DE69711669D1 - VERFAHREN ZUR HERSTELLUNG VON d,1-ALPHA-TOCOPHEROL - Google Patents

VERFAHREN ZUR HERSTELLUNG VON d,1-ALPHA-TOCOPHEROL

Info

Publication number: DE69711669D1
Authority: DE; Germany
Prior art keywords: tocopherol; alpha; producing
Prior art date: 1996-11-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69711669T

Other languages

English (en)

Other versions

DE69711669T2 (de

Inventor

Marcel Baak

Werner Bonrath

Horst Pauling

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

DSM IP Assets BV

Original Assignee

HOFFMANN LA ROCHE

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-11

Filing date

1997-11-10

Publication date

2002-05-08

1997-11-10 Application filed by HOFFMANN LA ROCHE, F Hoffmann La Roche AG filed Critical HOFFMANN LA ROCHE

2002-05-08 Publication of DE69711669D1 publication Critical patent/DE69711669D1/de

2002-10-02 Application granted granted Critical

2002-10-02 Publication of DE69711669T2 publication Critical patent/DE69711669T2/de

2017-11-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DE69711669T 1996-11-11 1997-11-10 VERFAHREN ZUR HERSTELLUNG VON d,1-ALPHA-TOCOPHEROL Expired - Lifetime DE69711669T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96118037		1996-11-11
PCT/EP1997/006227 WO1998021197A2 (en)	1996-11-11	1997-11-10	PROCESS FOR MANUFACTURING d,l-α-TOCOPHEROL

Publications (2)

Publication Number	Publication Date
DE69711669D1 true DE69711669D1 (de)	2002-05-08
DE69711669T2 DE69711669T2 (de)	2002-10-02

Family

ID=8223387

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69711669T Expired - Lifetime DE69711669T2 (de)	1996-11-11	1997-11-10	VERFAHREN ZUR HERSTELLUNG VON d,1-ALPHA-TOCOPHEROL

Country Status (8)

Country	Link
US (1)	US5908939A (de)
EP (1)	EP0937055B1 (de)
JP (1)	JP2001504111A (de)
CN (1)	CN1105714C (de)
DE (1)	DE69711669T2 (de)
DK (1)	DK0937055T3 (de)
ES (1)	ES2173500T3 (de)
WO (1)	WO1998021197A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458373B1 (en)	1997-01-07	2002-10-01	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
US7030155B2 (en)	1998-06-05	2006-04-18	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
FR2784104B1 (fr) *	1998-09-18	2002-12-27	Rhone Poulenc Nutrition Animal	Procede de preparation de la vitamine e
CA2288851A1 (en) *	1998-11-11	2000-05-11	F. Hoffmann-La Roche Ag	Process for manufacturing d,i-alpha-tocopherol
EP1000940A1 (de) *	1998-11-11	2000-05-17	F. Hoffmann-La Roche Ag	Verfahren zur Herstellung von d,l-alpha-Tocopherol
KR100452291B1 (ko) *	1999-12-14	2004-10-08	에스케이 주식회사	고수율 및 고순도로 ＤＬ-α-토코페롤를 제조하는 방법
US6369242B2 (en) *	2000-03-17	2002-04-09	Roche Vitamins Inc.	Tocopherol manufacture by tris(perfluorohydrocarbylsulphonyl) methane or metal methides thereof
DK1180517T3 (da) *	2000-08-18	2003-11-17	Roche Vitamins Ag	Fremgangsmåde til fremstilling af (all-rac)-alfa-tocopherol
KR20030093236A (ko)	2001-03-12	2003-12-06	더 퀸즈 유니버시티 오브 벨파스트	금속 비스-트리플이미드 화합물 및 이를 합성하는 방법
KR20030092107A (ko) *	2001-04-24	2003-12-03	메사추세츠 인스티튜트 오브 테크놀로지	탄소-헤테로원자 및 탄소-탄소 결합을 형성하는 구리-촉매방법
WO2003051812A1 (en) *	2001-12-14	2003-06-26	Dsm Ip Assets B.V.	Manufacture of trimethylhydroquinone diacylates
JP2005534700A (ja)	2002-08-02	2005-11-17	マサチューセッツ　インスティテュート　オブ　テクノロジー	銅触媒による炭素−ヘテロ原子および炭素−炭素結合の形成
ES2347552T3 (es) *	2003-01-13	2010-11-02	Dsm Ip Assets B.V.	Proceso para la fabricacion de acetato de alfa-tocoferilo.
CN100355745C (zh) *	2005-03-18	2007-12-19	清华大学	离子液体催化合成D,L－α－生育酚的方法
FR2889519B1 (fr) *	2005-08-04	2008-07-11	Rhodia Chimie Sa	Procede de c-alkylation de composes aromatiques hydroxyles avec un catalyseur de type tfsih
EP2050743A1 (de) *	2007-10-19	2009-04-22	Humboldt-Universität zu Berlin	Verfahren zur Synthese von Dl.(alpha)-Tocopherol und Mittel dafür
US8226850B1 (en) *	2009-09-22	2012-07-24	Clemson University Research Foundation	Thermally enhanced oxygen scavengers including a transition metal and a free radical scavenger
CN102276572B (zh) *	2011-09-14	2013-03-27	重庆大学	一种制备维生素e乙酸酯的方法
CN102285955B (zh) *	2011-09-14	2012-12-05	重庆大学	一种α-生育酚乙酸酯的制备方法
US9469620B2 (en)	2012-12-21	2016-10-18	Rhodia Operations	Process for forming a primary, a secondary or a tertiary amine via a direct amination reaction
CN104936941A (zh) *	2012-12-21	2015-09-23	罗地亚经营管理公司	用于经由直接胺化反应形成伯胺、仲胺或叔胺的方法
CN108017610B (zh) *	2017-12-22	2020-11-06	浙江新和成药业有限公司	一种维生素e的制备方法
CN108409704A (zh) *	2018-01-24	2018-08-17	上海优合生物科技有限公司	一种高纯度生育酚琥珀酸酯盐的制备方法
CN109705082B (zh) *	2018-12-19	2021-04-20	万华化学集团股份有限公司	一种制备维生素e乙酸酯的方法
CN113321669B (zh) *	2020-02-28	2023-03-24	中国科学院上海有机化学研究所	一种磺酰亚胺类金属盐、其制备方法及应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2723278A (en) *	1954-01-25	1955-11-08	Hoffmann La Roche	Preparation of alpha-tocopherol
GB1148652A (en) *	1965-07-20	1969-04-16	Dunlop Co Ltd	Polymer compositions comprising polymerized episulphides and a process for the preparation of reaction products of polymerized episulphides
US3459773A (en) *	1966-12-27	1969-08-05	Takasago Perfumery Co Ltd	Process for producing alpha-tocopherol and its esters
CH547278A (de) *	1971-01-11	1974-03-29	Hoffmann La Roche	Verfahren zur herstellung von chromanderivaten.
US4208334A (en) *	1978-12-22	1980-06-17	Hoffmann-La Roches Inc.	Process for preparation of α-tocopherol
US4634781A (en) *	1982-09-30	1987-01-06	Basf Corporation	Alpha tocopherol process
FR2637284B1 (fr) *	1988-10-05	1991-07-05	Elf Aquitaine	Methode de synthese de sulfonylimidures
DE4243464A1 (de) *	1992-12-22	1994-06-23	Basf Ag	Verfahren zur Herstellung von alpha-Tocopherol und alpha-Tocopherylacetat in flüssigem oder überkritischem Kohlendioxid
WO1994014794A1 (en) *	1992-12-28	1994-07-07	Yoshitomi Pharmaceutical Industries, Ltd.	8-methoxyquinolonecarboxylic acid derivative
US5526821A (en) *	1993-06-03	1996-06-18	Medical Biopsy, Inc.	Biopsy needle with sample retaining means
JP3848380B2 (ja) *	1993-12-14	2006-11-22	エーザイ・アール・アンド・ディー・マネジメント株式会社	α−トコフェロール誘導体の製造法
JP3166959B2 (ja) *	1994-03-11	2001-05-14	セントラル硝子株式会社	ルイス酸触媒
DE4425609A1 (de) *	1994-07-20	1996-01-25	Bayer Ag	Benzofuranyl- und Benzothienyloxazolidinone
JP3117369B2 (ja) *	1994-09-12	2000-12-11	セントラル硝子株式会社	スルホンイミドの製造方法
DE59610172D1 (de) *	1996-01-05	2003-04-03	Hoffmann La Roche	Verfahren zur Herstellung von d,l-alpha-Tocopherol in Gegenwart einer Perfluoralkylensulfonsäure als Katalysator

1997
- 1997-10-16 US US08/951,273 patent/US5908939A/en not_active Expired - Lifetime
- 1997-11-10 ES ES97950150T patent/ES2173500T3/es not_active Expired - Lifetime
- 1997-11-10 CN CN97199633A patent/CN1105714C/zh not_active Expired - Lifetime
- 1997-11-10 EP EP97950150A patent/EP0937055B1/de not_active Expired - Lifetime
- 1997-11-10 DK DK97950150T patent/DK0937055T3/da active
- 1997-11-10 WO PCT/EP1997/006227 patent/WO1998021197A2/en not_active Application Discontinuation
- 1997-11-10 JP JP52215398A patent/JP2001504111A/ja not_active Ceased
- 1997-11-10 DE DE69711669T patent/DE69711669T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK0937055T3 (da)	2002-07-29
ES2173500T3 (es)	2002-10-16
US5908939A (en)	1999-06-01
EP0937055B1 (de)	2002-04-03
CN1105714C (zh)	2003-04-16
JP2001504111A (ja)	2001-03-27
WO1998021197A3 (en)	1998-07-23
CN1237163A (zh)	1999-12-01
WO1998021197A2 (en)	1998-05-22
DE69711669T2 (de)	2002-10-02
EP0937055A2 (de)	1999-08-25

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DE69801489D1 (de)	2001-10-04	Verfahren zur herstellung von 1,1,1,3,3-pentafluorpropan
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DE69708544D1 (de)	2002-01-10	Verfahren zur herstellung von fluoromethyl-(1,1,1,3,3,3)-hexafluoroisopropylether
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DE59705109D1 (de)	2001-11-29	Verfahren zur herstellung von arylcyanaten
DE69726441D1 (de)	2004-01-08	Verfahren zur herstellung von 1,3-dioxolan-4-methanol-verbindungen
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DE69706976D1 (de)	2001-10-31	Kontinuierliches verfahren zur herstellung von hydrocarbylaluminoxanen
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DE69717115D1 (de)	2002-12-19	Verfahren zur herstellung von 1,1,1,3,3-pentafluorpropan
DE69724442D1 (de)	2003-10-02	Verfahren zur herstellung von 1,3-dioxolan-4-methanol-verbindungen
DE59905197D1 (de)	2003-05-28	Verfahren zur herstellung von hexandiol-1,6
ATE198318T1 (de)	2001-01-15	Verfahren zur herstellung von n-acetonylbenzamide
DE69711039D1 (de)	2002-04-18	Verfahren zur herstellung von 1,3-alkandiolen
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DE69708137D1 (de)	2001-12-13	Verfahren zur herstellung von difluormethan
DE69720077D1 (de)	2003-04-24	Verfahren zur herstellung von para-fluorphenol
DE59805432D1 (de)	2002-10-10	Verfahren zur herstellung von 2-cyclododecyl-1-propanol

Legal Events

Date	Code	Title	Description
2003-04-30	8364	No opposition during term of opposition
2004-08-26	8327	Change in the person/name/address of the patent owner	Owner name: DSM IP ASSETS B.V., TE HEERLEN, NL