DE69421665D1 - Anomere Fluorribosylamine - Google Patents

Anomere Fluorribosylamine

Info

Publication number: DE69421665D1
Authority: DE; Germany
Prior art keywords: anomeric; fluororibosylamines; difluororibosyl; deoxynucleosides; azide
Prior art date: 1993-09-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69421665T

Other languages

English (en)

Other versions

DE69421665T2 (de

Inventor

Larry Wayne Hertel

Charles David Jones

Julian Stanley Kroin

Thomas Edward Mabry

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-16

Filing date

1994-09-12

Publication date

1999-12-23

1994-09-12 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1999-12-23 Publication of DE69421665D1 publication Critical patent/DE69421665D1/de

2000-05-25 Application granted granted Critical

2000-05-25 Publication of DE69421665T2 publication Critical patent/DE69421665T2/de

2014-09-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Quinoline Compounds (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Noodles (AREA)

DE69421665T 1993-09-16 1994-09-12 Anomere Fluorribosylamine Expired - Lifetime DE69421665T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/122,876 US5480992A (en)	1993-09-16	1993-09-16	Anomeric fluororibosyl amines

Publications (2)

Publication Number	Publication Date
DE69421665D1 true DE69421665D1 (de)	1999-12-23
DE69421665T2 DE69421665T2 (de)	2000-05-25

Family

ID=22405359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69421665T Expired - Lifetime DE69421665T2 (de)	1993-09-16	1994-09-12	Anomere Fluorribosylamine

Country Status (15)

Country	Link
US (3)	US5480992A (de)
EP (1)	EP0647654B1 (de)
JP (1)	JP3762445B2 (de)
KR (1)	KR100322355B1 (de)
AT (1)	ATE186731T1 (de)
BR (1)	BR9403572A (de)
CA (1)	CA2130124C (de)
DE (1)	DE69421665T2 (de)
DK (1)	DK0647654T3 (de)
ES (1)	ES2139714T3 (de)
FI (1)	FI113179B (de)
GR (1)	GR3032603T3 (de)
HU (1)	HU220672B1 (de)
IL (2)	IL110932A (de)
TW (1)	TW342392B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6906495B2 (en) *	2002-05-13	2005-06-14	Splashpower Limited	Contact-less power transfer
US7214791B2 (en) *	2004-07-01	2007-05-08	Shenzhen Hande Technology Co., Ltd.	Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
KR20080099263A (ko) *	2006-02-07	2008-11-12	케마지스 리미티드	젬시타빈 및 관련된 중간체의 제조 방법
US20070249823A1 (en) *	2006-04-20	2007-10-25	Chemagis Ltd.	Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) *	2007-04-23	2008-10-23	Chemagis Ltd.	Gemcitabine production process

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2270235B1 (de) *	1974-02-15	1982-09-03	Sanofi Sa
FR2315500A2 (fr) *	1975-06-24	1977-01-21	Labaz	Procede de preparation d'un diazidocyclohexanediol
US4526988A (en) *	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor
US4879377A (en) *	1983-11-18	1989-11-07	Bristol-Myers Company	Nucleoside process
ATE92499T1 (de) *	1984-12-04	1993-08-15	Lilly Co Eli	Tumorbehandlung bei saeugetieren.
US4965374A (en) *	1987-08-28	1990-10-23	Eli Lilly And Company	Process for and intermediates of 2',2'-difluoronucleosides
JPH0232093A (ja) *	1988-06-08	1990-02-01	Merrell Dow Pharmaceut Inc	抗レトロウィルスジフルオロ化ヌクレオシド類

1993
- 1993-09-16 US US08/122,876 patent/US5480992A/en not_active Expired - Lifetime
1994
- 1994-08-11 TW TW083107347A patent/TW342392B/zh not_active IP Right Cessation
- 1994-08-15 CA CA002130124A patent/CA2130124C/en not_active Expired - Fee Related
- 1994-09-12 DK DK94306670T patent/DK0647654T3/da active
- 1994-09-12 IL IL11093294A patent/IL110932A/xx not_active IP Right Cessation
- 1994-09-12 ES ES94306670T patent/ES2139714T3/es not_active Expired - Lifetime
- 1994-09-12 DE DE69421665T patent/DE69421665T2/de not_active Expired - Lifetime
- 1994-09-12 EP EP94306670A patent/EP0647654B1/de not_active Expired - Lifetime
- 1994-09-12 AT AT94306670T patent/ATE186731T1/de active
- 1994-09-14 JP JP21985394A patent/JP3762445B2/ja not_active Expired - Fee Related
- 1994-09-15 FI FI944281A patent/FI113179B/fi not_active IP Right Cessation
- 1994-09-15 KR KR1019940023346A patent/KR100322355B1/ko not_active Expired - Fee Related
- 1994-09-15 HU HU9402646A patent/HU220672B1/hu not_active IP Right Cessation
- 1994-09-15 BR BR9403572A patent/BR9403572A/pt not_active Application Discontinuation
1995
- 1995-05-30 US US08/453,736 patent/US5541345A/en not_active Expired - Lifetime
- 1995-05-30 US US08/453,734 patent/US5594155A/en not_active Expired - Lifetime
2000
- 2000-02-09 GR GR20000400301T patent/GR3032603T3/el unknown
- 2000-07-10 IL IL13724800A patent/IL137248A0/xx unknown

Also Published As

Publication number	Publication date
IL110932A0 (en)	1994-11-28
GR3032603T3 (en)	2000-05-31
US5480992A (en)	1996-01-02
TW342392B (en)	1998-10-11
EP0647654B1 (de)	1999-11-17
IL110932A (en)	2003-05-29
IL137248A0 (en)	2001-07-24
ATE186731T1 (de)	1999-12-15
JPH07149783A (ja)	1995-06-13
ES2139714T3 (es)	2000-02-16
CA2130124A1 (en)	1995-03-17
FI944281A0 (fi)	1994-09-15
BR9403572A (pt)	1995-05-16
US5594155A (en)	1997-01-14
EP0647654A2 (de)	1995-04-12
HU9402646D0 (en)	1994-12-28
JP3762445B2 (ja)	2006-04-05
US5541345A (en)	1996-07-30
DE69421665T2 (de)	2000-05-25
HU220672B1 (hu)	2002-04-29
EP0647654A3 (de)	1995-05-03
KR950008529A (ko)	1995-04-19
CA2130124C (en)	2004-08-10
FI113179B (fi)	2004-03-15
KR100322355B1 (ko)	2002-11-30
DK0647654T3 (da)	2000-03-13
HUT72590A (en)	1996-05-28
FI944281L (fi)	1995-03-17

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DK0871631T3 (da)	2006-03-13	Antiparasitære marcfortiner og paraherquamider
TR199600456A2 (tr)	1996-12-21	Antidiabetik maddeler olarak ikame edilmis N-(indol-2-karbonil)-glisinamidler ve türevleri.
DE69415163D1 (de)	1999-01-21	ZUZAMMENSETUNG ENTHALTEND 1,1,1,2,3,4,4,5,5,5,-DECAFLUORPENTAN UND n-PROPANOL
ZA964646B (en)	1997-12-05	Substituted N-(indole-2-Carbonyl)-ß-alanimamides and derivatives as antidiabetic agents.
FI955315L (fi)	1995-11-06	HIV:n proteaasin inhibiittoreita, jotka ovat käyttökelpoisia AIDS'n hoitoon
DK0960127T3 (da)	2010-03-29	Isoleret dimert fibroblastaktiverende protein-alfa og anvendelser deraf
IT8819077A0 (it)	1988-01-15	Processo per la preparazione di 1,2 difluoroetano e di 1,1,2trifluoroetano.
DK0721457T3 (da)	1999-11-08	2',5'-Oligoadenylat-2',3'-cyclophosphater og 2',5'-oligo-adenylater med antipapillomavirusaktivitet
DE69010141D1 (de)	1994-07-28	Lager und Lageranordnung.
IT1240486B (it)	1993-12-17	Procedimento di ammollo enzimatico per pelli e pellami.
DK1431391T3 (da)	2005-12-19	RANTES-mutanter og terapeutiske anvendelser heraf
IT1268332B1 (it)	1997-02-27	Dispositivo manipolatore per la movimentazione, in particolare per l'orientamento di pezzi, utensili, o simili.
DK0647654T3 (da)	2000-03-13	Anomere fluor-ribosylaminer
MD930031A (ro)	1994-11-30	Bautura tare rachiu "chirsova"
ITRM930502A0 (it)	1993-07-29	Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
EP0600278A3 (de)	1995-01-25	Protein und Gen des Glutamatrezeptors.
FR2705687B1 (fr)	2002-09-20	Identification clonage et expression de l'enzyme malolactique.
FR2719067B1 (fr)	1996-05-31	Pavillon de loisir.
ITTO940327A0 (it)	1994-04-22	Procedimento e dispositivo per l'addolcimento elettrolitico di pezzi d'acciaio.
IT230191Y1 (it)	1999-05-05	Schienale di zaini e simili, perfezionato.
ES1023451Y (es)	1994-02-01	"almohada inflable de uso personal".
IT1293640B1 (it)	1999-03-08	Bottale per la follatura di pelli e pellame.
ZA964409B (en)	1997-12-01	Substituted N-(indole-2-carbonyl)-glycinamides and derivatives as antidiabetic agents.
ITRM930343A0 (it)	1993-05-24	Proteine ricombinanti, vettori per l'espressione e loro usi.
IT8623234V0 (it)	1986-09-30	Intelaiatura attrezzata particolarmente per bide' e simili.

Legal Events

Date	Code	Title	Description
2000-12-07	8364	No opposition during term of opposition
2010-05-20	8328	Change in the person/name/address of the agent	Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336
2011-06-16	8328	Change in the person/name/address of the agent	Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN