DE69736445D1 - Refluxinhibitoren - Google Patents

Refluxinhibitoren

Info

Publication number: DE69736445D1
Authority: DE; Germany
Prior art keywords: reflux inhibitors; reflux; inhibitors
Prior art date: 1996-09-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69736445T

Other languages

English (en)

Other versions

DE69736445T2 (de

Inventor

Anders Lehmann

Paul L R Andrews

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AstraZeneca AB

Original Assignee

AstraZeneca AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-18

Filing date

1997-09-15

Publication date

2006-09-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20403936&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69736445(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-09-15 Application filed by AstraZeneca AB filed Critical AstraZeneca AB

2006-09-14 Application granted granted Critical

2006-09-14 Publication of DE69736445D1 publication Critical patent/DE69736445D1/de

2007-03-15 Publication of DE69736445T2 publication Critical patent/DE69736445T2/de

2017-09-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/9426—GABA, i.e. gamma-amino-butyrate
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Pathology (AREA)
Analytical Chemistry (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
General Physics & Mathematics (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Food Science & Technology (AREA)
Otolaryngology (AREA)
Hospice & Palliative Care (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)

DE69736445T 1996-09-18 1997-09-15 Refluxinhibitoren Expired - Lifetime DE69736445T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9603408		1996-09-18
SE9603408A SE9603408D0 (sv)	1996-09-18	1996-09-18	Medical use

Publications (2)

Publication Number	Publication Date
DE69736445D1 true DE69736445D1 (de)	2006-09-14
DE69736445T2 DE69736445T2 (de)	2007-03-15

Family

ID=20403936

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69724809T Expired - Lifetime DE69724809T2 (de)	1996-09-18	1997-09-15	Refluxinhibitoren
DE69736445T Expired - Lifetime DE69736445T2 (de)	1996-09-18	1997-09-15	Refluxinhibitoren

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69724809T Expired - Lifetime DE69724809T2 (de)	1996-09-18	1997-09-15	Refluxinhibitoren

Country Status (35)

Country	Link
US (2)	US6117908A (de)
EP (2)	EP1344524B1 (de)
JP (1)	JP4098832B2 (de)
KR (2)	KR100553294B1 (de)
CN (1)	CN1117560C (de)
AR (1)	AR007747A1 (de)
AT (2)	ATE249212T1 (de)
AU (1)	AU714370B2 (de)
BR (1)	BR9711400A (de)
CA (1)	CA2265615C (de)
CZ (1)	CZ299997B6 (de)
DE (2)	DE69724809T2 (de)
DK (2)	DK0936906T3 (de)
EE (1)	EE03952B1 (de)
ES (2)	ES2206749T3 (de)
HK (2)	HK1022100A1 (de)
HU (1)	HU224968B1 (de)
ID (1)	ID19621A (de)
IL (1)	IL128961A (de)
IS (2)	IS2329B (de)
MY (1)	MY122020A (de)
NO (1)	NO326837B1 (de)
NZ (2)	NZ504244A (de)
PL (1)	PL190028B1 (de)
PT (2)	PT1344524E (de)
RU (1)	RU2199316C2 (de)
SA (1)	SA97180522B1 (de)
SE (1)	SE9603408D0 (de)
SI (2)	SI0936906T1 (de)
SK (1)	SK285744B6 (de)
TR (1)	TR199900591T2 (de)
TW (1)	TW548104B (de)
UA (1)	UA61081C2 (de)
WO (1)	WO1998011885A1 (de)
ZA (1)	ZA977969B (de)

Families Citing this family (59)

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AU714980B2 (en)	1996-07-24	2000-01-13	Warner-Lambert Company Llc	Isobutylgaba and its derivatives for the treatment of pain
AU8668598A (en)	1997-08-20	1999-03-08	University Of Oklahoma, The	Gaba analogs to prevent and treat gastrointestinal damage
US6127418A (en) *	1997-08-20	2000-10-03	Warner-Lambert Company	GABA analogs to prevent and treat gastrointestinal damage
EP0974351A3 (de) *	1998-04-24	2000-12-13	Jouveinal	Arzneimittel zur Vorbeugung und Behandlung von Magendarmschäden
US20080207755A1 (en) *	2000-05-31	2008-08-28	Pfizer Inc	Alpha 2 Delta Ligands For Fibromyalgia and Other Disorders
US7164034B2 (en) *	1999-06-10	2007-01-16	Pfizer Inc.	Alpha2delta ligands for fibromyalgia and other disorders
SE9904508D0 (sv) *	1999-12-09	1999-12-09	Astra Ab	New compounds
SE9904507D0 (sv) *	1999-12-09	1999-12-09	Astra Ab	New compounds
US7319095B2 (en) *	1999-12-09	2008-01-15	Astrazeneca Ab	Use of GABAB receptor agonists
TWI256314B (en) *	2000-02-09	2006-06-11	Mitsubishi Pharma Corp	Preventive-therapeutical medicament for gastroesophageal reflux disease
JP2004532259A (ja) *	2001-05-29	2004-10-21	デポメッドディベロップメントリミティド	胃食道逆流症及び夜間に胃酸分泌が回復する現象の治療方法
SE0102055D0 (sv) *	2001-06-08	2001-06-08	Astrazeneca Ab	New Compounds
AR033779A1 (es) *	2001-06-08	2004-01-07	Astrazeneca Ab	Compuestos utiles en la enfermedad de reflujo
SE0102057D0 (sv) *	2001-06-08	2001-06-08	Astrazeneca Ab	New Salts I
SE0102058D0 (sv) *	2001-06-08	2001-06-08	Astrazeneca Ab	New Salts II
GB0209481D0 (en) *	2002-04-24	2002-06-05	Novartis Ag	Organic compounds
SE0201940D0 (sv) *	2002-06-20	2002-06-20	Astrazeneca Ab	New combination II
SE0201943D0 (sv) *	2002-06-20	2002-06-20	Astrazeneca Ab	New use
SE0201939D0 (sv) *	2002-06-20	2002-06-20	Astrazeneca Ab	New combination
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EP2354120A1 (de)	2003-08-20	2011-08-10	XenoPort, Inc.	Synthese von Acyloxyalkylcarbamat-Prodrugs und Zwischenprodukten davon
JP2007535480A (ja) *	2003-09-12	2007-12-06	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	キメラｇａｂａｂ受容体
US8007827B2 (en) *	2004-04-02	2011-08-30	Impax Laboratories, Inc.	Pharmaceutical dosage forms having immediate release and/or controlled release properties
US20050220873A1 (en) *	2004-04-02	2005-10-06	Chien-Hsuan Han	Pharmaceutical dosage forms having immediate and controlled release properties that contain a GABAB receptor agonist
US20050226927A1 (en) *	2004-04-02	2005-10-13	Impax Laboratories, Inc.	Pharmaceutical dosage forms having immediate release and/or controlled release properties that contain a GABAB receptor agonist
US20050220863A1 (en) *	2004-04-02	2005-10-06	Chien-Hsuan Han	Pharmaceutical dosage forms having controlled release properties that contain a GABAB receptor agonist
SE0401653D0 (sv)	2004-06-24	2004-06-24	Astrazeneca Ab	New compounds
US7494985B2 (en) *	2004-11-03	2009-02-24	Xenoport, Inc.	Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
US7566738B2 (en) *	2004-11-03	2009-07-28	Xenoport, Inc.	Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2006071186A1 (en) *	2004-12-27	2006-07-06	Astrazeneca Ab	Use of gabab receptor agonists
BRPI0620415A2 (pt) *	2005-12-23	2011-11-08	Astrazeneca Ab	composto e sais farmaceuticamente e farmacologicamente aceitáveis do mesmo, e enantiÈmeros do composto e sais do mesmo, composição farmaceutica, e, uso de um composto opcionalmente em combinação com um agonista do receptor de gabab, e, métodos para o tratamento de doença, de um distúrbio, e de sìndrome
EP1968947A1 (de)	2005-12-23	2008-09-17	AstraZeneca AB	Modulatoren des gaba-b-rezeptors
BRPI0620372A2 (pt)	2005-12-23	2011-11-08	Astrazeneca Ab	composto, composição farmaceutica, e, uso de um composto
CA2632020A1 (en) *	2005-12-23	2007-06-28	Astrazeneca Ab	Imidazoles as gaba-b receptor modulators
CN101374824A (zh) *	2005-12-23	2009-02-25	阿斯利康(瑞典)有限公司	杂环gaba-b调节剂
US7585996B2 (en) *	2006-09-15	2009-09-08	Xenoport, Inc.	Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
NZ578204A (en)	2006-12-22	2012-05-25	Ironwood Pharmaceuticals Inc	Compositions comprising bile acid sequestrants for treating esophageal disorders
WO2008086492A1 (en) *	2007-01-11	2008-07-17	Xenoport, Inc.	Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment
EP2146996A4 (de) *	2007-04-18	2011-08-03	Astrazeneca Ab	Xanthinverbindungen mit einem positiven allosterischen gabab-rezeptormodulatoreffekt
TW200908957A (en) *	2007-06-15	2009-03-01	Xenoport Inc	Use of prodrugs of GABA analogs, antispasticity agents, and prodrugs of GABAB receptor agonists for treating spasticity
CN101743011A (zh) *	2007-07-25	2010-06-16	阿斯利康(瑞典)有限公司	(3-氨基-2-氟丙基)次膦酸用于治疗非糜烂性反流病的用途
US20090118365A1 (en) *	2007-11-06	2009-05-07	Xenoport, Inc	Use of Prodrugs of GABA B Agonists for Treating Neuropathic and Musculoskeletal Pain
US7868043B2 (en)	2008-01-25	2011-01-11	Xenoport, Inc.	Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
US7872046B2 (en) *	2008-01-25	2011-01-18	Xenoport, Inc.	Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
TWI369202B (en) *	2008-01-25	2012-08-01	Xenoport Inc	Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
US20100137442A2 (en) *	2008-02-01	2010-06-03	Xenoport, Inc.	Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment
US8993639B2 (en) *	2008-03-20	2015-03-31	Burt Shulman	Compound and method for treatment of gastroesophageal reflux
US8299291B2 (en) *	2008-08-07	2012-10-30	Xenoport, Inc.	Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
US7989641B2 (en)	2008-08-07	2011-08-02	Xenoport, Inc.	Methods of synthesizing N-hydroxysuccinimidyl carbonates
CN102341099A (zh) *	2009-03-03	2012-02-01	什诺波特有限公司	R-巴氯芬前药的持续释放口服剂型
CA2758245A1 (en) *	2009-04-17	2010-10-21	Xenoport, Inc.	Gamma-amino-butyric acid derivatives as gabab receptor ligands
WO2011113904A1 (en)	2010-03-17	2011-09-22	INSERM (Institut National de la Santé et de la Recherche Médicale)	Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
US8580850B2 (en)	2011-08-11	2013-11-12	Xenoport, Inc.	Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
CA2874737A1 (en)	2012-06-01	2013-12-05	Lynn Health Science Institute, Inc.	Use of baclofen to treat insomnia
EP3755314A1 (de) *	2018-02-22	2020-12-30	Diamyd Medical AB	Gaba-a-rezeptoragonisten zur behandlung von erkrankungen, die durch dysfunktion von beta-zellen beeinflusst werden
TW202412754A (zh) *	2022-06-07	2024-04-01	瑞士商意梭凱普公司	應用於食道黏膜的包含逆流抑制劑的藥物傳遞系統

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1996
- 1996-09-18 SE SE9603408A patent/SE9603408D0/xx unknown
1997
- 1997-09-04 ZA ZA9707969A patent/ZA977969B/xx unknown
- 1997-09-04 AR ARP970104051A patent/AR007747A1/es unknown
- 1997-09-12 TW TW086113275A patent/TW548104B/zh not_active IP Right Cessation
- 1997-09-12 ID IDP973172A patent/ID19621A/id unknown
- 1997-09-15 TR TR1999/00591T patent/TR199900591T2/xx unknown
- 1997-09-15 SI SI9730594T patent/SI0936906T1/xx unknown
- 1997-09-15 KR KR1019997002239A patent/KR100553294B1/ko not_active IP Right Cessation
- 1997-09-15 AU AU44064/97A patent/AU714370B2/en not_active Ceased
- 1997-09-15 DK DK97942346T patent/DK0936906T3/da active
- 1997-09-15 NZ NZ504244A patent/NZ504244A/xx not_active IP Right Cessation
- 1997-09-15 DE DE69724809T patent/DE69724809T2/de not_active Expired - Lifetime
- 1997-09-15 KR KR1020057018539A patent/KR100568659B1/ko not_active IP Right Cessation
- 1997-09-15 EP EP03013667A patent/EP1344524B1/de not_active Expired - Lifetime
- 1997-09-15 HU HU9903825A patent/HU224968B1/hu not_active IP Right Cessation
- 1997-09-15 SI SI9730749T patent/SI1344524T1/sl unknown
- 1997-09-15 US US08/952,400 patent/US6117908A/en not_active Expired - Lifetime
- 1997-09-15 AT AT97942346T patent/ATE249212T1/de active
- 1997-09-15 AT AT03013667T patent/ATE334700T1/de active
- 1997-09-15 NZ NZ334495A patent/NZ334495A/xx not_active IP Right Cessation
- 1997-09-15 UA UA99031298A patent/UA61081C2/uk unknown
- 1997-09-15 ES ES97942346T patent/ES2206749T3/es not_active Expired - Lifetime
- 1997-09-15 RU RU99107969/14A patent/RU2199316C2/ru not_active IP Right Cessation
- 1997-09-15 JP JP51458198A patent/JP4098832B2/ja not_active Expired - Fee Related
- 1997-09-15 DE DE69736445T patent/DE69736445T2/de not_active Expired - Lifetime
- 1997-09-15 WO PCT/SE1997/001555 patent/WO1998011885A1/en active Application Filing
- 1997-09-15 PT PT03013667T patent/PT1344524E/pt unknown
- 1997-09-15 CA CA002265615A patent/CA2265615C/en not_active Expired - Fee Related
- 1997-09-15 IL IL12896197A patent/IL128961A/en not_active IP Right Cessation
- 1997-09-15 BR BR9711400A patent/BR9711400A/pt not_active Application Discontinuation
- 1997-09-15 CZ CZ0093099A patent/CZ299997B6/cs not_active IP Right Cessation
- 1997-09-15 DK DK03013667T patent/DK1344524T3/da active
- 1997-09-15 EP EP97942346A patent/EP0936906B1/de not_active Expired - Lifetime
- 1997-09-15 SK SK305-99A patent/SK285744B6/sk not_active IP Right Cessation
- 1997-09-15 PL PL97332497A patent/PL190028B1/pl not_active IP Right Cessation
- 1997-09-15 ES ES03013667T patent/ES2268227T3/es not_active Expired - Lifetime
- 1997-09-15 CN CN97199600A patent/CN1117560C/zh not_active Expired - Fee Related
- 1997-09-15 EE EEP199900095A patent/EE03952B1/xx not_active IP Right Cessation
- 1997-09-15 PT PT97942346T patent/PT936906E/pt unknown
- 1997-09-16 MY MYPI97004296A patent/MY122020A/en unknown
- 1997-10-27 SA SA97180522A patent/SA97180522B1/ar unknown
1999
- 1999-03-15 IS IS5001A patent/IS2329B/is unknown
- 1999-03-17 NO NO19991287A patent/NO326837B1/no not_active IP Right Cessation
2000
- 2000-02-24 HK HK00101114A patent/HK1022100A1/xx not_active IP Right Cessation
- 2000-09-08 US US09/658,242 patent/US6664069B1/en not_active Expired - Fee Related
2003
- 2003-12-23 HK HK03109347A patent/HK1057004A1/xx not_active IP Right Cessation
2007
- 2007-03-19 IS IS8623A patent/IS2538B/is unknown

Also Published As

Publication number	Publication date
KR100568659B1 (ko)	2006-04-07
ZA977969B (en)	1998-03-18
EP1344524A1 (de)	2003-09-17
NZ334495A (en)	2000-09-29
IL128961A0 (en)	2000-02-17
US6664069B1 (en)	2003-12-16
TW548104B (en)	2003-08-21
PL190028B1 (pl)	2005-10-31
ES2268227T3 (es)	2007-03-16
EP1344524B1 (de)	2006-08-02
KR20000036185A (ko)	2000-06-26
BR9711400A (pt)	1999-08-17
HK1057004A1 (en)	2004-03-12
SI1344524T1 (sl)	2006-12-31
HK1022100A1 (en)	2000-07-28
CZ93099A3 (cs)	1999-09-15
ATE334700T1 (de)	2006-08-15
DK1344524T3 (da)	2006-10-30
MY122020A (en)	2006-03-31
AR007747A1 (es)	1999-11-10
SE9603408D0 (sv)	1996-09-18
IS2329B (is)	2008-01-15
UA61081C2 (uk)	2003-11-17
KR100553294B1 (ko)	2006-02-22
EP0936906A1 (de)	1999-08-25
PT1344524E (pt)	2006-11-30
SA97180522B1 (ar)	2006-04-04
AU714370B2 (en)	1999-12-23
NZ504244A (en)	2000-09-29
PT936906E (pt)	2003-12-31
IS2538B (is)	2009-09-15
DE69724809T2 (de)	2004-07-15
NO991287D0 (no)	1999-03-17
NO991287L (no)	1999-03-17
JP2001501604A (ja)	2001-02-06
KR20050101237A (ko)	2005-10-20
CN1117560C (zh)	2003-08-13
EE03952B1 (et)	2003-02-17
NO326837B1 (no)	2009-02-23
HUP9903825A2 (hu)	2001-05-28
HU224968B1 (en)	2006-04-28
SK30599A3 (en)	2000-01-18
CA2265615C (en)	2007-01-30
TR199900591T2 (xx)	1999-07-21
JP4098832B2 (ja)	2008-06-11
IL128961A (en)	2004-08-31
AU4406497A (en)	1998-04-14
DK0936906T3 (da)	2003-11-24
EP0936906B1 (de)	2003-09-10
DE69736445T2 (de)	2007-03-15
IS5001A (is)	1999-03-15
RU2199316C2 (ru)	2003-02-27
ES2206749T3 (es)	2004-05-16
CA2265615A1 (en)	1998-03-26
CZ299997B6 (cs)	2009-01-14
EE9900095A (et)	1999-10-15
US6117908A (en)	2000-09-12
ID19621A (id)	1998-07-23
HUP9903825A3 (en)	2001-06-28
WO1998011885A1 (en)	1998-03-26
DE69724809D1 (de)	2003-10-16
IS8623A (is)	2007-03-19
ATE249212T1 (de)	2003-09-15
PL332497A1 (en)	1999-09-13
CN1237105A (zh)	1999-12-01
SI0936906T1 (en)	2004-02-29
SK285744B6 (sk)	2007-07-06

Publication	Publication Date	Title
ATE334700T1 (de)	2006-08-15	Refluxinhibitoren
FI963597L (fi)	1996-11-14	Isoprenyylitransferaasi-inhibiittoreita
NO972930D0 (no)	1997-06-23	Fibronectin-adhesjonsinhibitorer
FI972160A0 (fi)	1997-05-21	Matriisimetalloproteaasi-inhibiittorit
ID19198A (id)	1998-06-28	Inhibitor metaloprotease heterosiklik
DK1004669T3 (da)	2007-08-27	Hidtil ukendte differentieringsinhibitor
NO20002121D0 (no)	2000-04-26	Benzotiazol-protein-tyrosin-kinaseinhibitorer
DK1027332T3 (da)	2004-10-04	Hidtil ukendte lactametalloproteaseinhibitorer
ID18416A (id)	1998-04-09	Inhibitor metaloprotease diheterosiklik
DK0958287T3 (da)	2003-01-20	Sulfamidmetalloprotease-inhibitorer
ID18141A (id)	1998-03-05	Inhibitor metaloprotease 1,3-diheterosiklik
LV12150A (lv)	1998-10-20	Farneziltransferazes inhibitori
ID18995A (id)	1998-05-28	Amida-amida inhibitor apo b-sekresi/mtp
ATE268781T1 (de)	2004-06-15	Thrombininhibitoren
NO20003256D0 (no)	2000-06-22	ACE inhibitor-MMP inhibitor kombinasjoner
ID18417A (id)	1998-04-09	Inhibitor ditentat metaloprotease
FI971156L (fi)	1997-03-19	5alfa-reduktaasi-inhibiittoreita
DE69733263D1 (de)	2005-06-16	Markierte elastase-inhibitoren
ATE252547T1 (de)	2003-11-15	Matrixmetalloproteinaseinhibitoren
FI964781L (fi)	1997-01-29	Uusia elastaasi-inhibiittoreita
ATE282629T1 (de)	2004-12-15	Thrombininhibitoren
PT948483E (pt)	2002-08-30	Inibidores da farnesil-transferase
DE69720957T2 (de)	2004-01-29	Ace-hemmer
BR9610514A (pt)	1999-03-30	Inibidores cicloantihelmínticos
EP1007548A4 (de)	2002-07-03	Tsetse-thrombin inhibitor

Legal Events

Date	Code	Title	Description
2007-08-23	8364	No opposition during term of opposition