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DE69520368D1 - Verfahren zur herstellung von 5-hydroxymethyl-thiazole - Google Patents

Verfahren zur herstellung von 5-hydroxymethyl-thiazole

Info

Publication number
DE69520368D1
DE69520368D1 DE69520368T DE69520368T DE69520368D1 DE 69520368 D1 DE69520368 D1 DE 69520368D1 DE 69520368 T DE69520368 T DE 69520368T DE 69520368 T DE69520368 T DE 69520368T DE 69520368 D1 DE69520368 D1 DE 69520368D1
Authority
DE
Germany
Prior art keywords
producing
hydroxymethylthiazole
hydroxymethyl thiazole
thiazole
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69520368T
Other languages
English (en)
Other versions
DE69520368T2 (de
Inventor
Robert Leanna
E Morton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE69520368D1 publication Critical patent/DE69520368D1/de
Publication of DE69520368T2 publication Critical patent/DE69520368T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69520368T 1994-11-22 1995-11-15 Verfahren zur herstellung von 5-hydroxymethyl-thiazole Expired - Fee Related DE69520368T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34369094A 1994-11-22 1994-11-22
PCT/US1995/014930 WO1996016050A1 (en) 1994-11-22 1995-11-15 Process for preparation of 5-hydroxymethylthiazole

Publications (2)

Publication Number Publication Date
DE69520368D1 true DE69520368D1 (de) 2001-04-19
DE69520368T2 DE69520368T2 (de) 2001-06-28

Family

ID=23347195

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69520368T Expired - Fee Related DE69520368T2 (de) 1994-11-22 1995-11-15 Verfahren zur herstellung von 5-hydroxymethyl-thiazole

Country Status (11)

Country Link
US (1) US5712400A (de)
EP (1) EP0793659B1 (de)
JP (1) JPH10509177A (de)
AT (1) ATE199714T1 (de)
DE (1) DE69520368T2 (de)
DK (1) DK0793659T3 (de)
ES (1) ES2156955T3 (de)
GR (1) GR3035865T3 (de)
MX (1) MX9703766A (de)
PT (1) PT793659E (de)
WO (1) WO1996016050A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001508452A (ja) 1997-01-22 2001-06-26 ノバルティス アクチェンゲゼルシャフト チアゾール誘導体の製造方法
WO1998045279A1 (en) * 1997-04-07 1998-10-15 Reilly Industries, Inc. Preparation of thiazoles using 1,3-dihalopropenes
AU6958898A (en) * 1997-04-07 1998-10-30 Reilly Industries, Inc. Preparation of heterocycles using 1,3-dihalopropenes
US5959118A (en) * 1997-08-29 1999-09-28 Abbott Laboratories Process for the preparation of 5-hydroxymethylthiazoles
US5773625A (en) * 1997-10-02 1998-06-30 Abbott Laboratories Process for the preparation of disubstituted carbonates
US6765019B1 (en) * 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
CN101260100A (zh) * 2008-04-21 2008-09-10 湖南有色凯铂生物药业有限公司 一种5-羟甲基噻唑的制备方法
CN101863853B (zh) * 2009-12-28 2012-12-19 安徽贝克联合制药有限公司 一锅煮法制备5-羟甲基噻唑工艺
EP3700893B1 (de) 2017-10-27 2021-11-17 Syngenta Participations AG Zusammensetzungen für die vektorsteuerung, verfahren und produkte diese verwendend
CN116375662B (zh) * 2022-12-30 2024-07-23 新沂市砥研医药技术研究院有限公司 一种高效的5-羟甲基噻唑医药中间体的纯化工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247464A (en) * 1979-10-01 1981-01-27 General Electric Company Liquid extraction method for recovering aromatic bisimides
DE3631538A1 (de) * 1986-09-17 1988-03-24 Bayer Ag Verfahren zur herstellung von 2-chlor-5-chlormethylthiazol
JPS63165334A (ja) * 1986-12-27 1988-07-08 Hodogaya Chem Co Ltd ２，６−ジクロロベンジルアルコ−ルの製造法
IE913840A1 (en) * 1990-11-20 1992-05-20 Abbott Lab Retroviral protease inhibiting compounds
WO1994014436A1 (en) * 1992-12-29 1994-07-07 Abbott Laboratories Retroviral protease inhibiting compounds

Also Published As

Publication number Publication date
DE69520368T2 (de) 2001-06-28
PT793659E (pt) 2001-07-31
WO1996016050A1 (en) 1996-05-30
MX9703766A (es) 1997-08-30
US5712400A (en) 1998-01-27
ATE199714T1 (de) 2001-03-15
JPH10509177A (ja) 1998-09-08
DK0793659T3 (da) 2001-06-11
EP0793659A1 (de) 1997-09-10
GR3035865T3 (en) 2001-08-31
ES2156955T3 (es) 2001-08-01
EP0793659B1 (de) 2001-03-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee