[go: up one dir, main page]

DE69831511D1 - Mikropartikel zum transport von arzneistoffen durch die schleimhaut und die blut-hirn-schranke - Google Patents

Mikropartikel zum transport von arzneistoffen durch die schleimhaut und die blut-hirn-schranke

Info

Publication number
DE69831511D1
DE69831511D1 DE69831511T DE69831511T DE69831511D1 DE 69831511 D1 DE69831511 D1 DE 69831511D1 DE 69831511 T DE69831511 T DE 69831511T DE 69831511 T DE69831511 T DE 69831511T DE 69831511 D1 DE69831511 D1 DE 69831511D1
Authority
DE
Germany
Prior art keywords
microparticles
tip
blood brain
medicinal products
brain disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69831511T
Other languages
English (en)
Other versions
DE69831511T2 (de
Inventor
Maria Rosa Gasco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE69831511D1 publication Critical patent/DE69831511D1/de
Application granted granted Critical
Publication of DE69831511T2 publication Critical patent/DE69831511T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69831511T 1997-12-01 1998-11-27 Mikropartikel zum transport von arzneistoffen durch die schleimhaut und die blut-hirn-schranke Expired - Lifetime DE69831511T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI002663A IT1296914B1 (it) 1997-12-01 1997-12-01 Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera
PCT/EP1998/007664 WO1999027918A1 (en) 1997-12-01 1998-11-27 Microparticles for drug delivery across mucosa and the blood-brain barrier

Publications (2)

Publication Number Publication Date
DE69831511D1 true DE69831511D1 (de) 2005-10-13
DE69831511T2 DE69831511T2 (de) 2006-06-14

Family

ID=11378297

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69831511T Expired - Lifetime DE69831511T2 (de) 1997-12-01 1998-11-27 Mikropartikel zum transport von arzneistoffen durch die schleimhaut und die blut-hirn-schranke

Country Status (8)

Country Link
US (1) US6419949B1 (de)
EP (1) EP1071408B1 (de)
AT (1) ATE303799T1 (de)
AU (1) AU2155199A (de)
DE (1) DE69831511T2 (de)
ES (1) ES2247736T3 (de)
IT (1) IT1296914B1 (de)
WO (1) WO1999027918A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1296914B1 (it) 1997-12-01 1999-08-03 Maria Rosa Gasco Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera
WO2000010531A1 (en) 1998-08-19 2000-03-02 Rtp Pharma Inc. Injectable aqueous dispersions of propofol
US7153525B1 (en) 2000-03-22 2006-12-26 The University Of Kentucky Research Foundation Microemulsions as precursors to solid nanoparticles
AU784191B2 (en) * 2000-04-11 2006-02-16 Ibergesfer, S.L. Structure for a washbasin
WO2002051390A2 (en) * 2000-12-27 2002-07-04 Ares Trading S.A. Amphiphilic lipid nanoparticles for peptide and/or protein incorporation
US7763663B2 (en) 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
NZ534377A (en) * 2002-03-13 2008-04-30 Collagenex Pharm Inc Water-based topical delivery system consisting of cholesterol, fatty acids water and a phospholipid/ceramide portion.
EA200401565A1 (ru) * 2002-05-24 2005-04-28 Неофарм, Инк. Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты)
JP2006518701A (ja) * 2002-05-24 2006-08-17 ネオファーム、インコーポレイティッド カルジオリピン組成物、その製造方法及び使用
US20050277611A1 (en) * 2002-10-16 2005-12-15 Neopharm, Inc. Cationic cardiolipin analoges and its use thereof
ITMI20022323A1 (it) * 2002-10-31 2004-05-01 Maria Rosa Gasco Composizioni farmaceutiche atte al trattamento di malattie oftalmiche.
US20050101605A1 (en) * 2003-11-07 2005-05-12 Ahmed Salah U. Oral liquid formulations of methotrexate
JP2007532629A (ja) * 2004-04-15 2007-11-15 キアスマ， インコーポレイテッド 生物学的障壁を横切る透過を促進し得る組成物
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
ITMI20041151A1 (it) * 2004-06-09 2004-09-09 Maria Rosa Gasco Nanoparticelle lipidiche come agenti veicolanti per acidi nucleici procedimento per la loro preparazione e loro uso
US20090180964A1 (en) * 2005-06-24 2009-07-16 Rao Papineni Transmucosal delivery of optical, spect, multimodal,drug or biological cargo laden nanoparticle(s) in small animals or humans
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
US20070154403A1 (en) * 2006-01-05 2007-07-05 Thomas Skold Oral, Pulmonary and Transmucosal Delivery Composition
US7914988B1 (en) * 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
EP1867323A1 (de) * 2006-06-13 2007-12-19 Farmatron Ltd. Pharmazeutische Zusammensetzungen mit verbesserter Permeation durch biologische Barrieren
EP2157911A2 (de) 2007-05-16 2010-03-03 Yeda Research And Development Co. Ltd. Beurteilung einer störung der blut-gehirn-schranke
GB2469965B (en) * 2008-02-18 2012-06-20 Csir Nanoparticle carriers for drug administration and process for producing same
EP2123262A1 (de) 2008-05-20 2009-11-25 Consorzio per il Centro di Biomedica Moleculare Scrl Zum Überschreiten der Blut-Hirn-Schranke fähige Polyelektrolyt-gekapselte Gold-Nanopartikel
CA2730760A1 (en) * 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles containing bioactive peptides
JP5623406B2 (ja) 2008-09-17 2014-11-12 キアズマ インコーポレイテッド 医薬組成物および関連する送達方法
US9147246B2 (en) 2009-08-18 2015-09-29 Ben-Gurion University Of The Negev Research And Development Authority Apparatus and method for analyzing stream of imaging data
US10275680B2 (en) 2011-10-19 2019-04-30 Tel Hashomer Medical Research Infrastructure And Services Ltd. Magnetic resonance maps for analyzing tissue
EP2645099A1 (de) * 2012-03-30 2013-10-02 Phares Pharmaceutical Research N.V. Biorelevante Zusammensetzungen
JP6526627B2 (ja) 2013-04-24 2019-06-05 テル ハショメール メディカル リサーチ インフラストラクチャー アンド サービシズ リミテッド 組織解析用の磁気共鳴マップ
WO2016098857A1 (ja) * 2014-12-19 2016-06-23 積水化学工業株式会社 製剤
CA2974196C (en) 2015-01-20 2023-12-12 TetraDerm Group LLC Versatile topical drug delivery vehicle and multifactorial tissue moisturizer that provides mucosal and skin barrier restoration
EP4527456A2 (de) 2015-02-03 2025-03-26 Amryt Endo, Inc. Verfahren zur behandlung von krankheiten
AU2017360346B2 (en) 2016-11-21 2023-11-23 Eirion Therapeutics, Inc. Transdermal delivery of large agents
EP3888635A4 (de) * 2019-01-07 2022-08-03 Pusan National University Industry-University Cooperation Foundation Arzneimittelabgabeplattform unter verwendung einer w/ö/w-trioleinemulsion zur förderung der öffnung der blut-hirn-schranke
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421468A1 (de) 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
US5250236A (en) * 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
DE4131562A1 (de) 1991-09-18 1993-03-25 Medac Klinische Spezialpraep Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln)
DE4327063A1 (de) * 1993-08-12 1995-02-16 Kirsten Dr Westesen Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften
US5858398A (en) * 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions
IT1292142B1 (it) * 1997-06-12 1999-01-25 Maria Rosa Gasco Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale
IT1296914B1 (it) 1997-12-01 1999-08-03 Maria Rosa Gasco Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera

Also Published As

Publication number Publication date
IT1296914B1 (it) 1999-08-03
ITMI972663A1 (it) 1999-06-01
EP1071408B1 (de) 2005-09-07
DE69831511T2 (de) 2006-06-14
US6419949B1 (en) 2002-07-16
EP1071408A1 (de) 2001-01-31
WO1999027918A1 (en) 1999-06-10
AU2155199A (en) 1999-06-16
ATE303799T1 (de) 2005-09-15
ES2247736T3 (es) 2006-03-01

Similar Documents

Publication Publication Date Title
DE69831511D1 (de) Mikropartikel zum transport von arzneistoffen durch die schleimhaut und die blut-hirn-schranke
AR020288A1 (es) Emulsion aceite en agua que comprende un agente biologicamente activo micronizado y un sistema emulsionante adecuado.
DE59309858D1 (de) Geschmacksmaskierte pharmazeutische Mittel
FR2755136B1 (fr) Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives et compositions pharmaceutiques les contenant
AR043272A1 (es) Una microparticula recubierta con una sustancia lipofilica que contiene una droga proteica o antigeno y formulaciones que la comprenden
DK1553927T3 (da) Gel-stabiliserede, nanopartikulære aktivstof-sammensætninger
BR0100335A (pt) Nanoemulsão óleo-em-água à base de lipìdios anfìfilos e de polìmeros catiÈnicos, composição cosmética de uso tópico, utilizações, processo de tratamento não-terapêutico e processo para espessar as nanoemulsões óleo-em-água
BR0100424A (pt) Nanoemulsão óleo-em-água que contém lipìdios anfìfilos e um polìmero não iÈnico, composição cosmética de uso tópico, suas utilizações, processo de tratamento não terapêutico e processo para espessar as nanoemulsões óleo-em -água
NZ501950A (en) Medicinal compositions for application to mucosa
ATE281844T1 (de) Orale verabreichung von nukleinsäure-impstoffen durch partikelkomplexe
CA2330330A1 (en) Pharmaceutical compositions comprising an amphoteric surfactant an alkoxylated cetyl alcohol and a polar drug
FR2732967B1 (fr) 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
MA26532A1 (fr) Derives d'amines cycliques, compositions pharmaceutiques les contenant, procede pour les preparer, et leur utilisation et tant que principe pharmaceutique agissant contre les maladies respiratoires.
NO961363D0 (no) Nytt emulsjonspreparat
ATE270544T1 (de) Halbfeste arzneizubereitung enthaltend isotretinoin
FR2778406B1 (fr) Derives d'alpha-cetoamides, procede pour leur preparation, preparations pharmaceutiques les contenant, et leur utilisation en tant que medicaments anti-viraux
DE69519685D1 (de) Oral anzuwendende arzneizubereitung mit verzögerter wirkstoffabgabe
CO5140102A1 (es) Formulacion farmaceutica en forma de pasta semisolida estabilizada para administracion oral que comprende omeprazol, de dos a cuatro agentes basificantes, un agente espesante y un vehiculo aceitoso hidrofobico
AR030862A1 (es) Formulaciones medicinales en aerosol
ES2154806T3 (es) Formulaciones de compuestos como dispersiones de nanoparticulas en aceites o acidos grasos digeribles.
IT1314185B1 (it) Composizione farmaceutica per somministrazione di sostanze attivescarsamente solubili in mezzi acquosi
DE59912782D1 (de) Topisches Arzneimittel mit einem Gehalt an Ciclosporin
EP1393734A4 (de) Arzneimittel gegen darmerkrankungen
DE69922017D1 (de) Arzneimittel und verfahren zur behandlung von intrazellulären infektionen
UY27341A1 (es) Formulación farmacéutica de sabor enmascarado y procedimiento para su preparación.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition