DE69612671D1 - Butyrat-medikamentvorstufen der milchsäure - Google Patents
Butyrat-medikamentvorstufen der milchsäureInfo
- Publication number
- DE69612671D1 DE69612671D1 DE69612671T DE69612671T DE69612671D1 DE 69612671 D1 DE69612671 D1 DE 69612671D1 DE 69612671 T DE69612671 T DE 69612671T DE 69612671 T DE69612671 T DE 69612671T DE 69612671 D1 DE69612671 D1 DE 69612671D1
- Authority
- DE
- Germany
- Prior art keywords
- lactic acid
- butyrate
- methods
- agents
- alone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title abstract 4
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 title abstract 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000004310 lactic acid Substances 0.000 title abstract 2
- 235000014655 lactic acid Nutrition 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000003211 malignant effect Effects 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 208000011580 syndromic disease Diseases 0.000 abstract 2
- 108010044495 Fetal Hemoglobin Proteins 0.000 abstract 1
- 108091005886 Hemoglobin subunit gamma Proteins 0.000 abstract 1
- 102100038617 Hemoglobin subunit gamma-2 Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000005980 beta thalassemia Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 208000034737 hemoglobinopathy Diseases 0.000 abstract 1
- 208000018337 inherited hemoglobinopathy Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
- C07C69/68—Lactic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US540345 | 1995-10-06 | ||
| US08/540,345 US5883123A (en) | 1995-10-06 | 1995-10-06 | Butyrate prodrugs derived from lactic acid |
| US08/640,260 US5912269A (en) | 1996-04-30 | 1996-04-30 | Butyrate prodrugs derived from lactic acid |
| US640260 | 1996-04-30 | ||
| PCT/US1996/015660 WO1997012855A1 (en) | 1995-10-06 | 1996-09-30 | Butyrate prodrugs of lactic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69612671D1 true DE69612671D1 (de) | 2001-06-07 |
| DE69612671T2 DE69612671T2 (de) | 2004-08-05 |
Family
ID=27066414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69612671T Expired - Lifetime DE69612671T2 (de) | 1995-10-06 | 1996-09-30 | Butyrat-medikamentvorstufen der milchsäure |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0863866B1 (de) |
| JP (1) | JPH11512743A (de) |
| KR (1) | KR19990063988A (de) |
| CN (1) | CN1201447A (de) |
| AT (1) | ATE200893T1 (de) |
| AU (1) | AU718983B2 (de) |
| BR (1) | BR9610850A (de) |
| CA (1) | CA2233606A1 (de) |
| DE (1) | DE69612671T2 (de) |
| DK (1) | DK0863866T3 (de) |
| ES (1) | ES2158351T3 (de) |
| GR (1) | GR3035899T3 (de) |
| HK (1) | HK1016153A1 (de) |
| IN (1) | IN181999B (de) |
| NZ (1) | NZ319877A (de) |
| PT (1) | PT863866E (de) |
| RU (1) | RU2175967C2 (de) |
| TW (1) | TW422834B (de) |
| WO (1) | WO1997012855A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880152A (en) * | 1995-10-06 | 1999-03-09 | Vertex Pharmaceuticals, Inc. | Butyrate prodrugs derived from lactic acid |
| US6225350B1 (en) | 1998-03-10 | 2001-05-01 | Vertex Pharmaceuticals, Inc. | Butyrate prodrugs derived from lactic acid |
| US6878361B2 (en) | 2001-07-10 | 2005-04-12 | Battelle Memorial Institute | Production of stable aqueous dispersions of carbon nanotubes |
| US6896864B2 (en) | 2001-07-10 | 2005-05-24 | Battelle Memorial Institute | Spatial localization of dispersed single walled carbon nanotubes into useful structures |
| DE60304989T2 (de) * | 2003-02-18 | 2007-03-29 | Clinique La Prairie Research S.A. | Zusammensetzungen enthaltend fötales Hämoglobin und bakterielles Endotoxin und fakultativ zusätzliche fötale Leberkomponenten |
| WO2005011696A1 (en) * | 2003-08-01 | 2005-02-10 | Fibrogen, Inc. | Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE277700C (de) * | ||||
| GB603189A (en) * | 1945-10-22 | 1948-06-10 | Howards & Sons Ltd | Manufacture of acyloxy-carboxylic acids |
| DE824041C (de) * | 1945-10-22 | 1951-12-10 | Howards & Sons Ltd | Verfahren zur Herstellung von aliphatischen a -Acyloxymonocarbonsaeuren |
| US2464992A (en) * | 1946-10-10 | 1949-03-22 | Chessie E Rehberg | Esters of acyloxycarboxylic acids |
| FR1578064A (de) * | 1968-05-20 | 1969-08-14 | ||
| NL9200481A (nl) * | 1992-03-13 | 1993-10-01 | Univ Groningen | Farmaceutisch preparaat met plaatsgerichte afgifte. |
| JPH08113795A (ja) * | 1994-10-14 | 1996-05-07 | T Hasegawa Co Ltd | 香料組成物 |
-
1996
- 1996-09-30 BR BR9610850A patent/BR9610850A/pt not_active Application Discontinuation
- 1996-09-30 AT AT96933967T patent/ATE200893T1/de not_active IP Right Cessation
- 1996-09-30 CN CN96197978A patent/CN1201447A/zh active Pending
- 1996-09-30 KR KR1019980702463A patent/KR19990063988A/ko not_active Application Discontinuation
- 1996-09-30 ES ES96933967T patent/ES2158351T3/es not_active Expired - Lifetime
- 1996-09-30 DE DE69612671T patent/DE69612671T2/de not_active Expired - Lifetime
- 1996-09-30 PT PT96933967T patent/PT863866E/pt unknown
- 1996-09-30 JP JP9514352A patent/JPH11512743A/ja not_active Ceased
- 1996-09-30 EP EP96933967A patent/EP0863866B1/de not_active Expired - Lifetime
- 1996-09-30 RU RU98108450/04A patent/RU2175967C2/ru not_active IP Right Cessation
- 1996-09-30 AU AU72498/96A patent/AU718983B2/en not_active Ceased
- 1996-09-30 DK DK96933967T patent/DK0863866T3/da active
- 1996-09-30 WO PCT/US1996/015660 patent/WO1997012855A1/en not_active Application Discontinuation
- 1996-09-30 NZ NZ319877A patent/NZ319877A/en unknown
- 1996-09-30 CA CA002233606A patent/CA2233606A1/en not_active Abandoned
- 1996-10-04 IN IN1755CA1996 patent/IN181999B/en unknown
- 1996-10-05 TW TW085112196A patent/TW422834B/zh not_active IP Right Cessation
-
1999
- 1999-03-16 HK HK99101097A patent/HK1016153A1/xx not_active IP Right Cessation
-
2001
- 2001-05-18 GR GR20010400754T patent/GR3035899T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0863866A1 (de) | 1998-09-16 |
| BR9610850A (pt) | 1999-07-13 |
| TW422834B (en) | 2001-02-21 |
| GR3035899T3 (en) | 2001-08-31 |
| CN1201447A (zh) | 1998-12-09 |
| ATE200893T1 (de) | 2001-05-15 |
| HK1016153A1 (en) | 1999-10-29 |
| PT863866E (pt) | 2001-09-28 |
| AU7249896A (en) | 1997-04-28 |
| IN181999B (de) | 1998-11-28 |
| NZ319877A (en) | 1999-09-29 |
| DK0863866T3 (da) | 2001-06-11 |
| WO1997012855A1 (en) | 1997-04-10 |
| RU2175967C2 (ru) | 2001-11-20 |
| KR19990063988A (ko) | 1999-07-26 |
| JPH11512743A (ja) | 1999-11-02 |
| ES2158351T3 (es) | 2001-09-01 |
| CA2233606A1 (en) | 1997-04-10 |
| AU718983B2 (en) | 2000-05-04 |
| EP0863866B1 (de) | 2001-05-02 |
| DE69612671T2 (de) | 2004-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TR200000481T2 (tr) | N-Alkonoilfenilalenin türevleri. | |
| DE69310634D1 (de) | Verwendung von Taxol zur Herstellung eines Arzneimittels zur Behandlung von Krebs | |
| HK1097449A1 (en) | Methods for in vivo delivery of biologics and compositions useful therefor | |
| TR200101124T2 (tr) | N-(2-aril-propiyonil)-sülfonamidler ve bunları içeren farmasötik preparasyonlar. | |
| ATE219363T1 (de) | Lösliche prodrugs von paclitaxel | |
| IT1203515B (it) | Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono | |
| HK160995A (en) | Complex compounds of bioflavonoids with phospholipids their preparation and use and pharmaceutical and cosmetic compositions containing them | |
| ATE215094T1 (de) | Komplement verwandte proteine und kohlenhydrate enthaltende zusammensetzungen und methoden zur herstellung und verwendung dieser zusammensetzungen | |
| BG101118A (en) | Therapeutical compounds | |
| IL112111A (en) | Peptides having growth hormone releasing properties and pharmaceutical compositions containing them | |
| EP0902789A4 (de) | ||
| DE69635670D1 (de) | Threitol-buttersäureester-enthaltende zusammensetzungen und ihre verwendung | |
| PT809437E (pt) | Tiois para promover crescimento de celulas progenitoras hematopoieticas | |
| IL108707A0 (en) | Vpr function and activity | |
| PL323363A1 (en) | Biaromatic propynyl or dienyl compounds | |
| IL126235A (en) | Compounds with growth hormone releasing properties, pharmaceutical compositions comprising them and their use | |
| DE69807672D1 (de) | Von milchsäure abgeleitete butyrat-prodrugs | |
| DE69612671D1 (de) | Butyrat-medikamentvorstufen der milchsäure | |
| DE69314586D1 (de) | Arzneimittelzusammensetzung enthaltend TCF-II | |
| UA32157A (uk) | Спосіб лікування діабетичної ретинопатії |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted |