2004-12-17 2006-12-05 Varian, Inc. Atmospheric pressure ionization with optimized drying gas flow
WO2006086273A2 (en) * 2005-02-09 2006-08-17 Waters Investments Limited Apparatus and method for positioning a discharge tube with respect to an orifice
US20080305555A1 (en) * 2005-08-17 2008-12-11 Waters Investments Limited Methods, Compositions and Devices For Performing Ionization Desorption on Silicon Derivatives
US20080083873A1 (en) * 2006-10-09 2008-04-10 Matthew Giardina Device and method for introducing multiple liquid samples at atmospheric pressure for mass spectrometry
US8507850B2 (en) 2007-05-31 2013-08-13 Perkinelmer Health Sciences, Inc. Multipole ion guide interface for reduced background noise in mass spectrometry
US7564029B2 (en) * 2007-08-15 2009-07-21 Varian, Inc. Sample ionization at above-vacuum pressures
EP2218093B1 (de) 2007-11-30 2018-03-21 Waters Technologies Corporation Vorrichtung zur durchführung von massenanalysen
US20140166875A1 (en) 2010-09-02 2014-06-19 Wayne State University Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry
WO2012031082A2 (en) * 2010-09-02 2012-03-08 University Of The Sciences In Philadelphia System and method for ionization of molecules for mass spectrometry and ion mobility spectrometry
US8853621B2 (en) 2010-10-25 2014-10-07 Wayne State University Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum
US8879064B2 (en) * 2011-12-23 2014-11-04 Electro Scientific Industries, Inc. Apparatus and method for transporting an aerosol
US9281174B2 (en) * 2011-12-28 2016-03-08 Micromass Uk Limited System and method for rapid evaporative ionization of liquid phase samples
WO2015128661A1 (en) * 2014-02-26 2015-09-03 Micromass Uk Limited Ambient ionisation with an impactor spray source
CN106463335B (zh) 2014-07-03 2019-02-19 株式会社岛津制作所 质谱分析装置
CN106373856B (zh) * 2015-07-23 2019-02-15 北京理工大学 电喷雾离子源及包含该离子源的lc-ms联用接口
JP6544430B2 (ja) * 2015-08-06 2019-07-17 株式会社島津製作所 質量分析装置
WO2017046849A1 (ja) * 2015-09-14 2017-03-23 株式会社日立ハイテクノロジーズ 質量分析装置
GB201519830D0 (en) * 2015-11-10 2015-12-23 Micromass Ltd A method of transmitting ions through an aperture
CN111902719B (zh) 2018-02-19 2024-05-07 塞尔诺生物科学有限责任公司 自动的质谱分析方法和仪器
US11222778B2 (en) * 2019-10-30 2022-01-11 Thermo Finnigan Llc Multi-electrospray ion source for a mass spectrometer
CN115831704B (zh) * 2023-02-23 2023-05-26 杭州凯莱谱精准医疗检测技术有限公司 含有分段式渐变式的离子传输通道的质谱设备

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JPH08297112A (ja) * 1995-04-27 1996-11-12 Shimadzu Corp 液体クロマトグラフ質量分析装置
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Also Published As

Publication number Publication date
EP0966022A2 (de) 1999-12-22
JP4560656B2 (ja) 2010-10-13
EP0966022B1 (de) 2007-05-30
US6410915B1 (en) 2002-06-25
CA2275140A1 (en) 1999-12-18
JP2000057989A (ja) 2000-02-25
DE69936168T2 (de) 2007-09-27
EP0966022A3 (de) 2002-01-30
CA2275140C (en) 2008-04-29

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Legal Events

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