DE69933186D1 - Methode zur Reinigung und Manipulation von Nukleinsäure mittels paramagnetischen Partikeln - Google Patents
Methode zur Reinigung und Manipulation von Nukleinsäure mittels paramagnetischen PartikelnInfo
- Publication number
- DE69933186D1 DE69933186D1 DE69933186T DE69933186T DE69933186D1 DE 69933186 D1 DE69933186 D1 DE 69933186D1 DE 69933186 T DE69933186 T DE 69933186T DE 69933186 T DE69933186 T DE 69933186T DE 69933186 D1 DE69933186 D1 DE 69933186D1
- Authority
- DE
- Germany
- Prior art keywords
- manipulation
- purification
- nucleic acid
- paramagnetic particles
- paramagnetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Compounds Of Iron (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/183,127 US5973138A (en) | 1998-10-30 | 1998-10-30 | Method for purification and manipulation of nucleic acids using paramagnetic particles |
| US183127 | 1998-10-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69933186D1 true DE69933186D1 (de) | 2006-10-26 |
| DE69933186T2 DE69933186T2 (de) | 2007-09-20 |
Family
ID=22671554
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69933186T Expired - Lifetime DE69933186T2 (de) | 1998-10-30 | 1999-09-20 | Methode zur Reinigung und Manipulation von Nukleinsäure mittels paramagnetischen Partikeln |
| DE69942639T Expired - Lifetime DE69942639D1 (de) | 1998-10-30 | 1999-09-20 | Verwendung von paramagnetischen Werkstoff zur Reinigung und Manipulation von Nukleinsäuren |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69942639T Expired - Lifetime DE69942639D1 (de) | 1998-10-30 | 1999-09-20 | Verwendung von paramagnetischen Werkstoff zur Reinigung und Manipulation von Nukleinsäuren |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5973138A (de) |
| EP (2) | EP1674571B1 (de) |
| JP (1) | JP4594467B2 (de) |
| AU (1) | AU771249B2 (de) |
| CA (1) | CA2287730C (de) |
| DE (2) | DE69933186T2 (de) |
| ES (2) | ES2270556T3 (de) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6884357B2 (en) | 1995-02-21 | 2005-04-26 | Iqbal Waheed Siddiqi | Apparatus and method for processing magnetic particles |
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US6872527B2 (en) * | 1997-04-16 | 2005-03-29 | Xtrana, Inc. | Nucleic acid archiving |
| EP1071691B1 (de) * | 1998-02-04 | 2005-09-28 | MERCK PATENT GmbH | Verfahren zur isolierung und aufreinigung von nucleinsäuren |
| JP4457425B2 (ja) * | 1998-09-08 | 2010-04-28 | アイシン精機株式会社 | モータの電機子コアとその電機子コアを用いたブラシ付直流モータ |
| US5973138A (en) * | 1998-10-30 | 1999-10-26 | Becton Dickinson And Company | Method for purification and manipulation of nucleic acids using paramagnetic particles |
| US20040005673A1 (en) | 2001-06-29 | 2004-01-08 | Kevin Jarrell | System for manipulating nucleic acids |
| WO2000040715A2 (en) | 1999-01-05 | 2000-07-13 | Trustees Of Boston University | Improved nucleic acid cloning |
| US6936414B2 (en) * | 1999-12-22 | 2005-08-30 | Abbott Laboratories | Nucleic acid isolation method and kit |
| US6672458B2 (en) * | 2000-05-19 | 2004-01-06 | Becton, Dickinson And Company | System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample |
| JP4792192B2 (ja) * | 2000-05-19 | 2011-10-12 | ベクトン・ディキンソン・アンド・カンパニー | 液体サンプル内の磁気応答性粒子を操作し、サンプルからｄｎａ又はｒｎａを収集するシステム及び方法 |
| US20050272085A1 (en) * | 2000-09-06 | 2005-12-08 | Hodge Timothy A | Methods for forensic and congenic screening |
| US20050266494A1 (en) * | 2000-09-06 | 2005-12-01 | Hodge Timothy A | System and method for computer network ordering of biological testing |
| EP1978110B1 (de) * | 2000-09-06 | 2010-05-26 | Transnetyx, Inc. | Computer-basiertes Verfahren und System zum Screenen von genomischer DNS |
| US20050239125A1 (en) * | 2000-09-06 | 2005-10-27 | Hodge Timothy A | Methods for genotype screening |
| US7494817B2 (en) * | 2000-09-06 | 2009-02-24 | Transnet Yx, Inc. | Methods for genotype screening using magnetic particles |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| WO2002098364A2 (en) * | 2001-06-06 | 2002-12-12 | The General Hospital Corporation | Magnetic-nanoparticle conjugates and methods of use |
| US20030040129A1 (en) * | 2001-08-20 | 2003-02-27 | Shah Haresh P. | Binding assays using magnetically immobilized arrays |
| WO2003097808A2 (en) | 2002-05-17 | 2003-11-27 | Becton, Dickinson And Company | Automated system for isolating, amplyifying and detecting a target nucleic acid sequence |
| US7601491B2 (en) * | 2003-02-06 | 2009-10-13 | Becton, Dickinson And Company | Pretreatment method for extraction of nucleic acid from biological samples and kits therefor |
| US20040157219A1 (en) * | 2003-02-06 | 2004-08-12 | Jianrong Lou | Chemical treatment of biological samples for nucleic acid extraction and kits therefor |
| US7731906B2 (en) | 2003-07-31 | 2010-06-08 | Handylab, Inc. | Processing particle-containing samples |
| ATE466105T1 (de) * | 2003-09-12 | 2010-05-15 | Biocontrol Systems Inc | Verfahren, zusammensetzungen und kits zur anreicherung und zum nachweis von mikroorganismen |
| WO2005061724A1 (en) * | 2003-12-10 | 2005-07-07 | The General Hospital Corporation | Self-assembling nanoparticle conjugates |
| DE10358137A1 (de) * | 2003-12-12 | 2005-07-07 | Merck Patent Gmbh | Verfahren und Kit zur Isolierung von RNA |
| WO2005093065A1 (en) * | 2004-03-16 | 2005-10-06 | Roche Diagnostics Gmbh | Improved method of isolating nucleic acids |
| US20050239091A1 (en) * | 2004-04-23 | 2005-10-27 | Collis Matthew P | Extraction of nucleic acids using small diameter magnetically-responsive particles |
| CA2502549C (en) | 2004-04-23 | 2016-02-16 | Becton, Dickinson And Company | Use of an extraction control in a method of extracting nucleic acids |
| ES2572382T3 (es) | 2004-05-03 | 2016-05-31 | Handylab Inc | Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US9267167B2 (en) * | 2004-06-28 | 2016-02-23 | Becton, Dickinson And Company | Dissolvable films and methods including the same |
| JP4476050B2 (ja) * | 2004-06-30 | 2010-06-09 | 株式会社ニデック | 視野計 |
| US20060024776A1 (en) * | 2004-08-02 | 2006-02-02 | Mcmillian Ray | Magnetic particle capture of whole intact organisms from clinical samples |
| CA2871777C (en) * | 2005-03-10 | 2015-07-28 | Matthew J. Hayes | System and methods for detecting multiple optical signals |
| US20060234251A1 (en) * | 2005-04-19 | 2006-10-19 | Lumigen, Inc. | Methods of enhancing isolation of RNA from biological samples |
| JP5295769B2 (ja) * | 2005-08-31 | 2013-09-18 | ティツー・バイオシステムズ・インコーポレーテッド | 分析物を検出するためのｎｍｒ装置 |
| US20070190526A1 (en) * | 2006-02-16 | 2007-08-16 | Nexgen Diagnostics Llc | Methods of extracting nucleic acids |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| EP3088083B1 (de) | 2006-03-24 | 2018-08-01 | Handylab, Inc. | Methode zur durchführung von pcr mittels einer kartusche mit mehreren bahnen |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8709787B2 (en) | 2006-11-14 | 2014-04-29 | Handylab, Inc. | Microfluidic cartridge and method of using same |
| CA2692186C (en) * | 2007-06-29 | 2019-03-12 | Becton, Dickinson And Company | Methods for extraction and purification of components of biological samples |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| JP5651011B2 (ja) | 2007-07-13 | 2015-01-07 | ハンディーラブ インコーポレイテッド | ポリヌクレオチド捕捉材料およびその使用方法 |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| WO2009026164A1 (en) * | 2007-08-17 | 2009-02-26 | The General Hospital Corporation | Magnetic resonance-based viscometers and methods |
| US20090088560A1 (en) * | 2007-10-02 | 2009-04-02 | Hong Shen | Process for Nucleic Acid Purification |
| WO2009129236A2 (en) * | 2008-04-14 | 2009-10-22 | Integrated Nano-Technologies Llc | Method for manipulating samples with magnetic nucleation nanoparticles |
| USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| ES2567067T3 (es) * | 2008-11-28 | 2016-04-19 | F. Hoffmann-La Roche Ag | Sistema y método para la extracción automática de ácidos nucleicos |
| EP2191900B1 (de) | 2008-11-28 | 2016-03-30 | F. Hoffmann-La Roche AG | System und Verfahren zur Behandlung von Nukleinsäuren enthaltenden Fluiden |
| CN113145296B (zh) | 2009-05-15 | 2024-03-29 | 简·探针公司 | 用于在执行磁性分离工序的仪器中实现磁体的自动移动的方法和设备 |
| US8039613B2 (en) | 2009-08-28 | 2011-10-18 | Promega Corporation | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods |
| US8222397B2 (en) | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| TW201113523A (en) | 2009-08-31 | 2011-04-16 | Mbio Diagnostics Inc | Integrated sample preparation and analyte detection |
| EP2547767A4 (de) * | 2010-03-16 | 2013-12-25 | Becton Dickinson Co | Verwendung von achromopeptidase für lyse bei raumtemperatur |
| US11542494B2 (en) * | 2010-09-02 | 2023-01-03 | Qiagen Gmbh | Method for isolating a target nucleic acid including small target nucleic acids with high yield |
| US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| JP5950920B2 (ja) | 2010-10-22 | 2016-07-13 | ティー２ バイオシステムズ インコーポレイテッド | 検体の検出のためのｎｍｒシステムおよび方法 |
| ES2617599T3 (es) | 2011-04-15 | 2017-06-19 | Becton, Dickinson And Company | Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| KR102121853B1 (ko) | 2011-09-30 | 2020-06-12 | 벡톤 디킨슨 앤드 컴퍼니 | 일체화된 시약 스트립 |
| EP2773892B1 (de) | 2011-11-04 | 2020-10-07 | Handylab, Inc. | Vorrichtung zur vorbereitung von polynukleotidproben |
| JP6178335B2 (ja) | 2011-12-21 | 2017-08-09 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | 磁気標識サンプル成分の無菌分離のためのフローサイトメトリーシステム |
| BR112014018995B1 (pt) | 2012-02-03 | 2021-01-19 | Becton, Dickson And Company | sistemas para executar ensaio automatizado |
| WO2013158281A1 (en) | 2012-04-20 | 2013-10-24 | T2 Biosystems, Inc. | Compositions and methods for detection of candida species |
| EP2912432B1 (de) | 2012-10-24 | 2018-07-04 | Genmark Diagnostics Inc. | Integrierte multiplex-zielanalyse |
| US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
| AU2013202805B2 (en) | 2013-03-14 | 2015-07-16 | Gen-Probe Incorporated | System and method for extending the capabilities of a diagnostic analyzer |
| JP6351702B2 (ja) | 2013-03-15 | 2018-07-04 | ジェンマーク ダイアグノスティクス， インコーポレイテッド | 変形可能流体容器を操作するためのシステム、方法、および装置 |
| USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
| US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| JP2017539080A (ja) | 2014-10-23 | 2017-12-28 | コーニング インコーポレイテッド | 高分子被包磁性ナノ粒子 |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
| JP2017537616A (ja) | 2014-11-14 | 2017-12-21 | コーニング インコーポレイテッド | インビトロ転写後のｒｎａ精製のための方法及びキット |
| FR3031063B1 (fr) | 2014-12-30 | 2017-02-10 | Biomerieux Sa | Complexe multicouches, procede de fabrication et utilisation du complexe |
| EP3405479A4 (de) | 2016-01-21 | 2019-08-21 | T2 Biosystems, Inc. | Nmr-verfahren und -systeme zur schnellen detektion von bakterien |
| DE112019004459T5 (de) | 2018-09-05 | 2021-07-15 | Adana Bilim Ve Teknoloji Universitesi | Anreicherung von proben mittels magnetischer partikel in mikrokanälen |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US280130A (en) | 1883-06-26 | Method of and apparatus for separating | ||
| US3985649A (en) | 1974-11-25 | 1976-10-12 | Eddelman Roy T | Ferromagnetic separation process and material |
| US4018886A (en) | 1975-07-01 | 1977-04-19 | General Electric Company | Diagnostic method and device employing protein-coated magnetic particles |
| US3970518A (en) * | 1975-07-01 | 1976-07-20 | General Electric Company | Magnetic separation of biological particles |
| GB1575805A (en) * | 1976-03-12 | 1980-10-01 | Technicon Instr | Automatic diagnostic apparatus |
| US4272510A (en) | 1976-04-26 | 1981-06-09 | Smith Kendall O | Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods |
| US4230685A (en) * | 1979-02-28 | 1980-10-28 | Northwestern University | Method of magnetic separation of cells and the like, and microspheres for use therein |
| EP0030086B2 (de) | 1979-11-13 | 1990-03-14 | TECHNICON INSTRUMENTS CORPORATION (a New York corporation) | Vereinigung von Reaktionsbehältern, Teile für ihre Herstellung und manuelles Immunoassayverfahren |
| NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
| US4672040A (en) * | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
| US4695393A (en) * | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| CH663476A5 (fr) | 1985-07-08 | 1987-12-15 | Serono Diagnostics Ltd | Enceinte pour le dosage d'anticorps ou d'antigenes dans un liquide biologique. |
| US5076950A (en) * | 1985-12-20 | 1991-12-31 | Syntex (U.S.A.) Inc. | Magnetic composition for particle separation |
| US4900677A (en) * | 1986-09-26 | 1990-02-13 | E. I. Du Pont De Nemours And Company | Process for rapid isolation of high molecular weight DNA |
| ZA877772B (en) * | 1986-10-23 | 1988-04-20 | Amoco Corporation | Target and background capture methods and apparatus for affinity assays |
| US4935342A (en) * | 1986-12-01 | 1990-06-19 | Syngene, Inc. | Method of isolating and purifying nucleic acids from biological samples |
| CA1297431C (en) * | 1987-04-24 | 1992-03-17 | F. Hoffmann-La Roche Ag | Process for the isolation of nucleic acids |
| US5395688A (en) * | 1987-10-26 | 1995-03-07 | Baxter Diagnostics Inc. | Magnetically responsive fluorescent polymer particles |
| US4923978A (en) * | 1987-12-28 | 1990-05-08 | E. I. Du Pont De Nemours & Company | Process for purifying nucleic acids |
| EP0446260B1 (de) * | 1988-11-21 | 1994-03-02 | Dynal A.S. | Sonden aus nukleinsäuren |
| GB8827160D0 (en) * | 1988-11-21 | 1988-12-29 | Apothekernes Lab | Detection & quantitative determination of rna & dna |
| US5512439A (en) * | 1988-11-21 | 1996-04-30 | Dynal As | Oligonucleotide-linked magnetic particles and uses thereof |
| US5075430A (en) * | 1988-12-12 | 1991-12-24 | Bio-Rad Laboratories, Inc. | Process for the purification of DNA on diatomaceous earth |
| US5234809A (en) * | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
| US5279936A (en) * | 1989-12-22 | 1994-01-18 | Syntex (U.S.A.) Inc. | Method of separation employing magnetic particles and second medium |
| FR2656318B1 (fr) * | 1989-12-27 | 1994-02-04 | Rhone Poulenc Chimie | Microspheres "core-shell" magnetisables a base d'organopolysiloxane reticule, leur procede de preparation et leur application en biologie. |
| US5523231A (en) * | 1990-02-13 | 1996-06-04 | Amersham International Plc | Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules |
| US5129936A (en) * | 1990-07-30 | 1992-07-14 | Wilson Harold W | Processes for the preparation of acid fortified paramagnetic iron sulfate salt compounds for use in the treatment of agricultural soils |
| US5491068A (en) * | 1991-02-14 | 1996-02-13 | Vicam, L.P. | Assay method for detecting the presence of bacteria |
| DE69329135T2 (de) * | 1992-09-24 | 2001-01-11 | Amersham Pharmacia Biotech Uk Ltd., Little Chalfont | Verfahren und Vorrichtung zur magnetischen Abscheidung |
| FI932866A0 (fi) * | 1993-06-21 | 1993-06-21 | Labsystems Oy | Separeringsfoerfarande |
| EP0689430B1 (de) * | 1993-03-17 | 1997-08-13 | Silica Gel Ges.M.B.H | Superparamagnetische teilchen, verfahren zu ihrer herstellung und verwendung derselben |
| GB9323305D0 (en) | 1993-11-11 | 1994-01-05 | Medinnova Sf | Isoaltion of nucleic acid |
| US5602042A (en) | 1994-04-14 | 1997-02-11 | Cytyc Corporation | Method and apparatus for magnetically separating biological particles from a mixture |
| ATE191086T1 (de) | 1994-07-27 | 2000-04-15 | Pilgrimm Herbert | Superparamagnetische teilchen, verfahren zur herstellung und deren verwendung |
| US5705628A (en) * | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
| GB9425138D0 (en) * | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| FR2732116B1 (fr) | 1995-03-21 | 1997-05-09 | Bio Merieux | Procede et dispositif pour la determination qualitative et/ou quantitative d'un analyte, notamment d'une bacterie, dans un echantillon, par voie magnetique |
| DE19520398B4 (de) * | 1995-06-08 | 2009-04-16 | Roche Diagnostics Gmbh | Magnetisches Pigment |
| JP3940935B2 (ja) * | 1996-06-11 | 2007-07-04 | 東洋紡績株式会社 | プラスミドｄｎａの抽出精製方法 |
| JPH09327291A (ja) * | 1996-06-11 | 1997-12-22 | Toyobo Co Ltd | Ｒｎａの抽出精製方法 |
| EP0818461B1 (de) * | 1996-07-12 | 2005-09-28 | Toyo Boseki Kabushiki Kaisha | Verfahren zur Isolierung von Ribonucleinsäuren. |
| US6027945A (en) * | 1997-01-21 | 2000-02-22 | Promega Corporation | Methods of isolating biological target materials using silica magnetic particles |
| US5973138A (en) * | 1998-10-30 | 1999-10-26 | Becton Dickinson And Company | Method for purification and manipulation of nucleic acids using paramagnetic particles |
-
1998
- 1998-10-30 US US09/183,127 patent/US5973138A/en not_active Expired - Lifetime
-
1999
- 1999-09-20 ES ES99118529T patent/ES2270556T3/es not_active Expired - Lifetime
- 1999-09-20 ES ES05112446T patent/ES2349717T3/es not_active Expired - Lifetime
- 1999-09-20 EP EP05112446A patent/EP1674571B1/de not_active Expired - Lifetime
- 1999-09-20 DE DE69933186T patent/DE69933186T2/de not_active Expired - Lifetime
- 1999-09-20 DE DE69942639T patent/DE69942639D1/de not_active Expired - Lifetime
- 1999-09-20 EP EP99118529A patent/EP1002860B1/de not_active Expired - Lifetime
- 1999-10-08 US US09/417,199 patent/US6433160B1/en not_active Expired - Lifetime
- 1999-10-22 JP JP30045299A patent/JP4594467B2/ja not_active Expired - Lifetime
- 1999-10-27 AU AU57073/99A patent/AU771249B2/en not_active Expired
- 1999-10-28 CA CA002287730A patent/CA2287730C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69933186T2 (de) | 2007-09-20 |
| EP1674571A2 (de) | 2006-06-28 |
| AU771249B2 (en) | 2004-03-18 |
| EP1002860A1 (de) | 2000-05-24 |
| EP1674571B1 (de) | 2010-07-28 |
| CA2287730C (en) | 2008-12-23 |
| US5973138A (en) | 1999-10-26 |
| JP4594467B2 (ja) | 2010-12-08 |
| CA2287730A1 (en) | 2000-04-30 |
| ES2349717T3 (es) | 2011-01-10 |
| EP1002860B1 (de) | 2006-09-13 |
| EP1674571A3 (de) | 2008-08-13 |
| ES2270556T3 (es) | 2007-04-01 |
| US6433160B1 (en) | 2002-08-13 |
| DE69942639D1 (de) | 2010-09-09 |
| JP2000159791A (ja) | 2000-06-13 |
| AU5707399A (en) | 2000-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69933186D1 (de) | Methode zur Reinigung und Manipulation von Nukleinsäure mittels paramagnetischen Partikeln | |
| DE59912604D1 (de) | Verfahren zur isolierung und aufreinigung von nucleinsäuren | |
| DE69928683D1 (de) | Verfahren zur amplifikation und zur sequenzierung von nukleinsäuren | |
| DE69833796D1 (de) | Gene und verfahren zur bekampfung von nematoden | |
| DE60106104D1 (de) | Verfahren zur Absorption von Acrylsäure und Verfahren zur Reinigung von Acrylsäure | |
| DE60114348D1 (de) | Verfahren zur Reinigung von Gasen | |
| DE60103180D1 (de) | Verfahren und vorrichtung zur überkritischen nassoxidation von stoffen | |
| DE10084502T1 (de) | Verfahren zur Reinigung von Nukleinsäure mit Siliciumcarbid | |
| DE60220578D1 (de) | Methode und Reagenzien zur Analyse der Nukleotidsequenz von Nukleinsäuren | |
| DE69805447D1 (de) | Verfahren zur biologischen abwasser- und abgasreinigung und biofilter dafür | |
| DE60235332D1 (de) | Verfahren zur Reinigung und Trocknung von Polymer-Hydrogelen | |
| ATE515578T1 (de) | Verfahren und vorrichtung zur nukleinsäurereinigung | |
| DE60234449D1 (de) | Mittel zur förderung des wachstums von schweinen und verfahren zur förderung des wachstums von schweinen | |
| DE60043207D1 (de) | Verfahren und Vorrichtung zur Reinigung von Gasen | |
| DE69929396D1 (de) | Verfahren zur Reinigung von hochsauerstoffhaltigen Abgasen | |
| DE69637579D1 (de) | Methode zur Amplifizierung von Nukleinsäure und entsprechende Regenzien dafür | |
| DE60040886D1 (de) | Vorrichtung und Verfahren zur Reinigung von leicht blockierende Substanzen enthaltenden organischen Stoffen | |
| DE69936623D1 (de) | Einrichtung und Methode zur Reduktion von Kohlenstoffmonoxid | |
| DE69502313D1 (de) | Verfahren zur biologischen Reinigung von Gasströmen | |
| DE60034088D1 (de) | Verfahren und Vorrichtung zur Absorption von Acrylverbindungen | |
| DE60323579D1 (de) | Methode zur Separierung von Nukleinsäuren und dafür verwendbare Reagenz | |
| DE69728802D1 (de) | Wirkstoffimmobilisierte Partikel und Verfahren zur Reinigung von Proteinen | |
| DE69932005D1 (de) | Vorrichtung und Verfahren zur Regeneration von Medien zur Flüssigkeitsbehandlung | |
| DE60100328D1 (de) | Verfahren zur Gewinnung und Reinigung von Cyclobutanon | |
| DE602004012134D1 (de) | Verfahren und system zur unterstützung des betriebs von arbeitszügen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |