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DE69817214D1 - Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren - Google Patents

Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren

Info

Publication number
DE69817214D1
DE69817214D1 DE69817214T DE69817214T DE69817214D1 DE 69817214 D1 DE69817214 D1 DE 69817214D1 DE 69817214 T DE69817214 T DE 69817214T DE 69817214 T DE69817214 T DE 69817214T DE 69817214 D1 DE69817214 D1 DE 69817214D1
Authority
DE
Germany
Prior art keywords
azaring
heterocyclic group
ach receptor
nicotinic ach
receptor modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69817214T
Other languages
English (en)
Other versions
DE69817214T2 (de
Inventor
Dan Peters
M Olsen
Feldbaek Nielsen
Ostergaard Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of DE69817214D1 publication Critical patent/DE69817214D1/de
Application granted granted Critical
Publication of DE69817214T2 publication Critical patent/DE69817214T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69817214T 1997-11-05 1998-11-05 Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren Expired - Lifetime DE69817214T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK125997 1997-11-05
DK125997 1997-11-05
DK85098 1998-06-26
DKPA199800850 1998-06-26
PCT/DK1998/000478 WO1999024422A1 (en) 1997-11-05 1998-11-05 Azaring-ether derivatives and their use as nicotinic ach receptor modulators

Publications (2)

Publication Number Publication Date
DE69817214D1 true DE69817214D1 (de) 2003-09-18
DE69817214T2 DE69817214T2 (de) 2004-06-09

Family

ID=26064766

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69817214T Expired - Lifetime DE69817214T2 (de) 1997-11-05 1998-11-05 Azaring-ether-derivate und ihre verwendung als nicotinic-ach-rezeptormodulatoren

Country Status (12)

Country Link
US (3) US6756386B1 (de)
EP (2) EP1357121A1 (de)
JP (1) JP2001522846A (de)
CN (1) CN1173972C (de)
AT (1) ATE247104T1 (de)
AU (1) AU747419B2 (de)
CA (1) CA2306477A1 (de)
DE (1) DE69817214T2 (de)
DK (1) DK1034174T3 (de)
HK (1) HK1032234A1 (de)
NZ (1) NZ503626A (de)
WO (1) WO1999024422A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002523413A (ja) * 1998-08-25 2002-07-30 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ニコチン性アセチルコリン受容体のリガンドとしてのピリジルエーテルおよびチオエーテル、ならびにその治療的用途
US6303638B1 (en) 1999-08-06 2001-10-16 The Regents Of The University Of California Substituted pyridines as modulators of the mammalian neuronal nicotinic acetylcholine receptor
EP1212319A2 (de) * 1999-09-14 2002-06-12 Abbott Laboratories 3-pyrrolidinyloxy-3' -pyridyl ether verbindungen verwendbar zur steuerung von chemischer synaptischer übertragung
DE10117686A1 (de) * 2001-04-09 2002-10-24 Celanese Ventures Gmbh Protonenleitende Membran und deren Verwendung
EP1448200A2 (de) * 2001-11-19 2004-08-25 Elan Pharmaceuticals, Inc. Derivate des (4-phenyl)piperidin-3-yl-phenylcarboxylats und verwandte verbindungen als beta-secretase inhibitoren zur behandlung von alzheimer
WO2004113297A2 (en) * 2003-06-24 2004-12-29 Neurosearch A/S Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
CA2529790A1 (en) * 2003-06-27 2005-01-27 Banyu Pharmaceutical Co., Ltd. Heteroaryloxy nitrogenous saturated heterocyclic derivative
EP1761518A1 (de) * 2004-06-18 2007-03-14 Neurosearch A/S Neuartige alkylsubstituierte piperidinderivate als monoamin neurotransmitter wiederaufnahme hemmer
EP1802258A4 (de) 2004-09-13 2015-09-23 Chrono Therapeutics Inc Biosynchrone transdermale arzneiabgabe
US20070134169A1 (en) * 2005-12-11 2007-06-14 Rabinoff Michael D Methods for smoking cessation or alcohol cessation or other addiction cessation
EP1977746B8 (de) 2007-04-02 2014-09-24 Parkinson's Institute Verfahren und Zusammensetzung zur Verringerung der Nebenwirkungen von therapeutischen Behandlungen
WO2016123406A1 (en) 2015-01-28 2016-08-04 Chrono Therapeutics Inc. Drug delivery methods and systems
JP6654960B2 (ja) * 2016-01-15 2020-02-26 日本曹達株式会社 ルテニウム錯体の製造方法
CA3049529A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
US11596779B2 (en) 2018-05-29 2023-03-07 Morningside Venture Investments Limited Drug delivery methods and systems

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR829845A (fr) 1936-12-04 1938-07-07 Delle Atel Const Electr Coupe-circuit à basse tension à élément fusible rechargeable
FR2306697A1 (fr) * 1975-04-10 1976-11-05 Sogeras Nouvelles pyrimidines utilisables comme medicaments antidiabetiques et hypocholesterolemiants
US4379161A (en) * 1979-06-07 1983-04-05 Michel Thominet Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics
DE3227741A1 (de) * 1982-07-24 1984-01-26 Hoechst Ag, 6230 Frankfurt 1-phenyl-isochinolinderivate und verfahren zu ihrer herstellung
US4592866A (en) * 1982-09-30 1986-06-03 A. H. Robins Company, Inc. Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof
ZA848275B (en) 1983-12-28 1985-08-28 Degussa New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
US4667031A (en) * 1985-10-15 1987-05-19 Ethyl Corporation Process for preparing oxazepinones
DE3835291A1 (de) * 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
DE4208254A1 (de) 1992-03-14 1993-09-16 Hoechst Ag Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid
IL107184A (en) * 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
AU3162695A (en) * 1994-08-03 1996-03-04 Asta Medica Aktiengesellschaft Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
GB2295387A (en) * 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
IL118279A (en) * 1995-06-07 2006-10-05 Abbott Lab Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
WO1997028128A1 (en) * 1996-02-02 1997-08-07 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
US5629325A (en) * 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
DE69725113T2 (de) 1997-02-25 2004-07-15 Akzo Nobel N.V. Azetidin- und Pyrrolidinderivate
JP2002523413A (ja) 1998-08-25 2002-07-30 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ニコチン性アセチルコリン受容体のリガンドとしてのピリジルエーテルおよびチオエーテル、ならびにその治療的用途
DE19904261A1 (de) 1999-02-03 2000-08-10 Basf Ag Verfahren zur Herstellung von Dimethylsulfit
RU2145680C1 (ru) 1999-06-28 2000-02-20 Открытое акционерное общество "Магистральные нефтепроводы Центральной Сибири" Пеногенератор (варианты)
GB0203968D0 (en) 2002-02-19 2002-04-03 Gavon Res & Dev Ltd Mixer
JP2003297848A (ja) 2002-04-01 2003-10-17 Matsushita Electric Ind Co Ltd 半導体装置の製造方法

Also Published As

Publication number Publication date
AU1022499A (en) 1999-05-31
US7202237B2 (en) 2007-04-10
CN1173972C (zh) 2004-11-03
WO1999024422A1 (en) 1999-05-20
AU747419B2 (en) 2002-05-16
US20070161614A1 (en) 2007-07-12
US20040242558A1 (en) 2004-12-02
CN1278258A (zh) 2000-12-27
US6756386B1 (en) 2004-06-29
JP2001522846A (ja) 2001-11-20
EP1357121A1 (de) 2003-10-29
EP1034174B1 (de) 2003-08-13
ATE247104T1 (de) 2003-08-15
DK1034174T3 (da) 2003-09-22
CA2306477A1 (en) 1999-05-20
HK1032234A1 (en) 2001-07-13
EP1034174A1 (de) 2000-09-13
NZ503626A (en) 2002-05-31
DE69817214T2 (de) 2004-06-09

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