DE69933875D1 - Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt. - Google Patents

Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt.

Info

Publication number: DE69933875D1
Authority: DE; Germany
Prior art keywords: protein; papilloma virus; administration system; human papilloma; similar particles
Prior art date: 1998-08-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69933875T

Other languages

English (en)

Other versions

DE69933875T2 (de

Inventor

S Lowe

U Jansen

G Joyce

L Mcclements

C Cook

Ching-Yee Ling

P Neeper

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-14

Filing date

1999-08-10

Publication date

2006-12-14

1999-08-10 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2006-12-14 Application granted granted Critical

2006-12-14 Publication of DE69933875D1 publication Critical patent/DE69933875D1/de

2007-05-31 Publication of DE69933875T2 publication Critical patent/DE69933875T2/de

2019-08-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/70—Vector systems having a special element relevant for transcription from fungi
- C12N2830/702—Vector systems having a special element relevant for transcription from fungi yeast

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DE69933875T 1998-08-14 1999-08-10 Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt. Expired - Lifetime DE69933875T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US9663898P	1998-08-14	1998-08-14
US96638P		1998-08-14
PCT/US1999/017931 WO2000009157A1 (en)	1998-08-14	1999-08-10	Protein delivery system using human papillomavirus virus-like particles

Publications (2)

Publication Number	Publication Date
DE69933875D1 true DE69933875D1 (de)	2006-12-14
DE69933875T2 DE69933875T2 (de)	2007-05-31

Family

ID=22258340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69933875T Expired - Lifetime DE69933875T2 (de)	1998-08-14	1999-08-10	Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt.

Country Status (8)

Country	Link
EP (1)	EP1105157B1 (de)
JP (1)	JP4563582B2 (de)
AT (1)	ATE344052T1 (de)
AU (1)	AU753391B2 (de)
CA (1)	CA2339324C (de)
DE (1)	DE69933875T2 (de)
ES (1)	ES2275350T3 (de)
WO (1)	WO2000009157A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7476517B2 (en)	1999-06-30	2009-01-13	Evotec Ag	Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics
US20040014033A1 (en)	1999-06-30	2004-01-22	Evotec Biosystems Ag, A Corporation Of Germany	Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics
DK1187928T3 (da) *	1999-06-30	2007-10-08	Evotec Ag	Viruslignende partikler, fremstilling og anvendelse ved screening samt ved funktionel genomics
GB0007231D0 (en) *	2000-03-24	2000-05-17	Chiron Spa	Modified rna for gene delivery
ATE424409T1 (de) *	2002-05-17	2009-03-15	Univ Cape Town	Chimere human papilloma virus 16 l1 proteine, welche ein l2 peptid enthalten, damit hergestellte virus-ähnliche partikel und methode zur herstellung der partikel
EP1608767B1 (de)	2003-03-24	2012-02-22	Merck Sharp & Dohme Corp.	Optimierte expression von hpv 31 l1 in hefe
MY140664A (en) *	2003-09-29	2010-01-15	Merck Sharp & Dohme	Optimized expression of hpv 45 l1 in yeast
MY139500A (en)	2003-11-12	2009-10-30	Merck Sharp & Dohme	Optimized expression of hpv 58 l1 in yeast
PT1730175E (pt)	2004-03-24	2010-06-25	Merck Sharp & Dohme	Expressão optimizada de hpv 52 l1 em levedura
WO2011151333A1 (en) *	2010-06-02	2011-12-08	Deutsches Krebsforschungszentrum	Papillomavirus l2 c-terminal peptides for vaccination
CA3040071A1 (en)	2015-12-17	2017-06-22	The Penn State Research Foundation	Paramyxovirus virus-like particles as protein delivery vehicles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5618536A (en) *	1992-09-03	1997-04-08	The United States Of America As Represented By The Department Of Health And Human Services	Chimeric papillomavirus-like particles
US5437951A (en) *	1992-09-03	1995-08-01	The United States Of America As Represented By The Department Of Health And Human Services	Self-assembling recombinant papillomavirus capsid proteins
DE4447664C2 (de) *	1994-10-07	1999-04-15	Lutz Prof Dr Gissmann	Fusionsproteine, Verfahren zu deren Herstellung sowie deren Anwendung
DE59511047D1 (de) *	1994-10-07	2006-06-14	Univ Loyola Chicago	Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung
CA2211995A1 (en) *	1995-02-24	1996-08-29	Cantab Pharmaceuticals Research Limited	Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation
GB9621091D0 (en) *	1996-10-09	1996-11-27	Fondation Pour Le Perfectionem	Attenuated microorganisms strains and their uses

1999
- 1999-08-10 JP JP2000564659A patent/JP4563582B2/ja not_active Expired - Lifetime
- 1999-08-10 EP EP99940951A patent/EP1105157B1/de not_active Expired - Lifetime
- 1999-08-10 ES ES99940951T patent/ES2275350T3/es not_active Expired - Lifetime
- 1999-08-10 AU AU54699/99A patent/AU753391B2/en not_active Expired
- 1999-08-10 AT AT99940951T patent/ATE344052T1/de not_active IP Right Cessation
- 1999-08-10 WO PCT/US1999/017931 patent/WO2000009157A1/en active IP Right Grant
- 1999-08-10 CA CA2339324A patent/CA2339324C/en not_active Expired - Lifetime
- 1999-08-10 DE DE69933875T patent/DE69933875T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1105157B1 (de)	2006-11-02
ES2275350T3 (es)	2007-06-01
DE69933875T2 (de)	2007-05-31
EP1105157A4 (de)	2004-12-08
AU5469999A (en)	2000-03-06
ATE344052T1 (de)	2006-11-15
CA2339324A1 (en)	2000-02-24
JP2002522056A (ja)	2002-07-23
AU753391B2 (en)	2002-10-17
CA2339324C (en)	2011-05-31
WO2000009157A1 (en)	2000-02-24
JP4563582B2 (ja)	2010-10-13
EP1105157A1 (de)	2001-06-13

Publication	Publication Date	Title
AUPN015794A0 (en)	1995-01-19	Variants of human papilloma virus antigens
HUP0004327A3 (en)	2003-08-28	Fusion proteins containing human papilloma virus (hpv) proteins and immunological fusion partner with t-helper epitopes to the hpv antigen, as well as vaccine formulations for treatment and/or profilaxis of hpv induced lesions
FI940054A0 (fi)	1994-01-05	Peptider av humant papillomavirus foer anvaendning i kompositioner som inducerar human T-cellsvar
DE69535018D1 (de)	2006-07-06	Papillomavirus vakzine
WO2001026681A3 (en)	2002-01-31	Method of obtaining cellular immune responses from proteins
NZ503830A (en)	2002-09-27	Papilloma virus capsomere vaccine formulations and methods of use
ES2150595T3 (es)	2000-12-01	Procedimiento de preparacion de un vector viral de por lo menos 20 kb por recombinacion homologa intermolecular en una celula procariota.
DE69435332D1 (de)	2011-02-17	Herstellung von menschlichem Papillomaviren Hüllprotein und Virus-ähnlichen Teilchen
DE69233186D1 (de)	2003-10-09	Karcinoembryonale antigen expremierende rekombinante viren und methoden ihrer anwendung
HUP9901039A2 (hu)	1999-07-28	Neisseria meningitidis B-csoportba tartozó külső-membrán-fehérjéjének (MB3) expressziója élesztőben, továbbá vakcinák
DE69933875D1 (de)	2006-12-14	Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt.
CY1107706T1 (el)	2013-04-18	Πεπτιδια ανταγωνιστες καρκινοεμβρυονικου αντιγονου (cea)
EE9900612A (et)	2000-08-15	Inimese papilloomiviiruse stabiliseeritud preparaadid
ATE341339T1 (de)	2006-10-15	Zusammensetzungen von rekombinanten papillomavirus vakzinen
EP0327180A3 (de)	1990-07-18	Impfstoff, der vom Oberflächengen des menschlichen Immundefizienzvirus Typ I abstammende Polypeptide enthält
TW200509964A (en)	2005-03-16	VP1 of foot-and-mouth disease virus
DK0952771T3 (da)	2008-05-19	Hidtil ukendte saponinpræparater og anvendelser deraf
ES2012815A6 (es)	1990-04-16	Un metodo para producir peptidos antigenicos relacionados con el antigeno p97 asociado a melanoma, y para preparar vacunas que los contienen.
潘养廉	1983	Submanifolds with parallel mean curvature and Gauss maps
YU30495A (sh)	1997-12-05	Postupak za dobijanje hbv površinskih proteina
NZ334582A (en)	2000-07-28	Polyprotein construct of a papillomavirus
AU2002242725A1 (en)	2002-09-24	Mhc-i-restricted presentation of hiv-1 virion antigens without viral replication. application to the stimulation of ctl and vaccination in vivo; analysis of vaccinating composition in vitro

Legal Events

Date	Code	Title	Description
2007-11-29	8364	No opposition during term of opposition
2010-09-23	8327	Change in the person/name/address of the patent owner	Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US
2013-02-07	R081	Change of applicant/patentee	Ref document number: 1105157 Country of ref document: EP Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., 07065-0900 RAHWAY, US Effective date: 20121213
2013-02-07	R082	Change of representative	Ref document number: 1105157 Country of ref document: EP Representative=s name: ABITZ & PARTNER, DE Effective date: 20121213