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DE69611315D1 - 5-Substituierte-3-(1,2,3,6-Tetrahydropyridin-4-yl) und 3-(Piperidin-4-yl)-1H-indole: 5-HT1F Agonisten - Google Patents

5-Substituierte-3-(1,2,3,6-Tetrahydropyridin-4-yl) und 3-(Piperidin-4-yl)-1H-indole: 5-HT1F Agonisten

Info

Publication number
DE69611315D1
DE69611315D1 DE69611315T DE69611315T DE69611315D1 DE 69611315 D1 DE69611315 D1 DE 69611315D1 DE 69611315 T DE69611315 T DE 69611315T DE 69611315 T DE69611315 T DE 69611315T DE 69611315 D1 DE69611315 D1 DE 69611315D1
Authority
DE
Germany
Prior art keywords
tetrahydropyridin
indoles
piperidin
substituted
ht1f agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69611315T
Other languages
English (en)
Other versions
DE69611315T2 (de
Inventor
James Edmund Audia
Bruce Anthony Dressmann
James Joseph Droste
James Erwin Fritz
Stephen Warren Kaldor
Daniel James Koch
Krushinski, Jr
Dennis Charles Thompson
Jeffrey Scott Nissen
Vincent Patrick Rocco
John Mehnert Schaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69611315D1 publication Critical patent/DE69611315D1/de
Publication of DE69611315T2 publication Critical patent/DE69611315T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69611315T 1995-03-20 1996-03-19 5-Substituierte-3-(1,2,3,6-Tetrahydropyridin-4-yl) und 3-(Piperidin-4-yl)-1H-indole: 5-HT1F Agonisten Expired - Fee Related DE69611315T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40755395A 1995-03-20 1995-03-20

Publications (2)

Publication Number Publication Date
DE69611315D1 true DE69611315D1 (de) 2001-02-01
DE69611315T2 DE69611315T2 (de) 2001-05-31

Family

ID=23612560

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69611315T Expired - Fee Related DE69611315T2 (de) 1995-03-20 1996-03-19 5-Substituierte-3-(1,2,3,6-Tetrahydropyridin-4-yl) und 3-(Piperidin-4-yl)-1H-indole: 5-HT1F Agonisten

Country Status (25)

Country Link
US (2) US5708008A (de)
EP (1) EP0733628B9 (de)
JP (1) JPH11502816A (de)
KR (1) KR19980703048A (de)
CN (1) CN1184425A (de)
AR (1) AR002971A1 (de)
AT (1) ATE198332T1 (de)
AU (1) AU702322B2 (de)
BR (1) BR9601061A (de)
CA (1) CA2215322A1 (de)
CZ (1) CZ288897A3 (de)
DE (1) DE69611315T2 (de)
DK (1) DK0733628T3 (de)
EA (1) EA001113B1 (de)
ES (1) ES2153078T3 (de)
GR (1) GR3035487T3 (de)
HU (1) HUP9800417A3 (de)
MX (1) MX9706969A (de)
NO (1) NO974220L (de)
NZ (1) NZ305166A (de)
PL (1) PL322843A1 (de)
PT (1) PT733628E (de)
SI (1) SI0733628T1 (de)
TR (1) TR199700993T1 (de)
WO (1) WO1996029075A1 (de)

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TWI826514B (zh) 2018-09-04 2023-12-21 美商美國禮來大藥廠 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥
TWI829107B (zh) 2019-07-09 2024-01-11 美商美國禮來大藥廠 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備
CN113336633B (zh) * 2021-05-14 2022-12-06 武汉工程大学 一种5-羟基-2-萘满酮的合成方法
CN113233964A (zh) * 2021-05-14 2021-08-10 武汉工程大学 一种5-甲氧基-2-萘满酮的合成方法
CN114539120A (zh) * 2022-03-09 2022-05-27 台州学院 一种吲哚类钾离子通道激动剂的制备方法

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Also Published As

Publication number Publication date
SI0733628T1 (en) 2001-06-30
NZ305166A (en) 1998-12-23
US5708008A (en) 1998-01-13
AR002971A1 (es) 1998-05-27
EP0733628B1 (de) 2000-12-27
AU5311296A (en) 1996-10-08
AU702322B2 (en) 1999-02-18
DE69611315T2 (de) 2001-05-31
PT733628E (pt) 2001-06-29
KR19980703048A (ko) 1998-09-05
CZ288897A3 (cs) 1998-02-18
BR9601061A (pt) 1998-01-06
CA2215322A1 (en) 1996-09-26
EA199700251A1 (ru) 1998-04-30
CN1184425A (zh) 1998-06-10
TR199700993T1 (xx) 1998-03-21
ATE198332T1 (de) 2001-01-15
NO974220L (no) 1997-11-04
EP0733628A1 (de) 1996-09-25
WO1996029075A1 (en) 1996-09-26
GR3035487T3 (en) 2001-05-31
HUP9800417A2 (hu) 1999-06-28
EP0733628B9 (de) 2002-06-12
NO974220D0 (no) 1997-09-12
MX9706969A (es) 1997-11-29
PL322843A1 (en) 1998-02-16
JPH11502816A (ja) 1999-03-09
HUP9800417A3 (en) 2001-04-28
ES2153078T3 (es) 2001-02-16
US5962474A (en) 1999-10-05
EA001113B1 (ru) 2000-10-30
DK0733628T3 (da) 2001-02-05

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