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DE69928040D1 - Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung - Google Patents

Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung

Info

Publication number
DE69928040D1
DE69928040D1 DE69928040T DE69928040T DE69928040D1 DE 69928040 D1 DE69928040 D1 DE 69928040D1 DE 69928040 T DE69928040 T DE 69928040T DE 69928040 T DE69928040 T DE 69928040T DE 69928040 D1 DE69928040 D1 DE 69928040D1
Authority
DE
Germany
Prior art keywords
hedgehog protein
preparation
hydrophobic
protein conjugate
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69928040T
Other languages
English (en)
Other versions
DE69928040T2 (de
Inventor
Angelika Esswein
Kurt Lang
Petra Rueger
Tilmann Seytter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curis Inc
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98107911A external-priority patent/EP0953575A1/de
Application filed by Curis Inc filed Critical Curis Inc
Application granted granted Critical
Publication of DE69928040D1 publication Critical patent/DE69928040D1/de
Publication of DE69928040T2 publication Critical patent/DE69928040T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69928040T 1998-04-30 1999-04-23 Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung Expired - Fee Related DE69928040T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98107911 1998-04-30
EP98107911A EP0953575A1 (de) 1998-04-30 1998-04-30 Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung
EP98116733 1998-09-03
EP98116733 1998-09-03

Publications (2)

Publication Number Publication Date
DE69928040D1 true DE69928040D1 (de) 2005-12-08
DE69928040T2 DE69928040T2 (de) 2006-07-27

Family

ID=26149214

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69928040T Expired - Fee Related DE69928040T2 (de) 1998-04-30 1999-04-23 Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung

Country Status (18)

Country Link
US (4) US6468978B1 (de)
EP (2) EP1557427A3 (de)
JP (1) JP3433136B2 (de)
KR (1) KR19990083621A (de)
CN (1) CN1233616A (de)
AT (1) ATE308563T1 (de)
AU (1) AU719797B2 (de)
CA (1) CA2269221A1 (de)
CY (1) CY1105683T1 (de)
DE (1) DE69928040T2 (de)
DK (1) DK0953576T3 (de)
ES (1) ES2252886T3 (de)
HU (1) HUP9901411A2 (de)
IL (1) IL129620A (de)
MA (1) MA26625A1 (de)
NO (1) NO992090L (de)
NZ (1) NZ335385A (de)
SG (1) SG80028A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136230A0 (en) * 1997-11-28 2001-05-20 Roche Diagnostics Gmbh An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
DK0953576T3 (da) * 1998-04-30 2006-03-20 Curis Inc Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse
DK0978285T3 (da) * 1998-08-07 2006-03-27 Curis Inc Stabilt farmaceutisk præparat af hedgehogproteiner og anvendelse deraf
TW570805B (en) * 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
WO2000035948A1 (en) * 1998-12-03 2000-06-22 Biogen, Inc. Methods and compositions for treating disorders involving excitotoxicity
EP1025861A1 (de) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung
CA2375700A1 (en) * 1999-06-01 2000-12-07 Biogen, Inc. Polymer conjugates of hedgehog proteins and uses
AU2001255767A1 (en) * 2000-04-28 2001-11-12 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
US7573637B2 (en) * 2004-08-03 2009-08-11 Seiko Epson Corporation Intrinsic polarizer and method of manufacturing an intrinsic polarizer
US8669418B2 (en) * 2005-12-22 2014-03-11 Vib Vzw Means and methods for mediating protein interference
WO2009108868A2 (en) * 2008-02-27 2009-09-03 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
US20100172889A1 (en) * 2008-12-05 2010-07-08 Catchmark Jeffrey M Degradable biomolecule compositions
US20110086236A1 (en) * 2009-10-13 2011-04-14 The Penn State Research Foundation Composites containing polypeptides attached to polysaccharides and molecules
KR20140038501A (ko) * 2011-06-06 2014-03-28 키네타 원, 엘엘씨 Shk-기초된 제약학적 조성물 및 이들을 제조하고 이용하는 방법
WO2015013065A1 (en) 2013-07-26 2015-01-29 The Penn State Research Foundation Polymer compositions and coatings
WO2017095201A1 (ko) * 2015-12-02 2017-06-08 한미약품 주식회사 지방산 유도체를 이용한 단백질 결합체 및 이의 제조방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
EP0513334A4 (en) * 1990-11-30 1993-08-04 Celtrix Laboratories, Inc. Use of a bone morphogenetic protein in synergistic combination with tgf--g(b) for bone repair
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
WO1995018856A1 (en) * 1993-12-30 1995-07-13 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing hedgehog-like proteins
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
GB9614871D0 (en) 1996-07-15 1996-09-04 Smithkline Beecham Plc Compounds
EP0966478A4 (de) * 1996-10-07 2002-08-21 Univ Johns Hopkins Med Neue vom igel abstammende polypeptide
IL136230A0 (en) * 1997-11-28 2001-05-20 Roche Diagnostics Gmbh An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
WO1999028343A2 (en) * 1997-12-03 1999-06-10 Biogen, Inc. Hydrophobically-modified protein compositions and methods
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
DK0953576T3 (da) * 1998-04-30 2006-03-20 Curis Inc Aktivt hedgehog-proteinkonjugat, fremgangsmåde til fremstilling heraf og anvendelse
DK0978285T3 (da) * 1998-08-07 2006-03-27 Curis Inc Stabilt farmaceutisk præparat af hedgehogproteiner og anvendelse deraf
AU2001255767A1 (en) * 2000-04-28 2001-11-12 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro

Also Published As

Publication number Publication date
US6818623B2 (en) 2004-11-16
AU719797B2 (en) 2000-05-18
NZ335385A (en) 2000-09-29
SG80028A1 (en) 2001-04-17
US20030139574A1 (en) 2003-07-24
CY1105683T1 (el) 2010-12-22
CA2269221A1 (en) 1999-10-30
HUP9901411A2 (hu) 1999-12-28
US20050148510A1 (en) 2005-07-07
DK0953576T3 (da) 2006-03-20
EP1557427A3 (de) 2005-10-19
HU9901411D0 (en) 1999-07-28
NO992090D0 (no) 1999-04-29
NO992090L (no) 1999-11-01
EP1557427A2 (de) 2005-07-27
US7153836B2 (en) 2006-12-26
JP2000053699A (ja) 2000-02-22
ES2252886T3 (es) 2006-05-16
IL129620A0 (en) 2000-02-29
MA26625A1 (fr) 2004-12-20
CN1233616A (zh) 1999-11-03
DE69928040T2 (de) 2006-07-27
EP0953576A1 (de) 1999-11-03
ATE308563T1 (de) 2005-11-15
US20070191274A1 (en) 2007-08-16
AU2500999A (en) 1999-11-11
KR19990083621A (ko) 1999-11-25
EP0953576B1 (de) 2005-11-02
US6468978B1 (en) 2002-10-22
IL129620A (en) 2009-06-15
JP3433136B2 (ja) 2003-08-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee