[go: up one dir, main page]

DE69431831D1 - Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung - Google Patents

Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung

Info

Publication number
DE69431831D1
DE69431831D1 DE69431831T DE69431831T DE69431831D1 DE 69431831 D1 DE69431831 D1 DE 69431831D1 DE 69431831 T DE69431831 T DE 69431831T DE 69431831 T DE69431831 T DE 69431831T DE 69431831 D1 DE69431831 D1 DE 69431831D1
Authority
DE
Germany
Prior art keywords
particles
suspensions
lipid
solid lipid
delivery systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431831T
Other languages
English (en)
Other versions
DE69431831T2 (de
Inventor
Kirsten Westesen
Britta Siekmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Publication of DE69431831D1 publication Critical patent/DE69431831D1/de
Application granted granted Critical
Publication of DE69431831T2 publication Critical patent/DE69431831T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/044—Suspensions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/48—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids
    • B01F23/482—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids using molten solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/51—Methods thereof
    • B01F23/511—Methods thereof characterised by the composition of the liquids or solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Dentistry (AREA)
  • Medical Informatics (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Geometry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • General Preparation And Processing Of Foods (AREA)
DE69431831T 1993-03-05 1994-03-04 Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung Expired - Fee Related DE69431831T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2750193A 1993-03-05 1993-03-05
CA002091152A CA2091152C (en) 1993-03-05 1993-03-05 Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
PCT/SE1994/000185 WO1994020072A1 (en) 1993-03-05 1994-03-04 Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof

Publications (2)

Publication Number Publication Date
DE69431831D1 true DE69431831D1 (de) 2003-01-16
DE69431831T2 DE69431831T2 (de) 2003-04-10

Family

ID=25675967

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431831T Expired - Fee Related DE69431831T2 (de) 1993-03-05 1994-03-04 Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung

Country Status (13)

Country Link
EP (1) EP0687172B1 (de)
JP (2) JP3916249B2 (de)
AT (1) ATE228821T1 (de)
AU (1) AU676279B2 (de)
CA (1) CA2091152C (de)
DE (1) DE69431831T2 (de)
DK (1) DK0687172T3 (de)
ES (1) ES2190439T3 (de)
FI (1) FI114006B (de)
NO (1) NO314285B1 (de)
NZ (1) NZ262541A (de)
PT (1) PT687172E (de)
WO (1) WO1994020072A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5785976A (en) * 1993-03-05 1998-07-28 Pharmacia & Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US5885486A (en) * 1993-03-05 1999-03-23 Pharmaciaand Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
PT101422B (pt) * 1993-12-06 1997-06-30 Ineti Inst Biotec Q F E Tecnol Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao
DE4440337A1 (de) * 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
US5747001A (en) * 1995-02-24 1998-05-05 Nanosystems, L.L.C. Aerosols containing beclomethazone nanoparticle dispersions
ATE274341T1 (de) 1995-02-24 2004-09-15 Elan Pharma Int Ltd Nanopartikel-dispersionen enthaltende aerosole
DE19517147C2 (de) * 1995-05-10 1999-07-01 Hexal Pharmaforschung Gmbh Aciclovir-Zubereitung
CZ299790B6 (cs) * 1996-08-22 2008-11-26 Skyepharma Canada Inc. Kompozice mikrocástic ve vode nerozpustné látky, farmaceutická kompozice, zpusob prípravy stabilních cástic, mikrocástice ve vode nerozpustné nebo slabe rozpustné slouceniny, kompozice obsahující tyto mikrocástice a zpusob prípravy mikrocástic
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
DE19641259A1 (de) * 1996-10-07 1998-04-16 Kade Pharma Fab Gmbh Arzneimittel auf Basis von Diclofenac
ES2172774T3 (es) * 1996-10-25 2002-10-01 Monsanto Technology Llc Composiciones y procedimiento para el tratamiento de plantas con sustancias quimicas exogenas.
ATE222694T1 (de) 1996-10-25 2002-09-15 Monsanto Technology Llc Zusammensetzung und verfahren zur behandlung von pflanzen mit exogenen chemikalien
GB9624615D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Chrystallisation process
GB9625589D0 (en) * 1996-12-10 1997-01-29 Boots Co Plc Therapeutic agents
IT1292142B1 (it) * 1997-06-12 1999-01-25 Maria Rosa Gasco Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale
US6423363B1 (en) * 1997-08-22 2002-07-23 Lipton, Division Of Conopco, Inc. Aqueous dispersion
WO1999029300A1 (en) * 1997-12-10 1999-06-17 Rtp Pharma Inc. Self-emulsifying fenofibrate formulations
IT1298575B1 (it) * 1998-02-06 2000-01-12 Vectorpharma Int Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di
SE512958C2 (sv) † 1998-04-30 2000-06-12 Triple Crown Ab Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning
GB9810859D0 (en) 1998-05-20 1998-07-22 Zeneca Ltd Crystallisation process
AU3776999A (en) * 1998-06-17 2000-01-05 Uniroyal Chemical Company, Inc. Biologically-active microdispersion composition
ITMI981528A1 (it) * 1998-07-03 2000-01-03 Recordati Ind Chimica E Farma Formulazioni topiche di aciclovir
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
EE05190B1 (et) 1998-11-20 2009-08-17 Rtp Pharma Inc. Dispergeeruvad fosfolipiididega stabiliseeritud mikroosakesed
IT1303787B1 (it) 1998-11-25 2001-02-23 Maria Rosa Gasco "nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule"
DE19919770A1 (de) * 1999-04-30 2000-11-02 Henkel Kgaa Verwendung nanoskaliger antimikrobieller Wirkstoffe in der Mund- und/oder Zahnpflege
SE517769C2 (sv) 1999-10-29 2002-07-16 Triple Crown Ab Kolesterol och blodfettsänkande komposition, innehållande fytosteroler, blandade med monoglycerider
KR20020026053A (ko) 2000-09-30 2002-04-06 노승권 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료
US20040077604A1 (en) 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
MXPA04002446A (es) * 2001-09-26 2004-07-23 Baxter Int Preparacion de nanoparticulas de tamano de submicras mediante dispersion y remocion de la fase liquida o solvente.
AU2003223852A1 (en) 2002-02-28 2003-09-09 Wolf-Dieter Juelich Micro/nanoparticle obtained from lipid-containing marine organisms for use in pharmaceutics and cosmetics
WO2003077679A1 (en) * 2002-03-20 2003-09-25 Eugene Science Inc. Plant sterol-containing food, and method for preparing the same
JP4452970B2 (ja) 2002-03-27 2010-04-21 日本臓器製薬株式会社 ジクロフェナクナトリウム経口製剤
EP1551457A1 (de) * 2002-07-16 2005-07-13 Elan Pharma International Limited Flüssige dosierzusammensetzungen von stabilen wirkstoffen in nanoteilchenform
ITMI20021725A1 (it) * 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.
CN102343094A (zh) 2002-12-09 2012-02-08 阿布拉西斯生物科学有限责任公司 组合物和传递药剂的方法
DE10312763A1 (de) * 2003-03-21 2004-09-30 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Verfahren zur Herstellung einer SLN-Dispersion
FR2852843B1 (fr) 2003-03-24 2008-05-23 Karim Ioualalen Systeme galenique permettant le masquage du gout
JP2004323444A (ja) * 2003-04-25 2004-11-18 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai 凍結乾燥微粒子製剤およびその製法
US7438903B2 (en) * 2003-06-06 2008-10-21 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
DE10357640A1 (de) 2003-08-27 2005-03-24 Beiersdorf Ag Kosmetische kugelförmige Zubereitungen zur topischen Anwendung
WO2005020940A1 (de) 2003-08-27 2005-03-10 Beiersdorf Ag Kapsel deren kapselhülle bei topischer anwendung nicht mehr gesondert warhnembar ist
EP1660033B1 (de) 2003-08-27 2010-11-10 Beiersdorf AG Kosmetische kugelförmige zubereitungen zur topischen anwendung
JP2005097295A (ja) * 2003-09-01 2005-04-14 Wakunaga Pharmaceut Co Ltd ビタミン安定液剤
JP2007530497A (ja) 2004-03-26 2007-11-01 セル セラピューティクス ヨーロッパ エス．アール．エル． 白金化合物のナノ粒子配合物
US7803366B2 (en) 2004-05-07 2010-09-28 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
EP1674085A1 (de) * 2004-12-22 2006-06-28 Universite Libre De Bruxelles Feste Lipidteilchen als pharmazeutische annehmbare Füllstoffe oder Träger zur Inhalation
CA2618655C (en) * 2005-07-18 2015-12-22 University Of Massachusetts Lowell Compositions and methods for making and using nanoemulsions
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
US7943666B2 (en) 2006-07-24 2011-05-17 Trinity Laboratories, Inc. Esters of capsaicin for treating pain
US20100172943A1 (en) 2006-12-01 2010-07-08 Anterios, Inc. Peptide nanoparticles and uses therefor
KR20090106493A (ko) 2006-12-01 2009-10-09 안테리오스, 인코퍼레이티드 양쪽성 엔티티 나노입자
WO2008102065A1 (fr) * 2007-02-14 2008-08-28 Commissariat A L'energie Atomique Emulsions fluorescentes pour l'imagerie optique
WO2008131170A1 (en) 2007-04-18 2008-10-30 Particle Sciences, Inc, Aerosol dispersions of particles with active pharmaceutical ingredients
KR20100050443A (ko) 2007-05-31 2010-05-13 안테리오스, 인코퍼레이티드 핵산 나노입자 및 이의 용도
JP5468271B2 (ja) * 2008-02-08 2014-04-09 花王株式会社 微粒子分散液の製造方法
DE102008035442A1 (de) 2008-07-26 2010-01-28 Ernst-Moritz-Arndt-Universität Greifswald Zubereitungen aus Artemisia Annua, ihre Umwandlung in Mikro- und Nanopartikel und ihre Verwendung
FR2934954B1 (fr) * 2008-08-14 2011-07-22 Commissariat Energie Atomique Emulsion fluorescente de vert d'indocyanine
FR2934953B1 (fr) 2008-08-14 2011-01-21 Commissariat Energie Atomique Nanoemulsions de nanocristaux
FR2934955B1 (fr) 2008-08-14 2011-07-08 Commissariat Energie Atomique Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions
ES2467676T3 (es) 2008-09-19 2014-06-12 Activus Pharma Co., Ltd. Polvo de un compuesto orgánico combinado para uso médico, método para producir el mismo y suspensión del mismo
WO2010138539A2 (en) 2009-05-27 2010-12-02 Elan Pharma International Ltd. Reduction of flake-like aggregation in nanoparticulate active agent compositions
AU2011248449B2 (en) 2010-05-03 2016-09-15 Teikoku Pharma Usa, Inc. Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
WO2012059936A1 (en) 2010-11-03 2012-05-10 Padma Venkitachalam Devarajan Pharmaceutical compositions for colloidal drug delivery
WO2013105026A1 (en) * 2012-01-09 2013-07-18 Department Of Biotechnology (Dbt) A process for preparing solid lipid sustained release nanoparticles for delivery of vitamins
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
JPWO2014054172A1 (ja) * 2012-10-05 2016-08-25 株式会社原田食品 ゾル状低カロリー食品素材および包装容器体入ゾル状低カロリー食品素材およびそれらの製造方法
WO2014085813A1 (en) * 2012-11-30 2014-06-05 Insmed Incorporated Prostacylin compositions and methods for using the same
EP2823811A1 (de) * 2013-07-09 2015-01-14 OTC GmbH Gerichtetes aktives Freisetzungssystem mit festen Lipidnanopartikeln
BR112016009207B1 (pt) 2013-10-25 2022-11-22 Insmed Incorporated Compostos de prostaciclina
WO2015155703A2 (en) 2014-04-09 2015-10-15 Nanoceutica Laboratories Pvt. Ltd Composition and method of producing nanoformulation of water insoluble bioactives in aqueous base
EP3904326A1 (de) 2014-11-18 2021-11-03 Insmed Incorporated Verfahren zur herstellung von treprostinil und treprostinilderivat-prodrugs
EP3510161A4 (de) 2016-08-23 2020-04-22 Akouos, Inc. Zusammensetzungen und verfahren zur behandlung von nicht altersbedingten hörschäden bei einer person
WO2018093465A1 (en) 2016-11-21 2018-05-24 Eirion Therapeutics, Inc. Transdermal delivery of large agents
BR112021021775A2 (pt) 2019-04-29 2022-01-04 Insmed Inc Composições de pó seco de pró-fármacos de treprostinil e métodos de uso destas
WO2021119271A1 (en) * 2019-12-10 2021-06-17 Capsugel Belgium Nv Particles containing a lipid matrix core and active ingredient
WO2021168362A1 (en) 2020-02-21 2021-08-26 Akouos, Inc. Compositions and methods for treating non-age-associated hearing impairment in a human subject

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
DE3702029A1 (de) * 1987-01-24 1988-08-04 Basf Ag Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung
EP0502119B1 (de) * 1989-11-13 1996-01-31 Scios Nova, Inc. Liposphären zur kontrollierten substanzabgabe
AU658608B2 (en) * 1991-03-25 1995-04-27 Astellas Pharma Europe B.V. Topical preparation containing a suspension of solid lipid particles

Also Published As

Publication number Publication date
FI954143A0 (fi) 1995-09-04
NZ262541A (en) 1997-04-24
JPH08507515A (ja) 1996-08-13
PT687172E (pt) 2003-04-30
AU6225394A (en) 1994-09-26
EP0687172A1 (de) 1995-12-20
CA2091152C (en) 2005-05-03
NO314285B1 (no) 2003-03-03
AU676279B2 (en) 1997-03-06
DK0687172T3 (da) 2003-03-17
DE69431831T2 (de) 2003-04-10
WO1994020072A1 (en) 1994-09-15
NO953461L (no) 1995-11-06
EP0687172B1 (de) 2002-12-04
ATE228821T1 (de) 2002-12-15
JP3916249B2 (ja) 2007-05-16
CA2091152A1 (en) 1994-09-06
FI954143A (fi) 1995-10-19
FI114006B (fi) 2004-07-30
NO953461D0 (no) 1995-09-04
JP2007023051A (ja) 2007-02-01
ES2190439T3 (es) 2003-08-01

Similar Documents

Publication Publication Date Title
DE69431831D1 (de) Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung
DE69707433T2 (de) Mikropartikel aus einem zusammengesetzten gel als wirkstoffträger
DE3783958T2 (de) Verzoegerte abgabe von makromolekularen polypeptiden.
DE69124357T2 (de) Protein Nanomatrizen und Verfahren zur Herstellung
CA2294172C (en) Pharmaceutical composition in form of solid lipidic microparticles suitable to parenteral administration
DE60033405T2 (de) Chimäre polypeptide, verfahren zur herstellung und verwendung dafür
US4394372A (en) Process for making lipid membrane structures
DE69231507T2 (de) Verfahren zur Zubereitung von biologisch aktiven Komponenten enthaltenden Mikrospheren
FI102811B1 (fi) Menetelmä vaikuttavaa ainetta sisältävien mikropartikkeleiden valmistamiseksi hydrolyyttisesti hajoavista polymeereistä
JP2002530323A5 (de)
ATE112675T1 (de) Granulare zubereitungen und verfahren zur ihrer herstellung.
LU91613I2 (fr) Paclitaxel albumin (Abraxane - paclitaxel)
DE69509671D1 (de) Pharmazeutische zusammensetzung mit einem schmelzbaren traegermaterial und verfahren zu seiner herstellung
NO962088L (no) Preparat for in vivo-produksjon av terapeutiske produkter
UA35569C2 (uk) Композиція для пролонгованого і контрольованого вивільнення пептидної лікарської речовини і спосіб її одержання, спосіб приготування суспензії, що призначена для парентерального введення
JPS63232840A (ja) 微小カプセル形物質の分散コロイド系の製造方法
JPH02502794A (ja) 表面活性剤とステロイドから形成される脂質小胞
DE69519685D1 (de) Oral anzuwendende arzneizubereitung mit verzögerter wirkstoffabgabe
Clements et al. Injectable biomaterials for delivery of interleukin-1 receptor antagonist: toward improving its therapeutic effect
JPH062224B2 (ja) 極小粒子形の蛋白質の分散性コロイド系の調製方法
CA2263765A1 (en) Methods for the production of protein particles useful for delivery of pharmacological agents
Strader et al. Encoding structure in intrinsically disordered protein biomaterials
Cui et al. Surface entrapment of polylysine in biodegradable poly (DL-lactide-co-glycolide) microparticles
Bouissou et al. Controlled release of the fibronectin central cell binding domain from polymeric microspheres
Rao et al. Controlled release systems for proteins based on gelatin microspheres

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee