[go: up one dir, main page]

DE69433220D1 - New structural vitamin D derivatives - Google Patents

New structural vitamin D derivatives

Info

Publication number
DE69433220D1
DE69433220D1 DE69433220T DE69433220T DE69433220D1 DE 69433220 D1 DE69433220 D1 DE 69433220D1 DE 69433220 T DE69433220 T DE 69433220T DE 69433220 T DE69433220 T DE 69433220T DE 69433220 D1 DE69433220 D1 DE 69433220D1
Authority
DE
Germany
Prior art keywords
vitamin
ring
derivatives
analogue
membered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69433220T
Other languages
German (de)
Other versions
DE69433220T2 (en
Inventor
Roger Bouillon
Maurits Vandewalle
Clercq Pierre Jean De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roger Bouillon Herent Be
Katholieke Universiteit Leuven
Universiteit Gent
Original Assignee
Laboratoire Theramex SAM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Theramex SAM filed Critical Laboratoire Theramex SAM
Application granted granted Critical
Publication of DE69433220D1 publication Critical patent/DE69433220D1/en
Publication of DE69433220T2 publication Critical patent/DE69433220T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/198—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/27—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/19—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing hydroxy groups
    • C07C47/192—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing hydroxy groups containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/28—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/36—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/28—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/37—Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/242—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/26—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to analogues of vitamin D, which lack the combined presence of the trans-fused six-membered C-ring and of five-membered D-ring, but still possess a central part consisting of a substituted chain of five atoms, atoms which correspond to positions 8, 14, 13, 17 and 20 of vitamin D, and at the ends of which are connected, at position 20 a structural moiety representing part of the side-chain of vitamin D or of an analogue of vitamin D, and at position 8 the DELTA (5,7)-diene moiety connected to the A-ring of the active 1-alpha-hydroxy metabolite or of an established vitamin D analogue, to their preparation process, to pharmaceutical preparations comprising these compounds and to their use in medicine.
DE69433220T 1993-07-09 1994-07-07 New structural vitamin D derivatives Expired - Lifetime DE69433220T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93202037 1993-07-09
EP93202037 1993-07-09

Publications (2)

Publication Number Publication Date
DE69433220D1 true DE69433220D1 (en) 2003-11-06
DE69433220T2 DE69433220T2 (en) 2004-08-19

Family

ID=8213977

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69423966T Expired - Lifetime DE69423966T2 (en) 1993-07-09 1994-07-07 NEW STRUCTURAL VITAMIN D DERIVATIVES
DE69433220T Expired - Lifetime DE69433220T2 (en) 1993-07-09 1994-07-07 New structural vitamin D derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69423966T Expired - Lifetime DE69423966T2 (en) 1993-07-09 1994-07-07 NEW STRUCTURAL VITAMIN D DERIVATIVES

Country Status (16)

Country Link
US (2) US6017907A (en)
EP (2) EP0972762B1 (en)
JP (2) JP4235256B2 (en)
CN (1) CN1103755C (en)
AT (2) ATE251133T1 (en)
AU (1) AU699200B2 (en)
CA (1) CA2166898C (en)
DE (2) DE69423966T2 (en)
DK (2) DK0707566T3 (en)
ES (2) ES2209327T3 (en)
GR (1) GR3033856T3 (en)
NO (1) NO314142B1 (en)
NZ (1) NZ271332A (en)
PT (2) PT972762E (en)
RU (1) RU2153491C2 (en)
WO (1) WO1995001960A1 (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2209327T3 (en) * 1993-07-09 2004-06-16 Laboratoire Theramex NEW STRUCTURAL ANALOGS OF VITAMIN D.
HUT77612A (en) * 1994-11-21 1998-06-29 Wisconsin Alumni Research Foundation 18,19-dinor-vitamin d compounds, pharmaceutical compositions containing the same, their use
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
PT771789E (en) * 1995-10-30 2000-05-31 Hoffmann La Roche 1 ALPHA 26-DI-HYDROXY-D-HOMO-VITAMIN D3
KR19990067173A (en) * 1995-10-31 1999-08-16 클라우스너 프리돌린, 롤란드 보러 24-homo-26,27-hexafluoro-cholecalciferol
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
DE19619036A1 (en) 1996-04-30 1997-11-13 Schering Ag New vitamin D derivatives with carbo- or heterocyclic substituents at C-25, process for their preparation and their use in the manufacture of medicinal products
CA2288629A1 (en) * 1997-05-23 1998-11-26 F. Hoffmann-La Roche Ag Cyclohexanediol derivatives
AU735676B2 (en) * 1997-06-10 2001-07-12 Mrc Holdings Pty Limited Method of treatment of liver tumours and pharmaceutical compositions for use therein
AUPO727097A0 (en) * 1997-06-10 1997-07-03 Unisearch Limited Method of treatment of hepatoma and pharmaceutical compositions for use therein
ATE238986T1 (en) 1997-09-08 2003-05-15 Hoffmann La Roche 1,3-DIHYDROXY-20,20-DIALKYL VITAMIN D3 ANALOGUE
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
AU2549099A (en) * 1998-02-24 1999-09-15 Chugai Seiyaku Kabushiki Kaisha 24-hydroxyvitamin d derivatives
US6184422B1 (en) 1998-02-26 2001-02-06 Hoffman-La Roche Inc. Cyclohexanediol derivatives
ATE515265T1 (en) * 1998-03-27 2011-07-15 Univ Oregon Health & Science VITAMIN D AND ITS ANALOGUES FOR THE TREATMENT OF TUMORS AND OTHER HYPERPROLIFERATIVE DISEASES
US5962707A (en) * 1998-08-18 1999-10-05 Wisconsin Alumni Research Foundation 19-nor-vitamin D3 compounds with calcemic activity
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
DE19935771A1 (en) 1999-07-23 2001-02-01 Schering Ag New vitamin D derivatives with cyclic substructures in the side chains, processes and intermediates for their manufacture and their use in the manufacture of pharmaceuticals
US6310262B1 (en) * 1999-10-18 2001-10-30 Basilea Pharmaceutica Ag Process for preparing retiferol derivatives
JP4970682B2 (en) * 1999-12-08 2012-07-11 ラボラトワール テラメックス Vitamin D precursors, methods and intermediates
US6191292B1 (en) * 1999-12-08 2001-02-20 Laboratoire Theramex Precursors of the A-ring of vitamin D and method and intermediates for the preparation thereof
GB0305332D0 (en) * 2003-03-10 2003-04-09 Leuven K U Res & Dev Biological evaluation of novel vitamin D analogues
JP2007501864A (en) * 2003-06-11 2007-02-01 ノバセア インコーポレイティッド Treatment of immune mediated diseases by active vitamin D compounds alone or in combination with other therapeutic agents
US20050074443A1 (en) * 2003-10-03 2005-04-07 Treadwell Benjamin V. Methods of attenuating autoimmune disease and compositions useful therefor
GB0422929D0 (en) * 2004-10-15 2004-11-17 Leuven K U Res & Dev Bioactive vitamin D analogues
US7713951B2 (en) * 2004-04-09 2010-05-11 Wisconsin Alumni Research Foundation 2-alkylidene-18,19-dinor-vitamin D compounds
GB0423091D0 (en) * 2004-10-19 2004-11-17 Leuven K U Res & Dev Bioactive vitamin d analogues
US20080069814A1 (en) * 2005-01-05 2008-03-20 Novacea, Inc. Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof
BRPI0610077A2 (en) * 2005-04-22 2010-05-25 Novacea Inc treatment, prevention and mitigation of pulmonary disorders associated with chemotherapy or radiotherapy with active or mimetic vitamin D compounds
JP2011510088A (en) * 2008-01-22 2011-03-31 ウイスコンシン アラムニ リサーチ ファンデーション 13,13-Dimethyl-des-C, D analog of 1α, 25-dihydroxy-19-nor-vitamin D3 compound and its topical composition dosage form and method for treating skin conditions thereby
US8109466B2 (en) * 2008-06-23 2012-02-07 Rohr, Inc. Thrust reverser cascade assembly and AFT cascade ring with flow deflector portion
SG173119A1 (en) 2009-01-27 2011-08-29 Berg Biosystems Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN102448466A (en) * 2009-05-20 2012-05-09 混合基因股份公司 New therapeutical uses of inecalcitol
BR112012003372A2 (en) 2009-08-14 2019-09-24 Berg Biosystems Llc vitamin d3 and the like for the treatment of alopecia.
SI2360145T1 (en) * 2010-01-26 2012-08-31 Hybrigenics Sa New process for isomerizing fused bicyclic structures and preparation of vitamin D analogs comprising the same
JP5711811B2 (en) * 2010-05-20 2015-05-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Vitamin D compound dissociation reagent
BR112013000941A2 (en) 2010-07-15 2017-10-31 Hybrigenics Sa 14-epi-analog formulations of vitamin d
EP2407152A1 (en) 2010-07-15 2012-01-18 Hybrigenics S.A. Formulations of 14-epi-analogues of vitamin D
US20120015913A1 (en) 2010-07-15 2012-01-19 Delansorne Remi Formulations of 14-EPI-Analogues of Vitamin D
CN103946710B (en) 2011-11-18 2015-08-26 霍夫曼-拉罗奇有限公司 The delivery formulations of vitamin D compounds
WO2013078559A1 (en) * 2011-11-30 2013-06-06 Alphora Research Inc. Process for preparation of (3r)-2,4-di-leaving group-3-methylbut-1-ene
EP2791123B1 (en) 2011-12-16 2018-07-18 Sandoz AG Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof
WO2013097042A1 (en) 2011-12-29 2013-07-04 Alphora Research Inc. 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation
JP6531911B2 (en) 2012-03-30 2019-06-19 サンド アーゲー Synthetic process for preparing macrocyclic C1-keto analogues of halichondrin B and useful intermediates therefor
AU2014228574B2 (en) 2013-03-14 2018-07-26 Aquinox Pharmaceuticals (Canada) Inc. SHIP1 modulators and methods related thereto
AU2014242041B2 (en) 2013-03-14 2018-07-26 Aquinox Pharmaceuticals (Canada) Inc. SHIP1 modulators and methods related thereto
KR20160013201A (en) 2013-05-29 2016-02-03 버그 엘엘씨 Preventing or mitigating chemotherapy induced alopecia using vitamin d
GB2515128B (en) 2013-06-10 2015-05-27 Givaudan Sa Improvements in or relating to organic compounds
EP3094615A4 (en) 2014-01-13 2017-11-08 P2 Science, Inc. Terpene-derived acids and esters and methods for preparing and using same
US10071944B2 (en) 2014-06-20 2018-09-11 P2 Science, Inc. Film ozonolysis in a tubular or multitubular reactor
US20170247314A1 (en) * 2014-08-06 2017-08-31 P2 Science, Inc. Fragrances from the esters of fatty acids
GB201421855D0 (en) * 2014-12-09 2015-01-21 Givaudan Sa Improvements in or relating to organic compounds
EP3313811A1 (en) 2015-06-26 2018-05-02 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
US10053415B2 (en) 2016-01-20 2018-08-21 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
WO2017223220A1 (en) 2016-06-21 2017-12-28 P2 Science, Inc. Flow-through reactors for the continuous quenching of peroxide mixtures and methods comprising the same
US10696605B2 (en) 2016-09-16 2020-06-30 P2 Science, Inc. Uses of vanadium to oxidize aldehydes and ozonides
CA3114469A1 (en) 2018-10-19 2020-04-23 P2 Science, Inc. New methods for disproportionation quenching of ozonides
CN110330522A (en) * 2019-07-29 2019-10-15 南京海融医药科技股份有限公司 A kind of preparation method of paricalcitol isomer impurities PY5

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH667087A5 (en) * 1984-01-30 1988-09-15 Wisconsin Alumni Res Found UNSATURATED 1-HYDROXYVITAMIN D-LINKS IN THE SIDE CHAIN.
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
DE3913310A1 (en) * 1989-04-20 1990-10-25 Schering Ag New 10,19-methylene-9,10-seco-pregnane derivs. - useful as vitamin=D analogues with anti-proliferative activity
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
ES2209327T3 (en) * 1993-07-09 2004-06-16 Laboratoire Theramex NEW STRUCTURAL ANALOGS OF VITAMIN D.

Also Published As

Publication number Publication date
EP0972762B1 (en) 2003-10-01
ES2209327T3 (en) 2004-06-16
RU2153491C2 (en) 2000-07-27
PT707566E (en) 2000-09-29
DE69423966D1 (en) 2000-05-18
ES2147238T3 (en) 2000-09-01
JP2006001944A (en) 2006-01-05
PT972762E (en) 2004-02-27
EP0707566B1 (en) 2000-04-12
US6017907A (en) 2000-01-25
DK0707566T3 (en) 2000-09-04
AU7492794A (en) 1995-02-06
JPH09500117A (en) 1997-01-07
ATE251133T1 (en) 2003-10-15
ATE191712T1 (en) 2000-04-15
DK0972762T3 (en) 2004-02-09
CA2166898A1 (en) 1995-01-19
DE69423966T2 (en) 2000-11-16
EP0707566A1 (en) 1996-04-24
EP0972762A2 (en) 2000-01-19
WO1995001960A1 (en) 1995-01-19
JP4235256B2 (en) 2009-03-11
NO314142B1 (en) 2003-02-03
NO960099D0 (en) 1996-01-09
GR3033856T3 (en) 2000-10-31
CN1130899A (en) 1996-09-11
CA2166898C (en) 2004-09-07
US6548715B1 (en) 2003-04-15
NO960099L (en) 1996-03-08
CN1103755C (en) 2003-03-26
NZ271332A (en) 2001-03-30
DE69433220T2 (en) 2004-08-19
EP0972762A3 (en) 2000-02-23
JP4312183B2 (en) 2009-08-12
AU699200B2 (en) 1998-11-26

Similar Documents

Publication Publication Date Title
ATE191712T1 (en) NEW STRUCTURAL VITAMIN D DERIVATIVES
ITMI920528A1 (en) 14-BETA IDROSSI-10-DEACETIL-BACCATINA III, ITS DERIVATIVES, THEIR PREPATION AND THERAPEUTIC USE
ES2070628T3 (en) USE OF COMPOUNDS ANALOGED TO 1,3-OXATIOLANE-NUCLEOSIDES IN THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF HEPATITIS B.
ES2147739T3 (en) PHOSPHONOOXIMETIL-ETERES OF TAXANE DERIVATIVES.
DK0449247T3 (en) Pharmaceutical formulation containing galanthamine for the treatment of alcoholism
ES2062431T3 (en) NEW 19-NOR-STEROIDS THAT HAVE IN POSITION 11BETA A CARBON CHAIN THAT INCLUDES AN AMIDA OR CARBAMATE FUNCTION, ITS PREPARATION PROCEDURE AND THE INTERMEDIATE PRODUCTS OF THIS PROCEDURE, ITS APPLICATION AS DRUGS AND PHARMACEUTICAL COMPOSITIONS
DE68902531D1 (en) DISPERSABLE PREPARATION.
GR900100644A (en) Derma atropho glycocorticoids leversal
DK0441279T3 (en) Bilobalide-phospholipid complexes, their use and compositions containing them
SE8704952D0 (en) PHARMACEUTICAL COMPOSITION
DK1078627T3 (en) A pharmaceutical composition comprising amoxillin and clavulanate
IT8721691A0 (en) DERIVATIVES OF 1,2,5,6-TETRAHYDROPYRDIN-3-CARBOXALDEHYDE OXYME, THEIR PREPARATION PROCEDURE AND THEIR USE AS MEDICINAL SUBSTANCES.
IT9019793A0 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING IPRIFLAVONE, PROCEDURE FOR THEIR PREPARATION AND RELATED THERAPEUTIC USE
NO902710D0 (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE R (-) 3-KINUCLIDINOL DERIVATIVES.
IT8721687A0 (en) DERIVATIVES OF THE OXYME OF 1,2,5,6-TETRAHYDROPYRIDIN-3-CARBOXA LDEHYDE, THEIR PREPARATION PROCEDURE AND THEIR USE AS MEDICINAL SUBSTANCES.
NO172491C (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1,3-DIOXANE-ALCOHIC ACID DERIVATIVES
NZ246598A (en) Trazodone derivatives; compounds and preparation, pharmaceutical compositions; intermediate compounds
MX9303392A (en) DERIVATIVES OF IMIDAZO BENZOXAZIN-1-ONA SUBSTITUTED AND PROCESS FOR ITS PREPARATION.
HUP0301334A2 (en) Combined compositions against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolited
NO922635D0 (en) NEW USE OF BENZIMIDAZOLINE-2-OXO-1-CARBOXYLIC ACID DERIVATIVES
ATE74505T1 (en) PAIN REMEDY.
ATE224401T1 (en) THIOCOLCHICOSIDE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS
IT9019675A0 (en) NEW DERIVATIVES OF 1.2.5.6.-TETRAHYDROPYRIDIN 3 CARBOXALDEHYDE OXYME, THEIR PREPARATION PROCEDURE AND THEIR USE AS A MEDICINAL SUBSTANCE
ITMI911841A1 (en) DERIVATIVES OF HESERIDINE USEFUL FOR THE TREATMENT OF DISEASES ASSOCIATED WITH COLINERGIC DISORDERS, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
ITMI911842A1 (en) DERIVATIVES OF HESERIDINE USEFUL FOR THE TREATMENT OF DISEASES ASSOCIATED WITH COLINERGIC DISORDERS, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: K.U. LEUVEN RESEARCH & DEVELOPMENT, LEUVEN, BE

Owner name: ROGER BOUILLON, HERENT, BE

Owner name: UNIVERSITEIT GENT, GENT, BE