DE69915951D1 - Verfahren zur Herstellung von Pyrrolidinderivaten - Google Patents
Verfahren zur Herstellung von PyrrolidinderivatenInfo
- Publication number
- DE69915951D1 DE69915951D1 DE69915951T DE69915951T DE69915951D1 DE 69915951 D1 DE69915951 D1 DE 69915951D1 DE 69915951 T DE69915951 T DE 69915951T DE 69915951 T DE69915951 T DE 69915951T DE 69915951 D1 DE69915951 D1 DE 69915951D1
- Authority
- DE
- Germany
- Prior art keywords
- cis
- butene
- preparation
- pyrrolidine derivatives
- pyrrolines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003235 pyrrolidines Chemical class 0.000 title abstract 2
- 150000004066 3-pyrrolines Chemical class 0.000 abstract 2
- IAQRGUVFOMOMEM-ARJAWSKDSA-N cis-but-2-ene Chemical class C\C=C/C IAQRGUVFOMOMEM-ARJAWSKDSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000005580 one pot reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 150000002978 peroxides Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 1
- JHHZLHWJQPUNKB-UHFFFAOYSA-N pyrrolidin-3-ol Chemical class OC1CCNC1 JHHZLHWJQPUNKB-UHFFFAOYSA-N 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25430498A JP4314597B2 (ja) | 1998-09-08 | 1998-09-08 | Ｎ−置換−３−ピロリン化合物の製造法 |
| JP25430498 | 1998-09-08 | ||
| JP33989398 | 1998-11-30 | ||
| JP33989398 | 1998-11-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69915951D1 true DE69915951D1 (de) | 2004-05-06 |
| DE69915951T2 DE69915951T2 (de) | 2005-01-20 |
Family
ID=26541624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69915951T Expired - Lifetime DE69915951T2 (de) | 1998-09-08 | 1999-09-07 | Verfahren zur Herstellung von Pyrrolidinderivaten |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6130338A (de) |
| EP (1) | EP0985664B1 (de) |
| AT (1) | ATE263149T1 (de) |
| CA (1) | CA2281393A1 (de) |
| DE (1) | DE69915951T2 (de) |
| ES (1) | ES2218955T3 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6130338A (en) | 1998-09-08 | 2000-10-10 | Toray Industries, Inc. | Method of producing pyrrolidine derivatives |
| DE10201458A1 (de) | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
| JP2005206526A (ja) * | 2004-01-23 | 2005-08-04 | Toray Fine Chemicals Co Ltd | １−ベンジル−３，４−エポキシピロリジン誘導体の製造方法 |
| US10383894B2 (en) * | 2010-03-17 | 2019-08-20 | Lutran Industries, Inc. | Human medicinal treatment using salt of peroxymonosulfuric acid |
| CN113307757B (zh) * | 2021-05-26 | 2022-04-29 | 南京德克瑞医药化工有限公司 | 一种医药中间体n-苄基-3-吡咯啉的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1929237A1 (de) * | 1968-06-12 | 1969-12-18 | Sankyo Co | Verfahren zur Herstellung von N-Acyl-3,4-epoxy-pyrrolidin-Derivaten |
| US3691198A (en) * | 1970-12-21 | 1972-09-12 | Cpc International Inc | Synthesis of 1-substituted-3-halopyrrolidines |
| JPS566971B2 (de) * | 1973-02-12 | 1981-02-14 | ||
| US4175099A (en) * | 1975-03-07 | 1979-11-20 | Exxon Research & Engineering Co. | Separation and recovery of ethylbenzene from C8 aromatic mixtures using rubidium-X sieves |
| US4230718A (en) * | 1979-01-09 | 1980-10-28 | A. H. Robins Company, Inc. | 1-Substituted-3,4-epoxypyrrolidines |
| US4605799A (en) * | 1980-08-13 | 1986-08-12 | Toray Industries, Inc. | Process for separating a halogenated toluene isomer |
| JPS59199642A (ja) * | 1983-04-28 | 1984-11-12 | Toray Ind Inc | ２，６−ジクロルトルエンの分離方法 |
| JPH06239808A (ja) * | 1993-02-15 | 1994-08-30 | Toray Ind Inc | ２−メチル−３−ニトロベンゾトリフルオライドの分離方法 |
| US5453560A (en) * | 1994-05-20 | 1995-09-26 | Uop | Process for adsorptive separation of ethylbenzene from aromatic hydrocarbons |
| US6130338A (en) | 1998-09-08 | 2000-10-10 | Toray Industries, Inc. | Method of producing pyrrolidine derivatives |
-
1999
- 1999-09-03 US US09/390,160 patent/US6130338A/en not_active Expired - Fee Related
- 1999-09-07 CA CA002281393A patent/CA2281393A1/en not_active Abandoned
- 1999-09-07 DE DE69915951T patent/DE69915951T2/de not_active Expired - Lifetime
- 1999-09-07 ES ES99307113T patent/ES2218955T3/es not_active Expired - Lifetime
- 1999-09-07 AT AT99307113T patent/ATE263149T1/de not_active IP Right Cessation
- 1999-09-07 EP EP99307113A patent/EP0985664B1/de not_active Expired - Lifetime
-
2000
- 2000-04-26 US US09/558,798 patent/US6479668B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6130338A (en) | 2000-10-10 |
| ATE263149T1 (de) | 2004-04-15 |
| US6479668B1 (en) | 2002-11-12 |
| EP0985664A3 (de) | 2000-05-10 |
| DE69915951T2 (de) | 2005-01-20 |
| ES2218955T3 (es) | 2004-11-16 |
| CA2281393A1 (en) | 2000-03-08 |
| EP0985664B1 (de) | 2004-03-31 |
| EP0985664A2 (de) | 2000-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |