DE69535641D1 - Morphogene protein-spezifische zelloberflächenrezeptoren und ihre verwendungen - Google Patents
Morphogene protein-spezifische zelloberflächenrezeptoren und ihre verwendungenInfo
- Publication number
- DE69535641D1 DE69535641D1 DE69535641T DE69535641T DE69535641D1 DE 69535641 D1 DE69535641 D1 DE 69535641D1 DE 69535641 T DE69535641 T DE 69535641T DE 69535641 T DE69535641 T DE 69535641T DE 69535641 D1 DE69535641 D1 DE 69535641D1
- Authority
- DE
- Germany
- Prior art keywords
- morphogen
- methods
- cell surface
- surface receptors
- identifying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010001857 Cell Surface Receptors Proteins 0.000 title abstract 3
- 102000006240 membrane receptors Human genes 0.000 title abstract 3
- 230000000921 morphogenic effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 102000005962 receptors Human genes 0.000 abstract 4
- 108020003175 receptors Proteins 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 2
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 abstract 1
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
- G01N33/567—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23642894A | 1994-04-29 | 1994-04-29 | |
| PCT/US1995/005467 WO1995030003A2 (en) | 1994-04-29 | 1995-04-28 | Morphogenic protein-specific cell surface receptors and uses therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69535641D1 true DE69535641D1 (de) | 2007-12-27 |
Family
ID=22889467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69535641T Expired - Lifetime DE69535641D1 (de) | 1994-04-29 | 1995-04-28 | Morphogene protein-spezifische zelloberflächenrezeptoren und ihre verwendungen |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US5863738A (de) |
| EP (1) | EP0756628B1 (de) |
| JP (1) | JPH10511840A (de) |
| AT (1) | ATE378407T1 (de) |
| AU (1) | AU702163B2 (de) |
| CA (1) | CA2187902A1 (de) |
| DE (1) | DE69535641D1 (de) |
| WO (1) | WO1995030003A2 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316217B1 (en) * | 1992-11-17 | 2001-11-13 | Ludwig Institute For Cancer Research | Activin receptor-like kinases, proteins having serine threonine kinase domains and polynucleotides encoding same |
| US5968752A (en) * | 1995-08-14 | 1999-10-19 | Creative Biomolecules, Inc. | Method for identifying an OP-1 analog which binds an ALK-1 receptor |
| US20040002117A1 (en) * | 1998-02-12 | 2004-01-01 | Hogan Patrick G. | Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases |
| DK1131087T4 (da) † | 1998-11-13 | 2009-08-03 | Stryker Corp | Lindring af prostatacancersymptomer |
| EP1721979B1 (de) | 1998-11-27 | 2010-09-15 | Ucb, S.A. | Zusammensetzungen und Verfahren zur Erhöhung der Knochenmineralisierung |
| US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| AU2002217843A1 (en) * | 2000-11-06 | 2002-05-15 | Thrasos, Inc. | Computer method and apparatus for classifying objects |
| CA2431552A1 (en) * | 2000-11-06 | 2002-05-16 | Thrasos, Inc. | Screening methods for bone morphogenetic mimetics |
| ATE349554T1 (de) * | 2001-10-31 | 2007-01-15 | Alcon Inc | Knochen-morphogene proteine (bmp), bmp-rezeptoren und bmp-bindungsproteine und ihre verwendung bei der diagnose und behandlung des glaukoms |
| AU2003221841A1 (en) | 2002-04-03 | 2003-10-27 | Celltech R And D, Inc. | Association of polymorphisms in the sost gene region with bone mineral density |
| MEP2808A (xx) | 2003-06-16 | 2010-02-10 | Celltech R & D Inc | Antitijela specifična za sklerositin i metode za povećanje mineralizacije kostiju |
| US8410246B2 (en) | 2004-06-17 | 2013-04-02 | Thrasos, Inc. | TDF-related compounds and analogs thereof |
| US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| EP3117833B1 (de) * | 2005-07-19 | 2019-01-23 | Stemgen S.P.A. | Hemmung des tumorerzeugenden potentials von tumor-stammzellen durch lif |
| WO2007035872A2 (en) | 2005-09-20 | 2007-03-29 | Thrasos Therapeutics, Inc. | Tdf-related compounds and analogs thereof |
| US8067562B2 (en) * | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
| SG10201509620SA (en) * | 2005-11-23 | 2015-12-30 | Acceleron Pharma Inc | Activin-actriia antagonists and uses for promoting bone growth |
| US8859752B2 (en) | 2006-04-18 | 2014-10-14 | The Trustees Of The University Of Pennsylvania | SIRNA-based therapy of Fibrodyplasia Ossificans Progressiva (FOP) |
| WO2007123896A2 (en) * | 2006-04-18 | 2007-11-01 | The Trustees Of The University Of Pennsylvania | Mutated acvr1 for diagnosis and treatment of fibrodyplasia ossificans progressiva (fop) |
| US9610327B2 (en) | 2007-03-06 | 2017-04-04 | Amgen Inc. | Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof |
| TW201718635A (zh) | 2007-03-06 | 2017-06-01 | 安美基公司 | 變異之活動素受體多肽及其用途 |
| US8501678B2 (en) | 2007-03-06 | 2013-08-06 | Atara Biotherapeutics, Inc. | Variant activin receptor polypeptides and uses thereof |
| ES2449753T3 (es) * | 2007-03-19 | 2014-03-21 | National Research Council Of Canada | Proteínas de fusión que comprenden dos dominios de unión tgf-beta |
| CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
| SG10201703067QA (en) | 2008-11-26 | 2017-05-30 | Amgen Inc | Variants Of Activin IIB Receptor Polypeptides And Uses Thereof |
| BRPI1014858A2 (pt) | 2009-03-30 | 2017-03-28 | Acceleron Pharma Inc | "antagonistas de bmp-alk3 e usos para promover o crescimento ósseo" |
| WO2014121221A1 (en) | 2013-02-01 | 2014-08-07 | Santa Maria Biotherapeutics, Inc. | Administration of an anti-activin-a compound to a subject |
| SMT202000095T1 (it) | 2010-05-14 | 2020-03-13 | Amgen Inc | Formulazioni di anticorpi anti-sclerostina ad alta concentrazione |
| CN103649118A (zh) | 2011-03-01 | 2014-03-19 | 安进公司 | 双特异性结合剂 |
| EA029956B1 (ru) | 2011-03-25 | 2018-06-29 | Эмджен Инк. | Кристаллы антител против склеростина и составы на их основе |
| HUE039786T2 (hu) | 2011-08-04 | 2019-02-28 | Amgen Inc | Csonthiány-defektusok kezelési módszere |
| CN104039828B (zh) | 2011-12-28 | 2017-07-21 | 安进公司 | 通过使用抗骨硬化蛋白抗体治疗牙槽骨流失的方法 |
| EP3626267A1 (de) | 2012-07-05 | 2020-03-25 | UCB Pharma, S.A. | Behandlung von knochenerkrankungen |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| FR3024462A1 (fr) * | 2014-07-29 | 2016-02-05 | Univ Pierre Et Marie Curie Paris 6 | Procede de production in vitro de progeniteurs adipocytaires et d'adipocytes |
| MA41142A (fr) | 2014-12-12 | 2017-10-17 | Amgen Inc | Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement |
| GB201604124D0 (en) | 2016-03-10 | 2016-04-27 | Ucb Biopharma Sprl | Pharmaceutical formulation |
| KR20200138254A (ko) | 2018-03-30 | 2020-12-09 | 암젠 인크 | C-말단 항체 변이체 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827367D0 (en) | 1988-11-23 | 1988-12-29 | Lawrence C A | Spinning of yarn |
| ATE162223T1 (de) * | 1989-03-28 | 1998-01-15 | Genetics Inst | Osteoinduktive zusammensetzungen |
| JP2845346B2 (ja) * | 1989-10-17 | 1999-01-13 | ストライカー・コーポレーション | 骨形成具 |
| ES2156862T3 (es) * | 1991-08-30 | 2001-08-01 | Curis Inc | Metodo para seleccionar proteinas morfogenicas. |
| WO1993019177A1 (en) * | 1992-03-18 | 1993-09-30 | The General Hospital Corporation | FOUR NOVEL RECEPTORS OF THE TGF-β RECEPTOR FAMILY |
| DE4225427A1 (de) * | 1992-07-31 | 1994-02-03 | Boehringer Mannheim Gmbh | Verfahren zur Gewinnung rekombinanter, biologisch aktiver, eukaryontischer alkalischer Phosphatase |
| US6316217B1 (en) * | 1992-11-17 | 2001-11-13 | Ludwig Institute For Cancer Research | Activin receptor-like kinases, proteins having serine threonine kinase domains and polynucleotides encoding same |
| US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| US6248554B1 (en) * | 1993-11-24 | 2001-06-19 | The Procter & Gamble Company | DNA sequence coding for a BMP receptor |
-
1995
- 1995-04-28 JP JP7528497A patent/JPH10511840A/ja not_active Withdrawn
- 1995-04-28 DE DE69535641T patent/DE69535641D1/de not_active Expired - Lifetime
- 1995-04-28 AU AU24662/95A patent/AU702163B2/en not_active Expired
- 1995-04-28 EP EP95918920A patent/EP0756628B1/de not_active Expired - Lifetime
- 1995-04-28 AT AT95918920T patent/ATE378407T1/de not_active IP Right Cessation
- 1995-04-28 US US08/481,337 patent/US5863738A/en not_active Expired - Lifetime
- 1995-04-28 CA CA002187902A patent/CA2187902A1/en not_active Abandoned
- 1995-04-28 WO PCT/US1995/005467 patent/WO1995030003A2/en active IP Right Grant
- 1995-06-02 US US08/448,371 patent/US6632618B1/en not_active Expired - Lifetime
-
2001
- 2001-10-18 US US09/982,543 patent/US7067260B2/en not_active Expired - Fee Related
-
2005
- 2005-04-04 US US11/098,889 patent/US20050233379A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050233379A1 (en) | 2005-10-20 |
| WO1995030003A3 (en) | 1995-12-14 |
| AU2466295A (en) | 1995-11-29 |
| WO1995030003A2 (en) | 1995-11-09 |
| EP0756628A1 (de) | 1997-02-05 |
| JPH10511840A (ja) | 1998-11-17 |
| EP0756628B1 (de) | 2007-11-14 |
| AU702163B2 (en) | 1999-02-18 |
| US6632618B1 (en) | 2003-10-14 |
| ATE378407T1 (de) | 2007-11-15 |
| US5863738A (en) | 1999-01-26 |
| CA2187902A1 (en) | 1995-11-09 |
| US20020155500A1 (en) | 2002-10-24 |
| US7067260B2 (en) | 2006-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |