[go: up one dir, main page]

DE69738454D1 - Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden - Google Patents

Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden

Info

Publication number
DE69738454D1
DE69738454D1 DE69738454T DE69738454T DE69738454D1 DE 69738454 D1 DE69738454 D1 DE 69738454D1 DE 69738454 T DE69738454 T DE 69738454T DE 69738454 T DE69738454 T DE 69738454T DE 69738454 D1 DE69738454 D1 DE 69738454D1
Authority
DE
Germany
Prior art keywords
oligonucleotides
retroviral
proteins
nucleocapside
specifically bind
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69738454T
Other languages
English (en)
Inventor
Alan Rein
Jose Casas-Finet
Robert Fisher
Matthew Fivash
Louis E Henderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE69738454D1 publication Critical patent/DE69738454D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69738454T 1996-05-20 1997-05-19 Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden Expired - Lifetime DE69738454D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1712896P 1996-05-20 1996-05-20
PCT/US1997/008936 WO1997044064A2 (en) 1996-05-20 1997-05-19 Oligonucleotides which specifically bind retroviral nucleocapsid proteins

Publications (1)

Publication Number Publication Date
DE69738454D1 true DE69738454D1 (de) 2008-02-21

Family

ID=21780880

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69738454T Expired - Lifetime DE69738454D1 (de) 1996-05-20 1997-05-19 Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden

Country Status (7)

Country Link
US (1) US6316190B1 (de)
EP (1) EP1011729B1 (de)
AT (1) ATE383172T1 (de)
AU (1) AU737926B2 (de)
CA (1) CA2255822A1 (de)
DE (1) DE69738454D1 (de)
WO (1) WO1997044064A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
US6221600B1 (en) * 1999-10-08 2001-04-24 Board Of Regents, The University Of Texas System Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
IL150196A0 (en) * 1999-12-13 2002-12-01 Bioniche Life Sciences Inc Therapeutically useful synthetic oligonucleotides
US20020091095A1 (en) * 1999-12-13 2002-07-11 Phillips Nigel C. Modulation of Fas and FasL expression
US6911541B2 (en) 2000-08-30 2005-06-28 North Carolina State University Promoter fragment that is recognized by the product of the tobacco Nic gene
EP1368467B1 (de) 2000-11-07 2007-04-25 North Carolina State University Putrescin-n-methyltransferasepromotor
US7115370B2 (en) 2002-06-05 2006-10-03 Capital Genomix, Inc. Combinatorial oligonucleotide PCR
CA2498777C (en) 2002-09-13 2015-01-13 Replicor, Inc. Non-sequence complementary antiviral oligonucleotides
US20050196382A1 (en) * 2002-09-13 2005-09-08 Replicor, Inc. Antiviral oligonucleotides targeting viral families
WO2004032869A2 (en) 2002-10-08 2004-04-22 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Services Identification of anti-hiv compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid
EP1493810A1 (de) * 2003-06-30 2005-01-05 Gentium S.p.A. Auf DNA-basierte Aptamere für Cathepsin G
PT2158316E (pt) 2007-05-11 2015-07-20 Adynxx Inc Expressão génica e dor
EP2437752A2 (de) * 2009-06-03 2012-04-11 Dicerna Pharmaceuticals, Inc. Peptid-dicer-substratstoffe und verfahren für spezifische genexpressionshemmung
WO2013170086A2 (en) 2012-05-10 2013-11-14 Adynxx, Inc. Formulations for the delivery of active ingredients
US10208358B2 (en) * 2014-04-14 2019-02-19 Indiana University Reasearch and Technology Corporation Generalizable assay for virus capsid assembly
PT3180434T (pt) 2014-08-15 2019-10-29 Adynxx Inc Chamarizes oligonucleotídicos para o tratamento da dor
EP3235828A1 (de) * 2016-04-21 2017-10-25 Genethon Stabile pseudotypisierte lentivirale teilchen und verwendungen davon
KR20220090289A (ko) 2020-12-22 2022-06-29 삼성전자주식회사 반도체 패키지
CN118475592A (zh) * 2022-05-23 2024-08-09 维克斯迪姆有限公司 使用病毒核衣壳的靶蛋白表达平台
KR102617592B1 (ko) * 2022-05-23 2023-12-29 주식회사 백스다임 바이러스 뉴클레오캡시드를 이용한 오량체형 독소 단백질 기반 목적 단백질 융합 오량체 제조 플랫폼
EP4530292A1 (de) * 2022-05-23 2025-04-02 Vaxdigm Co., Ltd. Plattform auf kristallinem protein mit verwendung von viralem nukleokapsid zur herstellung von zielproteinkondensierten selbstangeordneten nanopartikeln

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0500791T3 (da) * 1989-10-31 1998-04-06 Us Health Udformning og konstruktion af ikke-infektiøse human retrovirale mutanter, der mangler genomisk DNA
US5294536A (en) * 1992-04-23 1994-03-15 Pb Diagnostic Systems, Inc. Conjugates
DE4427219A1 (de) * 1994-08-01 1996-02-08 Max Planck Gesellschaft Nukleinsäure zur Initiation der Aktivität von RNase H bzw. reverser Transkriptase
US6001555A (en) * 1994-09-23 1999-12-14 The United States Of America As Represented By The Department Of Health And Human Services Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein

Also Published As

Publication number Publication date
CA2255822A1 (en) 1997-11-27
EP1011729A2 (de) 2000-06-28
WO1997044064A2 (en) 1997-11-27
WO1997044064A3 (en) 1998-05-14
US6316190B1 (en) 2001-11-13
AU3143897A (en) 1997-12-09
ATE383172T1 (de) 2008-01-15
EP1011729B1 (de) 2008-01-09
AU737926B2 (en) 2001-09-06

Similar Documents

Publication Publication Date Title
DE69738454D1 (de) Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden
CY1112101T1 (el) Νευροτροφικοι παραγοντες
DE69714654D1 (de) Verwendung von einem Metalloporphyrinkonjugat für den Nachweis biologischer Verbindungen
DE69939820D1 (de) Internalisierende erbb2 antikörper
DE69832293D1 (de) Zubereitungen zur abgabe von negativ geladenen molekülen
DK0593618T3 (da) Screeningsassay til påvisning af DNA-bindende molekyler
DE60041452D1 (de) CpG REZEPTOR (CpG-R) UND DARAUF BEZOGENE METHODEN
DE69835143D1 (de) Selektion von proteinen mittels rns-protein fusionen
ATE365916T1 (de) Biodetektoren für spezifische liganden
EA199800999A1 (ru) Переносчик для доставки вещества в эукариотические клетки и способ его получения
WO1999030165A3 (en) Processes for identifying a solvent condition suitable for determining a biophysical property of a protein
ATE319735T1 (de) Aufreinigung von substanzen aus einer biologischen probe
DE69913325D1 (de) Nephrin gen und protein
BR9710919A (pt) Proteina purificada sr-p70
CY1106349T1 (el) Συστηματα ανιχνευσης ανοσοπροσδιορισμου ιικου αντιγονου ηπατιτιδας c
ES2100051T3 (es) Sintesis de bloques dimeros y su uso en el ensamblaje de oligonucleotidos.
AR010744A1 (es) Inhibidores polipropilos de ciclofilina
EP1017716A4 (de) Car-rezeptoren, verwandte moleküle und methoden
EA199800843A1 (ru) Компьютерный способ создания химических структур, имеющих общие функциональные характеристики
DK0923644T3 (da) G-koblet receptor, der udviser selektiv selektivitet for ATP
DE60121456D1 (de) Farbstoff-markiertes peptid und dessen verwendung zur diagnostik
CY1106355T1 (el) Πρωτεϊνη συνδεομενη με αποπτινη
ATE219515T1 (de) Methoden und reagenzien zur regulierung von apoptosis
DK1208213T3 (da) Fremgangsmåde til fremstilling af proteiner i værtsceller under anvendelse af chaperoniner
EP1118659A4 (de) Expressionssysteme zur funktionellen expression von nukleinsäuren

Legal Events

Date Code Title Description
8332 No legal effect for de