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DE69528109D1 - Thieno -1,5- benzodiazepine for the treatment of gastrointestinal complaints - Google Patents

Thieno -1,5- benzodiazepine for the treatment of gastrointestinal complaints

Info

Publication number
DE69528109D1
DE69528109D1 DE69528109T DE69528109T DE69528109D1 DE 69528109 D1 DE69528109 D1 DE 69528109D1 DE 69528109 T DE69528109 T DE 69528109T DE 69528109 T DE69528109 T DE 69528109T DE 69528109 D1 DE69528109 D1 DE 69528109D1
Authority
DE
Germany
Prior art keywords
benzodiazepine
thieno
treatment
gastrointestinal complaints
complaints
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69528109T
Other languages
German (de)
Inventor
Beverley Greenwood
David Lloyd Garver Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69528109D1 publication Critical patent/DE69528109D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69528109T 1994-06-03 1995-06-02 Thieno -1,5- benzodiazepine for the treatment of gastrointestinal complaints Expired - Lifetime DE69528109D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/253,658 US5457101A (en) 1994-06-03 1994-06-03 Thieno[1,5]benzoidiazepine use

Publications (1)

Publication Number Publication Date
DE69528109D1 true DE69528109D1 (en) 2002-10-17

Family

ID=22961179

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528109T Expired - Lifetime DE69528109D1 (en) 1994-06-03 1995-06-02 Thieno -1,5- benzodiazepine for the treatment of gastrointestinal complaints

Country Status (14)

Country Link
US (1) US5457101A (en)
EP (1) EP0685233B1 (en)
JP (1) JPH07330608A (en)
KR (1) KR960000229A (en)
CN (1) CN1119101A (en)
AU (1) AU684924B2 (en)
CA (1) CA2150517A1 (en)
DE (1) DE69528109D1 (en)
HU (1) HUT71598A (en)
IL (1) IL113912A (en)
NO (1) NO306977B1 (en)
NZ (1) NZ272231A (en)
TW (1) TW372872B (en)
ZA (1) ZA954358B (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
CR5278A (en) 1995-03-24 1996-07-04 Lilly Co Eli ORAL FORMULATION OF 2-METHYL-THENO-BENZODIACEPINE
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
US5891461A (en) * 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
US5981523A (en) * 1996-02-05 1999-11-09 Eli Lilly And Company Compounds and methods for treating multiple sclerosis
JP2000506860A (en) * 1996-03-11 2000-06-06 イーライ・リリー・アンド・カンパニー How to treat autism
EA000758B1 (en) * 1996-03-11 2000-04-24 Эли Лилли Энд Компани Method for treating bipolar disorders
CZ298398A3 (en) * 1996-03-25 1999-06-16 Eli Lilly And Company Pharmaceutical preparation
CN1219878A (en) * 1996-03-25 1999-06-16 伊莱利利公司 Method for treating pain
EA000976B1 (en) * 1996-03-25 2000-08-28 Эли Лилли Энд Компани Composition for treating pain and method therefor
US5958934A (en) * 1996-05-23 1999-09-28 Syntex (U.S.A.) Inc. Aryl pyrimidine derivatives and uses thereof
US5952331A (en) * 1996-05-23 1999-09-14 Syntex (Usa) Inc. Aryl pyrimidine derivatives
US20030022889A1 (en) * 1997-04-15 2003-01-30 Bymaster Franklin P. Method for providing neuro-protective effects
WO1998046596A1 (en) * 1997-04-15 1998-10-22 Eli Lilly And Company Method for providing neuro-protective effects
CA2351719A1 (en) * 1998-11-23 2000-06-02 Sepracor Inc. Pharmaceutical compositions containing olanzapine-n-oxide
ATE286398T1 (en) 1998-11-23 2005-01-15 Sepracor Inc COMPOSITIONS AND METHODS CONTAINING DESMETHYLOLANZAPINE
JP2002530339A (en) 1998-11-23 2002-09-17 セプラコール， インク． 2-Hydroxymethylolanzapine compositions and methods
US7022698B2 (en) 1999-12-28 2006-04-04 U & I Pharmaceuticals, Ltd. Pharmaceutical compositions containing new polymorphic forms of olanzapine and uses thereof
US6348458B1 (en) 1999-12-28 2002-02-19 U & I Pharmaceuticals Ltd. Polymorphic forms of olanzapine
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
UA80095C2 (en) * 2001-07-20 2007-08-27 Lilly Co Eli 2 methyl-thieno-benzodiazepine lyophilized formulation and method for the preparation thereof
GB0203061D0 (en) * 2002-02-08 2002-03-27 Novartis Ag Organic compounds
GB0207091D0 (en) * 2002-03-26 2002-05-08 Ml Lab Plc Method of treatment
US7407788B2 (en) * 2002-11-21 2008-08-05 Danisco A/S, Genencor Division BGL7 beta-glucosidase and nucleic acids encoding the same
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
WO2004104493A2 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
GB0314149D0 (en) * 2003-06-18 2003-07-23 Generics Uk Ltd Novel amorphous forms
US20050272720A1 (en) * 2004-01-27 2005-12-08 Rolf Keltjens Process for making olanzapine Form I
EP1709053B1 (en) * 2004-01-27 2011-04-06 Synthon B.V. Stable salts of olanzapine
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP1781360A1 (en) 2004-08-12 2007-05-09 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
BRPI0608087A2 (en) * 2005-02-15 2009-11-10 Elan Pharma Int Ltd injectable and aerosol formulations of nanoparticulate benzodiazepine
WO2007020080A1 (en) * 2005-08-17 2007-02-22 Synthon B.V. A process for making olanzapine form i
US20070293479A1 (en) * 2006-05-18 2007-12-20 Osinga Niels J Olanzapine pharmaceutical composition
CL2007002807A1 (en) * 2006-09-29 2008-04-11 Synthon Bv PHARMACEUTICAL COMPOSITION IN SOLID STATE THAT INCLUDES OLANZAPINE OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME AND LACTOSE ANHYDRA; ORAL PHARMACEUTICAL TABLET; PROCEDURE FOR PREPARATION OF SUCH TABLET, USEFUL IN THE TREATMENT OF SKI
ES2594867T3 (en) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
WO2012051502A1 (en) 2010-10-14 2012-04-19 University Of Utah Research Foundation Methods and compositions related to neuroactive thiazoline compounds
US20210355138A1 (en) * 2016-08-11 2021-11-18 Eli Lilly And Company Aminothiazinies and their use as bace1 inhibitors
KR20200118081A (en) 2018-02-02 2020-10-14 알렉스자 파마스티칼즈, 인크. Electrical condensing aerosol device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
EP0582368B1 (en) * 1992-05-29 2001-01-24 Eli Lilly And Company Limited Thienobenzodiazepine derivatives for treatment of CNS disorders
EP0620222A3 (en) * 1993-04-14 1995-04-12 Lilly Co Eli Tetrahydro-beta-carbolines.
EP0749313A4 (en) * 1994-03-11 2001-10-24 Lilly Co Eli METHOD FOR TREATING STATES RELATED TO THE 5-HT2B RECEPTOR

Also Published As

Publication number Publication date
HUT71598A (en) 1996-01-29
ZA954358B (en) 1996-11-29
CA2150517A1 (en) 1995-12-04
NZ272231A (en) 2001-05-25
NO952130L (en) 1995-12-04
HU9501600D0 (en) 1995-07-28
NO952130D0 (en) 1995-05-30
CN1119101A (en) 1996-03-27
JPH07330608A (en) 1995-12-19
US5457101A (en) 1995-10-10
TW372872B (en) 1999-11-01
AU2042495A (en) 1995-12-14
KR960000229A (en) 1996-01-25
IL113912A0 (en) 1995-08-31
NO306977B1 (en) 2000-01-24
EP0685233A3 (en) 1996-04-03
EP0685233B1 (en) 2002-09-11
AU684924B2 (en) 1998-01-08
IL113912A (en) 1999-04-11
EP0685233A2 (en) 1995-12-06

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Legal Events

Date Code Title Description
8332 No legal effect for de