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DE69616376D1 - Verwendung von Tiagabin zur Behandlung von Schlafstörungen - Google Patents

Verwendung von Tiagabin zur Behandlung von Schlafstörungen

Info

Publication number
DE69616376D1
DE69616376D1 DE69616376T DE69616376T DE69616376D1 DE 69616376 D1 DE69616376 D1 DE 69616376D1 DE 69616376 T DE69616376 T DE 69616376T DE 69616376 T DE69616376 T DE 69616376T DE 69616376 D1 DE69616376 D1 DE 69616376D1
Authority
DE
Germany
Prior art keywords
sleep disorders
tiagabin
treatment
sub
agonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69616376T
Other languages
English (en)
Other versions
DE69616376T2 (de
Inventor
Marike Lancel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7766768&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69616376(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften
Priority to DE69616376T priority Critical patent/DE69616376T2/de
Application granted granted Critical
Publication of DE69616376D1 publication Critical patent/DE69616376D1/de
Publication of DE69616376T2 publication Critical patent/DE69616376T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69616376T 1995-07-13 1996-07-10 Verwendung von Tiagabin zur Behandlung von Schlafstörungen Expired - Fee Related DE69616376T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69616376T DE69616376T2 (de) 1995-07-13 1996-07-10 Verwendung von Tiagabin zur Behandlung von Schlafstörungen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19525598A DE19525598C2 (de) 1995-07-13 1995-07-13 Schlafmittel
DE69616376T DE69616376T2 (de) 1995-07-13 1996-07-10 Verwendung von Tiagabin zur Behandlung von Schlafstörungen

Publications (2)

Publication Number Publication Date
DE69616376D1 true DE69616376D1 (de) 2001-11-29
DE69616376T2 DE69616376T2 (de) 2002-06-27

Family

ID=7766768

Family Applications (4)

Application Number Title Priority Date Filing Date
DE19525598A Expired - Fee Related DE19525598C2 (de) 1995-07-13 1995-07-13 Schlafmittel
DE69616375T Expired - Fee Related DE69616375T2 (de) 1995-07-13 1996-07-10 Nicht-allosterische GABA A Agonisten zur Behandlung von Schlafstörungen
DE69616376T Expired - Fee Related DE69616376T2 (de) 1995-07-13 1996-07-10 Verwendung von Tiagabin zur Behandlung von Schlafstörungen
DE69616333T Expired - Fee Related DE69616333T2 (de) 1995-07-13 1996-07-10 Thip zur behandlung von schlafstörungen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE19525598A Expired - Fee Related DE19525598C2 (de) 1995-07-13 1995-07-13 Schlafmittel
DE69616375T Expired - Fee Related DE69616375T2 (de) 1995-07-13 1996-07-10 Nicht-allosterische GABA A Agonisten zur Behandlung von Schlafstörungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69616333T Expired - Fee Related DE69616333T2 (de) 1995-07-13 1996-07-10 Thip zur behandlung von schlafstörungen

Country Status (12)

Country Link
US (1) US5929065A (de)
EP (3) EP0840601B1 (de)
JP (3) JP3754705B2 (de)
AT (3) ATE207349T1 (de)
AU (1) AU723954B2 (de)
CA (1) CA2226582C (de)
CL (1) CL2003002785A1 (de)
DE (4) DE19525598C2 (de)
DK (3) DK0867184T3 (de)
ES (3) ES2165990T3 (de)
PT (3) PT867178E (de)
WO (1) WO1997002813A1 (de)

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US5914333A (en) * 1996-07-31 1999-06-22 Novo Nordisk A/S Treatment of psychotic disorders
IE970588A1 (en) 1997-08-01 2000-08-23 Elan Corp Plc Controlled release pharmaceutical compositions containing tiagabine
EP0991409B1 (de) * 1997-08-01 2002-01-30 ELAN CORPORATION, Plc Tiagabinhaltige arzneizubereitungen mit gesteuerter wirkstoffverabreichung
AU7405000A (en) * 1999-09-28 2001-04-30 H. Lundbeck A/S Melt granulated composition and modified release dosage form prepared from said composition
DE60133389T2 (de) * 2000-06-26 2008-06-26 Warner-Lambert Company Llc Gabapentinanaloga für schlafstörungen
HUP0400051A2 (hu) * 2001-05-21 2004-04-28 H. Lundbeck A/S Gabodaxolt tartalmazó granulált készítmények és eljárás az előállításukra
SI1641456T1 (sl) 2003-06-25 2010-06-30 Lundbeck & Co As H Gaboksadol za zdravljenje depresije in drugih afektivnih motenj
AR045540A1 (es) 2003-09-05 2005-11-02 Lundbeck & Co As H Metodo de elaboracion de 4,5,6,7 tetrahidroisoxazol [5,4-c] piridin-3-ol (thip)
US20070032553A1 (en) * 2003-09-10 2007-02-08 Mckernan Ruth Use of gabaa receptor agonists for the treatment of hearing, vestibular and attention disorders, intention tremor and restless leg syndrome
ES2515092T3 (es) * 2003-12-11 2014-10-29 Sunovion Pharmaceuticals Inc. Combinación de un sedante y un modulador neurotransmisor y métodos de mejorar la calidad del sueño y de tratar la depresión
US20050137222A1 (en) * 2003-12-18 2005-06-23 H. Lundbeck A/S Treatment of insomnia in human patients
TW200528098A (en) * 2003-12-18 2005-09-01 Lundbeck & Co As H Treatment of insomnia in human patients
US20050215521A1 (en) * 2003-12-22 2005-09-29 Karim Lalji Modafinil combination therapy for improving sleep quality
US20050164987A1 (en) * 2003-12-24 2005-07-28 Barberich Timothy J. Melatonin combination therapy for improving sleep quality
GB0402118D0 (en) 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
WO2005079851A2 (en) * 2004-02-18 2005-09-01 Sepracor, Inc. Dopamine-agonist combination therapy with sedatives for improving sleep quality
US20080269278A1 (en) * 2004-04-02 2008-10-30 H. Lundbeck A/S Treatment of Impaired Respiratory Function with Gaboxadol
GB0417558D0 (en) * 2004-08-06 2004-09-08 Merck Sharp & Dohme Novel combination therapy
WO2006083682A2 (en) 2005-01-28 2006-08-10 H.Lundbeck A/S Polymorphic forms of a gabaa agonist
JP5380930B2 (ja) * 2007-07-24 2014-01-08 大正製薬株式会社 睡眠改善剤
PT3372229T (pt) 2014-06-06 2021-06-17 Ovid Therapeutics Inc Métodos para aumentar a inibição tónica e tratar a síndrome de angelman
CN107428776B (zh) 2015-03-24 2020-10-23 H.隆德贝克有限公司 制造4,5,6,7-四氢异噁唑并[5,4-c]吡啶-3-醇
US9682069B2 (en) 2015-07-17 2017-06-20 Ovid Therapeutics Inc Methods of treating Dravet syndrome
KR20180031721A (ko) 2015-07-17 2018-03-28 오비드 테라퓨틱스 인크. 가복사돌로 발달장애들을 치료하는 방법들
BR112019002538A2 (pt) 2016-08-11 2019-05-21 Ovid Therapeutics Inc. uso de uma composição farmacêutica compreendendo um modulador alostérico, uso de uma composição farmacêutica compreendendo garboxadol ou um sal farmaceuticamente aceitável do mesmo, e composição farmacêutica para a administração parenteral
US10071083B2 (en) 2017-02-03 2018-09-11 Ovid Therapeutics Inc Use of gaboxadol in the treatment of tinnitus
EP3648762A4 (de) 2017-08-04 2021-03-24 Ovid Therapeutics, Inc. Verwendung von gaboxadol bei der behandlung von diabetes und verwandten erkrankungen
AU2019345312A1 (en) 2018-09-20 2021-03-25 Ovid Therapeutics Inc. Use of gaboxadol for the treatment of tourette syndrome, tics and stuttering
US11123332B2 (en) 2018-11-21 2021-09-21 Certego Therapeutics Inc. Gaboxadol for reducing risk of suicide and rapid relief of depression
CN113382782A (zh) 2018-12-14 2021-09-10 雷蒙多·法西奥 武术训练装置
US11690829B2 (en) 2018-12-17 2023-07-04 Ovid Therapeutics Inc. Use of gaboxadol for the treatment of non-24 hour sleep-wake disorder
US11364228B2 (en) 2019-12-18 2022-06-21 Ovid Therapeutics Inc. Gaboxadol for therapeutic treatment of 1p36 deletion syndrome
WO2021236876A2 (en) 2020-05-20 2021-11-25 Certego Therapeutics Inc. Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders
KR102773472B1 (ko) * 2021-05-21 2025-02-27 한국식품연구원 구릿대 추출물을 유효성분으로 포함하는 수면장애 또는 불면증의 예방, 개선 또는 치료용 조성물
WO2023015395A1 (en) * 2021-08-11 2023-02-16 Psyched Wellness Ltd. Amanita muscaria extracts and compounds and their beneficial and therapeutic use

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US4362731A (en) * 1980-09-01 1982-12-07 Sandoz Ltd. Myotonolytic use of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridin-3-ol and derivatives thereof
US4786647A (en) * 1986-06-30 1988-11-22 University Of Florida Method for eliciting anxiolysis
US5167228A (en) * 1987-06-26 1992-12-01 Brigham And Women's Hospital Assessment and modification of endogenous circadian phase and amplitude
US5192550A (en) * 1990-05-07 1993-03-09 Alza Corporation Dosage form for treating central nervous system disorders
US5185446A (en) * 1990-09-04 1993-02-09 Neurogen Corporation Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
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US6077839A (en) * 1992-03-19 2000-06-20 Allergan Sales, Inc. Method for reducing intraocular pressure in the mammalian eye by administration of gamma aminobutyric acid (GABA) agonists

Also Published As

Publication number Publication date
DK0867178T3 (da) 2002-02-18
EP0867178B1 (de) 2001-10-24
ES2166110T3 (es) 2002-04-01
DK0840601T3 (da) 2002-02-18
JP3754705B2 (ja) 2006-03-15
DE19525598C2 (de) 1997-09-25
JPH11509194A (ja) 1999-08-17
CA2226582C (en) 2008-02-19
DE69616376T2 (de) 2002-06-27
DE69616375T2 (de) 2002-07-11
DE19525598A1 (de) 1997-01-16
DE69616375D1 (de) 2001-11-29
ATE207352T1 (de) 2001-11-15
EP0840601A1 (de) 1998-05-13
DK0867184T3 (da) 2002-02-18
ATE207356T1 (de) 2001-11-15
AU6613796A (en) 1997-02-10
ATE207349T1 (de) 2001-11-15
JP2005047925A (ja) 2005-02-24
PT867178E (pt) 2002-04-29
ES2166111T3 (es) 2002-04-01
WO1997002813A1 (en) 1997-01-30
EP0867184B1 (de) 2001-10-24
US5929065A (en) 1999-07-27
EP0840601B1 (de) 2001-10-24
CL2003002785A1 (es) 2005-04-08
AU723954B2 (en) 2000-09-07
ES2165990T3 (es) 2002-04-01
EP0867178A1 (de) 1998-09-30
DE69616333T2 (de) 2002-07-04
JP2009057382A (ja) 2009-03-19
PT840601E (pt) 2002-04-29
EP0867184A1 (de) 1998-09-30
PT867184E (pt) 2002-04-29
CA2226582A1 (en) 1997-01-30
DE69616333D1 (de) 2001-11-29

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee