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DE69836082D1 - Membranproteine aus säugetierzellen; verwandte reagentien - Google Patents

Membranproteine aus säugetierzellen; verwandte reagentien

Info

Publication number
DE69836082D1
DE69836082D1 DE69836082T DE69836082T DE69836082D1 DE 69836082 D1 DE69836082 D1 DE 69836082D1 DE 69836082 T DE69836082 T DE 69836082T DE 69836082 T DE69836082 T DE 69836082T DE 69836082 D1 DE69836082 D1 DE 69836082D1
Authority
DE
Germany
Prior art keywords
mammalian cells
membrane proteins
related reagents
proteins
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69836082T
Other languages
English (en)
Other versions
DE69836082T2 (de
Inventor
Alexander B Bakker
Joseph H Phillips
Lewis L Lanier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69836082D1 publication Critical patent/DE69836082D1/de
Application granted granted Critical
Publication of DE69836082T2 publication Critical patent/DE69836082T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69836082T 1997-08-01 1998-07-31 Membranproteine aus säugetierzellen; verwandte reagentien Expired - Lifetime DE69836082T2 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US904905 1986-09-08
US90490597A 1997-08-01 1997-08-01
US6371797P 1997-10-29 1997-10-29
US63717P 1997-10-29
US99082097A 1997-12-15 1997-12-15
US990820 1997-12-15
US6969297P 1997-12-16 1997-12-16
US69692P 1997-12-16
US8916898P 1998-06-12 1998-06-12
US89168P 1998-06-12
PCT/US1998/015316 WO1999006557A2 (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents

Publications (2)

Publication Number Publication Date
DE69836082D1 true DE69836082D1 (de) 2006-11-16
DE69836082T2 DE69836082T2 (de) 2007-05-10

Family

ID=27535631

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69836082T Expired - Lifetime DE69836082T2 (de) 1997-08-01 1998-07-31 Membranproteine aus säugetierzellen; verwandte reagentien

Country Status (8)

Country Link
EP (3) EP1003861B1 (de)
JP (3) JP2001512017A (de)
AT (2) ATE523593T1 (de)
AU (1) AU8661498A (de)
DE (1) DE69836082T2 (de)
ES (1) ES2274574T3 (de)
PT (1) PT1003861E (de)
WO (1) WO1999006557A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196164B2 (en) 1997-07-08 2007-03-27 Human Genome Sciences, Inc. Secreted protein HHTLF25
EP1557425A3 (de) * 1997-07-08 2005-08-17 Human Genome Sciences, Inc. Humanes sekeretiertes Protein
WO2002024940A2 (en) * 2000-09-20 2002-03-28 Institut National De La Sante Et De La Recherche Medicale (I.N.S.E.R.M.) Means for the identification of compounds capable of inhibiting karap-transduced signals
JP2004522742A (ja) 2000-12-08 2004-07-29 ベイラー　カレッジ　オブ　メディシン 免疫応答の改変において使用するためのｔｒｅｍ−１スプライス改変体
CA2433474A1 (en) * 2001-02-23 2002-09-06 Human Genome Sciences, Inc. 70 human secreted proteins
JP2008518629A (ja) * 2004-11-08 2008-06-05 シェーリング コーポレイション Ｍｄｌ−１の腫瘍との関連およびその方法
AR059193A1 (es) * 2006-01-31 2008-03-12 Bayer Schering Pharma Ag Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
CN101986783A (zh) 2007-04-23 2011-03-16 先灵公司 抗mdl-1抗体
WO2012112528A1 (en) * 2011-02-18 2012-08-23 Merck Sharp & Dohme Corp. Use of mdl-1 antagonists to treat spondylarthropathy
US20140227719A1 (en) 2011-09-23 2014-08-14 Merck Sharp & Dohme Corp Mdl-1 ligand
UA115540C2 (uk) 2011-11-16 2017-11-27 Бьорінгер Інгельхайм Інтернаціональ Гмбх Антитіло до il-36r
AR090915A1 (es) 2012-05-04 2014-12-17 Intervet Int Bv Proteina de fusion de proteina linfopoyetina estromal timica canina con la region fc de igg
WO2014117121A1 (en) * 2013-01-28 2014-07-31 St. Jude Children's Research Hospital, Inc. A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
AU2014216515A1 (en) * 2013-02-15 2015-10-08 Thomas Jefferson University Kit for tumor imaging
PT3143134T (pt) 2014-05-15 2020-12-04 Nat Univ Singapore Células assassinas naturais modificadas e seus usos
CN107580628B (zh) 2014-09-17 2022-01-07 诺华股份有限公司 用于过继免疫疗法的具有嵌合受体的靶向细胞毒性细胞
CN117384929A (zh) 2017-03-27 2024-01-12 新加坡国立大学 一种编码由细胞表达的嵌合受体的多核苷酸
EP3749685A4 (de) 2018-02-09 2021-12-22 National University of Singapore Aktivierung von chimären nkg2d-rezeptoren und verwendungen davon in der immuntherapie mit natürlichen killerzellen
CN108728527B (zh) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 Hcst基因作为诊治子痫前期的靶标
CN118546959A (zh) 2019-03-05 2024-08-27 恩卡尔塔公司 Cd19定向性嵌合抗原受体及其在免疫疗法中的用途
MX2021010783A (es) 2019-03-08 2021-09-30 Boehringer Ingelheim Int Formulaciones de anticuerpo anti-il-36r.
WO2022015920A1 (en) 2020-07-17 2022-01-20 Boehringer Ingelheim International Gmbh Anti-il-36r antibodies for the treatment of neutrophilic dermatoses

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2046920B1 (de) 1969-06-19 1974-05-03 Citizen Watch Co Ltd
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
WO1996026961A2 (en) * 1995-02-28 1996-09-06 National Jewish Center For Immunology And Respiratory Medicine Peptidyl compounds comprising an itim motif which regulate hematopoietic function and their use
WO1997020046A1 (en) * 1995-11-30 1997-06-05 Schering Corporation Dnam, an nk antigen and adhesion molecule of the immunoglobulin superfamily
WO1999002546A1 (en) * 1997-07-08 1999-01-21 Human Genome Sciences, Inc. 123 human secreted proteins
EP0972029A1 (de) * 1997-03-07 2000-01-19 Human Genome Sciences, Inc. 70 humane sekretierte proteine
EP0977855A2 (de) * 1997-04-30 2000-02-09 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptide assoziiert mit aktivatorrezeptoren und deren biologische anwendungen
ES2267192T3 (es) * 1997-08-01 2007-03-01 Serono Genetics Institute S.A. Ests 5' para proteinas secretadas no especificas de tejido.
EP1000152A2 (de) * 1997-08-01 2000-05-17 Genset 5' ests für sekretierte proteine, die im muskel und anderen mesodermalen geweben exprimiert werden

Also Published As

Publication number Publication date
PT1003861E (pt) 2007-01-31
EP1798286A2 (de) 2007-06-20
EP1003861B1 (de) 2006-10-04
EP1798287A3 (de) 2007-11-14
DE69836082T2 (de) 2007-05-10
ATE523593T1 (de) 2011-09-15
EP1003861A2 (de) 2000-05-31
EP1798286A3 (de) 2007-11-14
AU8661498A (en) 1999-02-22
WO1999006557A2 (en) 1999-02-11
JP4855513B2 (ja) 2012-01-18
EP1798287A2 (de) 2007-06-20
JP2001512017A (ja) 2001-08-21
ES2274574T3 (es) 2007-05-16
EP1798286B1 (de) 2011-09-07
WO1999006557A3 (en) 1999-05-20
JP2010099076A (ja) 2010-05-06
JP2010099077A (ja) 2010-05-06
ATE341626T1 (de) 2006-10-15

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