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DE69528978D1 - Lactamverbindungen als Inhibitoren der Cholesterin-Esterase - Google Patents

Lactamverbindungen als Inhibitoren der Cholesterin-Esterase

Info

Publication number
DE69528978D1
DE69528978D1 DE69528978T DE69528978T DE69528978D1 DE 69528978 D1 DE69528978 D1 DE 69528978D1 DE 69528978 T DE69528978 T DE 69528978T DE 69528978 T DE69528978 T DE 69528978T DE 69528978 D1 DE69528978 D1 DE 69528978D1
Authority
DE
Germany
Prior art keywords
inhibitors
cholesterol esterase
alkyl
lactam compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69528978T
Other languages
English (en)
Inventor
Byron Rubin
C Mattes
C Mungal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of DE69528978D1 publication Critical patent/DE69528978D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69528978T 1994-06-14 1995-06-13 Lactamverbindungen als Inhibitoren der Cholesterin-Esterase Expired - Lifetime DE69528978D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/259,593 US5474993A (en) 1994-06-14 1994-06-14 Lactam inhibitors of cholesterol esterase
PCT/US1995/007450 WO1995034566A1 (en) 1994-06-14 1995-06-13 Lactam inhibitors of cholesterol esterase

Publications (1)

Publication Number Publication Date
DE69528978D1 true DE69528978D1 (de) 2003-01-09

Family

ID=22985566

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528978T Expired - Lifetime DE69528978D1 (de) 1994-06-14 1995-06-13 Lactamverbindungen als Inhibitoren der Cholesterin-Esterase

Country Status (9)

Country Link
US (1) US5474993A (de)
EP (1) EP0765330B1 (de)
JP (1) JPH10504283A (de)
AT (1) ATE228520T1 (de)
AU (1) AU693565B2 (de)
CA (1) CA2192984A1 (de)
DE (1) DE69528978D1 (de)
HU (1) HU221426B (de)
WO (1) WO1995034566A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US6264937B1 (en) 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
CA2324800A1 (en) * 1999-11-10 2001-05-10 Mary Anne Hickman Use of apo b secretion/mtp inhibitors
CA2324801A1 (en) * 1999-11-10 2001-05-10 Andrew Gordon Swick Use of apo b secretion/mtp inhibitors and anti-obesity agents
CO5271688A1 (es) * 1999-11-10 2003-04-30 Pfizer Prod Inc Uso de inhibidor de secrecion de apoliproteinas b y/o de proteina de transferencia de trigliceridos microsmales
IL139450A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Methods of administering apo b-secretion/mtp inhibitors
US7115279B2 (en) 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3311638A (en) * 1961-08-16 1967-03-28 Bristol Myers Co Anhydropenicillins
JPS608117B2 (ja) * 1977-02-08 1985-02-28 財団法人微生物化学研究会 新生理活性物質エステラスチンおよびその製造法
GB2023604B (en) * 1978-05-25 1982-07-28 Microbial Chem Res Found Physiologically active derivatives of esterastin and production thereof
US4202284A (en) * 1978-12-29 1980-05-13 Parsons Joe T Sr Sewing machine table
US5053502A (en) * 1986-07-21 1991-10-01 Schering Corporation Anhydro penicillin derivatives
US5132300A (en) * 1989-06-01 1992-07-21 Pfizer Inc. Beta-lactam elastase inhibitors
US5093371A (en) * 1990-07-02 1992-03-03 University Of Iowa Research Foundation Naphthyl ketone inhibitors of cholesterol esterase and their use as hypolipidemic and hypocaloric agents

Also Published As

Publication number Publication date
US5474993A (en) 1995-12-12
EP0765330B1 (de) 2002-11-27
WO1995034566A1 (en) 1995-12-21
HU9603451D0 (en) 1997-02-28
EP0765330A1 (de) 1997-04-02
HUT76612A (en) 1997-10-28
EP0765330A4 (de) 2000-04-26
HU221426B (en) 2002-10-28
JPH10504283A (ja) 1998-04-28
CA2192984A1 (en) 1995-12-21
AU2704095A (en) 1996-01-05
AU693565B2 (en) 1998-07-02
ATE228520T1 (de) 2002-12-15

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Legal Events

Date Code Title Description
8332 No legal effect for de