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DE69434492D1 - Phosphodiesterase des menschlichen gehirns - Google Patents

Phosphodiesterase des menschlichen gehirns

Info

Publication number
DE69434492D1
DE69434492D1 DE69434492T DE69434492T DE69434492D1 DE 69434492 D1 DE69434492 D1 DE 69434492D1 DE 69434492 T DE69434492 T DE 69434492T DE 69434492 T DE69434492 T DE 69434492T DE 69434492 D1 DE69434492 D1 DE 69434492D1
Authority
DE
Germany
Prior art keywords
phosphodiesterase
human brain
brain
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434492T
Other languages
English (en)
Other versions
DE69434492T2 (de
Inventor
George P Livi
Laughlin M Mc
Theodore J Torphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of DE69434492D1 publication Critical patent/DE69434492D1/de
Application granted granted Critical
Publication of DE69434492T2 publication Critical patent/DE69434492T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69434492T 1993-03-10 1994-03-10 Phosphodiesterase des menschlichen gehirns Expired - Lifetime DE69434492T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2933493A 1993-03-10 1993-03-10
US29334 1993-03-10
PCT/US1994/002612 WO1994020079A1 (en) 1993-03-10 1994-03-10 Human brain phosphodiesterase

Publications (2)

Publication Number Publication Date
DE69434492D1 true DE69434492D1 (de) 2006-02-02
DE69434492T2 DE69434492T2 (de) 2006-07-13

Family

ID=21848517

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69435280T Expired - Lifetime DE69435280D1 (de) 1993-03-10 1994-03-10 Phosphodiesterase des menschlichen Gehirns und Screening-Verfahren
DE69434492T Expired - Lifetime DE69434492T2 (de) 1993-03-10 1994-03-10 Phosphodiesterase des menschlichen gehirns

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69435280T Expired - Lifetime DE69435280D1 (de) 1993-03-10 1994-03-10 Phosphodiesterase des menschlichen Gehirns und Screening-Verfahren

Country Status (5)

Country Link
US (3) US6306583B1 (de)
EP (2) EP0752853B1 (de)
JP (1) JPH08508640A (de)
DE (2) DE69435280D1 (de)
WO (1) WO1994020079A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069240A (en) * 1994-03-01 2000-05-30 Icos Corporation Cloning by complementation and related processes
US20020068351A1 (en) * 1994-03-10 2002-06-06 Smithkline Beecham Corporation Human brain phosphodiesterase
AU4270596A (en) * 1994-12-23 1996-07-19 Celltech Therapeutics Limited Human phosphodiesterase type ivc, and its production and use
CA2279675A1 (en) 1995-12-15 1997-06-16 Enzo Therapeutics, Inc. Property effecting and/or property exhibiting constructs for localizing a nucleic acid construct within a cell for therapeutic and diagnostic uses
WO1998030718A1 (en) * 1997-01-09 1998-07-16 Merck Frosst Canada Co. System for stably expressing a high-affinity camp phosphodiesterase and use thereof
US5922557A (en) * 1997-01-09 1999-07-13 Merck & Co., Inc. System for stably expressing a high-affinity camp phosphodiesterase and use thereof
AU2005201269C1 (en) * 1999-01-13 2008-09-04 Curis, Inc. Regulators of the PCT or smoothened pathway, compositions and uses related thereto
JP2003531619A (ja) * 2000-04-28 2003-10-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング ｃＡＭＰホスホジエステラーゼ７型（ＰＤＥ７ａ３）のスプライス変異体
US6737301B2 (en) 2000-07-13 2004-05-18 Isothermal Systems Research, Inc. Power semiconductor switching devices, power converters, integrated circuit assemblies, integrated circuitry, power current switching methods, methods of forming a power semiconductor switching device, power conversion methods, power semiconductor switching device packaging methods, and methods of forming a power transistor
DE10251673A1 (de) 2001-11-09 2003-07-10 Hoffmann La Roche Alström-Syndrom-Gen, Genvarianten, codiertes Protein und Verfahren zur Diagnose des Alström-Syndroms
IS7221A (is) * 2001-11-15 2004-04-15 Memory Pharmaceuticals Corporation Hringlaga adenosínmónófosfat fosfódíesterasa 4D7 ísóform og aðferðir til notkunar þeirra
WO2004042390A2 (en) * 2002-11-08 2004-05-21 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4b (pde4b)
ATE397751T1 (de) * 2003-02-17 2008-06-15 Bayer Healthcare Ag Diagnostik- und therapie- verfahren von mit 5- ht1f rezeptor verbundenen haematologischen krankheiten
ATE397755T1 (de) * 2003-03-17 2008-06-15 Bayer Healthcare Ag Diagnostik- und therapie- verfahren von mit dopaminrezeptor d3 (drd3) verbundenen krankheiten
TWI328009B (en) 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
GB0521563D0 (en) 2005-10-21 2005-11-30 Glaxo Group Ltd Novel compounds
ATE504586T1 (de) 2006-08-01 2011-04-15 Glaxo Group Ltd Pyrazoloä3,4-büpyridinverbindungen und ihre verwendung als pde4-inhibitoren

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1201668A (en) 1977-11-08 1986-03-11 Genentech, Inc. Synthetic dna and method therefor
US4366246A (en) 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
CH656640A5 (de) 1977-11-08 1986-07-15 Genentech Inc Verfahren zur herstellung eines polypeptids.
US4411994A (en) 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
FR2480779B2 (fr) 1979-08-30 1986-07-18 Anvar Vecteur contenant une sequence nucleotidique de l'antigene de surface du virus de l'hepatite b et procede de fabrication d'une molecule immunogene mettant en oeuvre ce vecteur
US4342832A (en) 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4425437A (en) 1979-11-05 1984-01-10 Genentech, Inc. Microbial polypeptide expression vehicle
US4418149A (en) 1980-01-10 1983-11-29 President And Fellows Of Harvard College Fused hybrid gene
US4443539A (en) 1980-02-05 1984-04-17 The Upjohn Company Process for preparing bovine growth hormone
US4430428A (en) 1980-02-05 1984-02-07 The Upjohn Company Composition of matter and process
US4446235A (en) 1982-03-22 1984-05-01 Genentech, Inc. Method for cloning human growth hormone varient genes
EP0095361B1 (de) 1982-05-25 1989-07-26 Eli Lilly And Company Klonbildungsvektoren für die Expression von exogenem Protein
US4511652A (en) 1982-06-03 1985-04-16 The Regents Of The University Of California High efficiency eukaryotic metallothionein promoter system
GB2125047B (en) 1982-08-09 1986-02-19 Ciba Geigy Ag Yeast hybrid vectors and their use for the production of polypeptides
AU577259B2 (en) 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
CA1224432A (en) 1982-08-17 1987-07-21 Gary N. Buell Dna sequences, recombinant dna molecules and processes for producing bovine growth hormone-like polypeptides in high yield
US5190931A (en) * 1983-10-20 1993-03-02 The Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US6080540A (en) * 1990-04-20 2000-06-27 Cold Spring Harbor Laboratory Cloning of mammalian genes in microbial organisms and methods for pharmacological screening
US5441981A (en) * 1994-01-27 1995-08-15 Buckman Laboratories International, Inc. Synergistic antimicrobial compositions containing a halogenated acetophenone and an organic acid
US8767063B1 (en) 2013-07-26 2014-07-01 Berger Geosciences, LLC System for monitoring a marine well for shallow-water flow
TWI532361B (zh) 2013-12-27 2016-05-01 國立臺灣科技大學 自動尋景拍攝方法及其系統

Also Published As

Publication number Publication date
EP1281770A2 (de) 2003-02-05
US5932477A (en) 1999-08-03
WO1994020079A1 (en) 1994-09-15
US6306583B1 (en) 2001-10-23
US6150150A (en) 2000-11-21
DE69435280D1 (de) 2010-04-15
EP0752853B1 (de) 2005-09-21
EP1281770B1 (de) 2010-03-03
JPH08508640A (ja) 1996-09-17
DE69434492T2 (de) 2006-07-13
EP0752853A4 (de) 1997-07-16
EP1281770A3 (de) 2004-11-24
EP0752853A1 (de) 1997-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition