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DE69815305D1 - Triarylmethylfreie radikale als bildverbesserungsmittel - Google Patents

Triarylmethylfreie radikale als bildverbesserungsmittel

Info

Publication number
DE69815305D1
DE69815305D1 DE69815305T DE69815305T DE69815305D1 DE 69815305 D1 DE69815305 D1 DE 69815305D1 DE 69815305 T DE69815305 T DE 69815305T DE 69815305 T DE69815305 T DE 69815305T DE 69815305 D1 DE69815305 D1 DE 69815305D1
Authority
DE
Germany
Prior art keywords
free radicals
image improvement
improvement agents
triaryl methyl
methyl free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69815305T
Other languages
English (en)
Other versions
DE69815305T2 (de
Inventor
Mikkel Thaning
Goeran Pettersson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Amersham Health AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9704669.2A external-priority patent/GB9704669D0/en
Application filed by Amersham Health AS filed Critical Amersham Health AS
Application granted granted Critical
Publication of DE69815305D1 publication Critical patent/DE69815305D1/de
Publication of DE69815305T2 publication Critical patent/DE69815305T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C07B61/02—Generation of organic free radicals; Organic free radicals per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Epidemiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69815305T 1997-03-06 1998-03-06 Triarylmethylfreie radikale als bildverbesserungsmittel Expired - Lifetime DE69815305T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9704669 1997-03-06
GBGB9704669.2A GB9704669D0 (en) 1997-03-06 1997-03-06 Free radicals
US882147 1997-06-25
US08/882,147 US6013810A (en) 1997-03-06 1997-06-25 Free radicals
PCT/GB1998/000672 WO1998039277A1 (en) 1997-03-06 1998-03-06 Triarylmethyl free radicals as image enhancing agents

Publications (2)

Publication Number Publication Date
DE69815305D1 true DE69815305D1 (de) 2003-07-10
DE69815305T2 DE69815305T2 (de) 2004-04-29

Family

ID=26311128

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69815305T Expired - Lifetime DE69815305T2 (de) 1997-03-06 1998-03-06 Triarylmethylfreie radikale als bildverbesserungsmittel

Country Status (5)

Country Link
EP (1) EP0966414B1 (de)
AU (1) AU6506598A (de)
DE (1) DE69815305T2 (de)
ES (1) ES2201462T3 (de)
WO (1) WO1998039277A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO338547B1 (no) * 2004-07-30 2016-09-05 Ge Healthcare As Fremgangsmåte for fremstilling av en flytende sammensetning omfattende hyperpolarisert 13C-pyruvat, sammensetningen og anvendelse av den for fremstilling av hyperpolarisert 13C-pyruvat
PL1797102T3 (pl) 2004-07-30 2015-10-30 Ge Healthcare As Kompozycja zawierająca rodnik triarylometylowy przydatna w diagnostyce metodą MRI
ES2545377T3 (es) 2004-07-30 2015-09-10 Ge Healthcare As Radicales y su uso como agentes paramagnéticos en un proceso de polarización nuclear dinámica
AU2006321057B2 (en) 2005-12-01 2012-11-01 Ge Healthcare As Method of dynamic nuclear polarisation (DNP) using a trityl radical and a paramagnetic metal ion
EP2072061A1 (de) 2007-12-19 2009-06-24 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
EP2268321B1 (de) 2008-05-02 2013-10-09 General Electric Company Verfahren zur Bestimmung einer Alanintransaminase-Aktivität durch 13C-MR-Detektion mit Hilfe von hyperpolarisiertem 13C-Pyruvat
US8697034B2 (en) 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
WO2011029854A1 (en) 2009-09-10 2011-03-17 Ge Healthcare Limited 13c-mr detection using hyperpolarised 13c-fructose
FR2967158A1 (fr) * 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
DE102018126261A1 (de) 2018-10-22 2020-04-23 Universität Bielefeld Tritylverbindungen vom Finland-Typ

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728370A (en) * 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals

Also Published As

Publication number Publication date
DE69815305T2 (de) 2004-04-29
ES2201462T3 (es) 2004-03-16
EP0966414A1 (de) 1999-12-29
AU6506598A (en) 1998-09-22
EP0966414B1 (de) 2003-06-04
WO1998039277A1 (en) 1998-09-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO

8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB

R082 Change of representative

Ref document number: 966414

Country of ref document: EP

Representative=s name: J D REYNOLDS & CO., GB