DE69632726D1 - Verwendung von thiazerin-, oxazepin-, und diazepinverbindungen, zur hemmung von hiv, herpesvirus und zur unterdruckung der immunabwehr - Google Patents
Verwendung von thiazerin-, oxazepin-, und diazepinverbindungen, zur hemmung von hiv, herpesvirus und zur unterdruckung der immunabwehrInfo
- Publication number
- DE69632726D1 DE69632726D1 DE69632726T DE69632726T DE69632726D1 DE 69632726 D1 DE69632726 D1 DE 69632726D1 DE 69632726 T DE69632726 T DE 69632726T DE 69632726 T DE69632726 T DE 69632726T DE 69632726 D1 DE69632726 D1 DE 69632726D1
- Authority
- DE
- Germany
- Prior art keywords
- herpesvirus
- thiazerine
- oxazepine
- impress
- inhibit hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241001529453 unidentified herpesvirus Species 0.000 title abstract 2
- 150000004908 diazepines Chemical class 0.000 title 1
- 230000007124 immune defense Effects 0.000 title 1
- SFJGCXYXEFWEBK-UHFFFAOYSA-N oxazepine Chemical compound O1C=CC=CC=N1 SFJGCXYXEFWEBK-UHFFFAOYSA-N 0.000 title 1
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
- DHZYXWMZLAKTQV-UHFFFAOYSA-N diazepin-3-one Chemical class O=C1C=CC=CN=N1 DHZYXWMZLAKTQV-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- LKZKGRRDUWVNSR-UHFFFAOYSA-N oxazepin-3-one Chemical class O=C1NOC=CC=C1 LKZKGRRDUWVNSR-UHFFFAOYSA-N 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US408431 | 1995-03-22 | ||
| US08/408,431 US5612330A (en) | 1994-03-07 | 1995-03-22 | Methods for inhibiting and controlling viral growth |
| PCT/US1996/001098 WO1996029077A1 (en) | 1995-03-22 | 1996-01-26 | Use of thiazepine, oxazepine and diazepine coumpounds for inhibiting hiv, herpesvirus and suppressing the immune system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69632726D1 true DE69632726D1 (de) | 2004-07-22 |
| DE69632726T2 DE69632726T2 (de) | 2004-10-14 |
Family
ID=23616271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69632726T Expired - Fee Related DE69632726T2 (de) | 1995-03-22 | 1996-01-26 | Verwendung von thiazerin-, oxazepin-, und diazepinverbindungen, zur hemmung von hiv, herpesvirus und zur unterdruckung der immunabwehr |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5612330A (de) |
| EP (1) | EP0817635B1 (de) |
| JP (1) | JPH11502814A (de) |
| AT (1) | ATE269084T1 (de) |
| CA (1) | CA2211179A1 (de) |
| DE (1) | DE69632726T2 (de) |
| DK (1) | DK0817635T3 (de) |
| ES (1) | ES2222477T3 (de) |
| MX (1) | MX9705709A (de) |
| PT (1) | PT817635E (de) |
| WO (1) | WO1996029077A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612330A (en) * | 1994-03-07 | 1997-03-18 | Warner-Lambert Company | Methods for inhibiting and controlling viral growth |
| US6218103B1 (en) * | 1997-04-16 | 2001-04-17 | Arch Development Corporation | Herpes simplex virus US3 and ICP4 as inhibitors of apoptosis |
| CA2227688C (en) | 1998-01-16 | 2007-07-31 | James W. Critchfield | Methods and compositions for inhibition of viral replication |
| US7015212B1 (en) | 1999-05-12 | 2006-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Thiazepine inhibitors of HIV-1 integrase |
| AU2001281142A1 (en) * | 2000-08-16 | 2002-02-25 | Japan Tobacco Inc. | Diazepinones as antiviral agents |
| TW200607503A (en) * | 2004-05-17 | 2006-03-01 | Tibotec Pharm Ltd | 1-heterocyclyl-1, 5-dihydro-pyrido[3, 2-b]indol-2-ones |
| ATE479693T1 (de) | 2004-09-17 | 2010-09-15 | Idenix Pharmaceuticals Inc | Phosphoindole als hiv-inhibitoren |
| US7674822B2 (en) | 2004-11-24 | 2010-03-09 | Wyeth | PTP1b inhibitors |
| CN102731451B (zh) | 2006-06-27 | 2015-07-29 | 武田药品工业株式会社 | 稠环化合物 |
| US7960428B2 (en) | 2006-09-29 | 2011-06-14 | Idenix Pharmaceuticals, Inc. | Enantiomerically pure phosphoindoles as HIV inhibitors |
| CA2722211C (en) * | 2008-04-24 | 2017-02-14 | Indena S.P.A. | Compositions for the treatment of vaginal infections with chronic inflammation |
| US9840515B2 (en) | 2010-12-09 | 2017-12-12 | University of Pittsburgh—of the Commonwealth System of Higher Education | Protein kinase D inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4013641A (en) * | 1975-10-08 | 1977-03-22 | Xerox Corporation | Indolobenzoxazepines |
| AU5883794A (en) * | 1993-01-20 | 1994-08-15 | A. Menarini Industrie Farmaceutiche Riunite S.R.L. | Diazepin derivatives and antiviral compositions |
| US5489586A (en) * | 1994-03-07 | 1996-02-06 | Warner-Lambert Company | Method for treating inflammatory disease in humans |
| US5612330A (en) * | 1994-03-07 | 1997-03-18 | Warner-Lambert Company | Methods for inhibiting and controlling viral growth |
-
1995
- 1995-03-22 US US08/408,431 patent/US5612330A/en not_active Expired - Fee Related
-
1996
- 1996-01-26 EP EP96903713A patent/EP0817635B1/de not_active Expired - Lifetime
- 1996-01-26 DE DE69632726T patent/DE69632726T2/de not_active Expired - Fee Related
- 1996-01-26 PT PT96903713T patent/PT817635E/pt unknown
- 1996-01-26 MX MX9705709A patent/MX9705709A/es not_active IP Right Cessation
- 1996-01-26 JP JP8528389A patent/JPH11502814A/ja not_active Ceased
- 1996-01-26 WO PCT/US1996/001098 patent/WO1996029077A1/en not_active Ceased
- 1996-01-26 CA CA002211179A patent/CA2211179A1/en not_active Abandoned
- 1996-01-26 DK DK96903713T patent/DK0817635T3/da active
- 1996-01-26 AT AT96903713T patent/ATE269084T1/de not_active IP Right Cessation
- 1996-01-26 ES ES96903713T patent/ES2222477T3/es not_active Expired - Lifetime
- 1996-09-11 US US08/712,063 patent/US5703069A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996029077A1 (en) | 1996-09-26 |
| US5612330A (en) | 1997-03-18 |
| DE69632726T2 (de) | 2004-10-14 |
| PT817635E (pt) | 2004-10-29 |
| JPH11502814A (ja) | 1999-03-09 |
| ATE269084T1 (de) | 2004-07-15 |
| CA2211179A1 (en) | 1996-09-26 |
| MX9705709A (es) | 1997-10-31 |
| US5703069A (en) | 1997-12-30 |
| EP0817635B1 (de) | 2004-06-16 |
| DK0817635T3 (da) | 2004-09-27 |
| EP0817635A1 (de) | 1998-01-14 |
| ES2222477T3 (es) | 2005-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |