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DE69434784D1 - Bakterielle ausscheidungsproteine und darauf beruhende azelluläre impfstoffe - Google Patents

Bakterielle ausscheidungsproteine und darauf beruhende azelluläre impfstoffe

Info

Publication number
DE69434784D1
DE69434784D1 DE69434784T DE69434784T DE69434784D1 DE 69434784 D1 DE69434784 D1 DE 69434784D1 DE 69434784 T DE69434784 T DE 69434784T DE 69434784 T DE69434784 T DE 69434784T DE 69434784 D1 DE69434784 D1 DE 69434784D1
Authority
DE
Germany
Prior art keywords
vaccines
proteins
pct
azellular
corporate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434784T
Other languages
English (en)
Other versions
DE69434784T2 (de
Inventor
H Robert Masure
Barbara J Pearce
Elaine Tuomanen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Application granted granted Critical
Publication of DE69434784D1 publication Critical patent/DE69434784D1/de
Publication of DE69434784T2 publication Critical patent/DE69434784T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/03—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
    • C12Y102/03003—Pyruvate oxidase (1.2.3.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69434784T 1993-09-01 1994-09-01 Bakterielle ausscheidungsproteine und darauf beruhende azelluläre impfstoffe Expired - Lifetime DE69434784T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11654193A 1993-09-01 1993-09-01
US116541 1993-09-01
US245511 1994-05-18
US08/245,511 US5928900A (en) 1993-09-01 1994-05-18 Bacterial exported proteins and acellular vaccines based thereon
PCT/US1994/009942 WO1995006732A2 (en) 1993-09-01 1994-09-01 Bacterial exported proteins and acellular vaccines based thereon

Publications (2)

Publication Number Publication Date
DE69434784D1 true DE69434784D1 (de) 2006-08-17
DE69434784T2 DE69434784T2 (de) 2007-06-14

Family

ID=26814346

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434784T Expired - Lifetime DE69434784T2 (de) 1993-09-01 1994-09-01 Bakterielle ausscheidungsproteine und darauf beruhende azelluläre impfstoffe

Country Status (14)

Country Link
US (2) US5928900A (de)
EP (1) EP0721506B1 (de)
JP (1) JP3722834B2 (de)
AT (1) ATE332376T1 (de)
AU (1) AU709405B2 (de)
CA (1) CA2170726A1 (de)
DE (1) DE69434784T2 (de)
DK (1) DK0721506T3 (de)
ES (1) ES2267096T3 (de)
FI (1) FI960977L (de)
NO (1) NO321826B1 (de)
NZ (1) NZ273497A (de)
PT (1) PT721506E (de)
WO (1) WO1995006732A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031548A1 (en) * 1994-05-16 1995-11-23 The Uab Research Foundation Streptococcus pneumoniae capsular polysaccharide genes and flanking regions
US6245335B1 (en) 1996-05-01 2001-06-12 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
US5834278A (en) * 1996-05-01 1998-11-10 The Rockefeller University Bacterial peptide methionine sulfoxide reductase an adhesion-associated protein, and antibiotic therapies based thereon
US6165989A (en) 1996-05-14 2000-12-26 Smithkline Beecham Corporation Era of Streptococcus pneumoniae
WO1998006734A1 (en) * 1996-08-16 1998-02-19 Smithkline Beecham Corporation Novel prokaryotic polynucleotides, polypeptides and their uses
US5928895A (en) * 1996-09-24 1999-07-27 Smithkline Beecham Corporation IgA Fc binding protein
US5882896A (en) 1996-09-24 1999-03-16 Smithkline Beecham Corporation M protein
US5882871A (en) * 1996-09-24 1999-03-16 Smithkline Beecham Corporation Saliva binding protein
ES2277362T5 (es) * 1996-10-31 2014-12-18 Human Genome Sciences, Inc. Antígenos y vacunas de streptococcus pneumoniae
WO1998021337A2 (en) 1996-11-12 1998-05-22 Regents Of The University Of Minnesota C3 BINDING PROTEIN OF $i(STREPTOCOCCUS PNEUMONIAE)
US20040242522A1 (en) * 1997-02-14 2004-12-02 Volkin David B. Polynucleotide vaccine formulations
US6676943B1 (en) 1997-04-24 2004-01-13 Regents Of The University Of Minnesota Human complement C3-degrading protein from Streptococcus pneumoniae
DK1098980T3 (da) 1998-07-22 2014-09-29 Stichting Dienst Landbouwkundi Streptococcus suis-vacciner og diagnostiske tests
EP1801218A3 (de) * 1998-07-27 2007-10-10 Sanofi Pasteur Limited Nukleinsäuren und Proteine aus Pneumokokken
US6936252B2 (en) 1998-07-27 2005-08-30 Microbial Technics Limited Streptococcus pneumoniae proteins and nucleic acid molecules
DE69935986D1 (de) * 1998-07-27 2007-06-14 Sanofi Pasteur Ltd Streptococcus pneumoniae proteine und nukleinsäuren
US7098182B2 (en) 1998-07-27 2006-08-29 Microbial Technics Limited Nucleic acids and proteins from group B streptococcus
EP1624064A3 (de) * 1998-07-27 2006-05-10 Microbial Technics Limited Nukleinsäuren und entsprechende Proteine aus streptococcus pneumoniae
EP1790729A3 (de) * 1998-07-27 2007-07-25 Sanofi Pasteur Limited Streptococcus pneumoniae Proteine und Nukleinsäuren
US20030134407A1 (en) 1998-07-27 2003-07-17 Le Page Richard William Falla Nucleic acids and proteins from Streptococcus pneumoniae
EP1144640A3 (de) * 1998-07-27 2001-11-28 Microbial Technics Limited Nukleinsaüren und entsprechende proteine aus streptococcus pneumoniae
WO2000006736A2 (en) * 1998-07-27 2000-02-10 Microbial Technics Limited Nucleic acids and proteins from group b streptococcus
DE69940439D1 (de) 1998-12-21 2009-04-02 Medimmune Inc Streptococcus pneumoniae proteine und immunogene fragmente für impstoffe
GB9921125D0 (en) * 1999-09-07 1999-11-10 Microbial Technics Limited Proteins
WO2001079299A1 (en) 2000-04-13 2001-10-25 The Rockefeller University Enhancement of antibody-mediated immune responses
EP1205552A1 (de) * 2000-11-09 2002-05-15 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Streptokokkenvirulenz mit ORF aus Streptococcus suis
WO2002061070A2 (en) * 2001-02-02 2002-08-08 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Environmentally regulated genes, involved in the virulence of streptococcus suis
US20030082595A1 (en) * 2001-08-03 2003-05-01 Bo Jiang Nucleic acids of aspergillus fumigatus encoding industrial enzymes and methods of use
NO20026286D0 (no) * 2002-12-30 2002-12-30 Amersham Health As Nye peptider
EP2023143A1 (de) * 2007-08-06 2009-02-11 Boehringer Ingelheim Vetmedica Gmbh Immunogene Streptokokkus-Proteine
EP2897638A1 (de) * 2012-09-24 2015-07-29 Montana State University-Bozeman Rekombinanter lactococcus lactis zur expression des escherichia coli-kolonisationsfaktor-antigens i (cfa/i) fimbriae und verfahren zu deren verwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274425B1 (de) * 1987-01-06 1993-12-15 Asahi Kasei Kogyo Kabushiki Kaisha Pyruvat-Oxidase, ihre Herstellung und Verwendung
DE68929323T2 (de) * 1988-12-16 2002-04-18 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Pneumolysin-mutanten und pneumokokken-impfstoffe daraus
CA2104014C (en) * 1991-02-15 2000-05-02 David E. Briles Structural gene of pneumococcal protein
AU3065892A (en) * 1991-11-14 1993-06-15 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Pneumococcal fimbrial protein a vaccines
CA2127550A1 (en) * 1992-01-08 1993-07-22 Vincent Fischetti Multifunctional surface protein of streptococci

Also Published As

Publication number Publication date
CA2170726A1 (en) 1995-03-09
ES2267096T3 (es) 2007-03-01
NO960839L (no) 1996-04-19
ATE332376T1 (de) 2006-07-15
FI960977L (fi) 1996-04-30
JP3722834B2 (ja) 2005-11-30
US5981229A (en) 1999-11-09
WO1995006732A3 (en) 1995-06-01
DE69434784T2 (de) 2007-06-14
NZ273497A (en) 1998-03-25
WO1995006732A2 (en) 1995-03-09
EP0721506B1 (de) 2006-07-05
JPH09504686A (ja) 1997-05-13
PT721506E (pt) 2006-10-31
NO321826B1 (no) 2006-07-10
AU709405B2 (en) 1999-08-26
US5928900A (en) 1999-07-27
NO960839D0 (no) 1996-02-29
DK0721506T3 (da) 2006-10-30
EP0721506A1 (de) 1996-07-17
AU7680994A (en) 1995-03-22
FI960977A0 (fi) 1996-03-01

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