DE69605430D1 - Chinolin-2-on derivate als serotonin antagonisten - Google Patents

Chinolin-2-on derivate als serotonin antagonisten

Info

Publication number: DE69605430D1
Authority: DE; Germany
Prior art keywords: chinolin; derivatives; serotonin antagonists; serotonin; antagonists
Prior art date: 1995-09-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69605430T

Other languages

English (en)

Other versions

DE69605430T2 (de

Inventor

Cort Gary Mc

Christian Hoornaert

Genevieve Dellac

Michel Aletru

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Synthelabo SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-15

Filing date

1996-09-12

Publication date

2000-01-05

1995-09-15 Priority claimed from FR9510815A external-priority patent/FR2738822B1/fr

1995-09-21 Priority claimed from FR9511083A external-priority patent/FR2739100B1/fr

1996-09-12 Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA

2000-01-05 Publication of DE69605430D1 publication Critical patent/DE69605430D1/de

2000-07-13 Application granted granted Critical

2000-07-13 Publication of DE69605430T2 publication Critical patent/DE69605430T2/de

2016-09-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE69605430T 1995-09-15 1996-09-12 Chinolin-2-on derivate als serotonin antagonisten Expired - Lifetime DE69605430T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9510815A FR2738822B1 (fr)	1995-09-15	1995-09-15	Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
FR9511083A FR2739100B1 (fr)	1995-09-21	1995-09-21	Derives de 4-(omega-(4-(4-fluorobenzoyl)piperidin-1-yl)- alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
PCT/FR1996/001401 WO1997010238A1 (fr)	1995-09-15	1996-09-12	Derives de quinolein-2(1h)-one comme antagonistes de la serotonine

Publications (2)

Publication Number	Publication Date
DE69605430D1 true DE69605430D1 (de)	2000-01-05
DE69605430T2 DE69605430T2 (de)	2000-07-13

Family

ID=26232206

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69605430T Expired - Lifetime DE69605430T2 (de)	1995-09-15	1996-09-12	Chinolin-2-on derivate als serotonin antagonisten

Country Status (29)

Country	Link
US (1)	US5958924A (de)
EP (1)	EP0850235B1 (de)
JP (1)	JP3335362B2 (de)
KR (1)	KR100422850B1 (de)
CN (1)	CN1094490C (de)
AR (1)	AR003996A1 (de)
AT (1)	ATE187172T1 (de)
AU (1)	AU715879B2 (de)
BG (1)	BG63779B1 (de)
BR (1)	BR9610579A (de)
CA (1)	CA2228038C (de)
CO (1)	CO4750663A1 (de)
CZ (1)	CZ288149B6 (de)
DE (1)	DE69605430T2 (de)
DK (1)	DK0850235T3 (de)
EE (1)	EE04116B1 (de)
ES (1)	ES2142089T3 (de)
GR (1)	GR3032618T3 (de)
HU (1)	HU222745B1 (de)
IL (1)	IL123600A (de)
NO (1)	NO323841B1 (de)
NZ (1)	NZ318436A (de)
PL (1)	PL184808B1 (de)
RU (1)	RU2167874C2 (de)
SI (1)	SI0850235T1 (de)
SK (1)	SK282222B6 (de)
TR (1)	TR199800464T1 (de)
UA (1)	UA44332C2 (de)
WO (1)	WO1997010238A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3335362B2 (ja) *	1995-09-15	2002-10-15	サノフィ―サンテラボ	キノレイン−２（１ｈ）−オン誘導体セロトニンアンタゴニスト
FR2761071B1 (fr) *	1997-03-20	1999-12-03	Synthelabo	Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
FR2761067B1 (fr) *	1997-03-20	1999-04-23	Synthelabo	Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique
FR2797874B1 (fr) *	1999-08-27	2002-03-29	Adir	Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE60119894D1 (de) *	2000-01-20	2006-06-29	Eisai Co Ltd	Piperidinverbindungen und diese enthaltenden medikamente
FR2812548B1 (fr) *	2000-08-01	2002-09-20	Sanofi Synthelabo	Utilisation de derives de quinolein-2(1h)-one ou un de leurs sels pharmaceutiquement acceptable pour la preparation d'un medicament destine au traitement de l'insuffisance renale
RU2267485C2 (ru) *	2003-10-07	2006-01-10	Общество С Ограниченной Ответственностью "Асинэкс Медхим"	Производные 3-аминометилхинолона-2 в качестве ингибиторов no-синтетазы и способ их получения, биологически активные соединения и фармацевтическая композиция на их основе
RU2284325C2 (ru) *	2003-12-17	2006-09-27	Общество С Ограниченной Ответственностью "Асинэкс Медхим"	Производные фенил-3-аминометил-хинолона-2 в качестве ингибиторов no-синтетазы, способ их получения, биологически активные соединения и фармацевтическая композиция на их основе
GB0420722D0 (en)	2004-09-17	2004-10-20	Addex Pharmaceuticals Sa	Novel allosteric modulators
TWI320783B (en)	2005-04-14	2010-02-21	Otsuka Pharma Co Ltd	Heterocyclic compound
TWI417095B (zh)	2006-03-15	2013-12-01	Janssen Pharmaceuticals Inc	１，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
FR2909670B1 (fr) *	2006-12-12	2010-07-30	Sanofi Aventis	Derive fluore de quinoleine-2(1h)-one,son procede de preparation et son utilisation comme intermediaire de synthese
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en)	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
ATE516272T1 (de)	2007-09-14	2011-07-15	Ortho Mcneil Janssen Pharm	1,3-disubstituierte 4-(aryl-x-phenyl)-1h-pyridin- 2-one
US9114138B2 (en)	2007-09-14	2015-08-25	Janssen Pharmaceuticals, Inc.	1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones
CN102143955B (zh)	2008-09-02	2013-08-14	Omj制药公司	作为代谢型谷氨酸受体调节剂的3-氮杂二环[3.1.0]己烷衍生物
MX2011003500A (es) *	2008-10-02	2011-05-02	Taisho Pharma Co Ltd	Derivado de 7-piperidinoalquil-3,4-dihidroquinolona.
CA2744138C (en)	2008-11-28	2015-08-11	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
CN102439008B (zh)	2009-05-12	2015-04-29	杨森制药有限公司	1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
NZ596053A (en)	2009-05-12	2013-05-31	Janssen Pharmaceuticals Inc	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US9271967B2 (en)	2010-11-08	2016-03-01	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
US9012448B2 (en)	2010-11-08	2015-04-21	Janssen Pharmaceuticals, Inc.	1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
EP2661435B1 (de)	2010-11-08	2015-08-19	Janssen Pharmaceuticals, Inc.	1,2,4-triazol[4,3-a]pyridinderivate und ihre verwendung als positive allosterische mglur2-rezeptormodulatoren
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR102461134B1 (ko)	2014-01-21	2022-10-28	얀센 파마슈티카 엔.브이.	대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
LT3431106T (lt)	2014-01-21	2021-02-10	Janssen Pharmaceutica Nv	Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
MA44007A (fr)	2016-02-05	2018-12-19	Denali Therapeutics Inc	Inhibiteurs du récepteur interagissant avec protéine kinase 1
ES2912295T3 (es)	2016-12-09	2022-05-25	Denali Therapeutics Inc	Compuestos útiles como inhibidores de RIPK1
CN108707109A (zh) *	2018-08-29	2018-10-26	常州沃腾化工科技有限公司	一种2-甲氧基-4-三氟甲基吡啶-3-磺酰氯的制备方法
AU2023206890A1 (en)	2022-01-12	2024-08-22	Denali Therapeutics Inc.	Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2345422C2 (de) *	1973-09-08	1983-12-22	Dr. Karl Thomae Gmbh, 7950 Biberach	Substituierte Isochinolyl-arylpiperazine diese enthaltende Arzneimittel sowie Verfahren zu deren Herstellung
NL8001369A (nl) *	1980-03-06	1981-10-01	Acf Chemiefarma Nv	Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen.
IT1155357B (it) *	1982-07-06	1987-01-28	Ravizza Spa	Processo per la preparazione della kentanserina
CA1278792C (en) *	1985-05-06	1991-01-08	Joseph P. Yevich	Antipsychotic fused-ring pyridinylpiperazine derivatives
KR910006138B1 (ko) *	1986-09-30	1991-08-16	에자이 가부시끼가이샤	환상아민 유도체
FR2644786B1 (fr) *	1989-03-21	1993-12-31	Adir Cie	Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
RU1774624C (ru) *	1990-11-11	1995-02-09	Украинская фармацевтическая академия	Диэтиламиноэтиламида 1-пропил-2-оксо-4-гидроксихинолин-3-карбоновой кислоты гидрохлорид, проявляющий анестезирующую, противоаритмическую, антиоксидантную, антимикробную и фунгицидную активность
US5457099A (en) *	1992-07-02	1995-10-10	Sawai Pharmaceutical Co., Ltd.	Carbostyril derivatives and antiallergic agent
JP3335362B2 (ja) *	1995-09-15	2002-10-15	サノフィ―サンテラボ	キノレイン−２（１ｈ）−オン誘導体セロトニンアンタゴニスト

1996
- 1996-09-12 JP JP51170797A patent/JP3335362B2/ja not_active Expired - Fee Related
- 1996-09-12 KR KR10-1998-0701920A patent/KR100422850B1/ko not_active Expired - Fee Related
- 1996-09-12 IL IL12360096A patent/IL123600A/en not_active IP Right Cessation
- 1996-09-12 DE DE69605430T patent/DE69605430T2/de not_active Expired - Lifetime
- 1996-09-12 AR ARP960104322A patent/AR003996A1/es active IP Right Grant
- 1996-09-12 AT AT96931112T patent/ATE187172T1/de active
- 1996-09-12 TR TR1998/00464T patent/TR199800464T1/xx unknown
- 1996-09-12 CA CA002228038A patent/CA2228038C/en not_active Expired - Fee Related
- 1996-09-12 WO PCT/FR1996/001401 patent/WO1997010238A1/fr active IP Right Grant
- 1996-09-12 SK SK346-98A patent/SK282222B6/sk not_active IP Right Cessation
- 1996-09-12 DK DK96931112T patent/DK0850235T3/da active
- 1996-09-12 CZ CZ1998786A patent/CZ288149B6/cs not_active IP Right Cessation
- 1996-09-12 CN CN96198333A patent/CN1094490C/zh not_active Expired - Fee Related
- 1996-09-12 NZ NZ318436A patent/NZ318436A/xx not_active IP Right Cessation
- 1996-09-12 HU HU9802940A patent/HU222745B1/hu not_active IP Right Cessation
- 1996-09-12 BR BR9610579A patent/BR9610579A/pt not_active Application Discontinuation
- 1996-09-12 CO CO96048698A patent/CO4750663A1/es unknown
- 1996-09-12 PL PL96325467A patent/PL184808B1/pl not_active IP Right Cessation
- 1996-09-12 ES ES96931112T patent/ES2142089T3/es not_active Expired - Lifetime
- 1996-09-12 UA UA98031235A patent/UA44332C2/uk unknown
- 1996-09-12 EE EE9800089A patent/EE04116B1/xx not_active IP Right Cessation
- 1996-09-12 US US09/011,482 patent/US5958924A/en not_active Expired - Lifetime
- 1996-09-12 EP EP96931112A patent/EP0850235B1/de not_active Expired - Lifetime
- 1996-09-12 AU AU69919/96A patent/AU715879B2/en not_active Ceased
- 1996-09-12 SI SI9630151T patent/SI0850235T1/xx unknown
- 1996-09-12 RU RU98106501/04A patent/RU2167874C2/ru not_active IP Right Cessation
1998
- 1998-03-11 BG BG102316A patent/BG63779B1/bg unknown
- 1998-03-13 NO NO19981141A patent/NO323841B1/no not_active IP Right Cessation
2000
- 2000-02-09 GR GR20000400317T patent/GR3032618T3/el unknown

Also Published As

Publication number	Publication date
JP3335362B2 (ja)	2002-10-15
HUP9802940A3 (en)	2001-11-28
AR003996A1 (es)	1998-09-30
AU715879B2 (en)	2000-02-10
CA2228038A1 (en)	1997-03-20
BG63779B1 (bg)	2002-12-29
EP0850235B1 (de)	1999-12-01
PL325467A1 (en)	1998-07-20
HUP9802940A2 (hu)	1999-05-28
MX9802028A (es)	1998-09-30
UA44332C2 (uk)	2002-02-15
WO1997010238A1 (fr)	1997-03-20
JPH11514982A (ja)	1999-12-21
AU6991996A (en)	1997-04-01
CZ78698A3 (cs)	1998-06-17
KR100422850B1 (ko)	2004-07-23
NO981141L (no)	1998-05-15
HU222745B1 (hu)	2003-09-29
CN1094490C (zh)	2002-11-20
SI0850235T1 (en)	2000-04-30
EE9800089A (et)	1998-10-15
BR9610579A (pt)	1999-07-06
CO4750663A1 (es)	1999-03-31
BG102316A (en)	1999-03-31
NZ318436A (en)	1999-02-25
ES2142089T3 (es)	2000-04-01
HK1014868A1 (en)	1999-10-08
EP0850235A1 (de)	1998-07-01
DE69605430T2 (de)	2000-07-13
US5958924A (en)	1999-09-28
DK0850235T3 (da)	2000-05-29
GR3032618T3 (en)	2000-05-31
TR199800464T1 (xx)	1998-05-21
NO981141D0 (no)	1998-03-13
CN1202168A (zh)	1998-12-16
KR19990044666A (ko)	1999-06-25
IL123600A (en)	2001-05-20
EE04116B1 (et)	2003-08-15
CA2228038C (en)	2009-04-21
SK282222B6 (sk)	2001-12-03
PL184808B1 (pl)	2002-12-31
CZ288149B6 (en)	2001-05-16
ATE187172T1 (de)	1999-12-15
NO323841B1 (no)	2007-07-09
SK34698A3 (en)	1998-08-05
RU2167874C2 (ru)	2001-05-27
IL123600A0 (en)	1998-10-30

Publication	Publication Date	Title
DE69605430D1 (de)	2000-01-05	Chinolin-2-on derivate als serotonin antagonisten
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