DE69925253D1 - Qualitatives differentielles screening - Google Patents

Qualitatives differentielles screening

Info

Publication number: DE69925253D1
Authority: DE; Germany
Prior art keywords: situation; originating; nucleic acids; cdna; identifying
Prior art date: 1998-03-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69925253T

Other languages

English (en)

Other versions

DE69925253T2 (de

Inventor

Fabien Schweighoffer

Laurent Bracco

Bruno Tocque

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ExonHit Therapeutics SA

Original Assignee

ExonHit Therapeutics SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-11

Filing date

1999-03-11

Publication date

2005-06-16

1999-03-11 Application filed by ExonHit Therapeutics SA filed Critical ExonHit Therapeutics SA

2005-06-16 Application granted granted Critical

2005-06-16 Publication of DE69925253D1 publication Critical patent/DE69925253D1/de

2006-02-09 Publication of DE69925253T2 publication Critical patent/DE69925253T2/de

2019-03-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000012216 screening Methods 0.000 title 1
108020004707 nucleic acids Proteins 0.000 abstract 9
150000007523 nucleic acids Chemical class 0.000 abstract 9
102000039446 nucleic acids Human genes 0.000 abstract 9
239000002299 complementary DNA Substances 0.000 abstract 7
238000010367 cloning Methods 0.000 abstract 6
108020004999 messenger RNA Proteins 0.000 abstract 6
238000000034 method Methods 0.000 abstract 5
108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 3
239000007791 liquid phase Substances 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002452 interceptive effect Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Analytical Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Paper (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Sanitary Device For Flush Toilet (AREA)
Threshing Machine Elements (AREA)
Lock And Its Accessories (AREA)
Medicines Containing Plant Substances (AREA)

DE69925253T 1998-03-11 1999-03-11 Qualitatives differentielles screening Expired - Lifetime DE69925253T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9802997A FR2775984B1 (fr)	1998-03-11	1998-03-11	Criblage differentiel qualitatif
FR9802997		1998-03-11
PCT/FR1999/000547 WO1999046403A1 (fr)	1998-03-11	1999-03-11	Criblage differentiel qualitatif

Publications (2)

Publication Number	Publication Date
DE69925253D1 true DE69925253D1 (en)	2005-06-16
DE69925253T2 DE69925253T2 (de)	2006-02-09

Family

ID=9523928

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69925253T Expired - Lifetime DE69925253T2 (de)	1998-03-11	1999-03-11	Qualitatives differentielles screening

Country Status (13)

Country	Link
US (1)	US6251590B1 (de)
EP (2)	EP1062364B1 (de)
JP (1)	JP4527280B2 (de)
AT (1)	ATE295426T1 (de)
AU (1)	AU760656B2 (de)
CA (1)	CA2323231C (de)
DE (1)	DE69925253T2 (de)
DK (2)	DK1062364T3 (de)
ES (2)	ES2551441T3 (de)
FR (1)	FR2775984B1 (de)
IL (1)	IL138249A0 (de)
PT (2)	PT1062364E (de)
WO (1)	WO1999046403A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6881571B1 (en)	1998-03-11	2005-04-19	Exonhit Therapeutics S.A.	Qualitative differential screening
US20030165931A1 (en) *	1998-03-11	2003-09-04	Bruno Tocque	Qualitative differential screening
US20040241728A1 (en) *	1999-01-06	2004-12-02	Chondrogene Limited	Method for the detection of lung disease related gene transcripts in blood
US7473528B2 (en) *	1999-01-06	2009-01-06	Genenews Inc.	Method for the detection of Chagas disease related gene transcripts in blood
US20070105121A1 (en) *	1999-01-06	2007-05-10	Chondrogene Limited	Method for the detection of schizophrenia related gene transcripts in blood
US20040241726A1 (en) *	1999-01-06	2004-12-02	Chondrogene Limited	Method for the detection of allergies related gene transcripts in blood
US20060134635A1 (en) *	2001-02-28	2006-06-22	Chondrogene Limited	Method for the detection of coronary artery disease related gene transcripts in blood
US20050123938A1 (en) *	1999-01-06	2005-06-09	Chondrogene Limited	Method for the detection of osteoarthritis related gene transcripts in blood
US20040248170A1 (en) *	1999-01-06	2004-12-09	Chondrogene Limited	Method for the detection of hyperlipidemia related gene transcripts in blood
US20040265868A1 (en) *	1999-01-06	2004-12-30	Chondrogene Limited	Method for the detection of depression related gene transcripts in blood
CA2359816C (en) *	1999-01-06	2010-08-03	Genenews Inc.	Method for the detection of gene transcripts in blood and uses thereof
US20040248169A1 (en) *	1999-01-06	2004-12-09	Chondrogene Limited	Method for the detection of obesity related gene transcripts in blood
US20050003394A1 (en) *	1999-01-06	2005-01-06	Chondrogene Limited	Method for the detection of rheumatoid arthritis related gene transcripts in blood
US6960439B2 (en)	1999-06-28	2005-11-01	Source Precision Medicine, Inc.	Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US6692916B2 (en)	1999-06-28	2004-02-17	Source Precision Medicine, Inc.	Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
FR2798392B1 (fr) *	1999-09-13	2005-07-15	Exonhit Therapeutics Sa	Marqueurs genetiques de la toxicite, preparation et utilisations
FR2798673B1 (fr) *	1999-09-16	2004-05-28	Exonhit Therapeutics Sa	Methodes et compositions pour la detection d'evenements pathologiques
US7361488B2 (en) *	2000-02-07	2008-04-22	Illumina, Inc.	Nucleic acid detection methods using universal priming
JP2002065259A (ja) *	2000-08-24	2002-03-05	Shinya Watanabe	核酸標識方法および核酸標識用キット
US7807447B1 (en)	2000-08-25	2010-10-05	Merck Sharp & Dohme Corp.	Compositions and methods for exon profiling
US6713257B2 (en) *	2000-08-25	2004-03-30	Rosetta Inpharmatics Llc	Gene discovery using microarrays
US6632610B2 (en)	2000-10-12	2003-10-14	Gensat S.A.	Methods of identification and isolation of polynucleotides containing nucleic acid differences
US20020168354A1 (en)	2000-11-10	2002-11-14	Daria Mochly-Rosen	psiepsilonRack peptide composition and method for protection against tissue damage due to ischemia
US7833779B2 (en) *	2001-07-25	2010-11-16	Jivan Biologies Inc.	Methods and systems for polynucleotide detection
US7340349B2 (en)	2001-07-25	2008-03-04	Jonathan Bingham	Method and system for identifying splice variants of a gene
FR2828693B1 (fr)	2001-08-14	2004-06-18	Exonhit Therapeutics Sa	Nouvelle cible moleculaire de la neurotoxicite
JP5236856B2 (ja)	2001-11-09	2013-07-17	ライフテクノロジーズコーポレーション	遺伝子発現プロファイルを用いる病気の同定、観測及び治療及び生物学的状態の同定
EP1456668B1 (de)	2001-12-05	2007-05-02	Sense Proteomic Limited	Protein arrays für allelvarianten und deren verwendung
FR2837215A1 (fr) *	2002-03-14	2003-09-19	Exonhit Therapeutics Sa	Variants de kallikrein-2 et kallikrein-3 humaines et leurs utilisations
US20050112705A1 (en) *	2002-03-14	2005-05-26	Laurent Bracco	Variants of human kallikrein-2 and kallikrein-3 and uses thereof
US7393635B2 (en) *	2002-05-16	2008-07-01	Dna Polymerase Technology, Inc.	Ribocloning: recombinant DNA construction using primers with ribo bases
GB0216629D0 (en) *	2002-07-17	2002-08-28	Pharma Gen S A	Method to analyze polymeric nucleic acid sequence variations
FR2844713A1 (fr) *	2002-09-25	2004-03-26	Exonhit Therapeutics Sa	Nouvelle cible de l'angiogenese et utilisations
GB0228557D0 (en) *	2002-12-06	2003-01-15	Pharma Gen S A	Method to analyze polymeric nucleic acid sequence variations
FR2848573B1 (fr) *	2002-12-13	2005-04-08	Exonhit Therapeutics Sa	Compositions et methodes pour la detection et le traitement de pathologies neurodegeneratives
FR2848569A1 (fr) *	2002-12-17	2004-06-18	Exonhit Therapeutics Sa	Variants de kallikrein-2 et kallikrein-3 humaines et leurs utilisations
FR2851247B1 (fr)	2003-02-19	2007-06-29	Exonhit Therapeutics Sa	Methodes et compositions pour le traitement de pathologies degeneratives oculaires
US7834163B2 (en)	2003-06-26	2010-11-16	Exonhit Therapeutics S.A.	Prostate specific genes and the use thereof as targets for prostate cancer therapy
WO2005017186A2 (en) *	2003-08-08	2005-02-24	Thomas Jefferson University	Method for rapid identification of alternative splicing
FR2862314A1 (fr) *	2003-11-13	2005-05-20	Exonhit Therapeutics Sa	Identification de marqueurs diagnostic pour les encephalopathies subaigues spongiformes transmissibles
FR2867485B1 (fr) *	2003-12-10	2008-02-22	Exonhit Therapeutics Sa	Identification de marqueurs diagnostics pour les encephalopathies subaigues spongiformes transmissibles
BRPI0416552A (pt) *	2003-11-13	2007-01-23	Exonhit Therapeutics Sa	método para detectar a presença ou risco de desenvolver uma encefalopatia em um mamìfero, utilização de uma sonda nucleica, de um iniciador nucleico e de um ácido nucleico, produto e kit
EP1586587A1 (de) *	2004-04-16	2005-10-19	Exonhit Therapeutics SA	Zusammensetzungen und Verfahren zum Nachweis der Angiogenese
US7569367B2 (en)	2005-09-07	2009-08-04	Roche Diagnostics Operations, Inc.	Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy
CN101506376A (zh) *	2006-07-03	2009-08-12	埃克森希特医疗股份有限公司	前列腺特异性转录物及其在前列腺癌治疗和诊断中的应用
EP2140022A2 (de) *	2007-03-30	2010-01-06	Oryzon Genomics, S.A.	Nukleinsäureanalyseverfahren
EP2287336A1 (de)	2009-07-31	2011-02-23	Exhonit Therapeutics SA	Verfahren und Methoden zur Alzheimer-Diagnose
EP3034620A1 (de)	2014-12-17	2016-06-22	Diaxonhit	Zusammensetzungen und Verfahren zur Diagnose von Schilddrüsenkrebs
FR3036287A1 (fr)	2015-05-19	2016-11-25	Univ Bordeaux	Traitement et detection des trypanosomes
EP3211096A1 (de)	2016-02-26	2017-08-30	Prestizia	Kombination von micrornas, welche die vorhersage der klinischen entwicklung von rektumkrebs ermöglichen

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01218590A (ja) *	1988-02-29	1989-08-31	Toa Nenryo Kogyo Kk	組換ワクチニアウイルスを用いたリンダペスト（牛疫）ウイルスワクチン
US5143854A (en)	1989-06-07	1992-09-01	Affymax Technologies N.V.	Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
FR2664287A1 (fr) *	1990-07-03	1992-01-10	Inst Nat Sante Rech Med	Nouveau polypeptide presentant une activite enzymatique, et gene codant pour ce polypeptide.
CA2149635A1 (en) *	1992-11-20	1994-06-09	David Tarin	Peptide corresponding to cd44 exon 6, antibodies specific for said peptide and use of these antibodies for diagnosis of tumors
US5955272A (en) *	1993-02-26	1999-09-21	University Of Massachusetts	Detection of individual gene transcription and splicing
US5521297A (en) *	1993-06-04	1996-05-28	Salk Institute Biotechnology/Industrial Associates	Nucleic acids encoding human metabotropic glutamate receptors
US5688918A (en) *	1993-08-02	1997-11-18	Health Research, Inc.	p53as protein and antibody therefor
US5679541A (en) *	1994-02-14	1997-10-21	California Institute Of Technology	Programmed cell death antagonist protein
PH31414A (en) *	1994-02-24	1998-10-29	Boehringer Ingelheim Int	Method of diagnosing cancer precancerous state, orsusceptibility to other forms of diseases by anal ysis of irf-1 specific rna in biopsy samples.
CA2186854A1 (en) *	1994-03-30	1995-10-12	William J. Alms	Human interleukin variants generated by alternative splicing
US7037647B1 (en) *	1995-02-24	2006-05-02	Sloan-Kettering Institute For Cancer Research	Prostate-specific membrane antigen and uses thereof
FR2732348B1 (fr) *	1995-03-31	1997-04-30	Rhone Poulenc Rorer Sa	Systeme d'expression conditionnel
FR2736915B1 (fr) *	1995-07-19	1997-08-22	Rhone Poulenc Rorer Sa	Variants de la proteine p53 et utilisations therapeutiques
JP2002515738A (ja)	1996-01-23	2002-05-28	アフィメトリックス，インコーポレイティド	核酸分析法
WO1997029212A1 (en)	1996-02-08	1997-08-14	Affymetrix, Inc.	Chip-based speciation and phenotypic characterization of microorganisms
EP0791660A1 (de) *	1996-02-22	1997-08-27	Smithkline Beecham Corporation	Neuer diagnostischer Marker für Spleissvarianten von Genen, verbunden mit neurologischen Funktionen
EP0806478A3 (de) *	1996-05-10	1999-06-09	Health Research, Inc.	P53as Protein und Antikörper dafür
AU3300397A (en) *	1996-06-03	1998-01-05	St. Jude Children's Research Hospital	Cyclin-c variants, and diagnostic and therapeutic uses thereof
DE69734141T2 (de) *	1996-06-05	2006-07-13	Bml Inc.	PROTEIN, DAS FÜR MENSCHLICHE Th2-ZELLEN SPEZIFISCH IST, DAFÜR KODIERENDES GEN UND KORRESPONDIERENDE TRANSFORMANTE, REKOMBINANTER VEKTOR UND MONOKLONALER ANTKÖRPER
US5958738A (en) *	1997-03-24	1999-09-28	Roche Diagnostics Corporation	Procedure for subtractive hybridization and difference analysis
US6716621B1 (en) *	1998-02-09	2004-04-06	Boehringer Ingelheim International Gmbh	Isolated DNA or gene responsible for Parkinson's disease

1998
- 1998-03-11 FR FR9802997A patent/FR2775984B1/fr not_active Expired - Fee Related
- 1998-03-24 US US09/046,920 patent/US6251590B1/en not_active Expired - Lifetime
1999
- 1999-03-11 IL IL13824999A patent/IL138249A0/xx not_active IP Right Cessation
- 1999-03-11 ES ES05003839.7T patent/ES2551441T3/es not_active Expired - Lifetime
- 1999-03-11 EP EP99909002A patent/EP1062364B1/de not_active Expired - Lifetime
- 1999-03-11 AU AU28399/99A patent/AU760656B2/en not_active Ceased
- 1999-03-11 CA CA2323231A patent/CA2323231C/fr not_active Expired - Fee Related
- 1999-03-11 ES ES99909002T patent/ES2243047T3/es not_active Expired - Lifetime
- 1999-03-11 JP JP2000535770A patent/JP4527280B2/ja not_active Expired - Fee Related
- 1999-03-11 DK DK99909002T patent/DK1062364T3/da active
- 1999-03-11 DE DE69925253T patent/DE69925253T2/de not_active Expired - Lifetime
- 1999-03-11 DK DK05003839.7T patent/DK1566453T3/en active
- 1999-03-11 EP EP05003839.7A patent/EP1566453B1/de not_active Expired - Lifetime
- 1999-03-11 WO PCT/FR1999/000547 patent/WO1999046403A1/fr active IP Right Grant
- 1999-03-11 PT PT99909002T patent/PT1062364E/pt unknown
- 1999-03-11 AT AT99909002T patent/ATE295426T1/de active
- 1999-03-11 PT PT50038397T patent/PT1566453E/pt unknown

Also Published As

Publication number	Publication date
EP1062364A1 (de)	2000-12-27
FR2775984A1 (fr)	1999-09-17
CA2323231A1 (fr)	1999-09-16
FR2775984B1 (fr)	2006-09-15
EP1566453B1 (de)	2015-09-09
AU2839999A (en)	1999-09-27
EP1566453A2 (de)	2005-08-24
PT1566453E (pt)	2015-11-13
AU760656B2 (en)	2003-05-22
IL138249A0 (en)	2001-10-31
ATE295426T1 (de)	2005-05-15
EP1062364B1 (de)	2005-05-11
DE69925253T2 (de)	2006-02-09
EP1566453A3 (de)	2009-11-18
DK1062364T3 (da)	2005-09-05
US6251590B1 (en)	2001-06-26
CA2323231C (fr)	2011-06-21
WO1999046403A1 (fr)	1999-09-16
DK1566453T3 (en)	2015-11-09
JP4527280B2 (ja)	2010-08-18
ES2551441T3 (es)	2015-11-19
PT1062364E (pt)	2005-09-30
ES2243047T3 (es)	2005-11-16
JP2002505887A (ja)	2002-02-26

Publication	Publication Date	Title
DE69925253D1 (en)	2005-06-16	Qualitatives differentielles screening
Kassavetis et al.	1981	Pausing and termination of transcription within the early region of bacteriophage T7 DNA in vitro.
Lawton et al.	1990	The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes.
CA1340160C (en)	1998-12-08	Method and reagents for detecting nucleic acid sequences
EP0967271A1 (de)	1999-12-29	Neue carbonyl-reduktase, gene welche diese kodieren und methoden zu deren verwendung
MX9702204A (es)	1997-06-28	Tratamiento con ribozimas de enfermedades o condiciones relacionadas con niveles de lipoproteina (a) [lp(a)] en plasma, inhibiendo apolipoproteina (a) [apo(a)].
HK1015416A1 (en)	1999-10-15	Expression monitoring by hybridization to high density oligonucleotide arrays
WO1995023225A3 (en)	1996-02-01	Method and reagent for inhibiting the expression of disease related genes
CA2039517A1 (en)	1991-10-04	Dna probe signal amplification
AU2891797A (en)	1997-11-26	Nucleic acid molecules coding for debranching enzymes from potato
WO1998051789A3 (en)	1999-03-18	A method to clone mrnas and display of differentially expressed transcripts (dodet)
AU7847798A (en)	1998-07-03	Fluorescent nucleotide analog hairpin formation for detection of nuclei c acid hybridization
Ma et al.	2002	Major conformational changes occur during the transition from an initiation complex to an elongation complex by T7 RNA polymerase
WO1998050530A3 (en)	1999-07-29	Enzymatic nucleic acids: synthesis, selection and use
Press et al.	1989	Control of the expression of c-sis mRNA in human glioblastoma cells by phorbol ester and transforming growth factor β
AU7210196A (en)	1997-06-05	In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
WO2001040522A3 (en)	2002-08-22	Short shared nucleotide sequences
AU4255899A (en)	1999-11-23	Method for non-radioactive detection of membrane-bonded nucleic acids and test kit
Cho et al.	1995	Decreasing the distance between the two conserved sequence elements of histone pre-messenger RNA interferes with 3'processing in vitro.
EP0811696A3 (de)	1998-01-07	Verfahren zur Gewinnung von Nukleotidsequenzen durch "randomly primed" Amplifikation
ATE321062T1 (de)	2006-04-15	Verfahren zur herstellung endotoxinfreier nukleinsäuren
La Du et al.	1971	Genetic regulation of plasma cholinesterase in man
Rudbeck et al.	2000	Human 18 kDa phosphotyrosine protein phosphatase (ACP1) polymorphism: studies of rare variants provide evidence that substitutions within or near alternatively spliced exons affect splicing result
Hernandez-Pacheco et al.	2005	Matrix γ-Carboxyglutamic Acid Protein (MGP) G-7A and T-138C Gene Polymorphisms in Indian (Mayo and Teenek) and Mestizo Populations from Mexico
EP2009116A3 (de)	2009-06-10	Oligonucleotid zur Erkennung von Salmonellen und Salmonellen-Erkennungsverfahren

Legal Events

Date	Code	Title	Description
2006-06-08	8364	No opposition during term of opposition