DE69636597D1 - Endothelin rezeptor antagonisten - Google Patents

Endothelin rezeptor antagonisten

Info

Publication number: DE69636597D1
Authority: DE; Germany
Prior art keywords: receptor antagonists; endothelin receptor; endothelin; antagonists; receptor
Prior art date: 1995-08-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69636597T

Other languages

English (en)

Other versions

DE69636597T2 (de

Inventor

Ignacio Luengo

Duncan Elliott

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-02

Filing date

1996-08-02

Publication date

2006-11-16

1996-08-02 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

2006-11-16 Application granted granted Critical

2006-11-16 Publication of DE69636597D1 publication Critical patent/DE69636597D1/de

2007-08-16 Publication of DE69636597T2 publication Critical patent/DE69636597T2/de

2016-08-03 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

DE69636597T 1995-08-02 1996-08-02 Endothelin rezeptor antagonisten Expired - Fee Related DE69636597T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US179295P	1995-08-02	1995-08-02
US1792		1995-08-02
US1098296P	1996-02-01	1996-02-01
US10982		1996-02-01
PCT/US1996/012581 WO1997004772A1 (en)	1995-08-02	1996-08-02	Endothelin receptor antagonists

Publications (2)

Publication Number	Publication Date
DE69636597D1 true DE69636597D1 (de)	2006-11-16
DE69636597T2 DE69636597T2 (de)	2007-08-16

Family

ID=26669471

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69619116T Expired - Fee Related DE69619116T2 (de)	1995-08-02	1996-08-02	Endothelinrezeptorantagonisten
DE69636597T Expired - Fee Related DE69636597T2 (de)	1995-08-02	1996-08-02	Endothelin rezeptor antagonisten

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69619116T Expired - Fee Related DE69619116T2 (de)	1995-08-02	1996-08-02	Endothelinrezeptorantagonisten

Country Status (25)

Country	Link
US (5)	US5969151A (de)
EP (2)	EP0843551B1 (de)
JP (2)	JP2001517195A (de)
KR (1)	KR19990036032A (de)
CN (1)	CN1196680A (de)
AP (1)	AP9801182A0 (de)
AT (1)	ATE341324T1 (de)
AU (2)	AU6646396A (de)
BG (1)	BG102229A (de)
BR (1)	BR9609914A (de)
CA (2)	CA2228296A1 (de)
CZ (1)	CZ30498A3 (de)
DE (2)	DE69619116T2 (de)
EA (1)	EA000952B1 (de)
ES (2)	ES2171697T3 (de)
HU (1)	HU220776B1 (de)
MX (1)	MX9800975A (de)
NO (1)	NO980422L (de)
NZ (1)	NZ315846A (de)
OA (1)	OA10755A (de)
PL (1)	PL184272B1 (de)
RO (1)	RO115802B1 (de)
SK (1)	SK282584B6 (de)
TR (1)	TR199800152T1 (de)
WO (2)	WO1997004772A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CO5021171A1 (es)	1997-12-08	2001-03-27	Smithkline Beechman Corp	Sal de monoargininilo del acido(e)-3-(1-n-butil-5-(2-(2- carboxifenil)metoxi-4-clorofenil)-1h-pirazol-4-il)-2- ((5-metoxi-2,3-dihidrobenzofuran-5-il)metil)-prop-2-enoico
DE10155076A1 (de) *	2001-11-09	2003-05-22	Merck Patent Gmbh	Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
CA2489428A1 (en) *	2002-06-27	2004-01-08	Nitromed, Inc.	Cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2006075955A1 (en) *	2005-01-13	2006-07-20	Astrazeneca Ab	Pyrazolyl acylsulfonamide derivatives as endothelin converting enzyme inhibitors and useful in the treatment of chronic obstructive pulmonary disease
US7521435B2 (en) *	2005-02-18	2009-04-21	Pharma Diagnostics, N.V.	Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
US8012038B1 (en)	2008-12-11	2011-09-06	Taylor Made Golf Company, Inc.	Golf club head
US10086240B1 (en)	2015-08-14	2018-10-02	Taylor Made Golf Company, Inc.	Golf club head
US10626096B2 (en)	2015-11-24	2020-04-21	Sanford Burnham Prebys Medical Discovery Institute	Azole derivatives as apelin receptor agonist
US10773135B1 (en)	2019-08-28	2020-09-15	Taylor Made Golf Company, Inc.	Golf club head

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1937241A1 (de) *	1968-08-02	1970-02-19	Sumitomo Chemical Co	3,5-Dioxopyrazolidinderivate und Verfahren zu ihrer Herstellung
JPH01211582A (ja) *	1988-02-16	1989-08-24	Tanabe Seiyaku Co Ltd	ベンゾジオキソール誘導体
CA2018443A1 (en) *	1989-06-14	1990-12-14	Joseph A. Finkelstein	Imidazolyl-alkenoic acids
EP0563238B1 (de) *	1990-12-14	2002-05-22	Smithkline Beecham Corporation	Imidazolyl-alkencarbonsäuren
FR2682379B1 (fr) *	1991-10-09	1994-02-11	Rhone Poulenc Agrochimie	Nouveaux phenylpyrazoles fongicides.
WO1994022830A1 (en) *	1993-03-31	1994-10-13	Smithkline Beecham Corporation	Chemical compounds
ES2156157T3 (es) *	1993-08-18	2001-06-16	Banyu Pharma Co Ltd	Derivado de ciclopenteno heteroaromatico fusionado con una actividad antagonista de la endotelina.
IL111613A0 (en) *	1993-11-12	1995-01-24	Rhone Poulenc Rorer Ltd	Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them
JPH10505085A (ja) *	1994-09-02	1998-05-19	スミスクライン・ビーチャム・コーポレイション	エンドセリン受容体拮抗薬

1996
- 1996-08-02 DE DE69619116T patent/DE69619116T2/de not_active Expired - Fee Related
- 1996-08-02 ES ES96926243T patent/ES2171697T3/es not_active Expired - Lifetime
- 1996-08-02 JP JP50788797A patent/JP2001517195A/ja not_active Ceased
- 1996-08-02 KR KR1019980700697A patent/KR19990036032A/ko not_active Application Discontinuation
- 1996-08-02 CA CA002228296A patent/CA2228296A1/en not_active Abandoned
- 1996-08-02 CN CN96197111A patent/CN1196680A/zh active Pending
- 1996-08-02 ES ES96928036T patent/ES2273350T3/es not_active Expired - Lifetime
- 1996-08-02 AT AT96928036T patent/ATE341324T1/de not_active IP Right Cessation
- 1996-08-02 AU AU66463/96A patent/AU6646396A/en not_active Abandoned
- 1996-08-02 AU AU67645/96A patent/AU717172B2/en not_active Ceased
- 1996-08-02 WO PCT/US1996/012581 patent/WO1997004772A1/en active IP Right Grant
- 1996-08-02 TR TR1998/00152T patent/TR199800152T1/xx unknown
- 1996-08-02 MX MX9800975A patent/MX9800975A/es not_active IP Right Cessation
- 1996-08-02 SK SK113-98A patent/SK282584B6/sk unknown
- 1996-08-02 RO RO98-00135A patent/RO115802B1/ro unknown
- 1996-08-02 JP JP9507907A patent/JPH11511133A/ja not_active Ceased
- 1996-08-02 CZ CZ98304A patent/CZ30498A3/cs unknown
- 1996-08-02 HU HU9902817A patent/HU220776B1/hu not_active IP Right Cessation
- 1996-08-02 AP APAP/P/1998/001182A patent/AP9801182A0/en unknown
- 1996-08-02 NZ NZ315846A patent/NZ315846A/xx unknown
- 1996-08-02 PL PL96324745A patent/PL184272B1/pl not_active IP Right Cessation
- 1996-08-02 EP EP96926243A patent/EP0843551B1/de not_active Expired - Lifetime
- 1996-08-02 EP EP96928036A patent/EP0841925B1/de not_active Expired - Lifetime
- 1996-08-02 BR BR9609914A patent/BR9609914A/pt not_active Application Discontinuation
- 1996-08-02 WO PCT/US1996/012661 patent/WO1997004773A1/en active IP Right Grant
- 1996-08-02 EA EA199800185A patent/EA000952B1/ru not_active IP Right Cessation
- 1996-08-02 CA CA002228293A patent/CA2228293A1/en not_active Abandoned
- 1996-08-02 DE DE69636597T patent/DE69636597T2/de not_active Expired - Fee Related
1998
- 1998-01-28 OA OA9800014A patent/OA10755A/en unknown
- 1998-01-30 NO NO980422A patent/NO980422L/no not_active Application Discontinuation
- 1998-02-02 BG BG102229A patent/BG102229A/xx unknown
- 1998-07-23 US US09/121,545 patent/US5969151A/en not_active Expired - Fee Related
1999
- 1999-01-08 US US09/227,361 patent/US5958968A/en not_active Expired - Fee Related
- 1999-06-29 US US09/342,989 patent/US6096897A/en not_active Expired - Fee Related
- 1999-12-14 US US09/460,487 patent/US6353116B1/en not_active Expired - Fee Related
2001
- 2001-11-30 US US10/021,461 patent/US6482956B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69619116T2 (de)	2002-09-19
EA199800185A1 (ru)	1998-10-29
CA2228296A1 (en)	1997-02-13
ES2171697T3 (es)	2002-09-16
US6482956B2 (en)	2002-11-19
EP0841925A1 (de)	1998-05-20
AU717172B2 (en)	2000-03-16
HU220776B1 (hu)	2002-05-28
ES2273350T3 (es)	2007-05-01
NZ315846A (en)	1999-01-28
SK11398A3 (en)	1998-07-08
JP2001517195A (ja)	2001-10-02
PL324745A1 (en)	1998-06-08
AP9801182A0 (en)	1998-01-31
US6096897A (en)	2000-08-01
KR19990036032A (ko)	1999-05-25
HUP9902817A2 (hu)	1999-12-28
PL184272B1 (pl)	2002-09-30
US5969151A (en)	1999-10-19
NO980422L (no)	1998-03-24
CA2228293A1 (en)	1997-02-13
WO1997004773A1 (en)	1997-02-13
DE69636597T2 (de)	2007-08-16
BG102229A (en)	1998-09-30
SK282584B6 (sk)	2002-10-08
WO1997004772A1 (en)	1997-02-13
JPH11511133A (ja)	1999-09-28
CZ30498A3 (cs)	1998-07-15
EP0843551A4 (de)	1998-08-12
US5958968A (en)	1999-09-28
EP0841925A4 (de)	2001-10-17
ATE341324T1 (de)	2006-10-15
EP0843551B1 (de)	2002-02-06
TR199800152T1 (xx)	1998-05-21
RO115802B1 (ro)	2000-06-30
AU6764596A (en)	1997-02-26
HUP9902817A3 (en)	2001-03-28
DE69619116D1 (de)	2002-03-21
NO980422D0 (no)	1998-01-30
AU6646396A (en)	1997-02-26
CN1196680A (zh)	1998-10-21
MX9800975A (es)	1998-04-30
BR9609914A (pt)	1999-07-06
OA10755A (en)	2002-12-13
EA000952B1 (ru)	2000-08-28
EP0843551A1 (de)	1998-05-27
US6353116B1 (en)	2002-03-05
US20020072614A1 (en)	2002-06-13
EP0841925B1 (de)	2006-10-04

Publication	Publication Date	Title
FI960953L (fi)	1996-09-19	Endoteliinireseptoriantagonisteja
NO972016D0 (no)	1997-04-30	Indolyl-Y-reseptorantagonister
BR9407933A (pt)	1996-11-26	Antagonistas de receptores de endotelina
NO983001D0 (no)	1998-06-26	Vitronectin-reseptor-antagonister
NO983003D0 (no)	1998-06-26	Vitronectin-reseptor-antagonister
NO983002D0 (no)	1998-06-26	Vitronectin-reseptor-antagonister
DE69327720D1 (de)	2000-03-02	Endothelin rezeptor antagonisten
DE69734833D1 (de)	2006-01-12	Vitronektin rezeptor antagonisten
FI960516A0 (fi)	1996-02-05	Substituoituja bifenyylisulfonamidiendoteliiniantagonisteja
BR9406572A (pt)	1996-01-30	Antagonistas receptores do endotelin
DK0741133T3 (da)	2004-04-26	Adhæsionsreceptorantagonister
ID24726A (id)	2000-08-03	Antagonis-antagonis reseptor trombin
ID24162A (id)	2000-07-13	Antagonis-antagonis reseptor vitronektin
BR9507220A (pt)	1997-09-09	Antagonistas de receptores de endotelina
DE69636597D1 (de)	2006-11-16	Endothelin rezeptor antagonisten
NO972612D0 (no)	1997-06-06	Pyridazoner som endotelinreseptorantagonister
DE69616364D1 (de)	2001-11-29	Endothelinrezeptorantagonisten
HU9602054D0 (en)	1996-09-30	Endothelin receptor antagonists
EP0841926A4 (de)	1999-08-04	Endothelinrezeptorantagonist
BR9603432A (pt)	1998-05-12	Antagonistas de receptores de endotelina
EP0841916A4 (de)	2001-04-11	Endothelinrezeptorantagonisten
EP0868180A4 (de)	1999-08-04	Endothelinm rezeptor antogonisten
ZA966593B (en)	1997-03-24	Endothelin receptor antagonists
GB9510203D0 (en)	1995-07-12	Novel endothelin receptor antagonists

Legal Events

Date	Code	Title	Description
2007-11-29	8364	No opposition during term of opposition
2010-06-24	8339	Ceased/non-payment of the annual fee