DE69926632D1 - Tetrahydrochinolinderivate als glycin antagonisten - Google Patents

Tetrahydrochinolinderivate als glycin antagonisten

Info

Publication number: DE69926632D1
Authority: DE; Germany
Prior art keywords: glycine antagonists; tetrahydrochinoline; derivatives; tetrahydrochinoline derivatives; antagonists
Prior art date: 1998-06-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69926632T

Other languages

English (en)

Other versions

DE69926632T2 (de

Inventor

Fabio Romano Di

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GlaxoSmithKline SpA

Original Assignee

GlaxoSmithKline SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-10

Filing date

1999-06-08

Publication date

2005-09-15

1998-06-10 Priority claimed from GBGB9812408.4A external-priority patent/GB9812408D0/en

1998-06-10 Priority claimed from GBGB9812410.0A external-priority patent/GB9812410D0/en

1999-06-08 Application filed by GlaxoSmithKline SpA filed Critical GlaxoSmithKline SpA

2005-09-15 Publication of DE69926632D1 publication Critical patent/DE69926632D1/de

2006-01-19 Application granted granted Critical

2006-01-19 Publication of DE69926632T2 publication Critical patent/DE69926632T2/de

2019-06-09 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DE69926632T 1998-06-10 1999-06-08 Tetrahydrochinolinderivate als glycinantagonisten Expired - Lifetime DE69926632T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB9812408		1998-06-10
GB9812410		1998-06-10
GBGB9812408.4A GB9812408D0 (en)	1998-06-10	1998-06-10	Heterocyclic compounds
GBGB9812410.0A GB9812410D0 (en)	1998-06-10	1998-06-10	Heterocyclic derivatives
PCT/EP1999/003936 WO1999064411A1 (en)	1998-06-10	1999-06-08	Tetrahydroquinoline derivatives as glycine antagonists

Publications (2)

Publication Number	Publication Date
DE69926632D1 true DE69926632D1 (de)	2005-09-15
DE69926632T2 DE69926632T2 (de)	2006-01-19

Family

ID=26313826

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69926632T Expired - Lifetime DE69926632T2 (de)	1998-06-10	1999-06-08	Tetrahydrochinolinderivate als glycinantagonisten

Country Status (33)

Country	Link
US (3)	US6362199B1 (de)
EP (1)	EP1086093B1 (de)
JP (1)	JP2002517492A (de)
KR (1)	KR100586762B1 (de)
CN (1)	CN1173970C (de)
AP (1)	AP2000002008A0 (de)
AR (1)	AR018632A1 (de)
AT (1)	ATE301650T1 (de)
AU (1)	AU753867B2 (de)
BG (1)	BG105123A (de)
BR (1)	BR9911145A (de)
CA (1)	CA2334727C (de)
CO (1)	CO5080785A1 (de)
CZ (1)	CZ293605B6 (de)
DE (1)	DE69926632T2 (de)
DK (1)	DK1086093T3 (de)
EA (1)	EA003276B1 (de)
EE (1)	EE200000733A (de)
ES (1)	ES2249010T3 (de)
HR (1)	HRP20000845A2 (de)
HU (1)	HUP0102767A3 (de)
ID (1)	ID27845A (de)
IL (2)	IL140062A0 (de)
IS (1)	IS5746A (de)
MY (1)	MY125037A (de)
NO (1)	NO321904B1 (de)
NZ (1)	NZ508638A (de)
OA (1)	OA11564A (de)
PE (1)	PE20000724A1 (de)
PL (1)	PL197160B1 (de)
TR (1)	TR200003652T2 (de)
TW (1)	TWI229079B (de)
WO (1)	WO1999064411A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY125037A (en) *	1998-06-10	2006-07-31	Glaxo Wellcome Spa	1,2,3,4 tetrahydroquinoline derivatives
US6455734B1 (en)	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
GB9929037D0 (en) *	1999-12-08	2000-02-02	Glaxo Wellcome Spa	Heterocyclic derivatives
DE10000311A1 (de)	2000-01-05	2001-07-12	Gruenenthal Gmbh	Aminomethyl-Phonyl-Cyclohexanonderivate
DE10005302A1 (de) *	2000-02-07	2002-01-17	Gruenenthal Gmbh	Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
DE10137487A1 (de)	2001-08-03	2003-03-27	Gruenenthal Gmbh	Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate
DE10137488A1 (de) *	2001-08-03	2003-02-20	Gruenenthal Gmbh	Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
US20090181966A1 (en) *	2002-10-04	2009-07-16	Millennium Pharmaceuticals, Inc.	PGD2 receptor antagonists for the treatment of inflammatory diseases
AU2003277285B2 (en) *	2002-10-04	2007-12-13	Millennium Pharmaceuticals, Inc.	PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) *	2002-10-04	2009-03-17	Millennium Pharmaceuticals, Inc.	PGD2 receptor antagonists for the treatment of inflammatory diseases
GB0327912D0 (en) *	2003-12-02	2004-01-07	Glaxo Group Ltd	Medicament
WO2006091674A1 (en) *	2005-02-24	2006-08-31	Millennium Pharmaceuticals, Inc.	Pgd2 receptor antagonists for the treatment of inflammatory diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2024516C1 (ru) *	1989-02-02	1994-12-15	Яманути Фармасьютикал Ко., Лтд.	Способ получения производного тетрагидробензимидазола или его фармацевтически приемлемой соли
US4902695A (en) *	1989-02-13	1990-02-20	Eli Lilly And Company	Excitatory amino acid receptor antagonists
IL93610A0 (en) *	1989-03-08	1990-12-23	Merck Sharp & Dohme	Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them
US5231102A (en) *	1989-03-08	1993-07-27	Merck Sharp & Dohme, Ltd.	Tetrahydroquinoline derivatives useful for neurodegenerative disorders
US5529999A (en)	1994-03-04	1996-06-25	Eli Lilly And Company	Antitumor compositions and methods of treatment
EP0854867B1 (de)	1995-09-29	2002-07-31	GLAXO WELLCOME S.p.A.	Tetrahydrochinoline als nmda antagonisten
GB9617305D0 (en) *	1996-08-17	1996-09-25	Glaxo Wellcome Spa	Heterocyclic compounds
MY125037A (en) *	1998-06-10	2006-07-31	Glaxo Wellcome Spa	1,2,3,4 tetrahydroquinoline derivatives

1999
- 1999-06-07 MY MYPI99002298A patent/MY125037A/en unknown
- 1999-06-08 CO CO99035699A patent/CO5080785A1/es unknown
- 1999-06-08 PL PL344694A patent/PL197160B1/pl not_active IP Right Cessation
- 1999-06-08 AR ARP990102714A patent/AR018632A1/es active IP Right Grant
- 1999-06-08 IL IL14006299A patent/IL140062A0/xx active IP Right Grant
- 1999-06-08 HU HU0102767A patent/HUP0102767A3/hu unknown
- 1999-06-08 DK DK99927911T patent/DK1086093T3/da active
- 1999-06-08 ID IDW20010061A patent/ID27845A/id unknown
- 1999-06-08 ES ES99927911T patent/ES2249010T3/es not_active Expired - Lifetime
- 1999-06-08 BR BR9911145-4A patent/BR9911145A/pt not_active Application Discontinuation
- 1999-06-08 KR KR1020007013994A patent/KR100586762B1/ko not_active Expired - Fee Related
- 1999-06-08 EA EA200001165A patent/EA003276B1/ru not_active IP Right Cessation
- 1999-06-08 AP APAP/P/2000/002008A patent/AP2000002008A0/en unknown
- 1999-06-08 PE PE1999000511A patent/PE20000724A1/es not_active Application Discontinuation
- 1999-06-08 NZ NZ508638A patent/NZ508638A/en not_active IP Right Cessation
- 1999-06-08 US US09/719,188 patent/US6362199B1/en not_active Expired - Fee Related
- 1999-06-08 AU AU45092/99A patent/AU753867B2/en not_active Ceased
- 1999-06-08 JP JP2000553420A patent/JP2002517492A/ja active Pending
- 1999-06-08 OA OA1200000335A patent/OA11564A/en unknown
- 1999-06-08 TR TR2000/03652T patent/TR200003652T2/xx unknown
- 1999-06-08 EP EP99927911A patent/EP1086093B1/de not_active Expired - Lifetime
- 1999-06-08 WO PCT/EP1999/003936 patent/WO1999064411A1/en active IP Right Grant
- 1999-06-08 DE DE69926632T patent/DE69926632T2/de not_active Expired - Lifetime
- 1999-06-08 AT AT99927911T patent/ATE301650T1/de active
- 1999-06-08 CA CA002334727A patent/CA2334727C/en not_active Expired - Fee Related
- 1999-06-08 HR HR20000845A patent/HRP20000845A2/hr not_active Application Discontinuation
- 1999-06-08 CZ CZ20004587A patent/CZ293605B6/cs not_active IP Right Cessation
- 1999-06-08 CN CNB998094145A patent/CN1173970C/zh not_active Expired - Fee Related
- 1999-06-08 EE EEP200000733A patent/EE200000733A/xx unknown
- 1999-06-17 TW TW088110159A patent/TWI229079B/zh not_active IP Right Cessation
2000
- 2000-11-30 IS IS5746A patent/IS5746A/is unknown
- 2000-12-04 IL IL140062A patent/IL140062A/en not_active IP Right Cessation
- 2000-12-07 NO NO20006227A patent/NO321904B1/no not_active IP Right Cessation
2001
- 2001-01-08 BG BG105123A patent/BG105123A/xx unknown
- 2001-11-16 US US09/990,513 patent/US6413985B1/en not_active Expired - Fee Related
2002
- 2002-05-14 US US10/145,258 patent/US6495566B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL140062A (en)	2007-05-15
OA11564A (en)	2004-05-24
NO20006227D0 (no)	2000-12-07
HRP20000845A2 (en)	2001-10-31
EA003276B1 (ru)	2003-04-24
MY125037A (en)	2006-07-31
CO5080785A1 (es)	2001-09-25
AU753867B2 (en)	2002-10-31
NO321904B1 (no)	2006-07-17
WO1999064411A1 (en)	1999-12-16
CZ20004587A3 (en)	2001-05-16
PL344694A1 (en)	2001-11-19
KR20010052722A (ko)	2001-06-25
CN1173970C (zh)	2004-11-03
BR9911145A (pt)	2001-03-06
AR018632A1 (es)	2001-11-28
DE69926632T2 (de)	2006-01-19
TR200003652T2 (tr)	2001-04-20
EP1086093A1 (de)	2001-03-28
JP2002517492A (ja)	2002-06-18
TWI229079B (en)	2005-03-11
AU4509299A (en)	1999-12-30
HK1034079A1 (en)	2001-10-12
EA200001165A1 (ru)	2001-06-25
PE20000724A1 (es)	2000-08-17
HUP0102767A2 (hu)	2001-12-28
ES2249010T3 (es)	2006-03-16
AP2000002008A0 (en)	2000-12-31
US6362199B1 (en)	2002-03-26
US6413985B1 (en)	2002-07-02
EP1086093B1 (de)	2005-08-10
NZ508638A (en)	2003-08-29
NO20006227L (no)	2001-02-08
CA2334727A1 (en)	1999-12-16
KR100586762B1 (ko)	2006-06-08
IL140062A0 (en)	2002-02-10
ID27845A (id)	2001-04-26
HUP0102767A3 (en)	2003-01-28
PL197160B1 (pl)	2008-03-31
CA2334727C (en)	2009-08-04
EE200000733A (et)	2002-06-17
US20020169186A1 (en)	2002-11-14
US20020052391A1 (en)	2002-05-02
DK1086093T3 (da)	2005-11-28
BG105123A (en)	2001-11-30
CZ293605B6 (cs)	2004-06-16
CN1311785A (zh)	2001-09-05
IS5746A (is)	2000-11-30
ATE301650T1 (de)	2005-08-15
US6495566B2 (en)	2002-12-17

Publication	Publication Date	Title
DE69930518D1 (de)	2006-05-11	Als antikrebsmittel verwendbare alkinyl-substituierte chinolin-2-on-derivate
DE69829192D1 (de)	2005-04-07	Neue substituierte imidazolverbindungen
IS5338A (is)	2000-01-13	Ný spíróasabísýklísk heterósýklísk efnasambönd
DK0915088T3 (da)	2003-01-27	D-prolinderivater
ID22850A (id)	1999-12-09	Senyawa-senyawa pirazina
ATE261429T1 (de)	2004-03-15	Neue 3-aryl-2-hydroxypropionsäure-derivate iii
ID23168A (id)	2000-03-23	Reseptor anatagonis vitronektin
ID20323A (id)	1998-11-26	Senyawa-senyawa triazinilaminostilbena
ATE221052T1 (de)	2002-08-15	Tetrahydrochinolinderivate als eaa antagonisten
ATE255098T1 (de)	2003-12-15	Substituierte chromanderivate
EE9900448A (et)	2000-04-17	Ühendid
DE59813430D1 (de)	2006-05-04	Perylenhydrazidimide als Carbonylderivatisierungsreagenzien
ATE255099T1 (de)	2003-12-15	Substituierte chromanderivate
NO20003694D0 (no)	2000-07-19	VLA-4 antagonister
DE69926632D1 (de)	2005-09-15	Tetrahydrochinolinderivate als glycin antagonisten
DE69735811D1 (de)	2006-06-08	Piperazinoderivate als neurokinin-antagonisten
DE69829567D1 (de)	2005-05-04	Angiotensinderivate
EE9900475A (et)	2000-06-15	Ühendid
EE9900602A (et)	2000-08-15	Ühendid
DE60012953D1 (de)	2004-09-16	3-amino-2-phenylpiperidinderivate als substanz p antagonisten
ID22983A (id)	1999-12-23	Senyawa-senyawa fluorometoksimino
IS5211A (is)	1999-10-12	Efnasambönd
EP1124552A4 (de)	2005-01-05	Chrysen-derivate als antitumormittel
DE69737634D1 (de)	2007-05-31	Insektizide oxadiazinverbindungen
NO20013095D0 (no)	2001-06-21	Arrangement for sömforberedelse

Legal Events

Date	Code	Title	Description
2006-08-31	8364	No opposition during term of opposition