DE69535428D1 - Verfahren zum Auffinden von differentiel exprimierte Gene - Google Patents
Verfahren zum Auffinden von differentiel exprimierte GeneInfo
- Publication number
- DE69535428D1 DE69535428D1 DE69535428T DE69535428T DE69535428D1 DE 69535428 D1 DE69535428 D1 DE 69535428D1 DE 69535428 T DE69535428 T DE 69535428T DE 69535428 T DE69535428 T DE 69535428T DE 69535428 D1 DE69535428 D1 DE 69535428D1
- Authority
- DE
- Germany
- Prior art keywords
- differentially expressed
- expressed genes
- finding
- finding differentially
- genes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19548594A | 1994-02-14 | 1994-02-14 | |
| US195485 | 1994-02-14 | ||
| PCT/US1995/001863 WO1995021944A1 (en) | 1994-02-14 | 1995-02-14 | Differentially expressed genes in healthy and diseased subjects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69535428D1 true DE69535428D1 (de) | 2007-05-03 |
| DE69535428T2 DE69535428T2 (de) | 2007-12-06 |
Family
ID=22721588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1995635428 Expired - Lifetime DE69535428T2 (de) | 1994-02-14 | 1995-02-14 | Verfahren zum Auffinden von differentiel exprimierte Gene |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP1813684A3 (de) |
| JP (1) | JPH09508800A (de) |
| DE (1) | DE69535428T2 (de) |
| WO (1) | WO1995021944A1 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US7323298B1 (en) | 1994-06-17 | 2008-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Microarray for determining the relative abundances of polynuceotide sequences |
| US7378236B1 (en) | 1994-06-17 | 2008-05-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method for analyzing gene expression patterns |
| US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US5866330A (en) | 1995-09-12 | 1999-02-02 | The Johns Hopkins University School Of Medicine | Method for serial analysis of gene expression |
| US5695937A (en) * | 1995-09-12 | 1997-12-09 | The Johns Hopkins University School Of Medicine | Method for serial analysis of gene expression |
| WO1997013877A1 (en) * | 1995-10-12 | 1997-04-17 | Lynx Therapeutics, Inc. | Measurement of gene expression profiles in toxicity determination |
| US6418382B2 (en) | 1995-10-24 | 2002-07-09 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5972693A (en) * | 1995-10-24 | 1999-10-26 | Curagen Corporation | Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5871697A (en) | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| EP0880598A4 (de) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | Verfahren zur analyse von nukleinsäure |
| US5861248A (en) * | 1996-03-29 | 1999-01-19 | Urocor, Inc. | Biomarkers for detection of prostate cancer |
| US6228589B1 (en) | 1996-10-11 | 2001-05-08 | Lynx Therapeutics, Inc. | Measurement of gene expression profiles in toxicity determination |
| US5928871A (en) * | 1996-11-18 | 1999-07-27 | The Rockefeller University | CDNA collections encoding proteins regulated during programmed cell death, and method of use thereof |
| WO1998051824A1 (en) * | 1997-05-15 | 1998-11-19 | Abbott Laboratories | Reagents and methods useful for detecting disease of the urinary tract |
| US6890749B2 (en) | 1997-05-15 | 2005-05-10 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the prostate |
| US5994076A (en) * | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
| US6333152B1 (en) | 1997-05-21 | 2001-12-25 | The Johnshopkins University | Gene expression profiles in normal and cancer cells |
| US6489455B2 (en) | 1997-05-21 | 2002-12-03 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
| JP2001522249A (ja) * | 1997-06-05 | 2001-11-13 | アボツト・ラボラトリーズ | 尿路の疾患の検出に有用な試薬および方法 |
| WO1999002734A1 (en) * | 1997-07-08 | 1999-01-21 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the urinary tract |
| EP1042504A2 (de) * | 1997-12-29 | 2000-10-11 | Genena Ltd. | Verfahren zur erkennung und charakterisierung von zellen und gewebe |
| US6265163B1 (en) | 1998-01-09 | 2001-07-24 | Lynx Therapeutics, Inc. | Solid phase selection of differentially expressed genes |
| WO2000055323A1 (en) * | 1999-03-16 | 2000-09-21 | Mitokor | Differential expression of organellar gene products |
| WO2000065091A2 (en) * | 1999-04-23 | 2000-11-02 | Curagen Corporation | Method of identifying ligands for the peroxisome proliferator activated receptor gamma using differential gene expression |
| US7122303B2 (en) | 1999-09-17 | 2006-10-17 | Agilent Technologies, Inc. | Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same |
| US7078167B2 (en) | 1999-09-17 | 2006-07-18 | Agilent Technologies, Inc. | Arrays having background features and methods for using the same |
| WO2001044512A2 (en) * | 1999-12-16 | 2001-06-21 | Curagen Corporation | Method of identifying ligands for the peroxisome proliferator activated receptor gamma using differential gene expression |
| US6413722B1 (en) | 2000-03-22 | 2002-07-02 | Incyte Genomics, Inc. | Polymer coated surfaces for microarray applications |
| US7666586B2 (en) | 2000-06-30 | 2010-02-23 | Aros Applied Biotechnology Aps | Gene expression in biological conditions |
| US6900013B1 (en) | 2000-08-25 | 2005-05-31 | Aviva Biosciences Corporation | Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization |
| EP1623010A4 (de) | 2003-04-25 | 2007-12-26 | Janssen Pharmaceutica Nv | Konservierung von rna in einer biologischen probe |
| EP2471921A1 (de) | 2004-05-28 | 2012-07-04 | Asuragen, Inc. | Verfahren und Zusammensetzungen mit microRNA |
| JP2008519606A (ja) | 2004-11-12 | 2008-06-12 | アンビオン インコーポレーティッド | ｍｉＲＮＡおよびｍｉＲＮＡ阻害分子に関する方法および組成物 |
| CN101384733A (zh) | 2006-02-13 | 2009-03-11 | 奥尔加·奥尔纳茨基 | 通过元素分析实施的基因表达检测 |
| JP5520605B2 (ja) | 2006-09-19 | 2014-06-11 | アシュラジェン インコーポレイテッド | 膵臓疾患で差次的に発現されるマイクロｒｎａおよびその使用 |
| WO2008036776A2 (en) | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
| US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| CA2723984A1 (en) | 2008-05-14 | 2009-11-19 | Genomic Health Inc. | Predictors of patient response to treatment with egf receptor inhibitors |
| EP3214174B1 (de) | 2010-03-04 | 2019-10-16 | InteRNA Technologies B.V. | Mirna-molekül, das über seine quelle definiert ist, und seine diagnostischen und therapeutischen verwendungen bei mit emt assoziierten krankheiten |
| EP2566973A4 (de) | 2010-05-04 | 2013-11-27 | Medimmune Llc | Optimierte diagnose und behandlung von muskelabbauerkrankungen |
| US9133524B2 (en) | 2010-07-01 | 2015-09-15 | The Regents Of The University Of California | Protein kinase ck2 gene mutations, amplifications and polymorphisms in human cancers and methods of use |
| NZ704322A (en) | 2010-07-06 | 2016-07-29 | Interna Technologies Bv | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
| CA2817882C (en) | 2010-11-17 | 2022-08-23 | Asuragen, Inc. | Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms |
| EP2474617A1 (de) | 2011-01-11 | 2012-07-11 | InteRNA Technologies BV | MIR zur Behandlung von Neoangiogenese |
| EP2681566A2 (de) | 2011-02-28 | 2014-01-08 | University of Iowa Research Foundation | Anti-müller-hormon-veränderungen in der schwangerschaft und vorhersage von schwangerschaftsnebenwirkungen und des geschlechts |
| US9644241B2 (en) | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| WO2013063519A1 (en) | 2011-10-26 | 2013-05-02 | Asuragen, Inc. | Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts |
| WO2013063544A1 (en) | 2011-10-27 | 2013-05-02 | Asuragen, Inc. | Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors |
| EP2870263A1 (de) | 2012-07-03 | 2015-05-13 | InteRNA Technologies B.V. | Diagnoseportfolio und dessen verwendungen |
| WO2014055117A1 (en) | 2012-10-04 | 2014-04-10 | Asuragen, Inc. | Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions |
| WO2014151551A1 (en) | 2013-03-15 | 2014-09-25 | Baylor Research Institute | Ulcerative colitis (uc)-associated colorectal neoplasia markers |
| EP2970909A4 (de) | 2013-03-15 | 2017-02-15 | The University of Chicago | Verfahren und zusammensetzungen in zusammenhang mit t-zell aktivität |
| EP2971132B1 (de) | 2013-03-15 | 2020-05-06 | Baylor Research Institute | Gewebe- und blutbasierte mirna-biomarker zur diagnose, prognose und vorhersage des metastasepotenzials bei kolorektalkrebs |
| US10550440B2 (en) | 2016-02-26 | 2020-02-04 | Arizona Board Of Regents On Behalf Of Arizona State University | Synthetic translation-sensing riboswitches and uses thereof |
| US11497762B2 (en) | 2017-11-03 | 2022-11-15 | Interna Technologies B.V. | MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation |
| WO2019104155A2 (en) | 2017-11-22 | 2019-05-31 | The University Of Chicago | Chemical probe-dependent evaluation of protein activity and uses thereof |
| US20220162198A1 (en) | 2019-04-12 | 2022-05-26 | The Regents Of The University Of California | Compositions and methods for increasing muscle mass and oxidative metabolism |
| WO2024028794A1 (en) | 2022-08-02 | 2024-02-08 | Temple Therapeutics BV | Methods for treating endometrial and ovarian hyperproliferative disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991007087A1 (en) * | 1989-11-13 | 1991-05-30 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| AU2240492A (en) * | 1991-06-20 | 1993-01-25 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | Sequences characteristic of human gene transcription product |
| CA2089045A1 (en) * | 1992-02-28 | 1993-08-29 | Stephanie J. Lemke | Differential screening protocol that allows the detection of marginally induced or repressed mrnas |
-
1995
- 1995-02-14 EP EP20070100727 patent/EP1813684A3/de not_active Withdrawn
- 1995-02-14 JP JP52141195A patent/JPH09508800A/ja not_active Ceased
- 1995-02-14 DE DE1995635428 patent/DE69535428T2/de not_active Expired - Lifetime
- 1995-02-14 WO PCT/US1995/001863 patent/WO1995021944A1/en active IP Right Grant
- 1995-02-14 EP EP95910257A patent/EP0743989B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69535428T2 (de) | 2007-12-06 |
| EP1813684A3 (de) | 2009-11-18 |
| EP1813684A2 (de) | 2007-08-01 |
| JPH09508800A (ja) | 1997-09-09 |
| EP0743989A4 (de) | 2000-11-08 |
| WO1995021944A1 (en) | 1995-08-17 |
| EP0743989B1 (de) | 2007-03-21 |
| EP0743989A1 (de) | 1996-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SMITHKLINE BEECHAM CORP., PHILADELPHIA, PA., US |
|
| 8364 | No opposition during term of opposition |