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DE69629474D1 - Antifungale tetrahydrofurane - Google Patents

Antifungale tetrahydrofurane

Info

Publication number
DE69629474D1
DE69629474D1 DE69629474T DE69629474T DE69629474D1 DE 69629474 D1 DE69629474 D1 DE 69629474D1 DE 69629474 T DE69629474 T DE 69629474T DE 69629474 T DE69629474 T DE 69629474T DE 69629474 D1 DE69629474 D1 DE 69629474D1
Authority
DE
Germany
Prior art keywords
ester
group
tetrahydrofurane
antifungal
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69629474T
Other languages
English (en)
Other versions
DE69629474T2 (de
Inventor
G Lovey
M Girijavallabhan
K Saksena
E Pike
Frank Bennet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69629474D1 publication Critical patent/DE69629474D1/de
Publication of DE69629474T2 publication Critical patent/DE69629474T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69629474T 1995-06-19 1996-06-17 Antifungale tetrahydrofurane Expired - Fee Related DE69629474T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30595P 1995-06-19 1995-06-19
US305P 1995-06-19
US59685296A 1996-02-05 1996-02-05
US596852 1996-02-05
PCT/US1996/009242 WO1997000255A1 (en) 1995-06-19 1996-06-17 Tetrahydrofuran antifungals

Publications (2)

Publication Number Publication Date
DE69629474D1 true DE69629474D1 (de) 2003-09-18
DE69629474T2 DE69629474T2 (de) 2004-06-24

Family

ID=26667465

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69629474T Expired - Fee Related DE69629474T2 (de) 1995-06-19 1996-06-17 Antifungale tetrahydrofurane

Country Status (10)

Country Link
EP (1) EP0837859B1 (de)
JP (1) JPH11507668A (de)
AT (1) ATE247108T1 (de)
AU (1) AU6257396A (de)
CA (1) CA2224707A1 (de)
DE (1) DE69629474T2 (de)
ES (1) ES2203707T3 (de)
IL (1) IL118668A0 (de)
MX (1) MX9710270A (de)
WO (1) WO1997000255A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0958289B1 (de) * 1997-02-11 2004-06-30 Janssen Pharmaceutica N.V. Azole enthaltende antifungale aminosäure-ester
EP0957101A1 (de) 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Wasserlösliche Azole als Breitspektrum-antifungus
MXPA01011117A (es) 1999-05-04 2002-06-04 Janssen Pharmaceutica Nv Eteres antifungicos.
US20100143455A1 (en) * 2008-09-08 2010-06-10 Nian Wu Triazole antifungal agents
BR112012029228A2 (pt) 2010-05-19 2021-08-03 Sandoz Ag processo para a preparação de um sal de cloreto de hidrogênio, sal de cloreto de hidrogênio, sal de cloreto de hidrogênio cristalino, uso de um sal e uso do processo
JP5956980B2 (ja) 2010-05-19 2016-07-27 サンド・アクチエンゲゼルシヤフト キラル化合物の調製の方法
BR112012029227B1 (pt) * 2010-05-19 2020-01-07 Sandoz Ag Processo para a preparação de um composto quiral, composto quiral e uso de um composto
WO2011144656A1 (en) * 2010-05-19 2011-11-24 Sandoz Ag Preparation of posaconazole intermediates
US9493428B2 (en) 2011-06-16 2016-11-15 Sandoz Ag Process for the preparation of a chiral compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
ES2159623T3 (es) * 1993-12-21 2001-10-16 Schering Corp Antifungicos de tetrahidrofurano.
PL181947B1 (en) * 1994-01-24 2001-10-31 Janssen Pharmaceutica Nv Water-soluble azole-type antimycotic agents

Also Published As

Publication number Publication date
IL118668A0 (en) 1996-10-16
AU6257396A (en) 1997-01-15
DE69629474T2 (de) 2004-06-24
WO1997000255A1 (en) 1997-01-03
CA2224707A1 (en) 1997-01-03
EP0837859B1 (de) 2003-08-13
MX9710270A (es) 1998-08-30
ES2203707T3 (es) 2004-04-16
ATE247108T1 (de) 2003-08-15
EP0837859A1 (de) 1998-04-29
JPH11507668A (ja) 1999-07-06

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee