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DE69414482D1 - Tumorgewebe - Charakterisierungs-Instrument - Google Patents

Tumorgewebe - Charakterisierungs-Instrument

Info

Publication number
DE69414482D1
DE69414482D1 DE69414482T DE69414482T DE69414482D1 DE 69414482 D1 DE69414482 D1 DE 69414482D1 DE 69414482 T DE69414482 T DE 69414482T DE 69414482 T DE69414482 T DE 69414482T DE 69414482 D1 DE69414482 D1 DE 69414482D1
Authority
DE
Germany
Prior art keywords
tumor tissue
characterization instrument
characterization
instrument
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69414482T
Other languages
English (en)
Other versions
DE69414482T2 (de
Inventor
Jerome Johnson Tiemann
Fay Audrey Marks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Application granted granted Critical
Publication of DE69414482D1 publication Critical patent/DE69414482D1/de
Publication of DE69414482T2 publication Critical patent/DE69414482T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4312—Breast evaluation or disorder diagnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4709—Backscatter

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
DE69414482T 1993-07-23 1994-07-14 Tumorgewebe - Charakterisierungs-Instrument Expired - Fee Related DE69414482T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/095,462 US5349954A (en) 1993-07-23 1993-07-23 Tumor tissue characterization apparatus and method

Publications (2)

Publication Number Publication Date
DE69414482D1 true DE69414482D1 (de) 1998-12-17
DE69414482T2 DE69414482T2 (de) 1999-06-24

Family

ID=22252144

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414482T Expired - Fee Related DE69414482T2 (de) 1993-07-23 1994-07-14 Tumorgewebe - Charakterisierungs-Instrument

Country Status (4)

Country Link
US (1) US5349954A (de)
EP (1) EP0635238B1 (de)
JP (1) JP3568992B2 (de)
DE (1) DE69414482T2 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5627907A (en) * 1994-12-01 1997-05-06 University Of Pittsburgh Computerized detection of masses and microcalcifications in digital mammograms
US5676663A (en) * 1995-11-21 1997-10-14 Kim; David S. Cone biopsy instrument
DE19544501A1 (de) * 1995-11-29 1997-06-05 Boehringer Mannheim Gmbh Vorrichtung für Lichtreflexionsmessungen
US6067372A (en) * 1996-02-22 2000-05-23 University Of Pittsburgh Method and system to enhance robust identification of abnormal regions in radiographs
US6109270A (en) * 1997-02-04 2000-08-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Multimodality instrument for tissue characterization
WO1998042248A2 (en) 1997-03-21 1998-10-01 Dynamics Imaging, Inc. Dynamic-functional imaging of biological objects using a non-rigid object holder
US6587578B2 (en) 1997-03-21 2003-07-01 Dobi Medical Systems, Inc. Dynamic-functional imaging of biological objects using a non-rigid object holder
US6124597A (en) * 1997-07-07 2000-09-26 Cedars-Sinai Medical Center Method and devices for laser induced fluorescence attenuation spectroscopy
US5978695A (en) 1997-08-18 1999-11-02 Lucid Inc. System for imaging mechanically stabilized tissue
US6048359A (en) * 1997-08-25 2000-04-11 Advanced Photodynamic Technologies, Inc. Spatial orientation and light sources and method of using same for medical diagnosis and photodynamic therapy
DE19841217B4 (de) * 1997-10-27 2005-06-16 Applied Photonics Worldwide, Inc., Reno Gerät und Verfahren zur spektroskopischen Analyse von menschlichem oder tierischem Gewebe oder Körperfluiden
US6055451A (en) 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
US6385474B1 (en) 1999-03-19 2002-05-07 Barbara Ann Karmanos Cancer Institute Method and apparatus for high-resolution detection and characterization of medical pathologies
CA2343401C (en) 1998-09-11 2009-01-27 Spectrx, Inc. Multi-modal optical tissue diagnostic system
DE19854291C2 (de) * 1998-11-19 2001-04-26 Werner Schramm Endoskopische Anordnung zum Untersuchen von biologischem Gewebe
US6138046A (en) * 1999-04-20 2000-10-24 Miravant Medical Technologies, Inc. Dosimetry probe
US6167297A (en) * 1999-05-05 2000-12-26 Benaron; David A. Detecting, localizing, and targeting internal sites in vivo using optical contrast agents
AU6894500A (en) * 1999-08-06 2001-03-05 Board Of Regents, The University Of Texas System Optoacoustic monitoring of blood oxygenation
US7006676B1 (en) 2000-01-21 2006-02-28 Medical Optical Imaging, Inc. Method and apparatus for detecting an abnormality within a host medium utilizing frequency-swept modulation diffusion tomography
US6751490B2 (en) * 2000-03-01 2004-06-15 The Board Of Regents Of The University Of Texas System Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit
US6697652B2 (en) * 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
GB0120027D0 (en) * 2001-08-16 2001-10-10 Isis Innovation Spectroscopic breath analysis
US20030045798A1 (en) * 2001-09-04 2003-03-06 Richard Hular Multisensor probe for tissue identification
US6939310B2 (en) * 2001-10-10 2005-09-06 Lifescan, Inc. Devices for physiological fluid sampling and methods of using the same
US6647285B2 (en) 2001-11-29 2003-11-11 The Regents Of The University Of California Optical probe with light fluctuation protection
US7013173B2 (en) * 2001-11-29 2006-03-14 The Regents Of The University Of California Optical probe with reference fiber
US8131332B2 (en) * 2002-04-04 2012-03-06 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence of various sites
WO2003096883A2 (en) * 2002-05-16 2003-11-27 Barbara Ann Karmanos Cancer Institute Combined diagnostic and therapeutic ultrasound system
US7285092B2 (en) 2002-12-18 2007-10-23 Barbara Ann Karmanos Cancer Institute Computerized ultrasound risk evaluation system
US20040077951A1 (en) * 2002-07-05 2004-04-22 Wei-Chiang Lin Apparatus and methods of detection of radiation injury using optical spectroscopy
US6926672B2 (en) * 2002-12-18 2005-08-09 Barbara Ann Karmanos Cancer Institute Electret acoustic transducer array for computerized ultrasound risk evaluation system
US6837854B2 (en) * 2002-12-18 2005-01-04 Barbara Ann Karmanos Cancer Institute Methods and systems for using reference images in acoustic image processing
US7806827B2 (en) * 2003-03-11 2010-10-05 General Electric Company Ultrasound breast screening device
US20040249268A1 (en) 2003-03-17 2004-12-09 Da Silva Luiz B. Optical biopsy system with single use needle probe
EP1620002B1 (de) * 2003-04-24 2012-01-04 The Board Of Regents, The University Of Texas System Nichtinvasive blutanalyse durch optische sondierung der venen unter der zunge
WO2005032342A2 (en) * 2003-09-30 2005-04-14 Vanderbilt University Methods and apparatus for optical spectroscopic detection of cell and tissue death
US20050190982A1 (en) * 2003-11-28 2005-09-01 Matsushita Electric Industrial Co., Ltd. Image reducing device and image reducing method
US20070287897A1 (en) * 2004-01-23 2007-12-13 Gregory Faris Optical Vascular Function Imaging System and Method for Detection and Diagnosis of Cancerous Tumors
ATE540610T1 (de) * 2004-06-07 2012-01-15 James Schellenberg System und mikrokathetervorrichtungen für die medizinische bilddarstellung der brust
US8548570B2 (en) * 2004-11-29 2013-10-01 Hypermed Imaging, Inc. Hyperspectral imaging of angiogenesis
US8224425B2 (en) * 2005-04-04 2012-07-17 Hypermed Imaging, Inc. Hyperspectral imaging in diabetes and peripheral vascular disease
WO2006058306A2 (en) 2004-11-29 2006-06-01 Hypermed, Inc. Medical hyperspectral imaging for evaluation of tissue and tumor
JP4423421B2 (ja) * 2004-12-01 2010-03-03 国立大学法人浜松医科大学 エバネッセントカテーテルシステム
EP1895891B1 (de) * 2005-03-10 2013-07-24 BABCHENKO, Anatoly Optischer sensor
WO2006107947A2 (en) 2005-04-04 2006-10-12 Hypermed, Inc. Hyperspectral imaging in diabetes and peripheral vascular disease
US8971984B2 (en) * 2005-04-04 2015-03-03 Hypermed Imaging, Inc. Hyperspectral technology for assessing and treating diabetic foot and tissue disease
US7962198B2 (en) * 2005-04-27 2011-06-14 The Trustees Of Dartmouth College System and method for spectral-encoded high-rate hemodynamic tomography
WO2006116672A2 (en) * 2005-04-27 2006-11-02 The Trustees Of Dartmouth College Systems and methods for tomographic image reconstruction
US8855738B2 (en) * 2005-08-18 2014-10-07 University Of Rochester Acoustically induced blood stasis and in vivo optical spectroscopy
CN101553162A (zh) * 2006-12-06 2009-10-07 皇家飞利浦电子股份有限公司 获取光学组织特性
US8870771B2 (en) * 2007-05-04 2014-10-28 Barbara Ann Karmanos Cancer Institute Method and apparatus for categorizing breast density and assessing cancer risk utilizing acoustic parameters
US10201324B2 (en) 2007-05-04 2019-02-12 Delphinus Medical Technologies, Inc. Patient interface system
US20110106113A1 (en) * 2007-07-13 2011-05-05 The Brigham And Women's Hospital, Inc. System and method for hernia mesh fixation
US20090287427A1 (en) * 2008-05-16 2009-11-19 Lockheed Martin Corporation Vision system and method for mapping of ultrasonic data into cad space
US20090287450A1 (en) * 2008-05-16 2009-11-19 Lockheed Martin Corporation Vision system for scan planning of ultrasonic inspection
US8206315B2 (en) * 2008-09-30 2012-06-26 Suros Surgical Systems, Inc. Real-time pathology
EP2389098A1 (de) * 2009-01-23 2011-11-30 Koninklijke Philips Electronics N.V. Für mindestens partiellen einsatz in einem trüben medium konfiguriertes optisches untersuchungsgerät
EP2391292B1 (de) * 2009-01-30 2017-01-04 Koninklijke Philips N.V. Untersuchungsgerät
AU2010241557B2 (en) * 2009-04-29 2014-05-22 Pharmacophotonics, Inc. Self-puncturing percutaneous optical sensor for optical sensing of intravascular fluid
FR2948007B1 (fr) 2009-07-20 2012-06-08 Chab Lama Al Sonde a aiguille fibree tranchante pour le diagnostic optique en profondeur de tumeurs.
US8369915B2 (en) * 2009-11-06 2013-02-05 Wisconsin Alumni Research Foundation Integrated miniaturized fiber optic probe
JP2013519454A (ja) 2010-02-12 2013-05-30 デルフィヌス メディカル テクノロジーズ，インコーポレイテッド 組織の病的反応を治療計画に特徴づける方法
WO2011100697A1 (en) 2010-02-12 2011-08-18 Delphinus Medical Technologies, Inc. Method of characterizing tissue of a patient
CN102985009B (zh) 2010-06-28 2016-08-17 皇家飞利浦电子股份有限公司 医学断层合成系统
US9763641B2 (en) 2012-08-30 2017-09-19 Delphinus Medical Technologies, Inc. Method and system for imaging a volume of tissue with tissue boundary detection
WO2014133500A1 (en) * 2013-02-27 2014-09-04 Empire Technology Development Llc Diagnostic needle probe
US10123770B2 (en) 2013-03-13 2018-11-13 Delphinus Medical Technologies, Inc. Patient support system
US10143443B2 (en) 2014-05-05 2018-12-04 Delphinus Medical Technologies, Inc. Method for representing tissue stiffness
DE102014107342B4 (de) 2014-05-24 2023-05-04 Frank Braun Vorrichtung und Verfahren zur Erkennung von Krebstumoren und anderen Gewebeveränderungen
US10743837B2 (en) 2014-08-04 2020-08-18 Delphinus Medical Technologies, Inc. Ultrasound waveform tomography method and system
US10285667B2 (en) 2014-08-05 2019-05-14 Delphinus Medical Technologies, Inc. Method for generating an enhanced image of a volume of tissue
EP3185783B1 (de) * 2014-08-28 2019-11-13 Koninklijke Philips N.V. Seitensicht-lungenbiopsievorrichtung

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58143243A (ja) * 1982-02-19 1983-08-25 Minolta Camera Co Ltd 非観血式血中色素測定装置
US4566438A (en) * 1984-10-05 1986-01-28 Liese Grover J Fiber-optic stylet for needle tip localization
US5167686A (en) * 1985-03-06 1992-12-01 C. R. Bard, Inc. Catheter system for controlled removal by radiant energy of biological obstructions
US5199431A (en) * 1985-03-22 1993-04-06 Massachusetts Institute Of Technology Optical needle for spectroscopic diagnosis
US5078150A (en) * 1988-05-02 1992-01-07 Olympus Optical Co., Ltd. Spectral diagnosing apparatus with endoscope
US5036853A (en) * 1988-08-26 1991-08-06 Polartechnics Ltd. Physiological probe
US5092331A (en) * 1989-01-30 1992-03-03 Olympus Optical Co., Ltd. Fluorescence endoscopy and endoscopic device therefor
US5048524A (en) * 1989-03-03 1991-09-17 Camino Laboratories, Inc. Blood parameter measurement
US5078142A (en) * 1989-11-21 1992-01-07 Fischer Imaging Corporation Precision mammographic needle biopsy system
US5127408A (en) * 1990-09-14 1992-07-07 Duke University Apparatus for intravascularly measuring oxidative metabolism in body organs and tissues
US5280788A (en) * 1991-02-26 1994-01-25 Massachusetts Institute Of Technology Devices and methods for optical diagnosis of tissue
JPH04106748U (ja) * 1991-02-28 1992-09-14 株式会社島津製作所 光生体計測装置
US5318023A (en) * 1991-04-03 1994-06-07 Cedars-Sinai Medical Center Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle

Also Published As

Publication number Publication date
EP0635238A1 (de) 1995-01-25
EP0635238B1 (de) 1998-11-11
JPH07163551A (ja) 1995-06-27
US5349954A (en) 1994-09-27
DE69414482T2 (de) 1999-06-24
JP3568992B2 (ja) 2004-09-22

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