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DE69528189D1 - Diazepinoindole inhibitoren von phosphodiesterase iv - Google Patents

Diazepinoindole inhibitoren von phosphodiesterase iv

Info

Publication number
DE69528189D1
DE69528189D1 DE69528189T DE69528189T DE69528189D1 DE 69528189 D1 DE69528189 D1 DE 69528189D1 DE 69528189 T DE69528189 T DE 69528189T DE 69528189 T DE69528189 T DE 69528189T DE 69528189 D1 DE69528189 D1 DE 69528189D1
Authority
DE
Germany
Prior art keywords
hydrogen
racemic forms
indolyl
haloalkyl
configuration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69528189T
Other languages
English (en)
Other versions
DE69528189T2 (de
Inventor
Yves Pascal
Indres Moodley
Alain Calvet
Jean-Louis Junien
G Dahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Holding France SCA
Original Assignee
Pfizer SAS France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer SAS France filed Critical Pfizer SAS France
Application granted granted Critical
Publication of DE69528189D1 publication Critical patent/DE69528189D1/de
Publication of DE69528189T2 publication Critical patent/DE69528189T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69528189T 1994-10-14 1995-10-13 Diazepinoindole inhibitoren von phosphodiesterase iv Expired - Fee Related DE69528189T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9412282A FR2725719B1 (fr) 1994-10-14 1994-10-14 Diazepino-indoles inhibiteurs de phosphodiesterases iv
PCT/FR1995/001354 WO1996011690A1 (fr) 1994-10-14 1995-10-13 Diazepino-indoles inhibiteurs de phosphodiesterases iv

Publications (2)

Publication Number Publication Date
DE69528189D1 true DE69528189D1 (de) 2002-10-17
DE69528189T2 DE69528189T2 (de) 2003-01-09

Family

ID=9467863

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528189T Expired - Fee Related DE69528189T2 (de) 1994-10-14 1995-10-13 Diazepinoindole inhibitoren von phosphodiesterase iv

Country Status (24)

Country Link
US (1) US5852190A (de)
EP (1) EP0785789B1 (de)
JP (1) JPH10507447A (de)
KR (1) KR970706826A (de)
CN (1) CN1097459C (de)
AT (1) ATE223720T1 (de)
AU (1) AU703773B2 (de)
BR (1) BR9509353A (de)
CA (1) CA2200628A1 (de)
CZ (1) CZ111497A3 (de)
DE (1) DE69528189T2 (de)
DK (1) DK0785789T3 (de)
ES (1) ES2181793T3 (de)
FR (1) FR2725719B1 (de)
HU (1) HUT77411A (de)
NO (1) NO971687L (de)
NZ (1) NZ294642A (de)
PL (1) PL319659A1 (de)
PT (1) PT785789E (de)
RU (1) RU2174517C2 (de)
SK (1) SK282766B6 (de)
UA (1) UA42793C2 (de)
WO (1) WO1996011690A1 (de)
ZA (1) ZA958669B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2746800B1 (fr) * 1996-03-29 1998-06-05 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases 4
FR2762841B1 (fr) * 1997-04-30 1999-07-02 Jouveinal Inst Rech Diazepino-indolones inhibitrices de phosphodiesterases iv
FR2776660B1 (fr) * 1998-03-27 2000-05-12 Parke Davis Diazepino-indoles de phosphodiesterases iv
AU777012B2 (en) 1999-08-21 2004-09-30 Takeda Gmbh Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
WO2001047891A1 (en) * 1999-12-28 2001-07-05 Eisai Co., Ltd. Heterocyclic compounds having sulfonamide groups
AU2001232175B2 (en) * 2000-03-03 2005-07-07 Pfizer Products Inc. Pyrazole ether derivatives as anti-inflammatory/analgesic agents
EP1161949A1 (de) 2000-06-09 2001-12-12 Warner-Lambert Company Verwendung von diazepinoindolen zur behandlung von chronisch obstruktiver lungenkrankheiten
EP1188438A1 (de) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen
EP1199074A1 (de) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen
DE10148290A1 (de) * 2001-09-29 2003-04-17 Bayer Cropscience Gmbh Heterocyclische Amide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
WO2006040645A1 (en) * 2004-10-11 2006-04-20 Ranbaxy Laboratories Limited N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma
RU2378279C1 (ru) * 2008-05-28 2010-01-10 Государственное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) CПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 1,2,3,6-ТЕТРАГИДРОПИРРОЛО[1,2-d][1,4]ДИАЗОЦИНОВ
EP3165224A1 (de) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Verwendung von pde4 hemmern zur prophylaxe und/oder therapie von dyslipoproteinaemie und verwandten erkrankungen
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4840947A (en) * 1986-10-14 1989-06-20 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas
FR2630440B1 (fr) * 1988-04-25 1991-09-20 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique
US5248679A (en) * 1988-09-09 1993-09-28 Fujisawa Pharmaceutical Co., Ltd. Tricyclic compounds
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.
US5393753A (en) * 1990-10-10 1995-02-28 Schering Corporation Substituted imidazobenzazepines

Also Published As

Publication number Publication date
NO971687L (no) 1997-06-13
DE69528189T2 (de) 2003-01-09
US5852190A (en) 1998-12-22
ATE223720T1 (de) 2002-09-15
FR2725719B1 (fr) 1996-12-06
CA2200628A1 (fr) 1996-04-25
JPH10507447A (ja) 1998-07-21
PT785789E (pt) 2002-12-31
RU2174517C2 (ru) 2001-10-10
FR2725719A1 (fr) 1996-04-19
ES2181793T3 (es) 2003-03-01
WO1996011690A1 (fr) 1996-04-25
KR970706826A (ko) 1997-12-01
DK0785789T3 (da) 2003-01-20
SK44897A3 (en) 1998-12-02
CZ111497A3 (cs) 1998-01-14
NO971687D0 (no) 1997-04-11
UA42793C2 (uk) 2001-11-15
EP0785789A1 (de) 1997-07-30
PL319659A1 (en) 1997-08-18
SK282766B6 (sk) 2002-12-03
EP0785789B1 (de) 2002-09-11
MX9702637A (es) 1997-07-31
CN1097459C (zh) 2003-01-01
AU3749495A (en) 1996-05-06
AU703773B2 (en) 1999-04-01
BR9509353A (pt) 1997-12-30
CN1160352A (zh) 1997-09-24
HUT77411A (hu) 1998-04-28
ZA958669B (en) 1997-04-14
NZ294642A (en) 2001-06-29

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PFIZER HOLDING FRANCE, PARIS, FR

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee