DE69406382D1 - Verfahren zur Herstellung von N-Phenyl-N-(4-Piperidinyl)Amid-Derivaten - Google Patents
Verfahren zur Herstellung von N-Phenyl-N-(4-Piperidinyl)Amid-DerivatenInfo
- Publication number
- DE69406382D1 DE69406382D1 DE69406382T DE69406382T DE69406382D1 DE 69406382 D1 DE69406382 D1 DE 69406382D1 DE 69406382 T DE69406382 T DE 69406382T DE 69406382 T DE69406382 T DE 69406382T DE 69406382 D1 DE69406382 D1 DE 69406382D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- piperidinyl
- phenyl
- amide derivatives
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- LKRMTUUCKBQGFO-UHFFFAOYSA-N n-phenylpiperidin-4-amine Chemical class C1CNCCC1NC1=CC=CC=C1 LKRMTUUCKBQGFO-UHFFFAOYSA-N 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939316863A GB9316863D0 (en) | 1993-08-13 | 1993-08-13 | Chemical process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69406382D1 true DE69406382D1 (de) | 1997-11-27 |
| DE69406382T2 DE69406382T2 (de) | 1998-02-26 |
Family
ID=10740452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69406382T Expired - Lifetime DE69406382T2 (de) | 1993-08-13 | 1994-08-11 | Verfahren zur Herstellung von N-Phenyl-N-(4-Piperidinyl)Amid-Derivaten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5599938A (de) |
| EP (1) | EP0638554B1 (de) |
| JP (1) | JP3429370B2 (de) |
| AT (1) | ATE159519T1 (de) |
| DE (1) | DE69406382T2 (de) |
| DK (1) | DK0638554T3 (de) |
| ES (1) | ES2109595T3 (de) |
| GB (1) | GB9316863D0 (de) |
| GR (1) | GR3025213T3 (de) |
| SG (1) | SG52444A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5866591A (en) * | 1996-09-11 | 1999-02-02 | Glaxo Wellcome Inc. | Stable formulations of remifentanil |
| CN101312949A (zh) * | 2005-11-17 | 2008-11-26 | 马林克罗特公司 | 合成瑞芬太尼的方法 |
| CA2637951A1 (en) * | 2006-01-24 | 2007-08-02 | Brian K. Cheng | Process for synthesizing remifentanil |
| EP3199523B1 (de) | 2016-01-29 | 2018-08-15 | Bioka s. r.o. | Das neue verfahren zur herstellung von n-phenyl-n- (4-piperidinyl) amid-derivate wie remifentanil und carfentanil |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179569A (en) * | 1975-03-14 | 1979-12-18 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-N-phenylamides |
| US3998834A (en) * | 1975-03-14 | 1976-12-21 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-n-phenylamides and -carbamates |
| US4584303A (en) * | 1984-04-09 | 1986-04-22 | The Boc Group, Inc. | N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds |
| US5019583A (en) * | 1989-02-15 | 1991-05-28 | Glaxo Inc. | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
-
1993
- 1993-08-13 GB GB939316863A patent/GB9316863D0/en active Pending
-
1994
- 1994-08-09 US US08/287,910 patent/US5599938A/en not_active Expired - Lifetime
- 1994-08-11 ES ES94202304T patent/ES2109595T3/es not_active Expired - Lifetime
- 1994-08-11 JP JP18867594A patent/JP3429370B2/ja not_active Expired - Lifetime
- 1994-08-11 AT AT94202304T patent/ATE159519T1/de active
- 1994-08-11 DK DK94202304.5T patent/DK0638554T3/da active
- 1994-08-11 EP EP94202304A patent/EP0638554B1/de not_active Expired - Lifetime
- 1994-08-11 SG SG1996004614A patent/SG52444A1/en unknown
- 1994-08-11 DE DE69406382T patent/DE69406382T2/de not_active Expired - Lifetime
-
1997
- 1997-10-29 GR GR970402850T patent/GR3025213T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2109595T3 (es) | 1998-01-16 |
| US5599938A (en) | 1997-02-04 |
| DE69406382T2 (de) | 1998-02-26 |
| JP3429370B2 (ja) | 2003-07-22 |
| EP0638554B1 (de) | 1997-10-22 |
| EP0638554A1 (de) | 1995-02-15 |
| GR3025213T3 (en) | 1998-02-27 |
| JPH07165713A (ja) | 1995-06-27 |
| SG52444A1 (en) | 1998-09-28 |
| ATE159519T1 (de) | 1997-11-15 |
| GB9316863D0 (en) | 1993-09-29 |
| DK0638554T3 (da) | 1998-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |