DE69836928D1 - Verbindungen und Verfahren zur Herstellung substituierter 4-Phenyl-4-cyanocyclohexansäuren - Google Patents

Verbindungen und Verfahren zur Herstellung substituierter 4-Phenyl-4-cyanocyclohexansäuren

Info

Publication number: DE69836928D1
Authority: DE; Germany
Prior art keywords: phenyl; substituted; compounds; processes; preparation
Prior art date: 1997-02-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69836928T

Other languages

English (en)

Other versions

DE69836928T2 (de

Inventor

Andrew Allen

Ann Marie Diederich

Li Liu

Wilford Mendelson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-12

Filing date

1998-02-12

Publication date

2007-03-08

1998-02-12 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

2007-03-08 Application granted granted Critical

2007-03-08 Publication of DE69836928D1 publication Critical patent/DE69836928D1/de

2007-11-08 Publication of DE69836928T2 publication Critical patent/DE69836928T2/de

2018-02-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

DE69836928T 1997-02-12 1998-02-12 Verbindungen und Verfahren zur Herstellung substituierter 4-Phenyl-4-cyanocyclohexansäuren Expired - Lifetime DE69836928T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3760897P	1997-02-12	1997-02-12
US37608P		1997-02-12

Publications (2)

Publication Number	Publication Date
DE69836928D1 true DE69836928D1 (de)	2007-03-08
DE69836928T2 DE69836928T2 (de)	2007-11-08

Family

ID=21895265

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE69831022T Expired - Lifetime DE69831022T2 (de)	1997-02-12	1998-02-12	Verbindungen und Verfahren zur Herstellung substituierter 4-Phenyl-4-Cyanocyclohexansäuren
DE69836928T Expired - Lifetime DE69836928T2 (de)	1997-02-12	1998-02-12	Verbindungen und Verfahren zur Herstellung substituierter 4-Phenyl-4-cyanocyclohexansäuren
DE69813596T Expired - Lifetime DE69813596T2 (de)	1997-02-12	1998-02-12	Verbindungen und verfahren zur herstellung substituierter 4-phenyl-4-cyanocyclohexansäuren

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69831022T Expired - Lifetime DE69831022T2 (de)	1997-02-12	1998-02-12	Verbindungen und Verfahren zur Herstellung substituierter 4-Phenyl-4-Cyanocyclohexansäuren

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE69813596T Expired - Lifetime DE69813596T2 (de)	1997-02-12	1998-02-12	Verbindungen und verfahren zur herstellung substituierter 4-phenyl-4-cyanocyclohexansäuren

Country Status (38)

Country	Link
US (1)	US6337408B1 (de)
EP (1)	EP1023279B8 (de)
JP (4)	JP3786971B2 (de)
KR (1)	KR100412008B1 (de)
CN (2)	CN1301982C (de)
AP (1)	AP1215A (de)
AR (2)	AR012550A1 (de)
AT (2)	ATE300517T1 (de)
AU (1)	AU725484B2 (de)
BG (1)	BG63541B1 (de)
BR (1)	BR9808637A (de)
CA (1)	CA2279951A1 (de)
CO (1)	CO4950534A1 (de)
CY (1)	CY2478B1 (de)
DE (3)	DE69831022T2 (de)
DK (2)	DK1023279T3 (de)
DZ (1)	DZ2423A1 (de)
EA (1)	EA001783B1 (de)
ES (3)	ES2246373T3 (de)
HK (1)	HK1037613A1 (de)
HU (1)	HUP0001801A3 (de)
ID (1)	ID23527A (de)
IL (7)	IL131270A (de)
MA (1)	MA24471A1 (de)
MY (1)	MY118813A (de)
NO (1)	NO993863D0 (de)
NZ (1)	NZ337084A (de)
OA (1)	OA11144A (de)
PL (1)	PL193366B1 (de)
PT (2)	PT1023279E (de)
SI (2)	SI1524268T1 (de)
SK (1)	SK108899A3 (de)
TR (1)	TR199901920T2 (de)
TW (1)	TW442455B (de)
UA (1)	UA58533C2 (de)
UY (2)	UY24882A1 (de)
WO (1)	WO1998034584A2 (de)
ZA (1)	ZA981125B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA67753C2 (uk) *	1997-10-10	2004-07-15	Смітклайн Бічам Корпорейшн	Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот
US6452022B1 (en) *	1997-10-10	2002-09-17	Smithkline Beecham Corporation	Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
UY26268A1 (es) *	1999-08-06	2001-01-31	Smithkline Beecham Corp	Procedimiento para preparar acidos a traves de alfa-cloroep xi- esteres ley 17164 art 127
US20040220424A1 (en) *	1999-08-06	2004-11-04	Smithkline Beecham Corporation	Process for preparing acids via alpha-chloroepoxy esters
GB9920152D0 (en) *	1999-08-25	1999-10-27	Smithkline Beecham Plc	Novel process
US6555572B2 (en)	2000-03-16	2003-04-29	Inflazyme Pharmaceuticals Ltd.	Benzylated PDE4 inhibitors
CN102491959B (zh) *	2011-12-19	2015-03-25	江苏澄扬作物科技有限公司	一种环氧乙烷衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8320943D0 (en) *	1983-08-03	1983-09-07	Lilly Industries Ltd	Organic compounds
JP3195352B2 (ja) *	1992-04-02	2001-08-06	スミスクライン・ビーチャム・コーポレイション	アレルギーおよび炎症疾患の治療用化合物
MX9301943A (es) *	1992-04-02	1994-08-31	Smithkline Beecham Corp	Compuestos.

1998
- 1998-02-10 MY MYPI98000536A patent/MY118813A/en unknown
- 1998-02-10 AR ARP980100587A patent/AR012550A1/es unknown
- 1998-02-10 UY UY24882A patent/UY24882A1/es not_active IP Right Cessation
- 1998-02-11 ZA ZA981125A patent/ZA981125B/xx unknown
- 1998-02-12 TR TR1999/01920T patent/TR199901920T2/xx unknown
- 1998-02-12 ID IDW990806A patent/ID23527A/id unknown
- 1998-02-12 JP JP53506598A patent/JP3786971B2/ja not_active Expired - Fee Related
- 1998-02-12 EA EA199900735A patent/EA001783B1/ru not_active IP Right Cessation
- 1998-02-12 DE DE69831022T patent/DE69831022T2/de not_active Expired - Lifetime
- 1998-02-12 ES ES02078056T patent/ES2246373T3/es not_active Expired - Lifetime
- 1998-02-12 AT AT02078056T patent/ATE300517T1/de not_active IP Right Cessation
- 1998-02-12 PL PL335031A patent/PL193366B1/pl not_active IP Right Cessation
- 1998-02-12 ES ES98908534T patent/ES2196551T3/es not_active Expired - Lifetime
- 1998-02-12 WO PCT/US1998/002749 patent/WO1998034584A2/en active IP Right Grant
- 1998-02-12 AU AU66544/98A patent/AU725484B2/en not_active Ceased
- 1998-02-12 DK DK98908534T patent/DK1023279T3/da active
- 1998-02-12 PT PT98908534T patent/PT1023279E/pt unknown
- 1998-02-12 CN CNB988023776A patent/CN1301982C/zh not_active Expired - Fee Related
- 1998-02-12 PT PT04078092T patent/PT1524268E/pt unknown
- 1998-02-12 DK DK04078092T patent/DK1524268T3/da active
- 1998-02-12 DZ DZ980033A patent/DZ2423A1/xx active
- 1998-02-12 MA MA24962A patent/MA24471A1/fr unknown
- 1998-02-12 BR BR9808637-5A patent/BR9808637A/pt not_active Application Discontinuation
- 1998-02-12 HU HU0001801A patent/HUP0001801A3/hu unknown
- 1998-02-12 CN CNA2006100819583A patent/CN1854131A/zh active Pending
- 1998-02-12 SI SI9830872T patent/SI1524268T1/sl unknown
- 1998-02-12 AP APAP/P/1999/001618A patent/AP1215A/en active
- 1998-02-12 DE DE69836928T patent/DE69836928T2/de not_active Expired - Lifetime
- 1998-02-12 EP EP98908534A patent/EP1023279B8/de not_active Expired - Lifetime
- 1998-02-12 ES ES04078092T patent/ES2280008T3/es not_active Expired - Lifetime
- 1998-02-12 NZ NZ337084A patent/NZ337084A/en unknown
- 1998-02-12 DE DE69813596T patent/DE69813596T2/de not_active Expired - Lifetime
- 1998-02-12 SK SK1088-99A patent/SK108899A3/sk unknown
- 1998-02-12 CO CO98007356A patent/CO4950534A1/es unknown
- 1998-02-12 KR KR10-1999-7007192A patent/KR100412008B1/ko not_active IP Right Cessation
- 1998-02-12 SI SI9830794T patent/SI1295869T1/sl unknown
- 1998-02-12 CA CA002279951A patent/CA2279951A1/en not_active Abandoned
- 1998-02-12 IL IL13127098A patent/IL131270A/xx not_active IP Right Cessation
- 1998-02-12 AT AT98908534T patent/ATE237603T1/de not_active IP Right Cessation
- 1998-07-20 TW TW087101889A patent/TW442455B/zh active
- 1998-08-06 UY UY25127A patent/UY25127A1/es not_active IP Right Cessation
- 1998-12-02 UA UA99084524A patent/UA58533C2/uk unknown
1999
- 1999-08-10 BG BG103651A patent/BG63541B1/bg unknown
- 1999-08-11 NO NO993863A patent/NO993863D0/no unknown
- 1999-08-12 OA OA9900176A patent/OA11144A/en unknown
2000
- 2000-03-22 US US09/533,368 patent/US6337408B1/en not_active Expired - Fee Related
2001
- 2001-01-30 HK HK01100673A patent/HK1037613A1/xx not_active IP Right Cessation
2002
- 2002-07-29 IL IL150955A patent/IL150955A/en not_active IP Right Cessation
2004
- 2004-01-05 JP JP2004000418A patent/JP4093967B2/ja not_active Expired - Fee Related
- 2004-06-09 JP JP2004171346A patent/JP4053023B2/ja not_active Expired - Fee Related
- 2004-06-09 JP JP2004171348A patent/JP4053024B2/ja not_active Expired - Fee Related
- 2004-09-08 CY CY0400070A patent/CY2478B1/xx unknown
2005
- 2005-01-06 IL IL16618605A patent/IL166186A0/xx unknown
- 2005-01-06 IL IL16618805A patent/IL166188A0/xx unknown
- 2005-01-06 IL IL16618505A patent/IL166185A0/xx unknown
- 2005-01-06 IL IL16618405A patent/IL166184A0/xx unknown
- 2005-01-06 IL IL16618705A patent/IL166187A0/xx unknown
2006
- 2006-04-05 AR ARP060101344A patent/AR050308A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2004269546A (ja)	2004-09-30
UA58533C2 (uk)	2003-08-15
PT1023279E (pt)	2003-08-29
EP1023279B1 (de)	2003-04-16
DK1023279T3 (da)	2003-07-21
JP4093967B2 (ja)	2008-06-04
JP2004292460A (ja)	2004-10-21
CN1246855A (zh)	2000-03-08
TW442455B (en)	2001-06-23
NO993863L (no)	1999-08-11
HK1037613A1 (en)	2002-02-15
PL193366B1 (pl)	2007-02-28
CN1854131A (zh)	2006-11-01
AR050308A2 (es)	2006-10-18
JP2004149546A (ja)	2004-05-27
ES2196551T3 (es)	2003-12-16
ATE237603T1 (de)	2003-05-15
HUP0001801A2 (hu)	2000-10-28
NO993863D0 (no)	1999-08-11
AU725484B2 (en)	2000-10-12
EA001783B1 (ru)	2001-08-27
KR20000070927A (ko)	2000-11-25
CN1301982C (zh)	2007-02-28
UY25127A1 (es)	1998-11-27
JP4053023B2 (ja)	2008-02-27
SK108899A3 (en)	2000-01-18
ES2280008T3 (es)	2007-09-01
CO4950534A1 (es)	2000-09-01
EP1023279A2 (de)	2000-08-02
BG63541B1 (bg)	2002-04-30
IL131270A0 (en)	2001-01-28
DE69836928T2 (de)	2007-11-08
PL335031A1 (en)	2000-03-27
SI1295869T1 (sl)	2005-12-31
CY2478B1 (en)	2005-06-03
TR199901920T2 (xx)	1999-11-22
AP1215A (en)	2003-10-14
AR012550A1 (es)	2000-11-08
DE69831022D1 (de)	2005-09-01
UY24882A1 (es)	2001-08-27
MY118813A (en)	2005-01-31
WO1998034584A2 (en)	1998-08-13
ATE300517T1 (de)	2005-08-15
JP4053024B2 (ja)	2008-02-27
IL166186A0 (en)	2006-01-15
DE69831022T2 (de)	2006-04-20
IL166188A0 (en)	2006-01-15
EA199900735A1 (ru)	2000-02-28
DZ2423A1 (fr)	2003-01-04
EP1023279B8 (de)	2003-08-13
AU6654498A (en)	1998-08-26
IL166187A0 (en)	2006-01-15
DE69813596T2 (de)	2004-02-12
IL150955A (en)	2006-07-05
DK1524268T3 (da)	2007-05-14
BG103651A (en)	2000-02-29
MA24471A1 (fr)	1998-10-01
ZA981125B (en)	1998-08-21
AP9901618A0 (en)	1999-09-30
PT1524268E (pt)	2007-03-30
HUP0001801A3 (en)	2001-12-28
IL131270A (en)	2005-05-17
JP2001510482A (ja)	2001-07-31
NZ337084A (en)	2001-04-27
ES2246373T3 (es)	2006-02-16
CA2279951A1 (en)	1998-08-13
WO1998034584A3 (en)	1998-11-19
IL166184A0 (en)	2006-01-15
BR9808637A (pt)	2000-07-04
JP3786971B2 (ja)	2006-06-21
ID23527A (id)	2000-04-27
DE69813596D1 (de)	2003-05-22
EP1023279A4 (de)	2000-10-04
OA11144A (en)	2003-04-17
US6337408B1 (en)	2002-01-08
SI1524268T1 (sl)	2007-04-30
IL166185A0 (en)	2006-01-15
KR100412008B1 (ko)	2003-12-24

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DE69705291D1 (de)	2001-07-26	Verfahren zur Herstellung von Distyrol-biphenylverbindungen
DE59905059D1 (de)	2003-05-22	Verfahren zur Herstellung von Hydroxyethylcyclohexanen und Hydroxyethylpiperidinen
DE69810718D1 (de)	2003-02-20	Verfahren zur Herstellung von Benzoxazinen
DE69703599D1 (de)	2001-01-04	Verfahren zur Herstellung von 2-H-Heptafluorpropan
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DE69826946D1 (de)	2004-11-18	Verfahren zur Herstellung von cis-Hexahydroisoindolinen
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Legal Events

Date	Code	Title	Description
2008-02-07	8364	No opposition during term of opposition