DE69511689D1 - Phosphonyldipeptide zur bekämpfung von kardiovasvakuläre erkrankungen - Google Patents
Phosphonyldipeptide zur bekämpfung von kardiovasvakuläre erkrankungenInfo
- Publication number
- DE69511689D1 DE69511689D1 DE69511689T DE69511689T DE69511689D1 DE 69511689 D1 DE69511689 D1 DE 69511689D1 DE 69511689 T DE69511689 T DE 69511689T DE 69511689 T DE69511689 T DE 69511689T DE 69511689 D1 DE69511689 D1 DE 69511689D1
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- alkyl
- pct
- groups
- alkyl moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004846 (C1-C4) allyl group Chemical group 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000006267 biphenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI940696A IT1274673B (it) | 1994-04-14 | 1994-04-14 | Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari |
| PCT/EP1995/001322 WO1995028417A1 (en) | 1994-04-14 | 1995-04-11 | Phosphonyldipeptides useful in the treatment of cardiovascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69511689D1 true DE69511689D1 (de) | 1999-09-30 |
| DE69511689T2 DE69511689T2 (de) | 2000-04-27 |
Family
ID=11368561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69511689T Expired - Fee Related DE69511689T2 (de) | 1994-04-14 | 1995-04-11 | Phosphonyldipeptide zur bekämpfung von kardiovasvakuläre erkrankungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5760285A (de) |
| EP (1) | EP0755405B1 (de) |
| AT (1) | ATE183750T1 (de) |
| AU (1) | AU2305895A (de) |
| DE (1) | DE69511689T2 (de) |
| ES (1) | ES2136848T3 (de) |
| IT (1) | IT1274673B (de) |
| WO (1) | WO1995028417A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1276161B1 (it) * | 1995-11-23 | 1997-10-27 | Zambon Spa | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
| US6166052A (en) * | 1998-03-11 | 2000-12-26 | Warner-Lambert Company | Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4379146A (en) * | 1981-02-17 | 1983-04-05 | Merck & Co., Inc. | Substituted phosphonamides as antihypertensives |
| US4432972A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
| IT1224405B (it) * | 1987-12-23 | 1990-10-04 | Simes | Composti attivi sul sistema cardiovascolare |
| FR2652087B1 (fr) * | 1989-09-15 | 1993-10-15 | Bioprojet Ste Civile | Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques. |
| US5294632A (en) * | 1991-05-01 | 1994-03-15 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipetide derivatives |
| US5155100A (en) * | 1991-05-01 | 1992-10-13 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipeptide derivatives |
| JPH05105698A (ja) * | 1991-06-13 | 1993-04-27 | Takeda Chem Ind Ltd | ホスホン酸誘導体、その製造法および用途 |
| IT1254521B (it) * | 1992-03-17 | 1995-09-25 | Zambon Spa | Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare |
-
1994
- 1994-04-14 IT ITMI940696A patent/IT1274673B/it active IP Right Grant
-
1995
- 1995-04-11 AU AU23058/95A patent/AU2305895A/en not_active Abandoned
- 1995-04-11 WO PCT/EP1995/001322 patent/WO1995028417A1/en active IP Right Grant
- 1995-04-11 DE DE69511689T patent/DE69511689T2/de not_active Expired - Fee Related
- 1995-04-11 EP EP95916625A patent/EP0755405B1/de not_active Expired - Lifetime
- 1995-04-11 ES ES95916625T patent/ES2136848T3/es not_active Expired - Lifetime
- 1995-04-11 US US08/702,701 patent/US5760285A/en not_active Expired - Fee Related
- 1995-04-11 AT AT95916625T patent/ATE183750T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5760285A (en) | 1998-06-02 |
| ES2136848T3 (es) | 1999-12-01 |
| EP0755405B1 (de) | 1999-08-25 |
| ITMI940696A1 (it) | 1995-10-14 |
| DE69511689T2 (de) | 2000-04-27 |
| WO1995028417A1 (en) | 1995-10-26 |
| ITMI940696A0 (it) | 1994-04-14 |
| IT1274673B (it) | 1997-07-24 |
| EP0755405A1 (de) | 1997-01-29 |
| AU2305895A (en) | 1995-11-10 |
| ATE183750T1 (de) | 1999-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |